Strontium Ranelate Causes Osteophytes Overgrowth in a model of Early Phase Osteoarthritis
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To evaluate the effect of Strontium Ranelate (SR) on cartilage, subchondral bone mass and structure in medial meniscectomized (MNX) guinea pigs. SR (625 mg/kg/day) did not protect cartilage from degeneration in MNX guinea pigs but subchondral bone was significantly enhanced. In early phase OA, SR administration causes osteophyte overgrowth, which may be related to incorporation into mineralizing osteophytes. This adverse effect is important for future studies of SR in OA.