Brivanib decreases the transcription of growth factors and their receptors in carbon tetrachloride.

Hepatic levels of growth factors and growth factor receptor mRNA were measured by real time PCR in sham and CCl₄ mice treated with no brivanib or with brivanib 25 mg/kg, 50 mg/kg, or 100 mg/kg. In all of the sham experiments, higher concentrations of brivanib decreased the mRNA levels of the growth factors and their receptors. (A) mRNA levels of PDGFB are not affected by brivanib treatment in CCl₄. (B) mRNA levels of PDGFRB decrease as the concentration of brivanib increases in CCl₄. (C) mRNA levels of TGFB1 decrease as the concentration of brivanib increases in CCl₄. (D) mRNA levels of TGFBR2 are lower in brivanib-treated CCl₄ mice compared to no brivanib. (E) mRNA levels of FGF2 are not affected by brivanib treatment in CCl₄. (F) mRNA levels of FGFR2 are lower in brivanib-treated CCl₄ mice compared to no brivanib. (G, H) mRNA levels of VEGFA and VEGFR2 decrease as the concentration of brivanib increases in CCl₄ mice.