Motesanib diphosphate in progressive differentiated thyroid cancer

None
Share this:
Embed*
Cite this:

Diaz-Cano, Salvador J. (2012): Motesanib diphosphate in progressive differentiated thyroid cancer. figshare.

http://dx.doi.org/10.6084/m9.figshare.97443
Retrieved 09:37, Dec 20, 2014 (GMT)

Description

Sherman et al. (July 3 issue)1 highlight the importance of selecting patients for alternative therapies, such as motesanib diphosphate, in the treatment of progressive differentiated thyroid carcinomas. Although radiographic indings are useful criteria for predicting a response to motesanib, they can be supplemented by the microscopical findings — in particular, growth pattern, necrosis, and desmoplastic reaction — which have been correlated with progression prediction.2 The genotypic alterations described in follicular-cell neoplasms control the mitogen-activated protein (MAP) kinase pathway and proliferation. Was any correlation found with proliferation markers? Which radiographic criteria were used to define progression in metastatic neoplasms? As for tumor progression, it normally refers to the acquisition of invasive capabilities in intraepithelial lesions or metastatic potential in invasive cancers.3

Links

Comments (0)

You must be logged in to post comments.

Cite "Filename"

Place your mouse over the citation text to select it

Embed "Motesanib diphosphate in progressive differentiated thyroid cancer"

Place your mouse over the embed code to select and copy it

Claim article

You claim request was sent. I will be handled in the next 24 hours.

Close window

Feedback

We appreciate all your comments, questions, suggestions or gratitude.

Login

The username or password entered are wrong.

Reset password

Your password will be sent to your registered e-mail address.

Create account

I agree to the Terms & Conditions *