Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

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modified on 2024-05-06, 20:26

Study assessing systemic mitochondrial function in primary open angle glaucoma, and it's association with the rate of visual field progression.

Three files attached. (1) Main_Paper_Data.csv : this file contains all the raw data including mitochondrial respiration metrics, NAD levels, Visual Field progression data and phenotypic information. (2) ddPCR_data.csv : this file contains the ddPCR raw data. (3)Lymph_Mon_Flowjo.csv : this file contains fluorescence intensity for lymphocytes and monocytes as measured by the MoxiGo II flow cytometer in PBMC.

Funding

This research was funded by Santen SenSyT (PhD Studentship through UCL awarded to D-GH), Fight for Sight (awarded to GL, grant number 5023/5024) , Glaucoma UK (awarded to D-GH, grant number UKEGS 2017/18), Rosetrees Trust (awarded to BP, grand number Seedcorn2020\100118), Alcon Research Institute (awarded to D-GH) and supported by the National Institute for Health and Care Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

Keywords

Glaucoma Mitochondria nicotinamid adenine dinucleotide mitochondrial respiration

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CC BY 4.0

Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

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