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Box plots showing [18F]FDG accumulation in the coronary arteries by autoradiography (A), ex vivo biodistribution analysis (B) or in vivo dual-gated PET/CT imaging (C).

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posted on 2015-06-29, 03:36 authored by Miikka Tarkia, Antti Saraste, Christoffer Stark, Tommi Vähäsilta, Timo Savunen, Marjatta Strandberg, Virva Saunavaara, Tuula Tolvanen, Jarmo Teuho, Mika Teräs, Olli Metsälä, Petteri Rinne, Ilkka Heinonen, Nina Savisto, Mikko Pietilä, Pekka Saukko, Anne Roivainen, Juhani Knuuti

Panel A shows [18F]FDG accumulation as an average plaque-to-normal vessel wall ratio as measured by autoradiography at the sites of normal vessel wall, intimal thickening or atheroma. Panel B shows average segmental [18F]FDG accumulation normalized to blood radioactivity in the segments without atherosclerosis, intimal thickening or atheroma plaques. Panel C shows segmental in vivo [18F]FDG signal as the highest target-to-background ratio (TBR) in the segments without atherosclerosis, intimal thickening or atheroma plaques.

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    uptakearteryatheroma type plaquesstage lesions16 segmentsatherosclerosis progressionCoronary segmentsEx vivopig modelratiotbrvessel wall6 monthsatherosclerotic lesions10 segmentsfarm pigsvivo PET imagingatherosclerotic inflammationPigs ObjectiveInflammationCoronary Atherosclerotic Lesionsargpig model.MethodsFirst3 daysvivo measurement

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