lsyc_a_1061671_sm6102.pdf (419.33 kB)
Concise Synthesis of (±)-Clopidogrel via Carboxylation of Benzylamine with CO2
Version 4 2015-10-08, 12:43
Version 3 2015-10-08, 12:43
Version 2 2015-10-08, 12:43
Version 1 2015-09-17, 00:00
journal contribution
posted on 2015-10-08, 12:43 authored by V. Venkataramasubramanian, Arumugam SudalaiA concise and efficient synthesis of (±)-clopidogrel, an antithrombotic agent, is achieved by inserting CO2 at the benzylic position as the key reaction without using any toxic transition metals. The overall yield of the synthetic process is 38% and the salient features include operationally simple process chemistry and fewer steps.