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Comorbidity associated with Ascaris suum infection during pulmonary fibrosis exacerbates chronic lung and liver inflammation and dysfunction but does not affect the parasite cycle in mice
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modified on 2019-11-19, 17:39 Ascariasis is
considered the most neglected tropical disease, and is a major problem for the
public health system. However, idiopathic pulmonary fibrosis (IPF) is a result
of chronic extracellular deposition of matrix in the pulmonary parenchyma, and
thickening of the alveolar septa, which reduces alveolar gas exchange.
Considering the high rates of ascariasis and pulmonary fibrosis, we believe
that these two diseases may co-exist and possibly lead to comorbidities. We
therefore investigated the mechanisms involved in comorbidity of Ascaris suum (A. suum) infection, which could interfere with the progression of
pulmonary fibrosis. In addition, we evaluated whether a previous lung fibrosis
could interfere with the pulmonary cycle of A.
suum in mice. The most important findings related
to comorbidity in which A. suum
infection exacerbated pulmonary and liver injury, inflammation and dysfunction, but did not promote excessive fibrosis in
mice during the investigated comorbidity period. Interestingly, we found that
pulmonary fibrosis did not alter the parasite cycle that transmigrated
preferentially through preserved but not fibrotic areas of the lungs.
Collectively, our results demonstrate that A.
suum infection leads to comorbidity, and contributes to the aggravation of
pulmonary dysfunction during pulmonary fibrosis, which also leads to
significant liver injury and inflammation, without changing the A. suum cycle in the lungs.