(1) Variables information +--------------------------------------------------------+ | var label | |--------------------------------------------------------| | ages Age at survey (yrs) | | sex Sex | | smallbin Smoking status | | hxdiabbin History of diabetes | | sbp SBP (mmHg) | | chol Cholesterol, mmol/L | | hdlc HDL cholesterol, mmol/L | | grscad3sd GRS_CAD_3GRSs (SDed) | | pgs39sd GRS_stroke_IS PGS000039 (SDed) | |--------------------------------------------------------| | z_ages Standardised ages: (ages - 55.9708)/8.0349 | | z_sbp Standardised sbp: (sbp - 136.8554)/18.6133 | | z_chol Standardised chol: (chol - 5.9124)/1.0579 | | z_hdlc Standardised hdlc: (hdlc - 1.4734)/0.3622 | +--------------------------------------------------------+ (2) HRs for CVD* per 1-SD higher continuous variables or contrasts for categorical variables -------------------------------------------------------------------------------------- Variable | est1_m1 est1_m2 est1_m3 est1_m4 est1_m5 est1_m6 -------------+------------------------------------------------------------------------ z_ages | 1.70 1.70 1.67 1.74 1.72 1.74 | sex | Male | 2.11 1.00 1.00 1.00 1.00 1.00 | smallbin | Current | 2.42 2.42 2.30 2.40 2.40 2.39 | hxdiabbin | Yes | 1.85 1.85 1.80 1.79 1.82 1.78 z_sbp | 1.31 1.31 1.29 1.29 1.30 1.29 z_chol | 1.21 1.21 1.20 1.19 1.20 1.18 z_hdlc | 0.77 0.77 0.81 0.78 0.77 0.78 z_lncrp | 1.19 grscad3sd | 1.31 1.27 pgs39sd | 1.18 1.10 -------------+------------------------------------------------------------------------ N_sub | 306654 306654 306654 306654 306654 306654 N_fail | 5680 5680 5680 5680 5680 5680 -------------------------------------------------------------------------------------- * Model 1 is adjusted for indicated variables, and stratified by centre. * Models 2 to 6 are stratified by centre and sex (hence coefficient for sex is redundant). (3) Log HRs for CVD* per 1 unit higher continuous variables or contrasts for categorical variables -------------------------------------------------------------------------------------- Variable | est2_m1 est2_m2 est2_m3 est2_m4 est2_m5 est2_m6 -------------+------------------------------------------------------------------------ ages | 0.0660 0.0660 0.0638 0.0686 0.0674 0.0692 | sex | Male | 0.7455 0.0000 0.0000 0.0000 0.0000 0.0000 | smallbin | Current | 0.8856 0.8850 0.8321 0.8758 0.8742 0.8706 | hxdiabbin | Yes | 0.6168 0.6156 0.5878 0.5831 0.5963 0.5755 sbp | 0.0145 0.0145 0.0137 0.0137 0.0140 0.0135 chol | 0.1826 0.1826 0.1736 0.1626 0.1750 0.1604 hdlc | -0.7208 -0.7200 -0.5936 -0.6823 -0.7112 -0.6813 lncrp | 0.1602 grscad3sd | 0.2667 0.2375 pgs39sd | 0.1662 0.0948 -------------+------------------------------------------------------------------------ N_sub | 306654 306654 306654 306654 306654 306654 N_fail | 5680 5680 5680 5680 5680 5680 -------------------------------------------------------------------------------------- * Model 1 is adjusted for indicated variables, and stratified by centre. * Models 2 to 6 are stratified by centre and sex (hence coefficient for sex is redundant). (4) Baseline survivor at 9 years for the above alternative models, summarised over centres. sex Variable | Mean SD p50 Min Max --------------------+-------------------------------------------------- Male est2_m1_s09 | .9999668 3.86e-06 .9999659 .9999617 .9999758 est2_m2_s09 | .9999288 7.99e-06 .9999276 .9999204 .9999468 est2_m3_s09 | .9999233 8.29e-06 .9999216 .9999148 .9999421 est2_m4_s09 | .999929 7.68e-06 .9999282 .9999205 .9999459 est2_m5_s09 | .999928 7.62e-06 .9999264 .9999202 .9999459 est2_m6_s09 | .9999286 7.48e-06 .9999275 .9999205 .9999455 --------------------+-------------------------------------------------- Female est2_m1_s09 | .9999668 3.98e-06 .9999659 .9999617 .9999758 est2_m2_s09 | .999966 4.51e-06 .9999647 .9999609 .9999776 est2_m3_s09 | .9999652 4.55e-06 .9999634 .99996 .9999767 est2_m4_s09 | .9999669 4.35e-06 .9999656 .9999619 .9999778 est2_m5_s09 | .9999659 4.46e-06 .9999644 .9999611 .9999773 est2_m6_s09 | .9999667 4.34e-06 .9999654 .9999619 .9999776 -----------------------------------------------------------------------