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{"sheet":"Inputs & Results","index":0,"n_rows":45,"n_cols":7,"rows_kept":45,"cut":false,"hidden":false,"merged":[[13,1,13,3],[14,1,14,3],[3,1,3,13],[6,1,6,13],[7,1,7,13],[8,1,8,13],[9,1,9,13],[10,1,10,13],[11,1,11,13]]}
[]
[null,"Model Information"]
[null,"DESCRIPTION"]
[null,"Screening strategies for Diabetic Retinal Diseases (DRD). We have made this model available for illustrative purposes so that the reader can change input parameters and see the relative impact on vision loss. This is not intended to make treatment or management decisions. The CAREVL model is an algorithmic tool (“Algorithm”) developed by faculty at the Johns Hopkins University School of Medicine, the University of Iowa, and the University of Wisconsin (“The Developers”).  The Algorithm is not an FDA-registered clinical decision support tool and has not been reviewed or approved for any use—including diagnosis or treatment of disease or other conditions—by the FDA.  The Developers are making the Algorithm publicly available for academic and research use only.  The Algorithm does not replace the independent clinical judgment of healthcare professionals or the performance of any clinical assessment.   The Algorithm is not intended for the diagnosis or treatment of any disease or condition in individual patients.  The Developers hereby disclaims any and all representations and warranties regarding the Algorithm, including warranties of fitness for use in clinical decision making and warranties that the Algorithm works as intended, is clinically safe, does not infringe third party intellectual property rights, and/or is free from defects and bugs. "]
[]
[null,"STRATEGIES"]
[null,"ECP"]
[null,"eye care provider"]
[null,"AI"]
[null,"artificial intelligence"]
[null,"No Screening"]
[null,"no screening"]
[]
[null,"Green cells are editable"]
[null,"Gray cells - no impact on calculation"]
[null,"INPUTS",null,null,null,"MODEL RESULTS"]
[null,"Description","Value","Reference in TreeAge",null,"Strategy","Payoff 4 - \nVision Loss per 100,000"]
[null,"Parameter Variables",null,null,null,"ECP",{"$f":"'1. Strategy Calcs'!M15","v":1625.1591071620414}]
[null,"Probability of progressing from No DRD to DRD Metabolic in the absence of treatment",0.05,"pNaturalHistoryToDRDMetabolic",null,"AI",{"$f":"'2. Strategy Calcs'!M15","v":1534.708783508042}]
[null,"Probability of progressing from DRD Metabolic to DRD Ophthalmic in the absence of treatment",0.02,"pNaturalHistoryDRDMetabolicToOphth",null,"No Screening",{"$f":"'3. Strategy Calcs'!J15","v":1636.9834316312501}]
[null,"Probability of progressing from DRD Metabolic to DRD Ophthalmic in the presence of treatment",0.01,"pTreatedDRDMetabolicToOphth"]
[null,"Relative Orrds increased adherence to DRD ophthalmic ",0.13,"rOddsIncAdherencetoOphthalmic"]
[null,"Probability of progressing from DRD Ophthalmic to vision loss in the absence of treatment",7.4999999999999997E-2,"pNaturalHistoryDRDOphthToVisionLoss"]
[null,"Probability of progressing from vision loss to irreversible vision loss in the absence of treatment",0.37,"pNaturalHistoryVisionLossToVisionLossIrreversible"]
[null,"Probability of progressing from DRD with vision loss to irreversible vision loss despite treatment",3.4000000000000002E-2,"pTreatedDRDVisionlossToVisionLossIrreversible"]
[null,"Relative Odds Increased adherence to DRD with vision loss ",0.97,"rOddsIncAdherencetoVisionLoss"]
[null,"Probability of adhering with metabolic management",0.24,"pAdheringToMetabolicManagement"]
[null,"Probability of patient following up with ECP after ECP screen positive",0.28999999999999998,"pAcceptsReferralAfterECP"]
[null,"Probability of patient accepting screening with ECP",0.2,"pAcceptsScreeningECP"]
