Figure_2.tif (1.19 MB)
3D off-lattice simulation confined to a 2D surface: small intestinal crypts and villus.
figure
posted on 2013-03-15, 09:01 authored by Gary R. Mirams, Christopher J. Arthurs, Miguel O. Bernabeu, Rafel Bordas, Jonathan Cooper, Alberto Corrias, Yohan Davit, Sara-Jane Dunn, Alexander G. Fletcher, Daniel G. Harvey, Megan E. Marsh, James M. Osborne, Pras Pathmanathan, Joe Pitt-Francis, James Southern, Nejib Zemzemi, David J. GavaghanLeft: cells are labelled according to their ancestor cell; each crypt gives rise to a monoclonal population, with a multiclonal villus comprised of cells from each crypt. Right: the same simulation, here with cells labelled according to Delta levels (non-dimensionalised); Delta-Notch patterning occurs due to a signalling model inside each cell, which depends on the activity of neighbouring cells, and is thought to lead to differentiation into secretory and absorbative cell types. See also Video S2.
