Data supporting "Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making"

Download all (153.95 GB) This item is shared privately
modified on 2023-01-27, 18:44

We used genetic and retrograde labeling to target pyramidal tract (PT), intratelencephalic (IT) and corticostriatal projection neurons and measured their cortex-wide activity. Each PyN type drove unique neural dynamics, both at the local and cortex-wide scale. Cortical activity and optogenetic inactivation during an auditory decision task revealed distinct functional roles. All PyNs in parietal cortex were recruited during perception of the auditory stimulus, but, surprisingly, PT neurons had the largest causal role. In frontal cortex, all PyNs were required for accurate choices but showed distinct choice-tuning. Our results reveal that rich, cell-type-specific cortical dynamics shape perceptual decisions.

Dataset supporting: Musall, S., Sun, X.R., Mohan, H. et al. Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making. Nat Neurosci (2023).


NIH R01EY022979, Deutsche Forschungsgemeinschaft (DFG, German Research Foundation; 368482240/GRK2416) and the Helmholtz association (VH-NG-1611). X.R.S. was supported by the NIH NRSA F32 MH120888

A cell-type specific explanation of visual decision circuits.

National Eye Institute

Find out more...

GRK 2416:  MultiSenses-MultiScales: Novel approaches to decipher neural processing in multisensory integration

Deutsche Forschungsgemeinschaft

Find out more...

Cortico-striatal representations of multisensory decision-making

National Institute of Mental Health

Find out more...

Research Institution(s)

University of California, Los Angeles, David Geffen School of Medicine

I confirm there is no human personally identifiable information in the files or description shared

  • Yes

I confirm the files and description shared may be publicly distributed under the license selected

  • Yes

Competing Interest Statement

The authors declare no competing interests