CMPD_CHEMBLID CANONICAL_SMILES PCHEMBL_VALUE ASSAY_CHEMBLID CHEMBL1000 OC(=O)COCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3 4.5 CHEMBL1676103 CHEMBL100415 CCCCN(Cc1cncn1Cc2ccc(cc2)C#N)[C@H]3CCN(Cc4ccccc4)C3=O 6.72 CHEMBL1027667 CHEMBL100454 CN1CCN(CC1)C2=Nc3ccccc3Nc4sc(CO)cc24 4.94 CHEMBL1036648 CHEMBL100566 O=C1[C@H](CCN1c2cccc3ncccc23)NCc4cncn4Cc5ccc(cc5)C#N 5.09 CHEMBL1027667 CHEMBL1008 CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3 6.26 CHEMBL656604 CHEMBL101740 CN(C)CC\C=C/1\c2ccccc2COc3ccccc13 5.19 CHEMBL1676103 CHEMBL104 Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4 5.52 CHEMBL1676103 CHEMBL1077638 CC(C)CN([C@H]1CCNC1)C(=O)c2cccc(c2Cl)C(F)(F)F 5.39 CHEMBL1112305 CHEMBL1077647 CC(C)CN([C@H]1CCNC1)C(=O)c2cc(Cl)ccc2Cl 4.7 CHEMBL1112305 CHEMBL1078162 CC(C)CN([C@H]1CCNC1)C(=O)c2cccc(Cl)c2C 4.28 CHEMBL1112305 CHEMBL1078169 CC(C)CN([C@H]1CCNC1)C(=O)c2ccccc2C(C)C 4.89 CHEMBL1112305 CHEMBL1078231 CCCC[C@H]1CN(CC2CCOCC2)C(=O)OC13CCN(CC3)C4(C)CCN(CC4)C(=O)c5c(C)ncnc5C 4.92 CHEMBL1114086 CHEMBL1078742 CC(C)CN([C@H]1CCNC1)C(=O)c2ccc(Cl)c(Cl)c2 4.76 CHEMBL1112305 CHEMBL1078983 COc1ccc(cc1CO)c2ccc3c(nc(nc3n2)N4C[C@@H](C)O[C@@H](C)C4)N5CCOCC5 5.08 CHEMBL2338825 CHEMBL1079264 Clc1cccc(C(=O)N([C@H]2CCNC2)c3ccccc3)c1Cl 5.1 CHEMBL1112305 CHEMBL1079313 CCOc1cc(CN2CCC(CC2)Nc3oc4ccc(cc4n3)S(=O)(=O)CC)ccc1OC 6.75 CHEMBL1113040 CHEMBL1079461 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5cccc(Cl)c5)n2C 5.8 CHEMBL1107671 CHEMBL1079462 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5ccc(F)cc5)n2C 5.7 CHEMBL1107671 CHEMBL1079475 Cn1c(SCCCN2C[C@@H]3C[C@@]3(C2)c4ccc(cc4)C(F)(F)F)nnc1c5cncnc5 5.5 CHEMBL1107671 CHEMBL1079480 Cc1cnc(cn1)c2nnc(SCCCN3C[C@@H]4C[C@@]4(C3)c5ccc(cc5)C(F)(F)F)n2C 6.1 CHEMBL1107671 CHEMBL1079481 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5ccc(cc5)C(F)(F)F)n2C 6 CHEMBL1107671 CHEMBL1079494 COc1ccc(cc1Cl)C23CC2CN(CCCSc4nnc(c5ocnc5C)n4C)C3 5.4 CHEMBL1107671 CHEMBL1079497 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CC5CC5(C4)c6ccc(Br)cc6)n3C 6.9 CHEMBL1107671 CHEMBL1079577 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CC5CC5(C4)c6ccc(cc6)C#N)n3C 6.2 CHEMBL1107671 CHEMBL1079578 COc1ccc(cc1)C23CC2CN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)C3 5.6 CHEMBL1107671 CHEMBL1079639 Cc1ccoc1c2nnc(SCCCN3C[C@@H]4C[C@@]4(C3)c5ccc(cc5)C(F)(F)F)n2C 6.7 CHEMBL1107671 CHEMBL1079640 Cc1ccc(cn1)c2nnc(SCCCN3C[C@@H]4C[C@@]4(C3)c5ccc(cc5)C(F)(F)F)n2C 6.1 CHEMBL1107671 CHEMBL1079667 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5ccccc5)n2C 5.8 CHEMBL1107671 CHEMBL1079814 Cc1cc(ccc1C23CC2CN(CCCSc4nnc(c5ocnc5C)n4C)C3)C(F)(F)F 6.4 CHEMBL1107671 CHEMBL1079822 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5ccc(cc5)C(C)(C)C)n2C 6.2 CHEMBL1107671 CHEMBL1079823 Cc1ncoc1c2nnc(SCCCN3C[C@H]4C[C@]4(C3)c5ccc(cc5)C(C)(C)C)n2C 6.4 CHEMBL1107671 CHEMBL1079824 Cc1ncoc1c2nnc(SCCCN3C[C@@H]4C[C@@]4(C3)c5ccc(cc5)C(C)(C)C)n2C 6 CHEMBL1107671 CHEMBL1079837 COc1ccc(cc1)C23CC2CN(CCCSc4nnc(c5ocnc5C)n4C)C3 5.6 CHEMBL1107671 CHEMBL1079938 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5cccc(c5F)C(F)(F)F)n2C 5.4 CHEMBL1107671 CHEMBL1079980 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5cccc(F)c5)n2C 5.7 CHEMBL1107671 CHEMBL1080046 CCCCc1ccc(cc1)S(=O)(=O)Nc2ccc3CCN(Cc4cc[nH]n4)CCc3c2 5.6 CHEMBL1109288 CHEMBL1080117 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CC5CC5(C4)c6ccc(Cl)cc6)n3C 5.7 CHEMBL1107671 CHEMBL1080126 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5ccc(c(F)c5)C(F)(F)F)n2C 6.2 CHEMBL1107671 CHEMBL1080164 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4C[C@H]5C[C@]5(C4)c6ccc(Br)cc6)n3C 6.3 CHEMBL1107671 CHEMBL1080165 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4C[C@@H]5C[C@@]5(C4)c6ccc(Br)cc6)n3C 6.6 CHEMBL1107671 CHEMBL1080189 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5ccccc5C(F)(F)F)n2C 5.2 CHEMBL1107671 CHEMBL1080293 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CC5CC5(C4)c6ccc(cc6)C(F)(F)F)n3C 6.8 CHEMBL1107671 CHEMBL1080489 COc1cccc(c1)C23CC2CN(CCCSc4nnc(c5ocnc5C)n4C)C3 5.2 CHEMBL1107671 CHEMBL1080490 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5ccc(Cl)cc5)n2C 6.1 CHEMBL1107671 CHEMBL1080584 CCOc1cc(CN2CCC(CC2)Nc3oc4ccc(cc4n3)C(=O)N)cc(OCC)c1F 6.37 CHEMBL1113040 CHEMBL1080787 CC(C)CN([C@H]1CCNC1)C(=O)c2cccc(Cl)c2Cl 4.7 CHEMBL1112305 CHEMBL1080789 Clc1cccc(C(=O)N(CCC2CC2)[C@H]3CCNC3)c1Cl 5.15 CHEMBL1112305 CHEMBL1080790 CC(C)(C)CN([C@H]1CCNC1)C(=O)c2cccc(Cl)c2Cl 4.78 CHEMBL1112305 CHEMBL1080846 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5ccc(Cl)c(Cl)c5)n2C 6 CHEMBL1107671 CHEMBL1080968 Clc1cccc(C(=O)N(C2CCCC2)[C@H]3CCNC3)c1Cl 4.99 CHEMBL1112305 CHEMBL1080969 CCC(CC)N([C@H]1CCNC1)C(=O)c2cccc(Cl)c2Cl 5.11 CHEMBL1112305 CHEMBL1081023 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5ccc(cc5F)C(F)(F)F)n2C 6 CHEMBL1107671 CHEMBL1081203 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CC5CC5(C4)c6ccccc6)n3C 5.3 CHEMBL1107671 CHEMBL1081237 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CC5CC5(C4)c6ccc(Cl)c(Cl)c6)n3C 5.8 CHEMBL1107671 CHEMBL1081401 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CC5CC5(C4)c6ccc(cc6)C(C)(C)C)n3C 6.6 CHEMBL1107671 CHEMBL1081408 COc1ccc(cc1C(F)(F)F)C23CC2CN(CCCSc4nnc(c5ocnc5C)n4C)C3 5.9 CHEMBL1107671 CHEMBL1081409 Cc1ncoc1c2nnc(SCCCN3C[C@@H]4C[C@@]4(C3)c5ccc(cc5)C(F)(F)F)n2C 6.1 CHEMBL1107671 CHEMBL1081580 Cc1ncoc1c2nnc(SCCCN3C[C@H]4C[C@]4(C3)c5ccc(cc5)C(F)(F)F)n2C 6.2 CHEMBL1107671 CHEMBL1081587 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5ccc(F)c(c5)C(F)(F)F)n2C 5.6 CHEMBL1107671 CHEMBL1081685 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4C[C@@H]5C[C@@]5(C4)c6ccc(cc6)C(F)(F)F)n3C 6.3 CHEMBL1107671 CHEMBL1081686 Cn1c(SCCCN2C[C@@H]3C[C@@]3(C2)c4ccc(cc4)C(F)(F)F)nnc1c5ccccc5 6.2 CHEMBL1107671 CHEMBL1081687 Cc1ncccc1c2nnc(SCCCN3C[C@@H]4C[C@@]4(C3)c5ccc(cc5)C(F)(F)F)n2C 5.3 CHEMBL1107671 CHEMBL1081746 Cc1nc(C)c(s1)c2nnc(SCCCN3C[C@@H]4C[C@@]4(C3)c5ccc(cc5)C(F)(F)F)n2C 5.7 CHEMBL1107671 CHEMBL1081747 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5ccc(Cl)cc5F)n2C 6 CHEMBL1107671 CHEMBL1081867 Cn1c(SCCCN2C[C@@H]3C[C@@]3(C2)c4ccc(cc4)C(F)(F)F)nnc1c5ccnnc5 5.4 CHEMBL1107671 CHEMBL1081868 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5cc(F)cc(c5)C(F)(F)F)n2C 5.7 CHEMBL1107671 CHEMBL1081869 Cc1ccc(c(F)c1)C23CC2CN(CCCSc4nnc(c5ocnc5C)n4C)C3 4.4 CHEMBL1107671 CHEMBL1081934 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5cccc(OC(F)(F)F)c5)n2C 6 CHEMBL1107671 CHEMBL1081957 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5cccc(c5)C(F)(F)F)n2C 5.1 CHEMBL1107671 CHEMBL1081966 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5ccc(OC(F)(F)F)cc5)n2C 6.5 CHEMBL1107671 CHEMBL1082106 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5ccc(Br)cc5)n2C 6.1 CHEMBL1107671 CHEMBL1082111 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5cc(ccc5F)C(F)(F)F)n2C 5 CHEMBL1107671 CHEMBL1082330 