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Loss of Klk5 expression reverses skin and whisker anomalies in Spink5-/- mice.

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posted on 2015-09-21, 03:15 authored by Laetitia Furio, Georgios Pampalakis, Iacovos P. Michael, Andras Nagy, Georgia Sotiropoulou, Alain Hovnanian

(A) Macroscopic appearance of wt, Spink5-/-, Klk5-/-, Spink5-/-Klk5-/- mice. Photos were taken 30 h after birth for wt, Klk5-/- and Spink5-/-Klk5-/- mice and 5 h for Spink5-/- mice; (B) Microscopic appearance of muzzle area (scale bar 1mm) and (C) whisker ultrastructure by scanning electron microscopy (SEM). Scale bar, 10μm.

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    PLOS Genetics

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    Netherton Syndrome Netherton Syndromeelectron microscopy analysesKlk 5 knockoutNS phenotypeSPINK 5 encodingKlk 5 deletioninflammationhair shaft defectsLEKTI deficiency resultsLEKTI serine protease inhibitorKlk 7 protease activitiesautosomal recessive skin diseaseskin barrier defectepidermal Klk 5KLK 5 Inactivation Reverses Cutaneous HallmarksKLK 5 inhibitionSpinkela17aKlk 5

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