[null,"Probability of patient accepting screening with AI",0.95,"pAcceptsScreeningAI"]
[null,"Sensitivity Screening for  DRD with AI",0.87,"sensScreeningAI"]
[null,"Sensitivity Screening for DRD with ECP",0.33,"sensScreeningECP"]
[null,"Specificity Screening for DRD with AI",0.91,"specScreeningAI"]
[null,"",1,"AAmodelAI"]
[null,"",2,"AAmodelECP"]
[null,"Probability of accepting follow up care in case of DRD with vision loss",0.57999999999999996,"pDRDVisionLossAcceptsReferral"]
[null,"Prevalence of DRD Metabolic",0.22,"prevDRDMetabolic"]
[null,"Prevalence DRD metabolic treated",0,"prevDRDMetabolicRx"]
[null,"Proportion of DRD Ophthalmic",0.04,"propDRDOphthalmic"]
[null,"Prevalence of DRD Ophthalmic treated ",0,"prevDRDOphthalmicRx"]
[null,"Prevalence of DRD with vision loss",0.01,"prevDRDVisionLoss"]
[null,"Prevalence of DRD with vision loss treated ",0,"prevDRDVisionLossRx"]
[null,"Probability of progressing from DRD Ophthalmic to vision loss in the presence of treatment",0.02,"pTreatedDRDOphthalmicToVisionLoss"]
[null,"Probability of patient following up with ECP after AI screen positive",0.75,"pAcceptsReferralAfterAI"]
[null,"Specificity Screening for DRD with ECP",0.99,"specScreeningECP"]

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[null,"Strategy",1,"ECP"]
[null,"States","All"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No DRD - State 1.1",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"DRD metabolic - State 1.2",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"DRD Metabolic treated - State 1.3",null,null,null,null,null,null,"DRD ophthalmic - State 1.4",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"DRD ophthalmic treated - State 1.5",null,null,null,null,null,null,"DRD Vision Loss - State 1.6",null,null,null,null,null,null,null,null,null,null,null,"DRD Vision Loss Treated - State 1.7",null,null,null,null,null,null,null,"Blindness - State 1.8"]
[null,null,null,"Cohort State Proportions",null,null,null,null,null,null,null,null,null,null,null,null,"Cohort %",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Cohort %",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Cohort %",null,null,null,null,null,null,"Cohort %",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Cohort %",null,null,null,null,null,null,"Cohort %",null,null,null,null,null,null,null,null,null,null,"Payoff 4 - Vision Loss","Cohort %",null,null,null,null,null,null,"Payoff 4 - Vision Loss","Cohort %","Payoff 4 - Vision Loss"]
[null,"Cycle",null,"No DRD","DRD metabolic","DRD Metabolic treated","DRD ophthalmic","DRD ophthalmic treated","DRD Vision Loss","DRD Vision Loss Treated","Blindness","Payoff 4 - Vision Loss",null,null,"Checksum of Cohort %",null,"1.1\n State","1.1.1\n Transition","1.1.1.1\n Transition","1.1.1.1.1\n Transition","1.1.1.1.1.1\n Transition","1.1.1.1.1.2\n Transition","1.1.1.1.2\n Transition","1.1.1.1.2.1\n Transition","1.1.1.1.2.2\n Transition","1.1.1.2\n Transition","1.1.1.2.1\n Transition","1.1.1.2.2\n Transition","1.1.2\n Transition","1.1.2.1\n Transition","1.1.2.2\n Transition","1.2\n State","1.2.1\n Transition","1.2.1.1\n Transition","1.2.1.1.1\n Transition","1.2.1.1.1.1\n Transition","1.2.1.1.1.1.1\n Transition","1.2.1.1.1.1.1.1\n Transition","1.2.1.1.1.1.1.2\n Transition","1.2.1.1.1.1.2\n Transition","1.2.1.1.1.1.2.1\n Transition","1.2.1.1.1.1.2.2\n Transition","1.2.1.1.1.2\n Transition","1.2.1.1.1.2.1\n Transition","1.2.1.1.1.2.2\n Transition","1.2.1.1.2\n Transition","1.2.1.1.2.1\n Transition","1.2.1.1.2.2\n Transition","1.2.1.2\n Transition","1.2.1.2.1\n Transition","1.2.1.2.2\n Transition","1.2.2\n Transition","1.2.2.1\n Transition","1.2.2.1.1\n Transition","1.2.2.1.1.1\n Transition","1.2.2.1.1.2\n