CN1c2nc(c(cc2C(CC1(C)C)C(=O)NCO)c3ccc(Cl)cc3)c4ccc(Cl)cc4Cl 7.4 CHEMBL1120225 CHEMBL1082447 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4ccc(C)nc4C 4.7 CHEMBL1827362 CHEMBL1082488 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cc(C)nc(n4)c5ccccc5 6.92 CHEMBL1827362 CHEMBL1082489 COc1ncc(cn1)c2ccc3cc(CCN4CCC[C@H]4C)ccc3n2 4.65 CHEMBL1827362 CHEMBL1082496 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4ccccn4 4.75 CHEMBL1827362 CHEMBL1082606 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4sc(nc4C)c5cccnc5 5.22 CHEMBL1827362 CHEMBL1082723 C[C@H]1Cc2c([nH]c3cc(Cl)c(F)cc23)[C@@]4(N1)C(=O)Nc5ccc(Cl)cc45 4.52 CHEMBL1247720 CHEMBL1082781 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4ccc(C)nc4 4.58 CHEMBL1827362 CHEMBL1083025 CC1(C)CC(NC(=O)CCO)c2cc(c3ccc(Cl)cc3)c(nc2O1)c4ccc(Cl)cc4Cl 6.42 CHEMBL1120225 CHEMBL1083118 CNC[C@@H](O)CCN1c2ccccc2N(c3cc(F)ccc3F)S1(=O)=O 4.89 CHEMBL1120746 CHEMBL1083274 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4oc(C)nc4C 4.4 CHEMBL1827362 CHEMBL1083405 CC(C)Oc1ccccc1CC(N2CCNCC2)c3ccccc3 5.2 CHEMBL1120514 CHEMBL1083406 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4ccncc4 4.55 CHEMBL1827362 CHEMBL1083407 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4ccc(Cl)nc4 5.44 CHEMBL1827362 CHEMBL1083409 CNC[C@@H](O)CCN1c2ccccc2N(c3ccccc3)S1(=O)=O 5.1 CHEMBL1120746 CHEMBL1083425 FC(F)Oc1ccccc1CC(N2CCNCC2)c3ccc(F)cc3 5.04 CHEMBL1120514 CHEMBL1083426 Fc1ccccc1C(Cc2ccccc2OC(F)(F)F)N3CCNCC3 5.12 CHEMBL1120514 CHEMBL1083427 Fc1cccc(c1)C(Cc2ccccc2OC(F)(F)F)N3CCNCC3 5.21 CHEMBL1120514 CHEMBL1083429 CNC[C@@H](O)CCN1c2ccccc2N(c3c(F)cccc3F)S1(=O)=O 4.7 CHEMBL1120746 CHEMBL1083447 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4ccc5nccnc5c4 5.08 CHEMBL1827362 CHEMBL1083448 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4ccc5OCOCc5c4 5.44 CHEMBL1827362 CHEMBL1083462 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cnn(c4C)c5ccc(nn5)N(C)C 4.75 CHEMBL1827362 CHEMBL1083463 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cnn(c4C)c5ccc(Cl)c(Cl)c5 6.22 CHEMBL1827362 CHEMBL1083562 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4nc5ccccc5s4 5.7 CHEMBL1827362 CHEMBL1083646 C[C@@H](O)C(=O)NC1CC(C)(C)Oc2nc(c(cc12)c3ccc(Cl)cc3)c4ccc(Cl)cc4Cl 6.92 CHEMBL1120225 CHEMBL1083705 C(C(N1CCNCC1)c2ccccc2)c3ccccc3OC4CC4 5.19 CHEMBL1120514 CHEMBL1083706 C(Oc1ccccc1CC(N2CCNCC2)c3ccccc3)C4CC4 5.53 CHEMBL1120514 CHEMBL1083707 C(C(N1CCNCC1)c2ccccc2)c3cccc4CCOc34 4.67 CHEMBL1120514 CHEMBL1083708 FC(F)Oc1ccccc1CC(N2CCNCC2)c3ccccc3 4.82 CHEMBL1120514 CHEMBL1083750 Cn1nccc1c2cc(NC(=O)c3ccc(F)cc3F)ccc2OCCN4CCOCC4 5.39 CHEMBL1119165 CHEMBL1083787 Fc1ccc(cc1)c2ccc(NC(=O)NCCCCN3CCCCC3)cn2 5.89 CHEMBL1118799 CHEMBL1083999 CN(C)CCCCc1ccc(cc1)C(C)(C)C 5.13 CHEMBL2208705 CHEMBL1084000 CN(C)CCCCc1ccc(cc1)C2(C)COC2 4.46 CHEMBL2208705 CHEMBL1084033 Fc1ccc(cc1)C(Cc2ccccc2OC(F)(F)F)N3CCNCC3 5.02 CHEMBL1120514 CHEMBL1084132 C(C1CCCCN1)N2CCN(C2)c3ccccc3 4.8 CHEMBL1106923 CHEMBL1084294 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4csc(n4)c5cc(Cl)nc(Cl)c5 4.69 CHEMBL1827362 CHEMBL1084309 FC(F)Oc1ccccc1CC(N2CCNCC2)c3ccccc3F 5.19 CHEMBL1120514 CHEMBL1084314 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4c[nH]nc4C 4.75 CHEMBL1827362 CHEMBL1084383 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4sc5ncnn5c4C 5.55 CHEMBL1827362 CHEMBL1084384 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cn5CCSc5n4 4.4 CHEMBL1827362 CHEMBL1084385 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4c(C)nc5ccccn45 5.1 CHEMBL1827362 CHEMBL1084400 FC(F)(F)c1cccc(c1)c2cc(CCCN3CCCCC3)nc(n2)C#N 6.8 CHEMBL1101904 CHEMBL1084401 CCC(CC)NCCCc1cc(nc(n1)C#N)c2cccc(c2)C(F)(F)F 6.5 CHEMBL1101904 CHEMBL1084402 CC(C)(C)NCCCc1cc(nc(n1)C#N)c2cccc(c2)C(F)(F)F 5.96 CHEMBL1101904 CHEMBL1084559 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4sc(C)nc4C 4.69 CHEMBL1827362 CHEMBL1084560 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cccnc4 4.92 CHEMBL1827362 CHEMBL1084577 FC(F)Oc1ccccc1CC(N2CCNCC2)c3cccc(F)c3 5.08 CHEMBL1120514 CHEMBL1084581 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4ccn[nH]4 4.4 CHEMBL1827362 CHEMBL1084582 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cn[nH]c4 4.4 CHEMBL1827362 CHEMBL1084616 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4ccn5ncnc5n4 4.68 CHEMBL1827362 CHEMBL1084617 COc1cccc(c1)C(=O)Nc2ccc(OCCN3CCOCC3)c(c2)c4ccnn4C 4.96 CHEMBL1119165 CHEMBL1084826 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4c(C)n[nH]c4C 4.4 CHEMBL1827362 CHEMBL1084827 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cnn(C)c4C 4.4 CHEMBL1827362 CHEMBL1084877 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cnn(c4C)c5cc(cc(C)n5)C(F)(F)F 4.78 CHEMBL1827362 CHEMBL1084878 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4csc(n4)c5ccccc5 5.8 CHEMBL1827362 CHEMBL1084879 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4csc(n4)c5ccc(OCC(F)(F)F)nc5 5.82 CHEMBL1827362 CHEMBL1085124 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4ccc(s4)c5ccc(C)s5 5.7 CHEMBL1827362 CHEMBL1085142 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4sc5nc6ccccc6n5c4C 5.76 CHEMBL1827362 CHEMBL1085325 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)C(C)(C)C 5.17 CHEMBL1827362 CHEMBL1085336 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4ccc(cc4)N5CCCCC5 5.55 CHEMBL1827362 CHEMBL1085337 CC1CCN(CC1)c2ccc3cc(CCN4CCC[C@H]4C)ccc3n2 4.65 CHEMBL1827362 CHEMBL1085396 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4c(C)onc4c5ccc(Cl)cc5 5.8 CHEMBL1827362 CHEMBL1085397 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4c(Cl)n(C)nc4c5ccccc5 5.22 CHEMBL1827362 CHEMBL1085398 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4c(C)onc4c5ccccc5 5.19 CHEMBL1827362 CHEMBL1085567 COc1ccccc1CC(N2CCNCC2)c3ccc(F)cc3 4.8 CHEMBL1120514 CHEMBL1085591 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)C4=NCCS4 4.6 CHEMBL1827362 CHEMBL1085592 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4sc(nc4C)c5cnccn5 4.5 CHEMBL1827362 CHEMBL1085627 CC(=O)N1CCN(CCOc2ccc(NC(=O)c3cccc(F)c3)cc2c4ccnn4C)CC1 5.39 CHEMBL1119165 CHEMBL1085641 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4onc(c4C)c5ccc(Cl)cc5 5.7 CHEMBL1827362 CHEMBL1085672 Clc1cccc(c1)N2CCN(CC3CCCCN3)C2=O 5.1 CHEMBL1106923 CHEMBL1085783 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4c(O)ccnc4C(F)(F)F 4.4 CHEMBL1827362 CHEMBL1085800 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4ccc(cc4)C#N 5.5 CHEMBL1827362 CHEMBL1085828 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cncnc4 4.4 CHEMBL1827362 CHEMBL1085841 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4sc(nc4C)c5ccncc5 5.32 CHEMBL1827362 CHEMBL1085866 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4sc(nc4C)c5ccccn5 4.95 CHEMBL1827362 CHEMBL1085959 COc1ccccc1CC(N2CCNCC2)c3ccccc3F 4.4 CHEMBL1120514 CHEMBL1085964 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cnccn4 4.61 