ISCRC dataset: ImmunoScore evaluation in ColoRectal Cancer patients.

In the realm of cancer research, specifically focusing on colorectal carcinomas (CRC), a novel diagnostic test referred to as "Immunoscore" (IS) has emerged. This test relies on assessing the density of tumour-infiltrating lymphocytes (TILs), specifically CD3 and CD8, in both the central area of the tumour (CT) and its invasive margin (IM). Immunoscore holds promise as a potential prognostic factor. A retrospective descriptive study was conducted within the Pathology Department of Habib Thameur Hospital in Tunis. The study's aim was to evaluate the prognostic efficacy of IS for patients with CRC by means of a comprehensive survival analysis.

This publication introduces the ISCRC dataset, which was meticulously compiled during the aforementioned study. The ISCRC dataset comprises digital slide images sourced from biopsies of 104 patients diagnosed with colorectal cancer. Using the Tissue Microarray (TMA) technique, an immunohistochemical investigation involving anti-CD3 and anti-CD8 markers was performed in regions designated as "Hot Spots" within the CT and IM. Each marker's percentage presence within its respective region was quantified. Subsequently, density classifications—"Low" or "High"—were assigned based on a predefined median percentage threshold. The IS was estimated utilizing a semi-quantitative method. The ISCRC dataset encompasses anonymized personal data, along with macroscopic and microscopic attributes.

This openly accessible dataset is poised to play a pivotal role in advancing both computer-aided diagnosis and research endeavours pertaining to colorectal cancer.