Fig_6.tif (1.41 MB)

Biodistribution and dosimetry.

figure

posted on 2015-06-11, 03:20 authored by Ada H. V. Repetto-Llamazares, Roy H. Larsen, Sebastian Patzke, Karianne G. Fleten, David Didierlaurent, Alexandre Pichard, Jean Pierre Pouget, Jostein Dahle

(A) Uptake of ¹⁷⁷Lu-HH1 (N = 6–8), ¹⁷⁷Lu-rituximab (N = 4–5), ¹⁷⁷Lu-IgG1 control (N = 5) in selected organs/tissues from nude mice with Ramos xenografts in percentage of injected activity per gram of tissue (%IA/g). Error bars = standard error. *: Significantly different from ¹⁷⁷Lu-HH1 (One-way ANOVA with Holm Sidak method for multiple comparisons, p < 0.05). (B) Dose rate per MBq of injected activity in selected organs of nude mice with Ramos xenografts treated with ¹⁷⁷Lu-HH1 (N = 6–8) and ¹⁷⁷Lu-rituximab (N = 4–5). (C) In vivo SPECT/CT multiplanar rendered view of a nude mouse with a Ramos xenograft in its right flank injected with 10 MBq of ¹⁷⁷Lu-HH1.