Beta-diversity (unweighted).

(A) NMDS plot based on unweighted (left) unifrac distance matrix of rarefied OTUs to 10,011 sequences. Samples treated with PMA prior to DNA extraction are indicated by a plus symbol. CCR: controlled cleanroom. UAF: uncontrolled adjoining facility. Variances are explained per each axis (NMDS1 and NMDS2, Stress = 0.06). (B) Distance based comparison heatmap combined with a hierarchical cluster analysis based on average neighbor (HCAN) of unweighted unifrac distances. Dissimilarity of samples is indicated by a color gradient from blue (similar) via white to red (dissimilar). Samples treated with PMA prior to DNA extraction are indicated by a plus symbol. CCR: controlled cleanroom. UAF: uncontrolled adjoining facility.