Figure_4.tif (3.02 MB)
Keratin deficient and wild-type KRAS driven lung tumors have comparable rates of proliferation and apoptosis.
figure
posted on 2013-03-12, 08:50 authored by Katharina König, Lydia Meder, Cornelia Kröger, Linda Diehl, Alexandra Florin, Ursula Rommerscheidt-Fuss, Philip Kahl, Eva Wardelmann, Thomas M. Magin, Reinhard Buettner, Lukas C. Heukamp(A) Ki-67 immunohistochemistry of a KII −/− deficient tumor (compare figure 5 from the same series of serial sections). (B) Formal analysis of 6 areas per lung of six Keratin wild-type and KII −/− tumors reveals similar Ki-67 proliferation index. Cleaved caspase 3 staining only showed single positive cells (red arrow) in in Keratin deficient (−/−) and Keratin expressing tumors (KII).
