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Analysis of mRNA expression, the histone code enrichment profiles of the MEOX2 and TWIST1 promoters and survival in NSCLC patients.

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posted on 2014-12-02, 03:36 authored by Federico Ávila-Moreno, Leonel Armas-López, Aldo M. Álvarez-Moran, Zoila López-Bujanda, Blanca Ortiz-Quintero, Alfredo Hidalgo-Miranda, Francisco Urrea-Ramírez, R. María Rivera-Rosales, Eugenia Vázquez-Manríquez, Erika Peña-Mirabal, José Morales-Gómez, Juan C. Vázquez-Minero, José L. Téllez-Becerra, Roberto Ramírez-Mendoza, Alejandro Ávalos-Bracho, Enrique Guzmán de Alba, Karla Vázquez-Santillán, Vilma Maldonado-Lagunas, Patricio Santillán-Doherty, Patricia Piña-Sánchez, Joaquin Zúñiga-Ramos

(A) MEOX2 expression in NSCLC and the LNAT-derived samples, and (B) TWIST1 expression in NSCLC and the LNAT-derived samples. Error bars represent standard errors of the mean of three replicates. (C) Histone modification enrichment profile of the MEOX2 promoter sequence. (D) Histone modification enrichment profile of the TWIST1 promoter sequence. Box plots represent the mean of three replicates. The analysis revealed a correlation between low mRNA expression and H3K27me3 enrichment. (E) Survival curve analyses based on Log-Rank (Mantel Cox) and Gehan-Breslow-Wilcoxon tests of the relative expression index of MEOX2 plus TWIST1 (p≤0.0027).