A new meroterpenoid tatenoic acid from the fungus Neosartorya tatenoi KKU-2NK23

Yim, Tongkheang; Kanokmedhakul, Kwanjai; Kanokmedhakul, Somdej; Sanmanoch, Wareerat; Boonlue, Sophon

doi:10.6084/m9.figshare.1147339.v3

gnpl_a_951353_sm3663.docx (4.4 MB)

A new meroterpenoid tatenoic acid from the fungus Neosartorya tatenoi KKU-2NK23

Version 3 2014-10-20, 14:25

Version 2 2014-10-20, 14:25

Version 1 2014-10-20, 14:25

journal contribution

posted on 2014-10-20, 14:25 authored by Tongkheang Yim, Kwanjai Kanokmedhakul, Somdej Kanokmedhakul, Wareerat Sanmanoch, Sophon Boonlue

A new meroterpenoid, named tatenoic acid (1), was isolated from the fungus Neosartorya tatenoi KKU-2NK23, together with five known compounds, aszonapyrones A and B (2 and 3), aszonalenin (4), ergosterol (5) and d-mannitol (6). Their structures were established on the basis of spectroscopic methods. Aszonapyrones A (2) exhibited antimalarial activity against Plasmodium falciparum, and it also exhibited cytotoxicity against two cancer cell lines, NCI-H187 and KB.