Proteins in the SNF2 Family
(as of July 1995 - see Eisen et al)

 

Protein Size (aa) Species Proposed Subfamily Possible Function/Comments References
SNF2 1703 S.cerevisiae SNF2 Transcription activation. DNA-dependent ATPase. Alters chromatin structure? 1, 2, 3
STH1 1359 S.cerevisiae SNF2 Cell cycle control. Required for normal growth. 1, 2
BRM 1638 D.melanogaster SNF2 Transcription activation of homeotic genes. 1, 2, 3
BRG1 1022 Mouse SNF2 Binds retinoblastoma protein. 1
BRG1 1613 Human SNF2 Transcription coactivation with hormone receptors. 1, 2
hBRM 1586 Human SNF2 Transcription coactivation with hormone receptors. 1, 2, 3
SNF2L 976 Human SNF2L ? 1
ISWI 1027 D.melanogaster SNF2L ? 1
F37A4.8 971 C.elegans SNF2L ? 1
YB95 1143 S.cerevisiae SNF2L ? 1
CHD-1 940 Mouse CHD1 Binds DNA. 1
SYGP4 1468 S.cerevisiae CHD1 ?  
ETL-1 1136 Mouse ETL1 Expressed very early in development. Concentrated in CNS and epithelium. 1
FUN30 1131 S.cerevisiae ETL1 Mutants have increased UV resistance.  
MOT1 1867 S.cerevisiae MOT1 Transcription repression. Removes TBP from DNA. DNA-dependent ATPase. 1
RAD26 1085 S.cerevisiae ERCC6 Transcription-coupled repair. 1, 2
ERCC6 1493 Human ERCC6 Transcription-coupled repair. Defective in Cockayne's syndrome group B. 1, 2
RAD54 898 S.cerevisiae RAD54 Recombination repair. 1
DNRPPX 852 S.pombe RAD54 ?  
YBS3 958 S.cerevisiae RAD54 ?  
NUCPRO 1298 Human RAD54 Defective in X-linked mental retardation/alpha-thalassemia 1
NUCPRO 996 Mouse RAD54 ?  
RAD16 790 S.cerevisiae RAD16 Nucleotide excision repair of silent genes. 1, 2, 3
RAD5 1169 S.cerevisiae RAD16 Post-replication repair. GT repeats more stable in mutants. 1, 2
RAD8 1133 S.pombe RAD16 Mutants have increased sensitivity to UV and gamma irradiation. 1
HIP116A 1009 Human RAD16 DNA-dependent ATPase. Binds HIV and SPH motifs of SV40 enhancer. 1
NPHCG42 506 A. californica none Viral encoded protein.  
lodestar 1061 D.melanogaster none Mutants have excessive chromosome breakage and tangling in mitosis. 1
HepA 968 E.coli none Induced by DNA damage.