Growth curves of the HeLa tumors and CNE2 tumors of a large size treated with KR-E. coli.

The black line indicates the volume change of tumors injected with E. coli that expressed no KillerRed. The red dotted line indicates the volume change of CNE2 tumors (volume = 150 mm³) injected with E. coli that expressed KillerRed. The red full line indicates the volume change of HeLa tumors injected with E. coli that expressed KillerRed. All tumors were irradiated at the same dose on the day 7. Before treatment, ^♦p > 0.05 (rank sum test), error bars indicate SEM. After treatment, *P< 0.01 (rank sum test), error bars indicate SEM.