Transition","1.2.2.1.2\n Transition","1.2.2.1.2.1\n Transition","1.2.2.1.2.2\n Transition","1.2.2.2\n Transition","1.2.2.2.1\n Transition","1.2.2.2.2\n Transition","1.3\n State","1.3.1\n Transition","1.3.1.1\n Transition","1.3.1.2\n Transition","1.3.2\n Transition","1.3.2.1\n Transition","1.3.2.2\n Transition","1.4\n State","1.4.1\n Transition","1.4.1.1\n Transition","1.4.1.1.1\n Transition","1.4.1.1.1.1\n Transition","1.4.1.1.1.1.1\n Transition","1.4.1.1.1.1.1.1\n Transition","1.4.1.1.1.1.1.2\n Transition","1.4.1.1.1.1.2\n Transition","1.4.1.1.1.1.2.1\n Transition","1.4.1.1.1.1.2.2\n Transition","1.4.1.1.1.2\n Transition","1.4.1.1.1.2.1\n Transition","1.4.1.1.1.2.2\n Transition","1.4.1.1.2\n Transition","1.4.1.1.2.1\n Transition","1.4.1.1.2.2\n Transition","1.4.1.2\n Transition","1.4.1.2.1\n Transition","1.4.1.2.2\n Transition","1.4.2\n Transition","1.4.2.1\n Transition","1.4.2.1.1\n Transition","1.4.2.1.1.1\n Transition","1.4.2.1.1.2\n Transition","1.4.2.1.2\n Transition","1.4.2.1.2.1\n Transition","1.4.2.1.2.2\n Transition","1.4.2.2\n Transition","1.4.2.2.1\n Transition","1.4.2.2.2\n Transition","1.5\n State","1.5.1\n Transition","1.5.1.1\n Transition","1.5.1.2\n Transition","1.5.2\n Transition","1.5.2.1\n Transition","1.5.2.2\n Transition","1.6\n State","1.6.1\n Transition","1.6.1.1\n Transition","1.6.1.1.1\n Transition","1.6.1.1.2\n Transition","1.6.1.2\n Transition","1.6.1.2.1\n Transition","1.6.1.2.2\n Transition","1.6.2\n Transition","1.6.2.1\n Transition","1.6.2.2\n Transition","1.6\nState","1.7\n State","1.7.1\n Transition","1.7.1.1\n Transition","1.7.1.2\n Transition","1.7.2\n Transition","1.7.2.1\n Transition","1.7.2.2\n Transition","1.7\nState","1.8\n State","1.8\nState",null,"pDRDMetabolicReferred","pDRDOphthalmicReferred"]
[null,null,null,null,null,null,null,null,null,null,null,"No Discount","Cum No Disc",null,null,null,"No DRD","Accepts Screening","Screen positive","Accepts Referral","Does not progress","Progresses to DRD Metabolic","Does not Accept Referral","Does not progress","Progresses to DRD Metabolic","Screen negative","Does not progress","Progresses to DRD Metabolic","Does not accept Screen","Does not progress","Progresses to DRD Metabolic","DRD metabolic","Offered Screening","Accepts Screening","Screen positive","Accepts Referral","Does not adhere to metabolic management","DRD metabolic","DRD ophthalmic","Adheres with metabolic control","DRD metabolic treated","DRD ophthalmic","Does not accept referral","DRD metabolic","DRD ophthalmic","Screen negative","DRD metabolic","DRD ophthalmic","Does not accept Screen","DRD metabolic","DRD ophthalmic","Referred","Accepts Referral","Does not adhere to metabolic management","DRD metabolic","DRD ophthalmic","Adheres with metabolic control","DRD metabolic treated","DRD ophthalmic","Does not accept referral","DRD metabolic","DRD ophthalmic","DRD Metabolic treated","Adheres with metabolic treatment","DRD metabolic treated","DRD ophthalmic","Does not adhere with metabolic treatment","DRD metabolic","DRD ophthalmic","DRD ophthalmic","Offered Screening","Accepts Screening","Screen positive","Accepts Referral","Does not adhere to ophthalmic management","DRD ophthalmic","DRD Vision loss","Adheres with ophthalmic management","DRD ophthalmic treated","DRD Vision loss","Does not Accept Referral","DRD ophthalmic","Progresses from DRD requiring ophthalmic control to vision loss","Screen negative","DRD ophthalmic","Progresses from DRD requiring ophthalmic control to vision loss","Does not accept Screen","DRD ophthalmic","Progresses from DRD requiring ophthalmic control to vision loss","Referred","Accepts Referral","Does not adhere to ophthalmic management","DRD ophthalmic","Progresses from DRD requiring