CHEMBL1827362 CHEMBL1086032 C[C@@H]1CCCN1CCc2ccc3ncccc3c2 4.4 CHEMBL1827362 CHEMBL1086034 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)C4CC4 4.36 CHEMBL1827362 CHEMBL1086072 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4csc(n4)c5csc(C)n5 4.91 CHEMBL1827362 CHEMBL1086073 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4csc(n4)c5cc(C)on5 5.55 CHEMBL1827362 CHEMBL1086074 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cnc5OCOc5c4 4.4 CHEMBL1827362 CHEMBL1086098 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4nnn(c4C)c5ccc(F)cc5F 5.55 CHEMBL1827362 CHEMBL1086273 COc1c(F)cccc1CC(N2CCNCC2)c3ccccc3 4.68 CHEMBL1120514 CHEMBL1086274 COc1cccc(F)c1CC(N2CCNCC2)c3ccccc3 5.07 CHEMBL1120514 CHEMBL1086275 FC(F)Oc1cccc(F)c1CC(N2CCNCC2)c3ccccc3 4.98 CHEMBL1120514 CHEMBL1086292 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4sc(nc4C)c5cccs5 5.43 CHEMBL1827362 CHEMBL1086315 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4ccc(C#N)s4 5.7 CHEMBL1827362 CHEMBL1086317 Cn1nccc1c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2OCCN4CCOCC4 6.05 CHEMBL1119165 CHEMBL1086513 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cnc(s4)c5ccccc5 5.87 CHEMBL1827362 CHEMBL1086514 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4ccc(cc4)N5C=CC(=O)C=C5 4.7 CHEMBL1827362 CHEMBL1086520 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4onc(Br)c4 6.06 CHEMBL1827362 CHEMBL1086521 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4nccs4 4.94 CHEMBL1827362 CHEMBL1086534 CCOC(=N)c1ccc(s1)c2ccc3cc(CCN4CCC[C@H]4C)ccc3n2 5.32 CHEMBL1827362 CHEMBL1086561 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4sc(nc4C)N5CCOCC5 4.69 CHEMBL1827362 CHEMBL1086579 CN1CCN(CC1)c2nc3c(N4CCN(Cc5cc(C)on5)CC4)c(Br)cnc3[nH]2 5.52 CHEMBL1118846 CHEMBL1086582 CN1CCN(CC1)c2nc3c(N4CCN(Cc5cc(C)on5)CC4)c(Cl)cnc3[nH]2 5.64 CHEMBL1118846 CHEMBL1086626 Cc1[nH]c(cc1C(=O)NCCCN2CCN(CC2)c3cccc(Cl)c3Cl)c4ccccc4 7 CHEMBL1217370 CHEMBL1086754 Cc1c(cc(c2ccccc2)n1C)C(=O)NCCCN3CCN(CC3)c4cccc(Cl)c4Cl 6.85 CHEMBL1217370 CHEMBL1086756 CCCn1c(C)c(cc1c2ccccc2)C(=O)NCCCN3CCN(CC3)c4cccc(Cl)c4Cl 6.27 CHEMBL1217370 CHEMBL1087268 C[C@H](Nc1nc(Nc2ncc(C)s2)cc(n1)N3CCN(C)CC3)c4ccc(F)cn4 4.89 CHEMBL1103133 CHEMBL1087269 C[C@H](Nc1nc(Nc2ncc(C)s2)cc(n1)N3CCOCC3)c4ccc(F)cn4 4.92 CHEMBL1103133 CHEMBL1087367 COc1ccc(Cn2c(nc3ccccc23)N4CC[C@H](C4)N(C)C)cc1 6.31 CHEMBL1110017 CHEMBL1087493 CCOCCn1c(nc2ccccc12)N3CC[C@@H](C3)N(C)C 6.63 CHEMBL1110017 CHEMBL1088 CN1CCCCC1CCN2c3ccccc3Sc4ccc(cc24)[S+](C)[O-] 6.26 CHEMBL829152 CHEMBL1088803 CCCCC(N1CCOCC1)C(O)(c2cccnc2)c3cccnc3 4.44 CHEMBL1108890 CHEMBL1088804 CCCCCCC(N1CCOCC1)C(O)(c2cccnc2)c3cccnc3 4.56 CHEMBL1108890 CHEMBL1088900 COc1nccnc1CC2=C(CCN(C)C)Cc3ccccc23 5.12 CHEMBL1115186 CHEMBL1088949 Cc1[nH]c2ccccc2c1CCN3Cc4ccc(\C=C\C(=O)NO)cc4C3 5.32 CHEMBL1111711 CHEMBL1089078 OCCN1CCC(CC1)N(C(=O)NCc2ccc(F)cc2)c3ccc(Br)cc3 5.1 CHEMBL1107892 CHEMBL1089159 OC(C(N1CCCC1)c2ccccc2)(c3cccnc3)c4cccnc4 4.7 CHEMBL1108890 CHEMBL1089164 Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(oc3C)c4ccc(F)cc4)c2)cc1 4.42 CHEMBL1110812 CHEMBL1089210 Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(oc3C)c4ccc(Cl)cc4)c2)cc1 4.53 CHEMBL1110812 CHEMBL1089301 Cc1[nH]c2ccccc2c1CCN3CCc4ccc(\C=C\C(=O)NO)cc4CC3 5.5 CHEMBL1111711 CHEMBL1089343 Cc1[nH]c2ccccc2c1C3CCCN(Cc4ccc(\C=C\C(=O)NO)cc4)C3 4.56 CHEMBL1111711 CHEMBL1089344 Cc1[nH]c2ccccc2c1C3CCN(Cc4ccc(\C=C\C(=O)NO)cc4)C3 4.87 CHEMBL1111711 CHEMBL1089359 Cc1[nH]c2ccccc2c1CC3CCCCN3Cc4ccc(\C=C\C(=O)NO)cc4 5.04 CHEMBL1111711 CHEMBL1089681 Clc1cc(Cl)cc(CNC(=O)N(C2CCN(CC2)C3CCCC3)c4ccc(Br)cc4)c1 7.22 CHEMBL1107892 CHEMBL1089700 Cc1[nH]c2ccccc2c1CCN3CCCC3c4ccc(\C=C\C(=O)NO)cc4 4.71 CHEMBL1111711 CHEMBL1089701 Cc1[nH]c2ccccc2c1CCN3CCc4cc(\C=C\C(=O)NO)ccc4C3 4.83 CHEMBL1111711 CHEMBL1089865 CN1C(=O)C(=Cc2cnn(c12)c3c(F)cccc3F)c4cc(ccc4C)C(=O)NC5CC5 4.44 CHEMBL1104518 CHEMBL1090159 OC(C(N1CCNCC1)c2ccccc2)(c3cccnc3)c4cccnc4 5.64 CHEMBL1108890 CHEMBL1090160 OC(C(N1CCCCC1)c2ccccc2)(c3cccnc3)c4cccnc4 4.85 CHEMBL1108890 CHEMBL1090175 COc1ccc2C(=C(CCN(C)C)Cc2c1)[C@@H](C)c3cnccn3 5.47 CHEMBL1115186 CHEMBL1090176 COc1nccnc1[C@H](C)C2=C(CCN(C)C)Cc3cc(C)ccc23 5.42 CHEMBL1115186 CHEMBL1090186 COc1ccc2C(=C(CCN(C)C)Cc2c1)[C@@H](C)c3nccnc3OC 5.3 CHEMBL1115186 CHEMBL1090188 Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(oc3C)c4ccc(cc4)C#N)c2)cc1 4.28 CHEMBL1110812 CHEMBL1090189 COc1ccc(cc1)c2oc(C)c(COc3cccc(CN(CC(=O)O)C(=O)Oc4ccc(C)cc4)c3)n2 5.07 CHEMBL1110812 CHEMBL1090211 Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3oc(nc3C)c4ccc(Cl)cc4)c2)cc1 4.7 CHEMBL1110812 CHEMBL1090526 COc1nccnc1[C@H](C)C2=C(CCN(C)C)Cc3cc(F)ccc23 5.75 CHEMBL1115186 CHEMBL1090528 C[C@H](C1=C(CCN(C)C)Cc2cc(C)ccc12)c3nccs3 6.21 CHEMBL1115186 CHEMBL1090818 OC(C(N1CCC1)c2ccccc2)(c3cccnc3)c4cccnc4 4.82 CHEMBL1108890 CHEMBL1090877 Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(oc3C)c4ccc(C)cc4)c2)cc1 4.59 CHEMBL1110812 CHEMBL1091069 COc1cccnc1[C@H](C)c2c(CCN(C)C)sc3ccccc23 5.52 CHEMBL1106982 CHEMBL1091163 OC(C(N1CCCOCC1)c2ccccc2)(c3cccnc3)c4cccnc4 5.45 CHEMBL1108890 CHEMBL1091218 Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(oc3C)c4ccc(cc4)C(F)(F)F)c2)cc1 4.59 CHEMBL1110812 CHEMBL1091605 CC(C)N(C)[C@@H]1CC[C@@H]([C@H](CS(=O)(=O)c2ccccc2)C1)N3CC[C@H](NC(=O)c4cccc(c4)C(F)(F)F)C3=O 4.52 CHEMBL1104433 CHEMBL1091664 Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(sc3C)c4ccc(Cl)cc4)c2)cc1 5 CHEMBL1110812 CHEMBL1091720 CCC(C)(C)Cc1c[nH]c(CCc2ccc(cc2)c3ccccn3)n1 5.92 CHEMBL1680285 CHEMBL1091775 C[C@@H](c1ccccn1)c2c(CCN3CCC3)sc4ccccc24 5.38 CHEMBL1106981 CHEMBL1091777 C[C@H](c1cccnc1)c2c(CCN(C)C)sc3ccccc23 6.31 CHEMBL1106982 CHEMBL1091782 C[C@@H](c1cscn1)c2c(CCN(C)C)sc3ccccc23 5.77 CHEMBL1106982 CHEMBL1091834 Fc1ccc(CNC(=O)N(C2CCN(Cc3ccncc3)CC2)c4ccc(Cl)cc4)cc1 5.42 CHEMBL1107892 CHEMBL1091836 Nc1cc(CN2CCC(CC2)N(C(=O)NCc3ccc(F)cc3)c4ccc(Cl)cc4)ccn1 6.42 CHEMBL1107892 CHEMBL1091879 CC(C)C(N1CCOCC1)C(O)(c2cccnc2)c3cccnc3 4.13 CHEMBL1108890 CHEMBL1091880 OC(C(Cc1ccccc1)N2CCOCC2)(c3cccnc3)c4cccnc4 4.82 CHEMBL1108890 CHEMBL1091919 CSc1nn2c3CCCCc3c(C)nc2c1S(=O)(=O)c4ccccc4 5.08 CHEMBL1117033 CHEMBL1092105 CCN1CCC(CC1)N(C(=O)NCc2ccc(F)cc2)c3ccc(Cl)cc3 5.18 CHEMBL1107892 CHEMBL1092106 CCN1CCC(CC1)N(C(=O)NCc2ccc(F)cc2)c3ccc(Cl)cn3 5.04 CHEMBL1107892 CHEMBL1092108 Brc1ccc(cc1)N(C2CCN(Cc3ccncc3)CC2)C(=O)NCc4ccccc4 5.64 CHEMBL1107892 CHEMBL1092109 Brc1ccc(cc1)N(C2CCN(Cc3ccnnc3)CC2)C(=O)NCc4ccccc4 4.86 CHEMBL1107892 CHEMBL1092126 C[C@@H](c1ncccc1C)c2c(CCN(C)C)sc3ccccc23 6.04 CHEMBL1106982 CHEMBL1092169 CC(C)(O)C(=O)c1oc2nc(c3ccccc3Cl)c(cc2c1NC(=O)CO)c4ccc(Cl)cc4 5.18 CHEMBL1114477 CHEMBL1092258 COc1ccc2C(=C(CCN(C)C)Cc2c1)Cc3cnccn3 5.68 CHEMBL1115186 CHEMBL1092259 CN(C)CCC1=C(Cc2cnccn2)c3ccc(Cl)cc3C1 6.96 CHEMBL1115186 CHEMBL1092377 C[C@@H](c1ncccc1F)c2c(CCN(C)C)sc3ccccc23 6.48 CHEMBL1106982 CHEMBL1092495 C[C@@H](c1ccc(F)cn1)c2c(CCN(C)C)sc3ccccc23 6.62 CHEMBL1106982 CHEMBL1092574 