Proteins in the SNF2 Family
(as of July 1995 - see Eisen et al)
Protein | Size (aa) | Species | Proposed Subfamily | Possible Function/Comments | References |
---|---|---|---|---|---|
SNF2 | 1703 | S.cerevisiae | SNF2 | Transcription activation. DNA-dependent ATPase. Alters chromatin structure? | 1, 2, 3 |
STH1 | 1359 | S.cerevisiae | SNF2 | Cell cycle control. Required for normal growth. | 1, 2 |
BRM | 1638 | D.melanogaster | SNF2 | Transcription activation of homeotic genes. | 1, 2, 3 |
BRG1 | 1022 | Mouse | SNF2 | Binds retinoblastoma protein. | 1 |
BRG1 | 1613 | Human | SNF2 | Transcription coactivation with hormone receptors. | 1, 2 |
hBRM | 1586 | Human | SNF2 | Transcription coactivation with hormone receptors. | 1, 2, 3 |
SNF2L | 976 | Human | SNF2L | ? | 1 |
ISWI | 1027 | D.melanogaster | SNF2L | ? | 1 |
F37A4.8 | 971 | C.elegans | SNF2L | ? | 1 |
YB95 | 1143 | S.cerevisiae | SNF2L | ? | 1 |
CHD-1 | 940 | Mouse | CHD1 | Binds DNA. | 1 |
SYGP4 | 1468 | S.cerevisiae | CHD1 | ? | |
ETL-1 | 1136 | Mouse | ETL1 | Expressed very early in development. Concentrated in CNS and epithelium. | 1 |
FUN30 | 1131 | S.cerevisiae | ETL1 | Mutants have increased UV resistance. | |
MOT1 | 1867 | S.cerevisiae | MOT1 | Transcription repression. Removes TBP from DNA. DNA-dependent ATPase. | 1 |
RAD26 | 1085 | S.cerevisiae | ERCC6 | Transcription-coupled repair. | 1, 2 |
ERCC6 | 1493 | Human | ERCC6 | Transcription-coupled repair. Defective in Cockayne's syndrome group B. | 1, 2 |
RAD54 | 898 | S.cerevisiae | RAD54 | Recombination repair. | 1 |
DNRPPX | 852 | S.pombe | RAD54 | ? | |
YBS3 | 958 | S.cerevisiae | RAD54 | ? | |
NUCPRO | 1298 | Human | RAD54 | Defective in X-linked mental retardation/alpha-thalassemia | 1 |
NUCPRO | 996 | Mouse | RAD54 | ? | |
RAD16 | 790 | S.cerevisiae | RAD16 | Nucleotide excision repair of silent genes. | 1, 2, 3 |
RAD5 | 1169 | S.cerevisiae | RAD16 | Post-replication repair. GT repeats more stable in mutants. | 1, 2 |
RAD8 | 1133 | S.pombe | RAD16 | Mutants have increased sensitivity to UV and gamma irradiation. | 1 |
HIP116A | 1009 | Human | RAD16 | DNA-dependent ATPase. Binds HIV and SPH motifs of SV40 enhancer. | 1 |
NPHCG42 | 506 | A. californica | none | Viral encoded protein. | |
lodestar | 1061 | D.melanogaster | none | Mutants have excessive chromosome breakage and tangling in mitosis. | 1 |
HepA | 968 | E.coli | none | Induced by DNA damage. |