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Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment and breast cancer survival

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modified on 2020-09-15, 16:11
The protein expression of Kaiso and LC3AB profiled by automated analysis of immunohistochemically stained tissue microarrays (TMAs).
The data containing tumors from a cohort of racially diverse breast cancer patients residing in a designated health disparities catchment area of East North Carolina. By this analysis, staining intensity in the nucleus or cytoplasm of each cell in the annotated tumor regions is assigned one of fours scores: from negative staining (0), to weak staining (+1), moderate staining (2+) or strong staining (3+). The percent of cells in the annotated regions demonstrating one of the 4 different intensities are then aggregated to derive an H-score (H-score= 3 x [%3+] + 2 x [%2+] + 1 [%1+]), thus generating a continuous score from 0-300.


The NIH/NCI Cancer Center Support Grant P30CA013696 (K.G.)

U54-MD007585-26 NIH/NIMHD (C.Y.)

U54 CA118623 (NIH/NCI) (C.Y.)

Department of Defense Grant (PC170315P1, W81XWH-18-1-0589 (C.Y)

The Brody School of Medicine Department of Oncology Cancer Research and Education Fund

National Institute of General Medical Sciences of the National Institutes of Health, Award Number U54GM128729.