COCCN(C)C(c1ccccc1)C(O)(c2cccnc2)c3cccnc3 5.46 CHEMBL1108890 CHEMBL1092597 COc1nccnc1[C@H](C)C2=C(CCN(C)C)Cc3ccccc23 5.12 CHEMBL1115186 CHEMBL1092598 C[C@H](C1=C(CCN(C)C)Cc2ccccc12)c3nccs3 5.43 CHEMBL1115186 CHEMBL1092599 C[C@H](C1=C(CCN(C)C)Cc2ccccc12)c3nc(C)cs3 5.72 CHEMBL1115186 CHEMBL1092600 CN(C)CCC1=C(Cc2cnccn2)c3ccc(C)cc3C1 6.28 CHEMBL1115186 CHEMBL1092649 CN(C)CCC1=C(Cc2cnccn2)c3ccc(F)cc3C1 6.23 CHEMBL1115186 CHEMBL1092650 COc1nccnc1CC2=C(CCN(C)C)Cc3cc(Cl)ccc23 6.64 CHEMBL1115186 CHEMBL1092652 CN(C)CCC1=C(Cc2cccnn2)c3ccc(Cl)cc3C1 6.66 CHEMBL1115186 CHEMBL1092662 CN(C)CCC1=C(Cc2cccnn2)c3ccc(F)cc3C1 6.05 CHEMBL1115186 CHEMBL1092663 C[C@H](C1=C(CCN(C)C)Cc2cc(C)ccc12)c3cnccn3 6.44 CHEMBL1115186 CHEMBL1092678 CC(C)N(C)[C@@H]1CC[C@@H]([C@H](CS(=O)(=O)c2ccc(C)cc2)C1)N3CC[C@H](NC(=O)c4cccc(c4)C(F)(F)F)C3=O 5.52 CHEMBL1104433 CHEMBL1092748 CC(C)N(C)[C@@H]1CC[C@@H]([C@H](CS(=O)(=O)c2ccccc2)C1)N3CC[C@H](NC(=O)c4cc(cc(c4)C(F)(F)F)C(F)(F)F)C3=O 5.4 CHEMBL1104433 CHEMBL1092765 C[C@H](c1cccnc1F)c2c(CCN(C)C)sc3ccccc23 5.64 CHEMBL1106982 CHEMBL1092766 C[C@H](c1cccnc1Cl)c2c(CCN(C)C)sc3ccccc23 5.82 CHEMBL1106982 CHEMBL1092901 CC(=O)N1CCC(CC1)c2[nH]nc(c3ccc(F)cc3)c2c4ccncc4 6.1 CHEMBL1107055 CHEMBL1092921 Fc1ccc(F)c(c1)C(=O)N2CCC(CCN3CC[C@H](C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F)CC2 5 CHEMBL1108768 CHEMBL1092931 Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(oc3C)c4cccc(Cl)c4)c2)cc1 5.14 CHEMBL1110812 CHEMBL1092941 CC(C)N(C)[C@@H]1CC[C@@H]([C@H](CS(=O)(=O)c2ccccc2)C1)N3CC[C@H](NC(=O)c4cc(F)cc(c4)C(F)(F)F)C3=O 4.66 CHEMBL1104433 CHEMBL1093051 ONC(=O)\C=C\c1ccc(CN2CCCC(C2)c3c[nH]c4ccccc34)c(F)c1 4.82 CHEMBL1111711 CHEMBL1093052 ONC(=O)\C=C\c1ccc(CN2CCCC(C2)c3c([nH]c4ccccc34)c5ccccc5)c(F)c1 4.71 CHEMBL1111711 CHEMBL1093053 CC(C)(C)c1[nH]c2ccccc2c1C3CCCN(Cc4ccc(\C=C\C(=O)NO)cc4F)C3 4.52 CHEMBL1111711 CHEMBL1093058 C[C@H](c1c(CCN(C)C)sc2ccccc12)n3cccn3 5.7 CHEMBL1106982 CHEMBL1093113 OCCN1CCC(CC1)N(C(=O)NCc2ccc(F)cc2)c3ccc(Cl)cc3 4.9 CHEMBL1107892 CHEMBL1093294 COc1ncccc1[C@@H](C)c2c(CCN(C)C)sc3ccccc23 5.75 CHEMBL1106982 CHEMBL1093351 CC(C)(C)c1[nH]c2ccccc2c1C3CCCN(Cc4ccc(\C=C\C(=O)NO)cc4Cl)C3 5 CHEMBL1111711 CHEMBL1093362 Cc1[nH]c2ccccc2c1CCN3CCc4ccc(\C=C\C(=O)NO)cc4C3 5.57 CHEMBL1111711 CHEMBL1093623 COc1ccc2C(=C(CCN(C)C)Cc2c1)[C@@H](C)c3nccs3 4.66 CHEMBL1115186 CHEMBL1093696 Fc1ccc(CNC(=O)N(C2CCN(Cc3ccnnc3)CC2)c4ccc(Cl)cc4)cc1 4.92 CHEMBL1107892 CHEMBL1094028 Brc1ccc(cc1)N(C2CCN(CC2)C3CCCC3)C(=O)NCc4ccccc4 6.75 CHEMBL1107892 CHEMBL1094029 Brc1ccc(cc1)N(C2CCN(CC2)C3CCCC3)C(=O)Nc4ccccc4 6.73 CHEMBL1107892 CHEMBL1094030 Fc1ccc(CNC(=O)N(C2CCN(CC2)C3CCCC3)c4ccc(Br)cc4)cc1 6.7 CHEMBL1107892 CHEMBL1094040 ONC(=O)\C=C\c1ccc(CN2CCCC(C2)c3c[nH]c4ccccc34)cc1 4.53 CHEMBL1111711 CHEMBL1094041 ONC(=O)\C=C\c1ccc(CN2CCCC(C2)c3c([nH]c4ccccc34)c5ccccc5)cc1 4.55 CHEMBL1111711 CHEMBL1094042 CC(C)(C)c1[nH]c2ccccc2c1C3CCCN(Cc4ccc(\C=C\C(=O)NO)cc4)C3 4.87 CHEMBL1111711 CHEMBL1094365 CCOCCn1nc(CC)c2nc(nc(Nc3cc(C)ccn3)c12)N4CCC(CC4)C(=O)O 5.96 CHEMBL1106530 CHEMBL1094521 C[C@H](O)C(=O)NC1CC(C)(C)Oc2nc(c(cc12)c3ccc(Cl)cc3)c4ccc(Cl)cc4Cl 6.47 CHEMBL1120225 CHEMBL1094847 CC(C)(O)C(=O)NC1CC(C)(C)Oc2nc(c3ccc(Cl)cc3Cl)c(cc12)c4ccc(Cl)cc4 6.42 CHEMBL1105740 CHEMBL1095121 CCc1nn(CCOCC(F)(F)F)c2c(Nc3ccncn3)nc(nc12)N4CCN[C@H](C)C4 5.85 CHEMBL1106514 CHEMBL1095150 Cc1n[nH]cc1C(=O)N[C@@H]2CC(C)(C)Oc3nc(c4ccc(Cl)cc4Cl)c(cc23)c5ccc(Cl)cc5 5.96 CHEMBL1105740 CHEMBL1095151 Cc1n[nH]c(C)c1C(=O)N[C@@H]2CC(C)(C)Oc3nc(c4ccc(Cl)cc4Cl)c(cc23)c5ccc(Cl)cc5 5.8 CHEMBL1105740 CHEMBL1095158 Cc1c[nH]nc1C(=O)N[C@@H]2CC(C)(C)Oc3nc(c4ccc(Cl)cc4Cl)c(cc23)c5ccc(Cl)cc5 5.28 CHEMBL1105740 CHEMBL1095159 CC1(C)CC(NC(=O)C(F)(F)CO)c2cc(c3ccc(Cl)cc3)c(nc2O1)c4ccc(Cl)cc4Cl 7.1 CHEMBL1105740 CHEMBL1095202 CCOCCn1c(nc2ccccc12)[C@@H]3CCCN(C3)C4CCOCC4 5.68 CHEMBL1110021 CHEMBL1095476 Cc1[nH]nc(C(=O)N[C@@H]2CC(C)(C)Oc3nc(c4ccc(Cl)cc4Cl)c(cc23)c5ccc(Cl)cc5)c1C 5.06 CHEMBL1105740 CHEMBL1095499 CC1(C)CC(NC(=O)C2(O)CC2)c3cc(c4ccc(Cl)cc4)c(nc3O1)c5ccc(Cl)cc5Cl 6.52 CHEMBL1105740 CHEMBL1095553 CC1(C)C[C@@H](NC(=O)c2n[nH]c3ccccc23)c4cc(c5ccc(Cl)cc5)c(nc4O1)c6ccc(Cl)cc6Cl 5.34 CHEMBL1105740 CHEMBL1095554 CC1(C)C[C@@H](NC(=O)c2ccc3[nH]ncc3c2)c4cc(c5ccc(Cl)cc5)c(nc4O1)c6ccc(Cl)cc6Cl 6.2 CHEMBL1105740 CHEMBL1095789 CCc1cc(n[nH]1)C(=O)N[C@@H]2CC(C)(C)Oc3nc(c4ccc(Cl)cc4Cl)c(cc23)c5ccc(Cl)cc5 5.92 CHEMBL1105740 CHEMBL1095819 CN1CCC[C@H](C1)c2nc3ccccc3n2Cc4ccc(F)cc4 6.14 CHEMBL1110021 CHEMBL1095845 Fc1cccc(O[C@@H]2CN[C@H](C2)C(=O)N3CCCN(CC3)C4CCC4)c1 5.52 CHEMBL1105770 CHEMBL1095846 Fc1ccc(O[C@@H]2CN[C@H](C2)C(=O)N3CCCN(CC3)C4CCC4)cc1 5.11 CHEMBL1105770 CHEMBL1095847 Clc1ccc(O[C@@H]2CN[C@H](C2)C(=O)N3CCCN(CC3)C4CCC4)cc1 5.7 CHEMBL1105771 CHEMBL1095877 Clc1cccc(O[C@@H]2CN[C@H](C2)C(=O)N3CCCN(CC3)C4CCC4)c1 5.14 CHEMBL1105771 CHEMBL1095990 CC(=O)N[C@@H]1CC(C)(C)Oc2nc(c(cc12)c3ccc(Cl)cc3)c4ccc(Cl)cc4Cl 6.27 CHEMBL1105740 CHEMBL1096182 Cc1cc(n[nH]1)C(=O)N[C@@H]2CC(C)(C)Oc3nc(c4ccc(Cl)cc4Cl)c(cc23)c5ccc(Cl)cc5 6 CHEMBL1105740 CHEMBL1096827 CC(=O)N1C[C@H](C[C@@H]1C(=O)N2CCCN(CC2)C3CCC3)Oc4cccc(F)c4 5.22 CHEMBL1105770 CHEMBL1097 CCN(CC)CCNC(=O)c1ccc(NC(=O)C)cc1 4 CHEMBL827807 CHEMBL1097455 CC(O)(C(=O)NC1CC(C)(C)Oc2nc(c3ccc(Cl)cc3Cl)c(cc12)c4ccc(Cl)cc4)C(F)(F)F 6.22 CHEMBL1105740 CHEMBL1097456 CC1(C)CC(NC(=O)CC(O)C(F)(F)F)c2cc(c3ccc(Cl)cc3)c(nc2O1)c4ccc(Cl)cc4Cl 5.61 CHEMBL1105740 CHEMBL1097701 FC(F)(F)c1ccc(NC(=O)CN2CCCN(Cc3nc4ccccc4[nH]3)CC2)cc1 5.3 CHEMBL1121059 CHEMBL1097718 Cc1cccc(Nc2nc(nc3c(C)nn(CCOCC(F)(F)F)c23)N4CCNCC4)n1 6.25 CHEMBL1106514 CHEMBL1097783 CCOCCn1nc(C)c2nc(NC3CCNCC3)nc(Nc4cc(C)ccn4)c12 5.55 CHEMBL1106530 CHEMBL1097841 CC1(C)C[C@@H](NC(=O)c2cn[nH]c2)c3cc(c4ccc(Cl)cc4)c(nc3O1)c5ccc(Cl)cc5Cl 6.42 CHEMBL1105740 CHEMBL1097882 Fc1ccc(O[C@@H]2CN[C@H](C2)C(=O)N3CCCN(CC3)C4CCCC4)cc1 5.34 CHEMBL1105771 CHEMBL1097883 O=C([C@H]1C[C@@H](CN1)Oc2ccc(cc2)C#N)N3CCCN(CC3)C4CCCC4 5.54 CHEMBL1105771 CHEMBL1098752 C[C@@H]1CN(CCN1)c2nc(Nc3ccncn3)c4c(n2)c(C)nn4CCOCC(F)(F)F 6.05 CHEMBL1106514 CHEMBL1098847 CC(=O)N[C@H]1CC(C)(C)Oc2nc(c(cc12)c3ccc(Cl)cc3)c4ccc(Cl)cc4Cl 5.58 CHEMBL1105740 CHEMBL1098851 FC(F)(F)c1ccccc1NCC(=O)N2CCCN(Cc3nc4ccccc4[nH]3)CC2 5.88 CHEMBL1121059 CHEMBL1098876 Cc1nc(n[nH]1)C(=O)N[C@@H]2CC(C)(C)Oc3nc(c4ccc(Cl)cc4Cl)c(cc23)c5ccc(Cl)cc5 5.7 CHEMBL1105740 CHEMBL1099069 CCc1nn(CCOCC(F)(F)F)c2c(Nc3ccncn3)nc(nc12)N4CCNCC4 5.29 CHEMBL1106514 CHEMBL11 CN(C)CCCN1c2ccccc2CCc3ccccc13 5.47 CHEMBL662305 CHEMBL1106 NC1=NCC2N1c3ccccc3Cc4ccccc24 4 CHEMBL766814 CHEMBL1107 CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c3cc(ccc13)C(F)(F)F 6.7 CHEMBL766814 CHEMBL1108 Fc1ccc(cc1)C(=O)CCCN2CCC(=CC2)N3C(=O)Nc4ccccc34 6.03 CHEMBL1909190 CHEMBL111 Cc1c(nn(c2ccc(Cl)cc2Cl)c1c3ccc(Cl)cc3)C(=O)NN4CCCCC4 5.32 CHEMBL1227232 CHEMBL1110 Cc1[nH]cnc1CN2CCc3c(C2=O)c4ccccc4n3C 5.49 CHEMBL766814 CHEMBL1112 Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl 5.41 CHEMBL3806884 CHEMBL111201 O[C@@H](CNCCc1ccc(NS(=O)(=O)c2ccc(cc2)c3nc(cs3)c4ccc(cc4)C(F)(F)F)cc1)c5cccnc5 