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Single-Cell ChIP-seq of Mouse Stromal Cells in PDX tumour models of resistance

Published on by Pacome Prompsy
Mouse stromal cells from PDX count matrices reformatted to be inputed in ChromSCape (https://github.com/vallotlab/ChromSCape), two of which had not been analyzed in our previous study (Grosselin et al., 2019, https://www.nature.com/articles/s41588-019-0424-9). The samples correspond to the mouse cells from patient-derived xenograft (PDX) originating from two different human donors. The HBCx-22 and HBCx-22-TamR datasets correspond to mouse cells from a pair of luminal ER+ breast PDXs: HBCx-22, responsive to Tamoxifen and HBCx-22-TamR, resistant to Tamoxifen. The HBCx-95 and HBCx-95-CapaR correspond to a triple-negative breast cancer (TNBC) tumor model of acquired resistance to chemotherapy. Row names of the matrices are 50,000-bp binned regions; Column names are barcodes corresponding to single cell; Cells contains raw counts, in mm10 reference.

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Funding

the ATIP Avenir program

Plan Cancer

SiRIC-Curie program SiRIC Grants #INCa-DGOS- 4654 and #INCa-DGOS-Inserm_12554

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