Aza-Michael reaction of 12-N-carboxamide of (–)-cytisine under high pressure conditions

P. Tsypysheva, Inna; N. Lobov, Alexander; V. Kovalskaya, Alena; R. Petrova, Polina; P. Ivanov, Sergey; A. Rameev, Shamil; S. Borisevich, Sophia; Safiullin, Rustam L.; S. Yunusov, Marat

doi:10.6084/m9.figshare.1210675.v2

gnpl_a_968150_sm2714.doc (27.98 MB)

Aza-Michael reaction of 12-N-carboxamide of (–)-cytisine under high pressure conditions

Version 2 2014-11-05, 10:21

Version 1 2014-11-05, 10:21

journal contribution

posted on 2014-11-05, 10:21 authored by Inna P. Tsypysheva, Alexander N. Lobov, Alena V. Kovalskaya, Polina R. Petrova, Sergey P. Ivanov, Shamil A. Rameev, Sophia S. Borisevich, Rustam L. Safiullin, Marat S. Yunusov

The first example of aza-Michael reaction of 12-N-carboxamide of quinolizidine alkaloid (–)-cytisine with α,β-unsaturated ketones, dimethyl acetylenedicarboxylate and β-nitrostyrene under high pressure condition has been described. It has been shown that the [4+2]-cycloaddition takes place in the case with N-phenylmaleimide.