6.66 CHEMBL3767769 CHEMBL1123 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2 4.69 CHEMBL1909190 CHEMBL1125 Cc1cc2C(=Nc3ccccc3Nc2s1)N4CCNCC4 4.85 CHEMBL1036648 CHEMBL113 CN1C(=O)N(C)c2ncn(C)c2C1=O 5.31 CHEMBL1676103 CHEMBL113461 C(C1CC1)N2CC3CN(CC4CC4)CC(C2)C35CCCC5 5.6 CHEMBL3430654 CHEMBL1136 CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]3N(CCCCn4cnc(c4)c5cccnc5)C(=O)O[C@]13C)OC 4.4 CHEMBL1042376 CHEMBL1169572 Cc1cc(Cl)ccc1c2nc3OC(C)(C)CC(N=C(O)C(O)C(F)(F)F)c3cc2c4ccc(Cl)cc4 6.39 CHEMBL1105740 CHEMBL1169701 CC(Oc1ccc(cc1C(=O)N2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F)S(=O)(=O)C)C(F)(F)F 5 CHEMBL1177037 CHEMBL1170071 CC(Oc1ccc(cc1C(=O)N2CCN(CC2)c3ccc(cn3)C(F)(F)F)S(=O)(=O)C)C(F)(F)F 4.7 CHEMBL1177037 CHEMBL1170608 Cl.Nc1ncc(cc1c2oc3ccccc3n2)c4cnn(c4)C5CCNCC5 6.13 CHEMBL1175155 CHEMBL1170790 Fc1cccc(Oc2ccc(cn2)C(=O)N3CCCN(CC3)C4CCC4)c1 5.46 CHEMBL1175790 CHEMBL1170953 Fc1ccc(Oc2ccc(nc2)C(=O)N3CCCN(CC3)C4CCC4)cc1 5.08 CHEMBL1175788 CHEMBL1171002 Clc1cccc(Oc2ccc(cn2)C(=O)N3CCCN(CC3)C4CCC4)c1 5.8 CHEMBL1175790 CHEMBL1171498 CC(Oc1ccc(cc1C(=O)N2CCN(CC2)c3ccc(cc3)C#N)S(=O)(=O)C)C(F)(F)F 5.92 CHEMBL1177037 CHEMBL1171499 CC(Oc1ccc(cc1C(=O)N2CCN(CC2)c3ccc(cc3)C(F)(F)F)S(=O)(=O)C)C(F)(F)F 5 CHEMBL1177037 CHEMBL1171649 CC(Oc1ccc(cc1C(=O)N2CCN(CC2)c3ncc(cc3F)C(F)(F)F)S(=O)(=O)C)C(F)(F)F 4.7 CHEMBL1177037 CHEMBL1171756 O=C(N1CCCN(CC1)C2CCC2)c3ccc(Oc4cccc(c4)C#N)nc3 5.27 CHEMBL1175790 CHEMBL1171786 OC(=O)c1ccccc1Oc2ccc(Cl)cc2NS(=O)(=O)c3ccc(Cl)c(Cl)c3 5.1 CHEMBL1174519 CHEMBL1171886 Clc1ccc(Oc2ccc(cn2)C(=O)N3CCCN(CC3)C4CCC4)cc1 5.85 CHEMBL1175790 CHEMBL1172199 CC(Oc1ccc(cc1C(=O)N2CCN(CC2)c3ccc(cc3F)C(F)(F)F)S(=O)(=O)C)C(F)(F)F 5.16 CHEMBL1177037 CHEMBL1172998 CS(=O)(=O)c1ccc(OCC(F)(F)F)c(c1)C(=O)N2CCN(CC2)c3ccc(cc3F)C#N 5.7 CHEMBL1177037 CHEMBL1172999 CC(Oc1ccc(cc1C(=O)N2CCN(CC2)c3ccc(cc3F)C#N)S(=O)(=O)C)C(F)(F)F 5.52 CHEMBL1177037 CHEMBL1173634 CC(C)COc1ccc(cc1C(=O)N2CCN(CC2)c3ccc(cc3F)C#N)S(=O)(=O)C 6.16 CHEMBL1177037 CHEMBL1173635 CC(C)Oc1ccc(cc1C(=O)N2CCN(CC2)c3ccc(cc3F)C#N)S(=O)(=O)C 5.48 CHEMBL1177037 CHEMBL1175 CNCC[C@H](Oc1cccc2ccccc12)c3cccs3 5 CHEMBL3430699 CHEMBL1189679 O=C1N(C[C@H]2CCCc3cccc1c23)[C@@H]4CN5CCC4CC5 5.4 CHEMBL3430712 CHEMBL1200396 Cl.CCCCN1CCCCC1C(=O)Nc2c(C)cccc2C 4.5 CHEMBL1820248 CHEMBL1200749 Cl.CCCCN1CCCC[C@H]1C(=O)Nc2c(C)cccc2C 4.89 CHEMBL1820248 CHEMBL1201187 CC(C)c1nnc(C)n1[C@@H]2C[C@H]3CC[C@@H](C2)N3CC[C@H](NC(=O)C4CCC(F)(F)CC4)c5ccccc5 4.1 CHEMBL3430736 CHEMBL1201193 CCCCN1CCCC[C@H]1C(=O)Nc2c(C)cccc2C 4.68 CHEMBL1676103 CHEMBL1204009 Cl.CCOC(=O)CCc1ccc(OC[C@H](O)CNC(C)(C)Cc2ccc3ccccc3c2)c(c1)C#N 8.77 CHEMBL1052905 CHEMBL1204409 Cl.Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5cc(F)cc(c5)C(F)(F)F)n2C 5.7 CHEMBL1107671 CHEMBL1209217 O=C(C1CCOC1)N2C[C@@H]3[C@H](CNc4nc(cs4)c5ccccn5)[C@@H]3C2 5.7 CHEMBL1212048 CHEMBL1210552 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5ccc(cc5)S(F)(F)(F)(F)F)n2C 6.1 CHEMBL1211615 CHEMBL1210614 Cc1ncoc1c2nnc(SCCCN3CC4CC4(C3)c5cccc(c5)S(F)(F)(F)(F)F)n2C 5.7 CHEMBL1211615 CHEMBL1212957 Cc1c(cc(c2cccnc2)n1C)C(=O)NCCCN3CCN(CC3)c4cccc(Cl)c4Cl 5.17 CHEMBL1217370 CHEMBL1214176 CCCn1c(C)c(cc1c2ccccc2)C(=O)N(C)CCCN3CCN(CC3)c4cccc(C)c4C 6.16 CHEMBL1217370 CHEMBL1214177 CN(CCCN1CCN(CC1)c2cccc(Cl)c2Cl)C(=O)c3cc(c4ccccc4)n(C)c3C 6.3 CHEMBL1217370 CHEMBL1214402 NC(=O)c1cnc(c2cnc3c(Nc4ccc(cn4)C(F)(F)F)ccnc3n2)c(c1)C(F)(F)F 5.23 CHEMBL1217643 CHEMBL1214595 Cc1cccc(N2CCN(CCNC(=O)c3cc(n(C)c3C)C(C)(C)C)CC2)c1C 4.93 CHEMBL1217370 CHEMBL1214597 Cl.Cc1c(cc(n1C)C(C)(C)C)C(=O)NCCN2CCN(CC2)c3cccc(Cl)c3Cl 5.16 CHEMBL1217370 CHEMBL1214731 Cn1cc(Br)c(n1)C(=O)N2CCN(CC(=O)c3ccc(F)cc3)CC2 4.72 CHEMBL1219105 CHEMBL1214946 Cn1cc(Cl)c(n1)C(=O)N2CCN(CC(=O)c3ccc(F)cc3)CC2 4.52 CHEMBL1219105 CHEMBL1215691 Fc1ccc(cc1)[C@H]2CC(=NN2c3ccc(cc3)C#N)c4ccc5NC(=O)Oc5c4 7.54 CHEMBL1219663 CHEMBL1215755 CN(C)CCN(C)C(=O)c1ccc(cc1)C2=NN(C(C2)c3ccc(F)cc3)c4ccc(cc4)C#N 6.77 CHEMBL1219663 CHEMBL12186 Fc1ccc(cc1)n2cc(C3=CCN(CCN4CCNC4=O)CC3)c5cc(Cl)ccc25 8 CHEMBL766816 CHEMBL1221915 CC(C)N1C[C@@H]([C@H](C1)C(=O)Nc2ccc(cc2F)N3C=CC=CC3=O)C(=O)Nc4ccc(Cl)cn4 4.92 CHEMBL1227350 CHEMBL1222240 CC[C@@H](CC(=O)NCC1CCCCC1)n2c(N)nc3cc(Cl)ccc23 5.13 CHEMBL1227789 CHEMBL1223259 CC(C)(C)c1nnc(s1)c2nn(c3ccccc3Cl)c(c2Cn4cncn4)c5ccc(Br)cc5 4.98 CHEMBL1227232 CHEMBL1223598 CC(C)c1ccc(cc1)S(=O)(=O)Cc2ccc(cc2)[C@]34CNC[C@H]3C4 5.9 CHEMBL1225700 CHEMBL1223600 CC(C)c1ccc(CS(=O)(=O)c2ccc(cc2)[C@]34CNC[C@H]3C4)cc1 5.5 CHEMBL1225700 CHEMBL1223601 CCCCc1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)[C@]34CNC[C@H]3C4 5.7 CHEMBL1225700 CHEMBL1223602 CCC(C)(C)c1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)[C@]34CNC[C@H]3C4 5.9 CHEMBL1225700 CHEMBL1223657 CC(C)c1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)C34CNCC3C4 5.3 CHEMBL1225700 CHEMBL1223753 Cc1cc2N(C3CCN(CC3)C4CCOCC4)C(=O)Nc2cc1F 4.9 CHEMBL2149604 CHEMBL1223815 Cc1ccc(CN2[C@@H]3CC[C@H]2C[C@H](C3)Oc4cccc(c4)C(=O)N)s1 6.59 CHEMBL1225864 CHEMBL1223816 NC(=O)c1cccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3CC4CCCCC4)c1 5.7 CHEMBL1225864 CHEMBL1223873 NC(=O)c1cccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1 6.22 CHEMBL1225864 CHEMBL1223951 NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1 5.52 CHEMBL1225864 CHEMBL1223952 NC(=O)c1cccc(C[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1 5.82 CHEMBL1225864 CHEMBL1223953 NC(=O)c1cccc(C[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1 6.6 CHEMBL1225864 CHEMBL1223954 NC(=O)c1cccc(S[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1 5.96 CHEMBL1225864 CHEMBL1223955 NC(=O)c1cccc(c1)[S+]([O-])[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4 4.7 CHEMBL1225864 CHEMBL1224024 CCCC1(CCCN1)C(=O)c2ccc(Cl)c(Cl)c2 5.51 CHEMBL1225490 CHEMBL1224065 NC(=O)c1cccc(N[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1 5.96 CHEMBL1225864 CHEMBL1224066 NC(=O)c1ccnc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1 6 CHEMBL1225864 CHEMBL1224067 NC(=O)c1cc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)ccn1 5.8 CHEMBL1225864 CHEMBL1224068 NC(=O)c1cncc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1 5.82 CHEMBL1225864 CHEMBL1224069 NC(=O)c1cccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)n1 6 CHEMBL1225864 CHEMBL1224138 NC(=O)c1cncc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)n1 4.82 CHEMBL1225864 CHEMBL1224139 NC(=O)c1cc(F)cc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1 6.17 CHEMBL1225864 CHEMBL1224140 Cc1cc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)cc(c1)C(=O)N 6.18 CHEMBL1225864 CHEMBL1224142 Cc1c(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)cccc1C(=O)N 5.96 CHEMBL1225864 CHEMBL1224151 COc1cc(\C=C\2/CCCN([C@@H](C)c3ccc(F)cc3)C2=O)ccc1n4cnc(C)c4 5.92 CHEMBL1954142 CHEMBL1224165 CCCC1(CCCN1)C(=O)c2cc(F)c3[nH]ccc3c2 5.23 CHEMBL1225490 CHEMBL1224213 NC(=O)c1ccccc1O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4 6.47 CHEMBL1225864 CHEMBL1224214 