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Data tables and graphs from study: 'The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats'

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modified on 29.11.2018, 10:55
This file set contains measurement data, statistical analysis and graphs of latency periods and duration times of epileptiform seizures in rats treated with orexin antagonist TCS OX2 29. See below for the article abstract background.

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Article abstract: Background: Current antiepileptic drugs are not able to prevent recurrent seizures in all patients. Orexins are excitatory hypothalamic neuropeptides that their receptors (OX1 and OX2) are found almost in all major regions of the brain. Pentylenetetrazol (PTZ)- induced kindling is a known experimental model for epileptic seizures. The purpose of this study was to evaluate the effect of OX2 receptor antagonist (TCS OX2 29) on seizures and anxiety-like behaviors of PTZ-kindled rats. In this research we used orexin receptor type 2 antagonist intracerebroventricular injections to investigate its effect on the pentylenetetrazol-induced kindled seizures and anxiety behaviors in Wistar rats.

Funding

Ferdowsi University of Mashhad (3/37138): Prof. Ali Moghimi, Mashhad University of Medical Sciences (922445): Dr. Ali Roohbakhsh

Research Data Support

Research data support provided by Springer Nature.