Gki567f2.jpg (57.03 kB)
Conservation patterns of known and predicted human miRNAs
figure
posted on 2011-12-30, 14:53 authored by Yael Altuvia, Pablo Landgraf, Gila Lithwick, Naama Elefant, Sébastien Pfeffer, Alexei Aravin, Michael J. Brownstein, Thomas Tuschl, Hanah MargalitCopyright information:
Taken from "Clustering and conservation patterns of human microRNAs"
Nucleic Acids Research 2005;33(8):2697-2706.
Published online 12 May 2005
PMCID:PMC1110742.
© The Author 2005. Published by Oxford University Press. All rights reserved
The conservation patterns are based on the UCSC phastCons scores (,) (). The chromosomal regions of the miRNAs with an additional 3000 nt flanking on both sides are presented. The chromosomal coordinates follow the build 34 assembly (hg16) of the human genome from UCSC (,) (). For simplicity the -axis displays the relative positions. Known miRNAs are designated by their Rfam name omitting the ‘hsa’ prefix (). The predicted miRNAs that were verified experimentally fall into two categories: (E)-verified experimentally in this study, and (S)-verified by similarity to a homologous miRNA in another organism. The miRNA orientation is marked by an arrow. () known large miRNA cluster; () known miRNA clustered pair; () example of a miRNA prediction that extends a known pair cluster; () reveals a new multi-member cluster; and () reveals a new clustered pair. The plots are not plotted to scale and, therefore, the conserved region width is a function of the length of the presented region; the longer the region, the narrower is the presented profile).