Gut and Oral Microbiome alterations of healthy volunteers with proton pump inhibitor and histamine-2 receptor antagonist

We aim to compare the effects of proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) on the gut microbiota through a longitudinal analysis.

We conducted a longitudinal study involving 49 healthy participants to compare the microbiome alterations caused by PPIs and H2RAs. Understanding the impact of these medications on the human microbiome is of utmost significance, as it can lead to a deeper understanding of the intricate interplay between gastric acid suppressants and the human microbiota and its correlation with the increased risk of various diseases. These insights will serve as valuable guidance for clinical practices and health management by optimizing treatment strategies, ensuring patients receive the best possible medical outcomes and overall well-being.