Fig_3.tif (373.3 kB)
Bisulfite sequencing of hMLH1 promoter at tissue level.
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posted on 2015-05-04, 04:23 authored by Sanmitra Basu, Subhadipa Majumder, Ankur Bhowal, Alip Ghosh, Sukla Naskar, Sumit Nandy, Subhabrata Mukherjee, Rajan Kumar Sinha, Keya Basu, Dilip Karmakar, Soma Banerjee, Sanghamitra Sengupta(a) and (b) A ball and stick model showing differential methylation of 20 CpG sites in hMLH1 promoter region spanning 200 bp (-766 to -566) under study in prostate cancer and BPH tissues. The grey balls represent unmethylated CpG and black balls represent methylated CpG in the string of DNA sequence. (c) Bar diagram comparing the proportion of methylation of 15 differentially modified CpGs in 50 tissues (prostate cancer: n = 25) and (BPH: n = 25). (d) Bar diagram showing elevated expression of DNMT1 and DNMT3b genes in prostate cancer compared to BPH patients at mRNA level. * indicates P <0.05.
