Evaluation of human mesenchymal-epithelial transition (MET) gene copy number in the selected studies.

NA: not available; NSCLC, non-small cell lung cancer; ADC, adenocarcinoma; SCC, squamous cell carcinoma; RT-PCR, real-time polymerase chain reaction; FISH, fluorescent in situ hybridization; SISH, silver in situ hybridization; BISH, bright-field in situ hybridization; IHC, immunohistochemistry; Cappuzzo scoring system: MET FISH-positive group was defined mean MET gene copy number≥5 copies per cell; UCCC criteria: the University of Colorado Cancer Center) criteria, MET gene status was classified into two groups according to the frequency of tumor cells with specific copy numbers of the MET gene and the chromosome 7 centromere: FISH-positive MET MET to CEP7 ratio ≥2; >15 copies of the MET signals in >10% of tumor cells; small gene cluster [4–10 copies]; or innumerable tight gene clusters in >10% the tumor cells); EGFR, epidermal growth factor receptor; HR: hazard ratio, obtained by estimated (E) or reported in text (R). “M” means the HR come from multivariate analysis, and “U” means HR come from univariate analysis.