CT
Dietary fibre, radiotherapy and bladder tumour
Published on by Chee Kin Then
Mouse bladder tumour flank xenografts were implanted into C57BL/6 mice when starting low (0.2% cellulose) and high fibre (5% psyllium, 5% psyllium plus 10% resistant starch, 5% psyllium plus 10% inulin) diets (N=29) and irradiated with 6Gy IR when they reached 100mm3 (N=60). For normal tissue studies, mice received 10-14Gy (N=84, acute) or 5x5Gy (N=39, late) IR to their lower abdomen. 16S rRNA sequencing was used for gut microbiota analysis.
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Funding
This work was funded by Cancer Research UK Programme grant C5255/A23279 and A31475. Then’s DPhil was funded by the Clarendon Fund, Balliol College and CRUK.
