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Effects of olmesartan on protein expression of angiotensin converting enzyme (ACE) isoforms and angiotensin II type 1 (AT1) receptor.

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posted on 2014-08-29, 03:14 authored by Naoko Matsushita, Toshihide Kashihara, Hisashi Shimojo, Satoshi Suzuki, Tsutomu Nakada, Yasuchika Takeishi, Ulrike Mende, Eiichi Taira, Mitsuhiko Yamada, Atsushi Sanbe, Masamichi Hirose

Expression of ACE (A), ACE2 (B), and AT1 receptor (C) in NTG, Gαq-TG, and Gαq-TG+olmesartan hearts. ACE isoform expression was normalized to actin expression and is expressed relative to NTG (set at 1). AT1 receptor was normalized to GAPDH and is expressed relative to NTG (set at 1). Data are the mean ± SE obtained from 6 mice for each group. Mice at the age of 32 weeks were used.

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    arrhythmia32 weeksangiotensin II type 1G αq mouse modelHeart failuredecrease ACE expressionsmhcChronic olmesartan administrationgeneangiotensin II type 1 receptor activationtrpcGalpha q Causes Angiotensin II Type 1 Receptor ActivationctgfNTG mouse ventriclesTransgenic Mice BackgroundTransgenic miceanpbnpG αq exhibtProgressive Heart Failureconstitutivelyqt

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