Strontium Ranelate Causes Osteophytes Overgrowth in a model of Early Phase Osteoarthritis
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To
evaluate the effect of Strontium Ranelate (SR) on cartilage, subchondral bone
mass and structure in medial meniscectomized (MNX) guinea pigs. SR
(625 mg/kg/day) did not protect cartilage from degeneration in MNX guinea pigs
but subchondral bone was significantly enhanced. In early phase OA, SR
administration causes osteophyte overgrowth, which may be related to
incorporation into mineralizing osteophytes. This adverse effect is important
for future studies of SR in OA.
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79.34 MB