NC(=O)c1ccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)cc1 6.17 CHEMBL1225864 CHEMBL1224215 Cc1cc(ccc1O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)C(=O)N 6 CHEMBL1225864 CHEMBL1224216 NC(=O)c1ccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c(F)c1 5.85 CHEMBL1225864 CHEMBL1224217 NC(=O)c1ccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)nc1 5.89 CHEMBL1225864 CHEMBL1224288 Oc1cccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1 5.8 CHEMBL1225864 CHEMBL1224638 CC(C)c1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)[C@]34CNC[C@H]3C4 6 CHEMBL1225700 CHEMBL1224639 CC(C)c1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)[C@@]34C[C@@H]3CN(C)C4 5.8 CHEMBL1225700 CHEMBL1224697 CCN1C[C@H]2C[C@]2(C1)c3ccc(NS(=O)(=O)c4ccc(cc4)C(C)C)cc3 5.9 CHEMBL1225700 CHEMBL1224698 CC(C)c1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)[C@@]34C[C@@H]3CN(CC=C)C4 7 CHEMBL1225700 CHEMBL1224699 COc1cc(ccc1NS(=O)(=O)c2ccc(cc2)C(C)C)[C@]34CNC[C@H]3C4 5.9 CHEMBL1225700 CHEMBL1224700 FC(F)(F)c1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)[C@]34CNC[C@H]3C4 6.1 CHEMBL1225700 CHEMBL1224701 FC(F)(F)Oc1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)[C@]34CNC[C@H]3C4 5 CHEMBL1225700 CHEMBL1230468 Cc1nn(C)c(C)c1NS(=O)(=O)c2c(Cl)cc(cc2Cl)c3ccnc(c3)N4CCNCC4 4.55 CHEMBL1954226 CHEMBL1235 CCNCc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O 5.02 CHEMBL949428 CHEMBL1235110 Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(=O)N)c1 5.5 CHEMBL1838283 CHEMBL123558 CN1CCN(CCCCN2C(=O)CN(\N=C\c3oc(cc3)c4ccc(Cl)cc4)C2=O)CC1 5.85 CHEMBL766814 CHEMBL1235773 COc1ccc2ncc(C#N)c(CCN3CCC(CC3)NCc4cc5SCOc5cn4)c2c1 5.7 CHEMBL1931723 CHEMBL1236391 CSc1nn(c2ccccc2)c3cc(NC(=O)C4CCNCC4)ccc13 5.09 CHEMBL1273561 CHEMBL1236904 CN1CCN(CC1)c2ccc(cc2)c3nc4ncc(Br)c(N5CCN(Cc6cc(C)on6)CC5)c4[nH]3 5.52 CHEMBL2214095 CHEMBL1241912 CNC(=O)c1ncn2c1COc3c(CCN4CCN(CC4)c5cccc6nc(C)ccc56)cccc23 5.8 CHEMBL1248763 CHEMBL1242717 Cc1ccc2c(cccc2n1)N3CCN(CCc4cccc5c4OCc6c(ncn56)C(=O)N7CCOCC7)CC3 6 CHEMBL1248763 CHEMBL1242923 O=C(Cc1ccccc1)NC2CCN(CCCN3C(=O)COc4ccccc34)CC2 4.7 CHEMBL2060137 CHEMBL124754 O=C(OC1CC2CC3CC(C1)N2CC3=O)c4c[nH]c5ccccc45 4.92 CHEMBL1676103 CHEMBL1255595 Cc1oc(CN2[C@@H]3CC[C@H]2C[C@@H](C3)Oc4cccc(c4)C(=O)N)cc1 8.55 CHEMBL1259359 CHEMBL1257214 Cc1nc(C)c(s1)c2nnc(SCCCN3CCC4(CCc5ccc(F)cc45)C3)n2C 5.2 CHEMBL1261450 CHEMBL1257215 Cc1ncoc1c2nnc(SCCCN3[C@@H]4CC[C@H]3C[C@H](C4)c5ccc(cc5)C(C)(C)C)n2C 6 CHEMBL1261450 CHEMBL1257226 C[C@@H](N1[C@@H]2CC[C@H]1C[C@@H](C2)Oc3cccc(c3)C(=O)N)c4ccccc4 7.89 CHEMBL1259359 CHEMBL1257227 C[C@H](N1[C@@H]2CC[C@H]1C[C@@H](C2)Oc3cccc(c3)C(=O)N)c4ccccc4 8.75 CHEMBL1259359 CHEMBL1257335 Cc1ncoc1c2nnc(SCCCNC3CC4CC4(C3)c5ccccc5)n2C 5.1 CHEMBL1261450 CHEMBL1257336 Cc1ncoc1c2nnc(SCCCN3[C@@H]4CC[C@H]3C[C@H](C4)c5ccc(cc5)C(F)(F)F)n2C 6.8 CHEMBL1261450 CHEMBL1257337 Cc1ncoc1c2nnc(SCCCN3[C@@H]4CC[C@H]3C[C@H](C4)c5cccc(c5)C(F)(F)F)n2C 6.3 CHEMBL1261450 CHEMBL1257347 C[C@@H](N1[C@@H]2CC[C@H]1C[C@@H](C2)Oc3cccc(c3)C(=O)N)c4ccc(C)s4 8.55 CHEMBL1259359 CHEMBL1257348 COc1cccc(c1)[C@@H](C)N2[C@@H]3CC[C@H]2C[C@@H](C3)Oc4cccc(c4)C(=O)N 8.34 CHEMBL1259359 CHEMBL1257447 Cc1ncoc1c2nnc(SCCCN3CCC4CC4(C3)c5ccccc5)n2C 5.2 CHEMBL1261450 CHEMBL1257448 Cc1ncoc1c2nnc(SCCCN3[C@@H]4CC[C@H]3C[C@H](C4)c5ccc(cc5F)C(F)(F)F)n2C 6.3 CHEMBL1261450 CHEMBL1257458 C[C@@H](N1[C@@H]2CC[C@H]1C[C@@H](C2)Oc3cccc(c3)C(=O)N)c4ccc(C)nc4 8.52 CHEMBL1259359 CHEMBL1257459 C[C@@H](N1[C@@H]2CC[C@H]1C[C@@H](C2)Oc3cccc(c3)C(=O)N)c4ccnc(Cl)c4 7.89 CHEMBL1259359 CHEMBL1257565 Cc1ncoc1c2nnc(SCCCN3CCC4(CC4C3)c5ccccc5)n2C 5.3 CHEMBL1261450 CHEMBL1257566 Cc1ncoc1c2nnc(SCCCN3CCC4CC4(C3)c5ccc(cc5)C(F)(F)F)n2C 5.7 CHEMBL1261450 CHEMBL1257577 NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc4cccs4)c1 9.37 CHEMBL1259359 CHEMBL1257578 Cc1ccc(CN2[C@@H]3CC[C@H]2C[C@@H](C3)Oc4cccc(c4)C(=O)N)s1 9.59 CHEMBL1259359 CHEMBL1257579 C[C@@H](N1[C@@H]2CC[C@H]1C[C@@H](C2)Oc3cccc(c3)C(=O)N)c4ccc(Cl)nc4 8.48 CHEMBL1259359 CHEMBL1257686 Cc1ncoc1c2nnc(SCCCN3CCC4(CC4C3)c5ccc(cc5)C(F)(F)F)n2C 6.1 CHEMBL1261450 CHEMBL1257687 Cc1ncoc1c2nnc(SCCCN3CCC4CC4(C3)c5cccc(c5)C(F)(F)F)n2C 5.7 CHEMBL1261450 CHEMBL1257698 NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3CCc4ccccc4)c1 9.42 CHEMBL1259359 CHEMBL1257808 Cc1ncoc1c2nnc(SCCCN3CCC4(CC4C3)c5cccc(c5)C(F)(F)F)n2C 6.7 CHEMBL1261450 CHEMBL1257809 Cc1ncoc1c2nnc(SCCCN3CCC4CC4(CC3)c5ccc(cc5)C(F)(F)F)n2C 5.8 CHEMBL1261450 CHEMBL1257820 NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3CCCc4ccccc4)c1 9.6 CHEMBL1259359 CHEMBL1257821 Cc1ccc(CN2[C@@H]3CC[C@H]2C[C@@H](C3)Oc4cccc(c4)C(=O)N)cc1 9.85 CHEMBL1259359 CHEMBL1257925 Cc1oc(c(C)n1)c2nnc(SCCCN3CCC4CC4(CC3)c5ccc(cc5)C(F)(F)F)n2C 5.9 CHEMBL1261450 CHEMBL1257926 Cc1nc(C)c(s1)c2nnc(SCCCN3CCC4CC4(CC3)c5ccc(cc5)C(F)(F)F)n2C 6.2 CHEMBL1261450 CHEMBL1257937 Cc1cccc(CN2[C@@H]3CC[C@H]2C[C@@H](C3)Oc4cccc(c4)C(=O)N)c1 9.28 CHEMBL1259359 CHEMBL1257938 Cc1ccccc1CN2[C@@H]3CC[C@H]2C[C@@H](C3)Oc4cccc(c4)C(=O)N 9.21 CHEMBL1259359 CHEMBL1258006 O=C(N[C@@H]1C2CCN(CC2)[C@H]1Cc3cccnc3)c4oc5ccccc5c4 4.27 CHEMBL2182407 CHEMBL1258034 Cn1c(SCCCN2CCC3CC3(CC2)c4ccc(cc4)C(F)(F)F)nnc1c5ccnnc5 5.3 CHEMBL1261450 CHEMBL1258035 Cc1ncoc1c2nnc(SCCCN[C@@H]3CC[C@@]4(CC34)c5ccc(cc5)C(F)(F)F)n2C 6.2 CHEMBL1261450 CHEMBL1258047 NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccncc4)c1 8.82 CHEMBL1259359 CHEMBL1258048 NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc4cccnc4)c1 8.46 CHEMBL1259359 CHEMBL1258153 Cc1ncoc1c2nnc(SCCCN[C@H]3CC[C@@]4(CC34)c5ccc(cc5)C(F)(F)F)n2C 5.6 CHEMBL1261450 CHEMBL1258164 NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccn4)c1 8.72 CHEMBL1259359 CHEMBL1258166 NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3CC4CC4)c1 8.14 CHEMBL1259359 CHEMBL1258268 Cc1ncoc1c2nnc(SCCCN[C@@H]3CC[C@@]4(CC34)c5ccc(cc5F)C(F)(F)F)n2C 6.2 CHEMBL1261450 CHEMBL1258269 Cl.Cc1ncoc1c2nnc(SCCCN[C@@H]3CC4C[C@@]4(C3)c5ccc(cc5F)C(F)(F)F)n2C 6 CHEMBL1261450 CHEMBL1258279 NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3CC4CCCCC4)c1 8.7 CHEMBL1259359 CHEMBL1258280 NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccc5OCOc5c4)c1 9.21 CHEMBL1259359 CHEMBL1258380 Cc1ncoc1c2nnc(SCCCN3CCC4(CCCc5cc(Br)ccc45)C3)n2C 6.2 CHEMBL1261450 CHEMBL1258381 Cc1ncoc1c2nnc(SCCCN3CCC4(CCCc5ccc(Br)cc45)C3)n2C 5.9 CHEMBL1261450 CHEMBL1258391 CS(=O)(=O)Cc1ccc(CN2[C@@H]3CC[C@H]2C[C@@H](C3)Oc4cccc(c4)C(=O)N)cc1 8.18 CHEMBL1259359 CHEMBL1258492 COc1ccc2c(CCCC23CCN(CCCSc4nnc(c5ocnc5C)n4C)C3)c1 5.7 CHEMBL1261450 CHEMBL1258493 COc1cccc2c1CCCC23CCN(CCCSc4nnc(c5ocnc5C)n4C)C3 5.7 CHEMBL1261450 CHEMBL1258503 NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3CC(=O)Nc4ccccc4)c1 9.14 CHEMBL1259359 CHEMBL1258605 COc1ccc2CCCC3(CCN(CCCSc4nnc(c5ocnc5C)n4C)C3)c2c1 5.2 CHEMBL1261450 CHEMBL1258606 Cc1ncoc1c2nnc(SCCCN3CCC4(CCOc5ccccc45)C3)n2C 5.2 CHEMBL1261450 CHEMBL1258615 CC(N1[C@@H]2CC[C@H]1C[C@@H](C2)Oc3cccc(c3)C(=O)N)c4ccccc4 8.22 CHEMBL1259359 CHEMBL1258616 