Insulation and facilitation strength depends on enhancer-promoter positions.

(A) Insulation (left) and facilitation (right) as a function of E-P genomic distance. For insulation, enhancer position remains fixed. For facilitation, an E-P pair is positioned symmetrically around the loop at each genomic distance. (B) Insulation for different positions of the enhancer within the loop with a constant genomic distance of 50 kb.