ophthalmic control to vision loss","Adheres with ophthalmic management","DRD ophthalmic treated","DRD Vision loss","Does not Accept Referral","DRD ophthalmic","Progresses from DRD requiring ophthalmic control to vision loss","DRD ophthalmic treated","Adheres to ophthalmic management","DRD ophthalmic treated","DRD Vision loss","Does not adhere with ophthalmic management","DRD ophthalmic","Progresses from DRD requiring ophthalmic control to vision loss","DRD Vision Loss","Accepts referral","Adheres to vision loss management","DRD Vision loss gets treated","Blindness","Does not adhere to vision loss management","Persistent vision loss","Blindness","Does not accept referral","Persistent vision loss","Blindness","DRD Vision Loss","DRD Vision Loss Treated","Adheres to vision loss management","DRD Vision loss gets treated","Blindness","Does not adhere vision loss management","Persistent vision loss","Blindness","DRD Vision Loss Treated","Blindness","Blindness"]
[]
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[]
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[null,"Strategy",2,"AI"]
[null,"States","All"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No DRD - State 2.1",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"DRD metabolic - State 2.2",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"DRD Metabolic treated - State 2.3",null,null,null,null,null,null,"DRD ophthalmic - State 2.4",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"DRD ophthalmic treated - State 2.5",null,null,null,null,null,null,"DRD Vision Loss - State 2.6",null,null,null,null,null,null,null,null,null,null,null,"DRD Vision Loss Treated - State 2.7",null,null,null,null,null,null,null,"Blindness - State 2.8"]
[null,null,null,"Cohort State Proportions",null,null,null,null,null,null,null,null,null,null,null,null,"Cohort %",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Cohort %",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Cohort %",null,null,null,null,null,null,"Cohort %",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Cohort %",null,null,null,null,null,null,"Cohort %",null,null,null,null,null,null,null,null,null,null,"Payoff 4 - Vision Loss","Cohort %",null,null,null,null,null,null,"Payoff 4 - Vision Loss","Cohort %","Payoff 4 - Vision Loss"]
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{"sheet":"3. Strategy Calcs","index":3,"n_rows":15,"n_cols":37,"rows_kept":15,"cut":false,"hidden":true,"merged":[[2,27,2,31],[2,32,2,33],[4,11,5,11],[2,13,2,16],[3,17,3,21],[2,17,2,21],[3,22,3,26],[2,22,2,26],[4,7,5,7],[4,8,4,9],[4,35,5,35],[4,36,5,36],[3,13,3,16],[3,27,3,30],[0,3,0,6],[3,3,3,5],[4,1,5,1],[4,3,5,3],[4,4,5,4],[4,5,5,5],[4,6,5,6]]}
[null,"Strategy",3,"No Screening"]
[null,"States","All"]
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[null,null,null,"Cohort State Proportions",null,null,null,null,null,null,null,null,null,"Cohort %",null,null,null,"Cohort %",null,null,null,null,"Cohort %",null,null,null,null,"Cohort %",null,null,null,"Payoff 4 - Vision Loss","Cohort %","Payoff 4 - Vision Loss"]
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[]
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[null,1,null,{"$f":"'3. Strategy Calcs'!N9","v":0.72314000000000001},{"$f":"'3. Strategy Calcs'!R9","v":0.25366},{"$f":"'3. Strategy Calcs'!W9","v":1.2540000000000003E-2},{"$f":"'3. Strategy Calcs'!AB9","v":6.96E-3},{"$f":"'3. Strategy Calcs'!AG9","v":3.7000000000000002E-3},{"$f":"'3. Strategy Calcs'!AF9 + '3. Strategy Calcs'!AH9","v":0},{"$f":"J8 + I9","v":0},null,1,null,{"$f":"0 + P8","v":0.72314000000000001},{"$f":"N9*(1)","v":0.72314000000000001},{"$f":"O9*(1-(pNaturalHistoryToDRDMetabolic))","v":0.68698300000000001},{"$f":"O9*(pNaturalHistoryToDRDMetabolic)","v":3.6157000000000002E-2},{"$f":"0 + '3. Strategy Calcs'!Q8 + U8","v":0.25366},0.25366,0.25366,{"$f":"T9*(1-(pNaturalHistoryDRDMetabolicToOphth))","v":0.2485868},{"$f":"T9*(pNaturalHistoryDRDMetabolicToOphth)","v":5.0731999999999999E-3},{"$f":"0 + '3. Strategy Calcs'!V8 + Z8","v":1.2540000000000003E-2},1.2540000000000003E-2,1.2540000000000003E-2,{"$f":"Y9*(1-(pNaturalHistoryDRDOphthToVisionLoss))","v":1.1599500000000002E-2},{"$f":"Y9*(pNaturalHistoryDRDOphthToVisionLoss)","v":9.4050000000000015E-4},{"$f":"0 + '3. Strategy Calcs'!AA8 + AD8","v":6.96E-3},{"$f":"AB9*(1)","v":6.96E-3},{"$f":"AC9*(1-(pNaturalHistoryVisionLossToVisionLossIrreversible))","v":4.3848000000000003E-3},{"$f":"AC9*(pNaturalHistoryVisionLossToVisionLossIrreversible)","v":2.5752000000000001E-3},{"$f":"0","v":0},{"$f":"0 + '3. Strategy Calcs'!AE8 + AG8","v":3.7000000000000002E-3},{"$f":"0","v":0},null,0,0]
[null,2,null,{"$f":"'3. Strategy Calcs'!N10","v":0.68698300000000001},{"$f":"'3. Strategy Calcs'!R10","v":0.28474379999999999},{"$f":"'3. Strategy Calcs'!W10","v":1.6672700000000002E-2},{"$f":"'3. Strategy Calcs'!AB10","v":5.3253000000000007E-3},{"$f":"'3. Strategy Calcs'!AG10","v":6.2751999999999999E-3},{"$f":"'3. Strategy Calcs'!AF10 + '3. Strategy Calcs'!AH10","v":0},{"$f":"J9 + I10","v":0},null,1,null,{"$f":"0 + P9","v":0.68698300000000001},{"$f":"N10*(1)","v":0.68698300000000001},{"$f":"O10*(1-(pNaturalHistoryToDRDMetabolic))","v":0.65263384999999996},{"$f":"O10*(pNaturalHistoryToDRDMetabolic)","v":3.4349150000000002E-2},{"$f":"0 + '3. Strategy Calcs'!Q9 + U9","v":0.28474379999999999},0.28474379999999999,0.28474379999999999,{"$f":"T10*(1-(pNaturalHistoryDRDMetabolicToOphth))","v":0.27904892399999998},{"$f":"T10*(pNaturalHistoryDRDMetabolicToOphth)","v":5.6948759999999998E-3},{"$f":"0 + '3. Strategy Calcs'!V9 + Z9","v":1.6672700000000002E-2},1.6672700000000002E-2,1.6672700000000002E-2,{"$f":"Y10*(1-(pNaturalHistoryDRDOphthToVisionLoss))","v":1.5422247500000003E-2},{"$f":"Y10*(pNaturalHistoryDRDOphthToVisionLoss)","v":1.2504525000000002E-3},{"$f":"0 + '3. Strategy Calcs'!AA9 + AD9","v":5.3253000000000007E-3},{"$f":"AB10*(1)","v":5.3253000000000007E-3},{"$f":"AC10*(1-(pNaturalHistoryVisionLossToVisionLossIrreversible))","v":3.3549390000000004E-3},{"$f":"AC10*(pNaturalHistoryVisionLossToVisionLossIrreversible)","v":1.9703610000000003E-3},{"$f":"0","v":0},{"$f":"0 + '3. Strategy Calcs'!AE9 + AG9","v":6.2751999999999999E-3},{"$f":"0","v":0},null,0,0]
[null,3,null,{"$f":"'3. Strategy Calcs'!N11","v":0.65263384999999996},{"$f":"'3. Strategy Calcs'!R11","v":0.31339807399999997},{"$f":"'3. Strategy Calcs'!W11","v":2.1117123500000001E-2},{"$f":"'3. Strategy Calcs'!AB11","v":4.6053915000000001E-3},{"$f":"'3. Strategy Calcs'!AG11","v":8.2455610000000002E-3},{"$f":"'3. Strategy Calcs'!AF11 + '3. Strategy Calcs'!AH11","v":0},{"$f":"J10 + I11","v":0},null,0.99999999999999989,null,{"$f":"0 + P10","v":0.65263384999999996},{"$f":"N11*(1)","v":0.65263384999999996},{"$f":"O11*(1-(pNaturalHistoryToDRDMetabolic))","v":0.62000215749999998},{"$f":"O11*(pNaturalHistoryToDRDMetabolic)","v":3.2631692499999997E-2},{"$f":"0 + '3. Strategy Calcs'!Q10 + U10","v":0.31339807399999997},0.31339807399999997,0.31339807399999997,{"$f":"T11*(1-(pNaturalHistoryDRDMetabolicToOphth))","v":0.30713011251999994},{"$f":"T11*(pNaturalHistoryDRDMetabolicToOphth)","v":6.2679614799999997E-3},{"$f":"0 + '3. Strategy Calcs'!V10 + Z10","v":2.1117123500000001E-2},2.1117123500000001E-2,2.1117123500000001E-2,{"$f":"Y11*(1-(pNaturalHistoryDRDOphthToVisionLoss))","v":1.9533339237500003E-2},{"$f":"Y11*(pNaturalHistoryDRDOphthToVisionLoss)","v":1.5837842625E-3},{"$f":"0 + '3. Strategy Calcs'!AA10 + AD10","v":4.6053915000000001E-3},{"$f":"AB11*(1)","v":4.6053915000000001E-3},{"$f":"AC11*(1-(pNaturalHistoryVisionLossToVisionLossIrreversible))","v":2.9013966450000001E-3},{"$f":"AC11*(pNaturalHistoryVisionLossToVisionLossIrreversible)","v":1.703994855E-3},{"$f":"0","v":0},{"$f":"0 + '3. Strategy Calcs'!AE10 + AG10","v":8.2455610000000002E-3},{"$f":"0","v":0},null,0,0]
