Dietary fibre, radiotherapy and bladder tumour

Mouse bladder tumour flank xenografts were implanted into C57BL/6 mice when starting low (0.2% cellulose) and high fibre (5% psyllium, 5% psyllium plus 10% resistant starch, 5% psyllium plus 10% inulin) diets (N=29) and irradiated with 6Gy IR when they reached 100mm³ (N=60). For normal tissue studies, mice received 10-14Gy (N=84, acute) or 5x5Gy (N=39, late) IR to their lower abdomen. 16S rRNA sequencing was used for gut microbiota analysis.