Table_1.xls (5.5 kB)
Inhibition of huPA-H99Y and huPA-H99Y exosite mutants by mupain-1 variants.
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posted on 2014-12-29, 20:16 authored by Baoyu Zhao, Peng Xu, Longguang Jiang, Berit Paaske, Tobias Kromann-Hansen, Jan K. Jensen, Hans Peter Sørensen, Zhuo Liu, Jakob T. Nielsen, Anni Christensen, Masood Hosseini, Kasper K. Sørensen, Niels Christian Nielsen, Knud J. Jensen, Mingdong Huang, Peter A. AndreasenThe Ki values (in µM) for inhibition of the indicated enzymes by the indicated peptides at 37°C are shown as means ± S.D; the numbers of determinations are indicated in parentheses. *These values are reproduced from previous publications [Andersen et al., 2008; Hosseini et al., 2011] and shown here to facilitate comparison.
Inhibition of huPA-H99Y and huPA-H99Y exosite mutants by mupain-1 variants.
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affinity bindingCyclic Peptidic Serine Protease InhibitorP 1 Argmurinepeptidesurface plasmon resonance analysisS 1 specificity pocketP 1 residuescarbonyl group aligningproteasemutagenesitypeArg 6 insertsnmrexosite interactionsinhibitornovel Arg analoguesPeptide Flexibility PeptidesupaCPAYSRYLDCvariant
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