PC
NOS2 knockout mice as a model of trichotillomania.
Published on by Plinio Casarotto
Description of the phenotype observed in mice lacking the nitric oxide synthase 2 (inducible NOS; iNOS; NOS2). The evolution of excessive barbering behavior (hair/whisker trimming) observed in these animals was counteracted by treatment with clomipramine or memantine. Both drugs are effective in the therapy for trichotillomania, a psychiatric condition where patients pull or trim the hair of many body areas.
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Funding
Fapesp (2011/02746-4 and 2012/17626-2), CNPq (471382/2011-6) and European Research Council (iPlasticity, # 322742).
