Nutrient-dependent / Pheromone–controlled thermodynamics and thermoregulation

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Kohl, James V. (2013): Nutrient-dependent / Pheromone–controlled thermodynamics and thermoregulation. figshare.
http://dx.doi.org/10.6084/m9.figshare.643393
Retrieved 15:44, Sep 18, 2014 (GMT)

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Natural selection for nutrients results in their metabolism to pheromones that control reproduction in species from microbes to man. In some species, sex differences in pheromones enable sexual selection. Using what is known about the molecular mechanisms common to species from microbes to man, an argument can be made from biological facts that extends to non-random nutrient-dependent pheromone-controlled adaptive evolution. This biological-based argument can be compared to arguments that might be made to support a cosmological / mathematical argument for random mutations theory.

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  • Kohl, JV (2013)  Nutrient--dependent / pheromone--controlled adaptive evolution: a model
    Socioaffective Neuroscience & Psychology, 3: 20553

    For additional support see miR-124 controls male reproductive success in Drosophila, which extends the concept of nutrient-dependent pheromone-controlled alternative splicings to adaptive evolution in invertebrates and vertebrates via conserved molecular mechanisms.

    For an alternative approach that incorporates mutations theory see: Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin

    Note, however, that the role of nutrient-dependent alternative splicings in sexual differentiation is fully supported by the report on Drosophilia, which refutes mutations theory as indicated in our 1996 review: From Fertilization to Adult Sexual Behavior (excerpted below).

    "Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes."

    14/06/2013    by J. Kohl

  • "Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills"

    Excerpt: "Our findings imply that a critical role for the oxytocin system in social recognition has been conserved across perceptual boundaries through evolution, from olfaction in rodents to visual memory in humans."

    Apparently, Larry Young is very close to admitting that ecological adaptation is nutrient-dependent and pheromone-controlled in all vertebrate. I wonder if he will acknowledge the history of my published works that led to my conclusions about the role of base pair flipping, alternative splicings of pre-mRNA, and amino acid substitutions that differentiate cell types in indivduals of all species. Alternatively, he may still be annoyed because he couldn't answer my question about how the sensory environment of any mammal could directly effect hormone secetion sans conditioned responses to olfactory/pheromonal input. But now, more than a decade later, in his latest work, it appears that we may be seeing him acknowledge the biological basis of exogenous oxytocin's affects, and why they vary.

    Excerpt: "Should we anticipate a problem with brain-directed social behavior in children of mother’s who adopt the new dietary choline recommendation? Could additional choline epigenetically alter brain development and cause too much prenatal synaptogenesis, too little synaptolysis, or altered apoptosis? Could sex differences in the mother–infant bond which are correlated with nutrient intake and pheromone production (Nguyen, Gesquiere, Alberts, & Altmann, 2012) and with oxytocin secretion (Donaldson & Young, 2008) be altered by a child whose mother ingested too much choline?"

    Does anyone else want to speculate or tell what they already know about other nutrients that may cause ASDs, or tell us why ASDs are now linked to olfaction and face recognition?  What took so long?

    30/12/2013    by J. Kohl

  • Evolutionary history and metabolic insights of ancient mammalian uricases

    Abstract excerpt: "Resurrected proteins reveal that ancestral uricases have steadily decreased in activity since the last common ancestor of mammals gave rise to descendent primate lineages. We were also able to determine the 3D distribution of amino acid replacements as they accumulated during evolutionary history..."

    My comment: This is an important refutation of mutation-driven evolution. It is based on models of climate change and diet change that lead to de novo gene creation, chromosomal rearrangements and nutrient-dependent pheromone-controlled ecological adaptations. The adaptations occur with loss of genes and stabilization of the genome, which is manifested in the nutrient-dependent pheromone-controlled morphological and behavioral phenotypes of different species from microbes to man.

    19/02/2014    by J. Kohl

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