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\ p None B a = c @ = Z ?N*8 X" 1 Arial1 Arial1 Arial1 Arial1 Arial1 Arial1 Arial General ` Table 1
Source
Target RNA vs. Target Function siRNA Exogenous viral RNA 1 vs 1 Cleavage of viral RNA miRNA Endogenous mammalian genome' Endogenous host RNA Exogenous viral RNA Network= Regulation of gene expression (adaptation to antiviral state) piRNA Endogenous viral elements! Endogenous or exogenous viral RNA6 1 v s 1 ; a m p l i f i c a t i o n p o s s i b l e v i a p i n g p o n g c y c l i n g F Cleavage of viral RNA; transcriptional silencing of integrated viruses cDNAs of exogenous viral RNAs Direct processing of viral RNAs tRNAU Multiple proposed mechanisms of action, e.g., steric hindrance of primer-binding site
d MbP?_ % * + &P &F