Data Set - Management and outcomes of severe dengue patients presenting with sepsis in a tropical country

This is a part of prospective observational (non-interventional) study of community-acquired sepsis and severe sepsis in Sunpasithiprasong Hospital, Ubon Ratchathani province, northeast Thailand (NCT02217592). We prospectively enrolled adult patients (age≥18 years) who were admitted with a primary diagnosis of suspected or documented infection made by the attending physician, were within 24 hours of hospital admission, and had at least three sepsis diagnostic criteria documented in the medical record. Blood was stored and later tested for dengue PCR assays.  

The manuscript reports the outcomes of adult dengue patients prior to the completion of the entire sepsis study because we believe that our study would have clinical implications for the management of patients presenting with sepsis in tropical countries where dengue is endemic. 

The fields contained in the database are as follows:

1. id: Unique identifier for each patient

2. gender: The gender of patients. Values are M and F.

3. age_group: Age of the patient. Values are ≥18 - <40 years, ≥40 - <60 years and ≥60 years old 

4. und_diabetes: Whether the patient had underlying disease of diabetes documented in the medical chart. Values are Yes and No.

5. und_hypertension: Whether the patient had underlying disease of hypertension documented in the medical chart. Values are Yes and No.

6. und_kidney_disease: Whether the patient had underlying disease of chronic kidney disease documented in the medical chart. Values are Yes and No.

7. und_others: Whether the patient had underlying disease of other diseases documented in the medical chart. Values are Yes and No.

8. dengue_PCR: Results of dengue PCR assays. Values are DEN1, DEN2, DEN3 and DEN4.

9. mortality28: 28-day mortality outcome. Values are Survived and Died.

10. scr_body_temp: Whether the patient met the SSC diagnostic criteria for sepsis, "Fever or hypothermia (body temperature >38.3oC or <36oC)". Values are Yes, No and N/A. N/A means that the information was not available.

11. scr_heart_rate: Whether the patient met the SSC diagnostic criteria for sepsis, "Heart rate >90/min". Values are Yes, No and N/A. N/A means that the information was not available.

12. scr_respiratory_rate: Whether the patient met the SSC diagnostic criteria for sepsis, "Tachypnoea (Respiratory rate >20/min)". Values are Yes, No and N/A. N/A means that the information was not available.

13. scr_gcs: Whether the patient met the SSC diagnostic criteria for sepsis, "Altered mental status (Glasgow Coma Scale <15 or <10T)". Values are Yes, No and N/A. N/A means that the information was not available in the medical chart at the time of enrollment.

14. scr_significant_edema: Whether the patient met the SSC diagnostic criteria for sepsis, "Significant edema or positive fluid balance". Values are Yes, No and N/A. N/A means that the information was not available.

15. scr_hyperglycemia: Whether the patient met the SSC diagnostic criteria for sepsis, "Hyperglycaemia (PG>140 mg/dL) in the absence of diabetes". Values are Yes, No and N/A. N/A means that the information was not available.

16. scr_wbc: Whether the patient met the SSC diagnostic criteria for sepsis, "Leukocytosis (WBC>12,000 u/L), leukopenia (<4,000 u/L) or immature forms >10%". Values are Yes, No and N/A. N/A means that the information was not available.

17. scr_sbp: Whether the patient met the SSC diagnostic criteria for sepsis, "Arterial hypotension (SBP<90 mmHg, MAP <70 mmHg or SBP drop >40 mmHg)". Values are Yes, No and N/A. N/A means that the information was not available.

18. scr_pulse_oximetry_level: Whether the patient met the SSC diagnostic criteria for sepsis, "Low oxygen saturation (SpO2 <95%) or required mechanical ventilation. Values are Yes, No and N/A. N/A means that the information was not available.

19. scr_creatinine_increase: Whether the patient met the SSC diagnostic criteria for sepsis, "Creatinine increase >0.5 mg/dL". Values are Yes, No and N/A. N/A means that the information was not available.

20. scr_inr: Whether the patient met the SSC diagnostic criteria for sepsis, "Coagulation abnormalities (INR >1.5 or aPTT >60s)". Values are Yes, No and N/A. N/A means that the information was not available.

21. scr_platelet_count: Whether the patient met the SSC diagnostic criteria for sepsis, "Thrombocytopenia (platelet count <100,000/uL)”. Values are Yes, No and N/A. N/A means that the information was not available.

22. scr_total_bilirubin: Whether the patient met the SSC diagnostic criteria for sepsis, "Hyperbilirubinaemia (plasma total bilirubin >4 mg/dL)". Values are Yes, No and N/A. N/A means that the information was not available.

23. scr_hyperlactatemia: Whether the patient met the SSC diagnostic criteria for sepsis, "Hyperlactataemia (>1 mmol/L)". Values are Yes, No and N/A. N/A means that the information was not available.

24. scr_decreased_capillary_refill: Whether the patient met the SSC diagnostic criteria for sepsis, "Decreased capillary refill or mottling". Values are Yes, No and N/A. N/A means that the information was not available.

25. duration_of_sysptoms: Duration of symptoms (days) prior to hospital admission 

26. mx_bolus_recorded: Whether management with bolus intravenous fluid administration was available in the medical chart. Values are Yes and No. 

27. mx_bolus_amount: Total amount of bolus intravenous fluid administration. Values are Yes and No. (if the volume was recorded)

28. mx_inotrope_administration: Whether management with inotrope administration was available in the medical chart. Values are Yes and No.

29. primary_dx_deng: Whether the primary diagnosis included dengue. Values are 1 (Yes) or 0 (No).

30. primary_dx_afi: Whether the primary diagnosis included acute febrile illness or systemic infection. Values are 1 (Yes) or 0 (No).

31: primary_dx_sshock: Whether the primary diagnosis included septic shock. Values are 1 (Yes) or 0 (No).

32: primary_dx_sepsis: Whether the primary diagnosis included sepsis. Values are 1 (Yes) or 0 (No).

33: primary_dx_pneumonia: Whether the primary diagnosis included pneumonia. Values are 1 (Yes) or 0 (No).

34: primary_dx_other: Whether the primary diagnosis did not include dengue, acute febrile illness, systemic infection, septic shock, sepsis and pneumonia. Values are 1 (Yes) or 0 (No).

35: ICD10_Dengue: Whether the final diagnosis included dengue (ICD10 of A90 or A91). Values are 1 (Yes) or 0 (No).

36: ICD10_SShock: Whether the final diagnosis included septic shock (ICD10 of R57.2, R65.1 or R65.21). Values are 1 (Yes) or 0 (No).

37: ICD10_Sepsis: Whether the final diagnosis included sepsis (ICD10 of A41, A41.9 or R65). Values are 1 (Yes) or 0 (No).

38: ICD10_Pneumonia:Whether the final diagnosis included pneumonia (ICD10 of J18). Values are 1 (Yes) or 0 (No).

39: sofa: Total Sequential Organ Failure Assessment (SOFA) Score.