[null,4,null,{"$f":"'3. Strategy Calcs'!N12","v":0.62000215749999998},{"$f":"'3. Strategy Calcs'!R12","v":0.33976180501999992},{"$f":"'3. Strategy Calcs'!W12","v":2.5801300717500003E-2},{"$f":"'3. Strategy Calcs'!AB12","v":4.4851809075000006E-3},{"$f":"'3. Strategy Calcs'!AG12","v":9.9495558550000002E-3},{"$f":"'3. Strategy Calcs'!AF12 + '3. Strategy Calcs'!AH12","v":0},{"$f":"J11 + I12","v":0},null,0.99999999999999989,null,{"$f":"0 + P11","v":0.62000215749999998},{"$f":"N12*(1)","v":0.62000215749999998},{"$f":"O12*(1-(pNaturalHistoryToDRDMetabolic))","v":0.58900204962499991},{"$f":"O12*(pNaturalHistoryToDRDMetabolic)","v":3.1000107875000002E-2},{"$f":"0 + '3. Strategy Calcs'!Q11 + U11","v":0.33976180501999992},0.33976180501999992,0.33976180501999992,{"$f":"T12*(1-(pNaturalHistoryDRDMetabolicToOphth))","v":0.33296656891959991},{"$f":"T12*(pNaturalHistoryDRDMetabolicToOphth)","v":6.7952361003999987E-3},{"$f":"0 + '3. Strategy Calcs'!V11 + Z11","v":2.5801300717500003E-2},2.5801300717500003E-2,2.5801300717500003E-2,{"$f":"Y12*(1-(pNaturalHistoryDRDOphthToVisionLoss))","v":2.3866203163687504E-2},{"$f":"Y12*(pNaturalHistoryDRDOphthToVisionLoss)","v":1.9350975538125002E-3},{"$f":"0 + '3. Strategy Calcs'!AA11 + AD11","v":4.4851809075000006E-3},{"$f":"AB12*(1)","v":4.4851809075000006E-3},{"$f":"AC12*(1-(pNaturalHistoryVisionLossToVisionLossIrreversible))","v":2.8256639717250003E-3},{"$f":"AC12*(pNaturalHistoryVisionLossToVisionLossIrreversible)","v":1.6595169357750002E-3},{"$f":"0","v":0},{"$f":"0 + '3. Strategy Calcs'!AE11 + AG11","v":9.9495558550000002E-3},{"$f":"0","v":0},null,0,0]
[null,5,null,{"$f":"'3. Strategy Calcs'!N13","v":0.58900204962499991},{"$f":"'3. Strategy Calcs'!R13","v":0.36396667679459993},{"$f":"'3. Strategy Calcs'!W13","v":3.0661439264087501E-2},{"$f":"'3. Strategy Calcs'!AB13","v":4.7607615255375003E-3},{"$f":"'3. Strategy Calcs'!AG13","v":1.1609072790775001E-2},{"$f":"'3. Strategy Calcs'!AF13 + '3. Strategy Calcs'!AH13","v":1636.9834316312501},{"$f":"J12 + I13","v":1636.9834316312501},null,0.99999999999999989,null,{"$f":"0 + P12","v":0.58900204962499991},null,null,null,{"$f":"0 + '3. Strategy Calcs'!Q12 + U12","v":0.36396667679459993},null,null,null,null,{"$f":"0 + '3. Strategy Calcs'!V12 + Z12","v":3.0661439264087501E-2},null,null,null,null,{"$f":"0 + '3. Strategy Calcs'!AA12 + AD12","v":4.7607615255375003E-3},null,null,null,{"$f":"AB13*(100000)","v":476.07615255375003},{"$f":"0 + '3. Strategy Calcs'!AE12 + AG12","v":1.1609072790775001E-2},{"$f":"AG13*(100000)","v":1160.9072790775001},null,0,0]
[]
[null,"Total",null,null,null,null,null,null,{"$f":"SUM(I8:I13)","v":1636.9834316312501},{"$f":"J13","v":1636.9834316312501}]

{"sheet":"State Trans Diag","index":4,"n_rows":38,"n_cols":17,"rows_kept":38,"cut":false,"hidden":true,"merged":[]}
["State Transition Diagram of Strategy:","ECP",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Tree Diagram"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
["State Transition Diagram of Strategy:","AI"]
[]
[null,"Same As","ECP"]
["State Transition Diagram of Strategy:","No Screening"]

{"sheet":"Original Data & Results","index":5,"n_rows":34,"n_cols":8,"rows_kept":34,"cut":false,"hidden":true,"merged":[[3,6,3,9],[9,6,9,9],[15,6,15,9]]}
[]
[null,"Original Data from TreeAge Pro Model"]
[]
[null,"INPUTS",null,null,null,null,"CURRENT MODEL RESULTS"]
