Low-grade neuroepithelial tumors with FGFR1 alterations

Published on by David Solomon
Representative scanned pathology slides from 26 cases of low-grade neuroepithelial tumors harboring FGFR1 alterations including kinase domain tandem duplication, in-frame fusion with TACC1, or hotspot missense mutations within the intracellular tyrosine kinase domain (either p.N546 or p.K656). This case series includes rosette-forming glioneuronal tumors, pilocytic astrocytomas, dysembryoplastic neuroepithelial tumors, and extraventricular neurocytomas. Included are hematoxylin and eosin stained sections from the 26 cases, and synaptophysin immunohistochemistry from 12 of the cases. These were scanned on an Aperio digital slide scanner, and the .SVS files can be viewed using the freely downloadable ImageScope software from Leica Biosystems. The complete clinical, histopathologic, genetic, and epigenomic features of these 26 cases are described in detail in the following report: Lucas CH, et al. Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor. Acta Neuropathologica Communications, 2020 Aug 28;8(1):151. PMID: 32859279

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National Institutes of Health, NIH Director's Early Independence Award (DP5 OD021403)