CC(N1[C@@H]2CC[C@H]1C[C@@H](C2)Oc3cccc(c3)C(=O)N)c4ccc(C)s4 8.8 CHEMBL1259359 CHEMBL1258712 Cc1ncoc1c2nnc(SCCCN3CCC4(CCc5cc(Br)ccc45)C3)n2C 6.5 CHEMBL1261450 CHEMBL1258713 Cc1ncoc1c2nnc(SCCCN3CCC4(CCc5c(Br)cccc45)C3)n2C 6.2 CHEMBL1261450 CHEMBL1258724 CC(N1[C@@H]2CC[C@H]1C[C@@H](C2)Oc3cccc(c3)C(=O)N)c4ccccc4C 8.31 CHEMBL1259359 CHEMBL1258725 NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3C4CCCc5ccccc45)c1 9.02 CHEMBL1259359 CHEMBL1258833 Cc1ncoc1c2nnc(SCCCN3CCC4(CCc5ccc(Br)cc45)C3)n2C 6.1 CHEMBL1261450 CHEMBL1258834 Cc1nc(C)c(s1)c2nnc(SCCCN3CCC4(CCc5ccc(Cl)cc45)C3)n2C 5.6 CHEMBL1261450 CHEMBL1258845 NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3C4CCCCC4)c1 7.82 CHEMBL1259359 CHEMBL1258846 CC(C)(N1[C@@H]2CC[C@H]1C[C@@H](C2)Oc3cccc(c3)C(=O)N)c4ccccc4 8.33 CHEMBL1259359 CHEMBL1258948 Cc1nc(C)c(s1)c2nnc(SCCCN3CCC4(CCc5cc(Cl)ccc45)C3)n2C 5.6 CHEMBL1261450 CHEMBL1258949 Cc1ncoc1c2nnc(SCCCN3CCC4(CCc5cc(F)ccc45)C3)n2C 5.6 CHEMBL1261450 CHEMBL1258961 NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3C4(CC4)c5ccccc5)c1 8.32 CHEMBL1259359 CHEMBL1258962 CC(N1[C@@H]2CC[C@H]1C[C@@H](C2)Oc3cccc(c3)C(=O)N)c4ccncc4 8.43 CHEMBL1259359 CHEMBL1264 CCCNCC(O)COc1ccc(O)cc1C(=O)CCc2ccccc2 4.4 CHEMBL827807 CHEMBL1269885 Cc1ncnc(C)c1C(=O)N2C[C@H]3CN(CCC(C4CCN(CC4)S(=O)(=O)C)c5cccc(F)c5)C[C@H]3C2 4.81 CHEMBL1272988 CHEMBL1269994 Cc1cc(N[C@H](CCCCNCc2ccc(F)cc2)C(=O)NO)cc(C)c1F 5.91 CHEMBL2013523 CHEMBL1270139 ONC(=O)c1cnc(nc1)N2C[C@H]3CN(Cc4ccc5ccccc5c4)C[C@H]3C2 5.39 CHEMBL1273133 CHEMBL1270208 FC(F)(F)COc1ncccc1CNC(=O)c2cncc(c2)c3ccc(Cl)cc3 4.72 CHEMBL1272892 CHEMBL12713 Fc1ccc(cc1)n2cc(C3CCN(CCN4CCNC4=O)CC3)c5cc(Cl)ccc25 7.85 CHEMBL841079 CHEMBL1271309 Cc1cc(C)cc(NC(=O)c2cncc(c2)c3ccc(cc3)C#N)c1 4.8 CHEMBL1272892 CHEMBL1271520 O=C(N[C@@H]1CN2CCC1CC2)c3cccc4oc(nc34)N5CCOCC5 5.5 CHEMBL1274536 CHEMBL1271606 Cc1nc2ccccc2n1C3C[C@H]4CC[C@@H](C3)N4CC[C@H](NC(=O)C5CCSCC5)c6cccc(F)c6 6.13 CHEMBL1273164 CHEMBL1271756 Cl.CC(C)c1cc(nc(C)n1)C(=O)NCCCN2CCN(CC2)c3cccc(Cl)c3Cl 5.27 CHEMBL1272925 CHEMBL1271816 Cl.Cc1nc(cc(n1)C(C)(C)C)C(=O)NCCCN2CCN(CC2)c3cccc(C)c3C 5.23 CHEMBL1272925 CHEMBL1272016 COc1ccccc1c2oc3cccc(C(=O)N[C@@H]4CN5CCC4CC5)c3n2 6.7 CHEMBL1274536 CHEMBL1272072 O=C(N[C@@H]1CN2CCC1CC2)c3cccc4oc(nc34)C5CC5 6.16 CHEMBL1274536 CHEMBL1272232 Nc1oc2cc(Cl)cc(C(=O)N[C@@H]3CN4CCC3CC4)c2n1 5.32 CHEMBL1274536 CHEMBL127457 CCOC(=O)C1C(CC2CCC1N2C)OC(=O)c3ccccc3 5.92 CHEMBL1676103 CHEMBL127701 FC(F)(F)CN1C(=O)[C@H](NC(=O)Cc2ccc(Cl)cc2Cl)N=C(c3ccccc3)c4ccccc14 5.62 CHEMBL686879 CHEMBL12780 Fc1ccc(cc1)n2cc(C3CCN(CCN4CCNC4=O)CC3)c5ccccc25 8.16 CHEMBL766816 CHEMBL1278114 OC(=O)CCNC1CC[C@@]2(C1)Cc3ccccc3Cc4ccccc24 4.2 CHEMBL1287098 CHEMBL128007 CN(C)CCN1C(=O)C(NC(=O)CCc2ccc(Cl)cc2Cl)N=C(c3ccccc3)c4ccccc14 7 CHEMBL686879 CHEMBL1288673 Fc1cccc(c1)N(C2CCN(CCC3(CCN(CC3)C(=O)c4c(F)cccc4F)c5cccc(F)c5)CC2)C(=O)NCc6ccc(cc6)C#N 5.92 CHEMBL1292008 CHEMBL1288674 Fc1cccc(c1)N(C2CCN(CCC3(CCN(CC3)C(=O)c4c(Cl)cccc4Cl)c5cccc(F)c5)CC2)C(=O)NCc6ccc(cc6)C#N 6 CHEMBL1292008 CHEMBL1288675 Oc1cc(F)ccc1C(=O)N2CCC(CCN3CCC(CC3)N(C(=O)NCc4ccc(cc4)C#N)c5cccc(F)c5)(CC2)c6cccc(F)c6 6.1 CHEMBL1292008 CHEMBL1288676 Fc1cccc(c1)N(C2CCN(CCC3(CCN(CC3)C(=O)c4ccc(cc4)C#N)c5cccc(F)c5)CC2)C(=O)NCc6ccc(cc6)C#N 6.4 CHEMBL1292008 CHEMBL1288677 NC(=O)c1cccc(c1)C(=O)N2CCC(CCN3CCC(CC3)N(C(=O)NCc4ccc(cc4)C#N)c5cccc(F)c5)(CC2)c6cccc(F)c6 4.7 CHEMBL1292008 CHEMBL1288689 CC(C)(O)C(=O)N1CCC(CCN2CCC(CC2)N(C(=O)NCc3ccc(cc3)C#N)c4cccc(F)c4)(CC1)c5cccc(F)c5 5 CHEMBL1292008 CHEMBL1289053 O=C1C=C(OCc2ccccc2)C=CN1c3ccc4c(cnn4CC5=NCCN5)c3 5.07 CHEMBL1292296 CHEMBL1289054 COC[C@H]1CCCN1CCn2ncc3cc(ccc23)N4C=CC(=CC4=O)OCc5ccccc5 6.1 CHEMBL1292296 CHEMBL1289062 CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c2ccc(cc2)c3ccc(F)nc3 6 CHEMBL1291783 CHEMBL1289063 CC(C)S(=O)(=O)N[C@H]1CN(C[C@@H]1c2ccc(cc2)c3ccc(F)nc3)c4ccccc4 7.1 CHEMBL1291783 CHEMBL1289083 CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)[C@@H]3CC[C@@](O)(CC3)c4ccccc4 4.77 CHEMBL1291445 CHEMBL1289097 CC(C)[C@@H](Nc1nc2C=CNC(=O)c2c3cc(F)ccc13)C(F)(F)F 5.46 CHEMBL1291240 CHEMBL1289169 OC[C@H]1CCCN1CCn2ncc3cc(ccc23)N4C=CC(=CC4=O)OCc5ccccc5 5.64 CHEMBL1292296 CHEMBL1289180 CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c2ccc(cc2)c3ccsc3 5.4 CHEMBL1291783 CHEMBL1289181 CC(C)S(=O)(=O)N[C@@H]1COC[C@@H]1c2ccc(cc2)c3ccc(cc3)C#N 4.9 CHEMBL1291783 CHEMBL1289203 CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)[C@@H]3CC[C@@](O)(CC3)c4ccc(C)cc4 4.96 CHEMBL1291445 CHEMBL1289218 CC(C)[C@@H](Nc1nc2C=CNC(=O)c2c3cnccc13)C(F)(F)F 5.85 CHEMBL1291240 CHEMBL1289267 FC(F)(F)Oc1ccc2[nH]c(nc2c1)[C@@H]3CC[C@@]4(CC3)CN(C(=O)O4)c5ccccc5 5.6 CHEMBL1293077 CHEMBL1289268 Fc1ccccc1N2C[C@@]3(CC[C@@H](CC3)c4nc5cc(OC(F)(F)F)ccc5[nH]4)OC2=O 5.2 CHEMBL1293077 CHEMBL1289282 CN(C)CCn1ncc2cc(ccc12)N3C=CC(=CC3=O)OCc4ccccc4 5.75 CHEMBL1292296 CHEMBL1289283 O=C1C=C(OCc2ccccc2)C=CN1c3ccc4c(cnn4CCN5CCCC5)c3 5.6 CHEMBL1292296 CHEMBL1289294 CC(C)S(=O)(=O)N[C@@H]1COC[C@@H]1c2ccc(cc2)c3ccc(F)nc3 4.9 CHEMBL1291783 CHEMBL1289316 CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)[C@@H]3CC[C@@](O)(CC3)c4ccc5OCOc5c4 4.89 CHEMBL1291445 CHEMBL1289386 Fc1ccc(cc1)N2C[C@@]3(CC[C@@H](CC3)c4nc5cc(OC(F)(F)F)ccc5[nH]4)OC2=O 6.1 CHEMBL1293077 CHEMBL1289399 CN(C)CCCn1ncc2cc(ccc12)N3C=CC(=CC3=O)OCc4ccccc4 5.85 CHEMBL1292296 CHEMBL1289400 CN(C)CC(O)Cn1ncc2cc(ccc12)N3C=CC(=CC3=O)OCc4ccccc4 4.92 CHEMBL1292296 CHEMBL1289503 FC(F)(F)Oc1ccc2[nH]c(nc2c1)[C@@H]3CC[C@@]4(CC3)CN(C(=O)O4)c5ccccn5 5.6 CHEMBL1293077 CHEMBL1289515 O[C@H]1CCN(CCn2ncc3cc(ccc23)N4C=CC(=CC4=O)OCc5ccccc5)C1 5.05 CHEMBL1292296 CHEMBL1289516 CO[C@H]1CCN(CCn2ncc3cc(ccc23)N4C=CC(=CC4=O)OCc5ccccc5)C1 5.75 CHEMBL1292296 CHEMBL1289609 Cc1cccc(n1)N2C[C@@]3(CC[C@@H](CC3)c4nc5cc(OC(F)(F)F)ccc5[nH]4)OC2=O 5.7 CHEMBL1293077 CHEMBL1289610 Cc1ncccc1N2C[C@@]3(CC[C@@H](CC3)c4nc5cc(OC(F)(F)F)ccc5[nH]4)OC2=O 4.3 CHEMBL1293077 CHEMBL1289623 O=C1C=C(OCc2ccccc2)C=CN1c3ccc4c(cnn4C[C@@H]5CCCN5)c3 5.7 CHEMBL1292296 CHEMBL1289714 Fc1cccc(n1)N2C[C@@]3(CC[C@@H](CC3)c4nc5cc(OC(F)(F)F)ccc5[nH]4)OC2=O 5.4 CHEMBL1293077 CHEMBL1289715 FC(F)(F)Oc1ccc2[nH]c(nc2c1)[C@@H]3CC[C@@]4(CC3)CN(C(=O)O4)c5cccnc5 5.1 CHEMBL1293077 CHEMBL1289726 CN1CCN=C1Cn2ncc3cc(ccc23)N4C=CC(=CC4=O)OCc5ccccc5 5.48 CHEMBL1292296 CHEMBL1289819 Fc1ncccc1N2C[C@@]3(CC[C@@H](CC3)c4nc5cc(OC(F)(F)F)ccc5[nH]4)OC2=O 4.8 CHEMBL1293077 CHEMBL1289820 FC(F)(F)c1ccc2[nH]c(nc2c1)[C@@H]3CC[C@@]4(CC3)CN(C(=O)O4)c5ccccc5 5.4 CHEMBL1293077 CHEMBL1289833 O=C1C=C(OCc2ccccc2)C=CN1c3ccc4c(cnn4CCN5CC6CC5CO6)c3 4.8 CHEMBL1292296 CHEMBL1289834 O=C1C=C(OCc2ccccc2)C=CN1c3ccc4c(cnn4CCN5CCNCC5)c3 4.79 CHEMBL1292296 CHEMBL1289936 FC(F)(F)c1ccc2[nH]c(nc2c1)[C@@H]3CC[C@@]4(CC3)CN(C(=O)O4)c5ccccn5 5.4 CHEMBL1293077 CHEMBL1289960 CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c2ccc(cc2)c3cccc(NS(=O)(=O)C)c3 4.5 CHEMBL1291783 CHEMBL1290037 O=C1O[C@@]2(CC[C@H](CC2)c3nc4cc(ccc4[nH]3)C#N)CN1c5ccccc5 5 CHEMBL1293077 CHEMBL1290038 Fc1ccc(cc1)N2C[C@@]3(CC[C@@H](CC3)c4nc5cc(ccc5[nH]4)C#N)OC2=O 