Cerebral malaria in mice deficient for NADPH oxidase or SOD1 or in the presence of DETC or DPI.

Plasmodium berghei Anka parasitized red blood cells (10⁶) were injected intraperitoneally (i.p.) into A, mice knocked out (KO) for NADPH oxidase or controls (n = 8). B, An aliquot of blood was collected at day 6 to determine parasitemia. C, P. berghei Anka infection of mice KO for SOD1 (n = 8). D, An aliquot of blood was collected at day 6 to determine parasitemia. E, P. berghei Anka infection of mice treated with SOD inhibitor, DETC (100 µL, 50 mg/Kg) (n = 10). F, An aliquot of blood was collected at day 6 to determine parasitemia. G, P. berghei Anka infection of mice treated with NADPH oxidase inhibitor, DPI (100 µl, 2 mg/Kg)(n = 10). H, An aliquot of blood was collected at day 6 to determine parasitemia. *, P≤0.05 (Log-rank test). NS, non-significant.