[null,"Description","Value","Reference in TreeAge",null,null,{"$f":"'Inputs & Results'!F17","v":"Strategy"},{"$f":"'Inputs & Results'!G17","v":"Payoff 4 - \nVision Loss per 100,000"}]
[null,"Parameter Variables",null,null,null,null,{"$f":"'Inputs & Results'!F18","v":"ECP"},{"$f":"'Inputs & Results'!G18","v":1625.1591071620414}]
[null,"Probability of progressing from No DRD to DRD Metabolic in the absence of treatment",0.05,"pNaturalHistoryToDRDMetabolic",null,null,{"$f":"'Inputs & Results'!F19","v":"AI"},{"$f":"'Inputs & Results'!G19","v":1534.708783508042}]
[null,"Probability of progressing from DRD Metabolic to DRD Ophthalmic in the absence of treatment",0.02,"pNaturalHistoryDRDMetabolicToOphth",null,null,{"$f":"'Inputs & Results'!F20","v":"No Screening"},{"$f":"'Inputs & Results'!G20","v":1636.9834316312501}]
[null,"Probability of progressing from DRD Metabolic to DRD Ophthalmic in the presence of treatment",0.01,"pTreatedDRDMetabolicToOphth"]
[null,"",0.13,"rOddsIncAdherencetoOphthalmic",null,null,"ORIGINAL MODEL RESULTS FROM EXCEL"]
[null,"Probability of progressing from DRD Ophthalmic to vision loss in the absence of treatment",7.4999999999999997E-2,"pNaturalHistoryDRDOphthToVisionLoss",null,null,"Strategy","Payoff 4 - \nVision Loss"]
[null,"Probability of progressing from vision loss to irreversible vision loss in the absence of treatment",0.37,"pNaturalHistoryVisionLossToVisionLossIrreversible",null,null,"ECP",1625.1591071620414]
[null,"Probability of progressing from DRD with vision loss to irreversible vision loss despite treatment",3.4000000000000002E-2,"pTreatedDRDVisionlossToVisionLossIrreversible",null,null,"AI",1534.708783508042]
[null,"",0.97,"rOddsIncAdherencetoVisionLoss",null,null,"No Screening",1636.9834316312501]
[null,"Probability of adhering with metabolic management",0.24,"pAdheringToMetabolicManagement"]
[null,"",4.0000000000000001E-3,"pNaturalHistoryToOphthalmic",null,null,"ORIGINAL MODEL RESULTS FROM TREEAGE PRO"]
[null,"Probability of patient following up with ECP after ECP screen positive",0.28999999999999998,"pAcceptsReferralAfterECP",null,null,"Strategy","Payoff 4 - \nVision Loss"]
[null,"Probability of patient accepting screening with ECP",0.2,"pAcceptsScreeningECP",null,null,"ECP",1625.1591071620414]
[null,"Probability of patient accepting screening with AI",0.95,"pAcceptsScreeningAI",null,null,"AI",1534.708783508042]
[null,"Sensitivity Screening for  DRD with AI",0.87,"sensScreeningAI",null,null,"No Screening",1636.9834316312501]
[null,"Sensitivity Screening for DRD with ECP",0.33,"sensScreeningECP"]
[null,"Specificity Screening for DRD with AI",0.91,"specScreeningAI"]
[null,"",1,"AAmodelAI"]
[null,"",2,"AAmodelECP"]
[null,"Probability of accepting follow up care in case of DRD with vision loss",0.57999999999999996,"pDRDVisionLossAcceptsReferral"]
[null,"Prevalence of DRD Metabolic",0.22,"prevDRDMetabolic"]
[null,"",0,"prevDRDMetabolicRx"]
[null,"",0.04,"propDRDOphthalmic"]
[null,"",0,"prevDRDOphthalmicRx"]
[null,"Prevalence of DRD with vision loss",0.01,"prevDRDVisionLoss"]
[null,"",0,"prevDRDVisionLossRx"]
[null,"Probability of progressing from DRD Ophthalmic to vision loss in the presence of treatment",0.02,"pTreatedDRDOphthalmicToVisionLoss"]
[null,"Probability of patient following up with ECP after AI screen positive",0.75,"pAcceptsReferralAfterAI"]
[null,"Specificity Screening for DRD with ECP",0.99,"specScreeningECP"]

{"sheet":"TP Internal Formulas","index":6,"n_rows":60,"n_cols":3,"rows_kept":60,"cut":false,"hidden":true,"merged":[[59,0,59,2],[2,0,2,10],[3,0,3,10],[37,0,37,10],[54,0,54,10],[58,0,58,2]]}
["EXTRAS"]
[]
["This worksheet includes elements from the TreeAge Pro model that are not actively used in the exported Excel model."]
