Synthesis, structure, urease inhibitory, and cytotoxic activities of two complexes with protocatechuic acid derivative and phenanthroline

Sheng, Gui-Hua; Zhou, Quan-Cheng; Hu, Xiao-Ming; Wang, Cun-Fang; Chen, Xiang-Fei; Xue, Di; Yan, Kai; Ding, Shuang-Shuang; Wang, Juan; Du, Zhi-Yun; Liu, Zhi-Hai; Zhang, Chun-Yang; Zhu, Hai-Liang

doi:10.6084/m9.figshare.1320703.v3

gcoo_a_1023718_sm6468.doc (181.5 kB)

Synthesis, structure, urease inhibitory, and cytotoxic activities of two complexes with protocatechuic acid derivative and phenanthroline

Version 3 2015-04-24, 17:35

Version 2 2015-04-24, 17:35

Version 1 2015-04-24, 17:35

journal contribution

posted on 2015-04-24, 17:35 authored by Gui-Hua Sheng, Quan-Cheng Zhou, Xiao-Ming Hu, Cun-Fang Wang, Xiang-Fei Chen, Di Xue, Kai Yan, Shuang-Shuang Ding, Juan Wang, Zhi-Yun Du, Zhi-Hai Liu, Chun-Yang Zhang, Hai-Liang Zhu

Two complexes, [Cu^II(L¹)(phen)₂](ClO₄) (1) and [Ni^II₂(L¹)₂(phen)₂(MeOH)₂](ClO₄)₂ (2), with HL¹, a ligand derived from protocatechuic acid (=2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid) and phen (=1,10-phenanthroline) were synthesized and characterized by C, H, and N elemental analysis, UV–vis, FT-IR, and single-crystal X-ray diffraction, which revealed that 1 is mononuclear and 2 is dinuclear. Both complexes crystallized in monoclinic space group C2/c. The urease inhibitory activity and in vitro cytotoxic activity of 1 and 2 were tested. The complexes showed strong inhibitory activity against jack bean urease and significantly suppressed the growth of A549, L929, and SW620 cell lines.