Figure_4.tif (2.7 MB)

Failure in synaptic plasticity in adult PLB1 mice.

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posted on 2011-11-11, 01:09 authored by Bettina Platt, Benjamin Drever, David Koss, Sandra Stoppelkamp, Amar Jyoti, Andrea Plano, Aneli Utan, Georgina Merrick, Duncan Ryan, Valeria Melis, Hong Wan, Marco Mingarelli, Emanuele Porcu, Louise Scrocchi, Andy Welch, Gernot Riedel

Electrophysiological characterisation in the CA1 region of hippocampal slices from PLB1_Triple and PLB1_WT mice at 3, 6 and 12 months. A: Input-output relationships of basic synaptic transmission (fEPSP slope vs. stimulus intensity; mean+SEM) were not affected in PLB1_Triple mice. B: LTP time courses (fEPSP slope as % of baseline, +/− SEM) revealed a significant impairment at 6 and 12 months (genotype effect (P<0.05) and genotype x time interaction (P<0.001)). Arrow: time point of tetanisation. C: Reduced paired-pulse facilitation was uncovered in PLB1_Triple mice at 6 and 12 months, but not in PS1 animals and 3-month old PLB1_Triple. Data (mean+SEM) are expressed as the slope ratio (S2/S1) vs. inter-stimulus interval (ISI). Significances are indicated as *: P<0.05; **: P<0.01; ***: P<0.001.