["They are included here for reference only."]
[]
["TreeAge Pro Variable Sensitivity Analysis Range"]
[]
["Name","Low","High"]
["pNaturalHistoryToDRDMetabolic",0,0.15]
["pNaturalHistoryDRDMetabolicToOphth",0,0.2]
["pTreatedDRDMetabolicToOphth",0,0.05]
["rOddsIncAdherencetoOphthalmic",0.1,10]
["pNaturalHistoryDRDOphthToVisionLoss",0,0.2]
["pNaturalHistoryVisionLossToVisionLossIrreversible",0,0.5]
["pTreatedDRDVisionlossToVisionLossIrreversible",0,0.05]
["rOddsIncAdherencetoVisionLoss",0.1,10]
["pAdheringToMetabolicManagement",0,1]
["pNaturalHistoryToOphthalmic",0,0.01]
["pAcceptsReferralAfterECP",0,1]
["pAcceptsScreeningECP",0,0.8]
["pAcceptsScreeningAI",0,1]
["sensScreeningAI",0,1]
["sensScreeningECP",0,1]
["specScreeningAI",0,1]
["AAmodelAI",0,1]
["AAmodelECP",0,2]
["pDRDVisionLossAcceptsReferral",0,0.75]
["prevDRDMetabolic",0,0.4]
["prevDRDMetabolicRx",0,0]
["propDRDOphthalmic",0,0.1]
["prevDRDOphthalmicRx",0,0]
["prevDRDVisionLoss",0,0.05]
["prevDRDVisionLossRx",0,0]
["pTreatedDRDOphthalmicToVisionLoss",0,0.5]
["pAcceptsReferralAfterAI",0,1]
["specScreeningECP",0,1]
[]
["Sensitivity analysis ranges are used in TreeAge Pro, but not in the converted Excel model."]
[]
[]
["TreeAge Pro Variable Formulas"]
[]
["Name","Value"]
["pDRDMetabolicReferred","if (_stage = 0; 1; 0)"]
["pDRDOphthalmicReferred","if (_stage = 0; 1; 0)"]
["pAdheringToVisionLossManagement","((1+rOddsIncAdherencetoVisionLoss) * pAdheringToOphthalmicManagement)/(1+ pAdheringToOphthalmicManagement*rOddsIncAdherencetoVisionLoss)"]
["spec","if(AAmodel=AAmodelAI; specScreeningAI;specScreeningECP)"]
["pAcceptsReferralAfterScreen","if(AAmodel=AAmodelAI; pAcceptsReferralAfterAI;pAcceptsReferralAfterECP)"]
["pAcceptsScreening","if(AAmodel=AAmodelAI; pAcceptsScreeningAI;pAcceptsScreeningECP)"]
["sens","if(AAmodel=AAmodelAI; sensScreeningAI;sensScreeningECP)"]
["AAmodel","AAmodelAI"]
["prevDRDOphthalmic","propDRDOphthalmic * prevDRDMetabolic"]
["pAdheringToOphthalmicManagement","((1+rOddsIncAdherencetoOphthalmic) * pAdheringToMetabolicManagement)/(1+pAdheringToMetabolicManagement*rOddsIncAdherencetoOphthalmic)"]
[]
["Formulas above are integrated into cohort analysis sheets in the converted Excel model."]
[]
[]
[]
["Green cells are editable"]
["Gray cells - no impact on calculation"]