Daniele et al., Peroxisome regulation in RPE - Supplemental Fig S1.pdf
Fig. S1 Relative expression of key peroxisomal enzymes required for completion of β-oxidation of DHA and other PUFA in various mouse tissues. Microarray expression analysis using the database GSE10246 showing relative expression of Decr2: 2,4, Di-enoyl CoA reductase, Eci2/Peci: Peroxisomal Δ3,Δ2-enoyl-CoA isomerase, and Ech1: Δ3,5Δ2,4-dienoyl-CoA isomerase. Sequential activity of DECR2 and PECI is specifically required after the initial ACOX1- mediated desaturation of CoA esters of PUFA during the first round of β-oxidation in peroxisomes, and prior to subsequent β-oxidation reactions.