5.8 CHEMBL1293077 CHEMBL1290058 CCN1C[C@H](NS(=O)(=O)C(C)C)[C@H](C1)c2ccc(cc2)c3cccc(NS(=O)(=O)C)c3 5.6 CHEMBL1291783 CHEMBL1290059 CC(C)N1C[C@H](NS(=O)(=O)C(C)C)[C@H](C1)c2ccc(cc2)c3cccc(NS(=O)(=O)C)c3 5.2 CHEMBL1291783 CHEMBL1290147 O=C1O[C@@]2(CC[C@H](CC2)c3nc4cc(ccc4[nH]3)C#N)CN1c5ccccn5 4.9 CHEMBL1293077 CHEMBL1290165 CC(C)S(=O)(=O)N[C@H]1CN(C[C@@H]1c2ccc(cc2)c3cccc(NS(=O)(=O)C)c3)c4ccccc4 5.89 CHEMBL1291783 CHEMBL1290166 CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c2ccc(cc2)c3ccc(cc3)C#N 5.7 CHEMBL1291783 CHEMBL1290275 CCN1C[C@H](NS(=O)(=O)C(C)C)[C@H](C1)c2ccc(cc2)c3ccc(cc3)C#N 6.4 CHEMBL1291783 CHEMBL1290391 CC(C)S(=O)(=O)N[C@H]1CN(C[C@@H]1c2ccc(cc2)c3ccc(cc3)C#N)c4ccccc4 6.1 CHEMBL1291783 CHEMBL1290503 CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c2ccc(cc2)c3cccc(NC(=O)C)c3 4.9 CHEMBL1291783 CHEMBL1290504 CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c2ccc(cc2)c3cccc(c3)C(=O)C 5.1 CHEMBL1291783 CHEMBL1290612 CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c2ccc(cc2)c3cccc(c3)C(F)(F)F 5.4 CHEMBL1291783 CHEMBL1290706 FC(F)(F)c1ccc2[nH]c(nc2c1)N3CCC4(CC3)CN(C(=O)O4)c5ccccc5 5.7 CHEMBL1293077 CHEMBL1290707 O=C1OC2(CCN(CC2)c3nc4ccccc4[nH]3)CN1c5ccccc5 6 CHEMBL1293077 CHEMBL1290731 CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c2ccc(cc2)c3cccnc3 4.5 CHEMBL1291783 CHEMBL1290732 CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c2ccc(cc2)c3cccnc3F 5.2 CHEMBL1291783 CHEMBL1294 COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 5.57 CHEMBL3761659 CHEMBL129583 CS(=O)(=O)Nc1ccc2OC3(CCN(CCc4ccc5nonc5c4)CC3)CC(=O)c2c1 8.1 CHEMBL827807 CHEMBL1323 CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]2CO[C@H]3OCC[C@@H]23)S(=O)(=O)c4ccc(N)cc4 4 CHEMBL3430725 CHEMBL1346 NC(=O)C([C@@H]1CCN(CCc2ccc3OCCc3c2)C1)(c4ccccc4)c5ccccc5 5.8 CHEMBL3430692 CHEMBL1365 NCC(O)COc1ccccc1C(=O)CCc2ccccc2 4.36 CHEMBL827807 CHEMBL138093 O=C1CCC(=NN1)c2ccc(Nc3ccncc3)cc2 5.98 CHEMBL1676103 CHEMBL1382 CC(C)N(CC[C@H](c1ccccc1)c2cc(C)ccc2O)C(C)C 6.8 CHEMBL3430747 CHEMBL1421 Cc1nc(Nc2ncc(s2)C(=O)Nc3c(C)cccc3Cl)cc(n1)N4CCN(CCO)CC4 4.3 CHEMBL3430694 CHEMBL1423 Fc1ccc(cc1)C(CCCN2CCC(CC2)N3C(=O)Nc4ccccc34)c5ccc(F)cc5 5.77 CHEMBL827807 CHEMBL142992 CC(C)N(CCc1c[nH]c2ccccc12)Cc3ccc(\C=C\C(=O)NO)cc3 5.23 CHEMBL1820401 CHEMBL147587 CCN(CC)Cc1ccc(Nc2ccnc3cc(Cl)ccc23)cc1O 5.41 CHEMBL949428 CHEMBL147806 CC(C)(C)NCc1ccc(Nc2ccnc3cc(Cl)ccc23)cc1O 5.13 CHEMBL949428 CHEMBL1493 CC1=C(Oc2c(cccc2C1=O)C(=O)OCCN3CCCCC3)c4ccccc4 4.62 CHEMBL1909190 CHEMBL1494 NCCC(Oc1ccc(cc1)C(F)(F)F)c2ccccc2 5.64 CHEMBL1676103 CHEMBL1504335 C(N1CCN(Cc2oc(nn2)c3ccccc3)CC1)c4ccccc4 4.56 CHEMBL2072927 CHEMBL1514 CC[C@H](OC(=O)C)C(C[C@H](C)N(C)C)(c1ccccc1)c2ccccc2 5.66 CHEMBL829152 CHEMBL1520 CCCc1nc(C)c2C(=O)N=C(Nn12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(CC)CC4 4.1 CHEMBL3430748 CHEMBL16 OC1=NC(=O)C(N1)(c2ccccc2)c3ccccc3 4 CHEMBL3430645 CHEMBL1614712 Nc1ncnc2c1c(cn2[C@@H]3C[C@H](CN4CCC4)C3)c5cccc(OCc6ccccc6)c5 6.89 CHEMBL3789410 CHEMBL1615150 Cc1cc(ccc1NC(=O)[C@H](C2CCCCC2)n3c(nc4cc(F)c(F)cc34)c5ccc(Cl)cc5)C(=O)O 6.16 CHEMBL1670716 CHEMBL1615186 C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CC1)OCc2ccc(Cl)cc2Cl)N(O)C=O)c3ncc(F)cn3 5.1 CHEMBL1686219 CHEMBL1615187 C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CCc2c(C)onc2C)CC1)N(O)C=O)c3ncc(F)cn3 4.19 CHEMBL1787063 CHEMBL1621 CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCC(O)C5=N1 5.89 CHEMBL1027667 CHEMBL1626 CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3 6.4 CHEMBL1909190 CHEMBL1627306 O[C@H](CCNC(=O)c1cc2ccccc2[nH]1)CN3CCN(CC3)c4cccc(Cl)c4Cl 6.42 CHEMBL3591528 CHEMBL1630 Cl.CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O 5.62 CHEMBL949428 CHEMBL1630579 CCN(CC)CCOCCC1=CCC2CC1C2(C)C 5.23 CHEMBL1909190 CHEMBL163238 Cc1cccc(C)c1NC(=O)CC23CCCN2CCC3 4.69 CHEMBL1036648 CHEMBL1641614 O=C1C=C(OCc2ccccc2)C=CN1c3ccc(OCCN4CCCC4)cc3 8.09 CHEMBL1648563 CHEMBL1642173 COc1cc(\C=C\c2nc3ccccc3[nH]2)ccc1n4cnc(C)c4 6.17 CHEMBL1648352 CHEMBL1642180 COc1cc(\C=C\C2=Nc3cc(ccc3C(=O)N2)C(F)(F)F)ccc1n4cnc(C)c4 6.06 CHEMBL1648352 CHEMBL1642183 COc1cc(\C=C\C2=Nc3sc4CCCc4c3C(=O)N2)ccc1n5cnc(C)c5 5.33 CHEMBL1648352 CHEMBL1642184 COc1cc(\C=C\c2nc(N)c3ccccc3n2)ccc1n4cnc(C)c4 6.85 CHEMBL1648352 CHEMBL1642185 COc1cc(\C=C\C2=Nc3ccccc3C(=O)N2c4ccccc4)ccc1n5cnc(C)c5 6 CHEMBL1648352 CHEMBL1642186 COc1cc(\C=C\C2=Nc3ccccc3C(=O)N2C)ccc1n4cnc(C)c4 6.51 CHEMBL1648352 CHEMBL1642187 COc1cc(\C=C\c2nc(N)nc(Nc3ccccc3)n2)ccc1n4cnc(C)c4 6.52 CHEMBL1648352 CHEMBL1642188 CCOC(=O)c1sc2nc(\C=C\c3ccc(c(OC)c3)n4cnc(C)c4)nc(N)c2c1C 6.01 CHEMBL1648352 CHEMBL1642189 COc1cc(\C=C\c2nc(N)c3c(oc4ccccc34)n2)ccc1n5cnc(C)c5 6.29 CHEMBL1648352 CHEMBL1642190 COc1cc(\C=C\c2nc(NCc3ccccc3)c4c5CCCc5sc4n2)ccc1n6cnc(C)c6 5.95 CHEMBL1648352 CHEMBL1642191 COc1cc(\C=C\c2nc(N)c3c4CCCCCc4sc3n2)ccc1n5cnc(C)c5 6.41 CHEMBL1648352 CHEMBL1642258 COc1cc(ccc1Nc2nc(Nc3cc4CCN(CC(=O)N(C)C)CCc4cc3OC)ncc2Cl)N5CCOCC5 5.41 CHEMBL1646084 CHEMBL1642362 Fc1cc2nc(c3ccc(Cl)cc3)n([C@@H](C4CCCCC4)C(=O)NC5CCCCC5)c2cc1Cl 5.8 CHEMBL1670716 CHEMBL1642471 Fc1ccccc1COC2=CC(=O)N(C=C2)c3ccc(OCCN4CCCC4)cc3 8.37 CHEMBL1648563 CHEMBL1642472 Fc1cccc(COC2=CC(=O)N(C=C2)c3ccc(OCCN4CCCC4)cc3)c1 8.54 CHEMBL1648563 CHEMBL1642474 Clc1cccc(COC2=CC(=O)N(C=C2)c3ccc(OCCN4CCCC4)cc3)c1 8.72 CHEMBL1648563 CHEMBL1642475 Clc1ccc(COC2=CC(=O)N(C=C2)c3ccc(OCCN4CCCC4)cc3)cc1 8.77 CHEMBL1648563 CHEMBL1642476 COc1ccc(COC2=CC(=O)N(C=C2)c3ccc(OCCN4CCCC4)cc3)cc1 8.92 CHEMBL1648563 CHEMBL1642477 FC(F)(F)c1ccc(COC2=CC(=O)N(C=C2)c3ccc(OCCN4CCCC4)cc3)cc1 8.62 CHEMBL1648563 CHEMBL1642479 O=C1C=C(OCc2ccc3ccccc3c2)C=CN1c4ccc(OCCN5CCCC5)cc4 9.17 CHEMBL1648563 CHEMBL1642482 O=C1C=C(OCc2ccccc2)C=CN1c3ccc(OCCN4CCCCC4)cc3 8.24 CHEMBL1648563 CHEMBL1642485 CCN(CC)CCOc1ccc(cc1)N2C=CC(=CC2=O)OCc3ccccc3 8.01 CHEMBL1648563 CHEMBL1642486 CC(C)N(CCOc1ccc(cc1)N2C=CC(=CC2=O)OCc3ccccc3)C(C)C 8.37 CHEMBL1648563 CHEMBL1642487 CN(CCOc1ccc(cc1)N2C=CC(=CC2=O)OCc3ccccc3)Cc4ccccc4 9.09 CHEMBL1648563 CHEMBL1642490 CN1CCCCC1COc2ccc(cc2)N3C=CC(=CC3=O)OCc4ccccc4 8.24 CHEMBL1648563 CHEMBL1642491 CN1CCCC1COc2ccc(cc2)N3C=CC(=CC3=O)OCc4ccccc4 8.03 CHEMBL1648563 CHEMBL1642492 CCN(CC)CCNc1ccc(cc1)N2C=CC(=CC2=O)OCc3ccccc3 8.16 CHEMBL1648563 CHEMBL1642493 CCN(CC)CCN(C)c1ccc(cc1)N2C=CC(=CC2=O)OCc3ccccc3 8.77 CHEMBL1648563 CHEMBL1642895 CN[C@H]1C[C@H](c2ccc(Cl)c(Cl)c2)c3ccccc3C1 5.64 CHEMBL1647137 CHEMBL1642896 CN[C@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc3C1 5.28 CHEMBL1647137 CHEMBL1642897 CN[C@@H]1C[C@H](c2ccc(Cl)c(Cl)c2)c3ccccc3C1 5.8 CHEMBL1647137 CHEMBL1642906 CNC[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc3C1 5.79 CHEMBL1647137 CHEMBL1642908 CNC[C@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc3C1 5.7 CHEMBL1647137 CHEMBL1642912 NCC[C@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc3C1 4.88 CHEMBL1647137 CHEMBL1642913 NCC[C@@H]1C[C@H](c2ccc(Cl)c(Cl)c2)c3ccccc3C1 5.82 CHEMBL1647137 CHEMBL1643511 CNC1CCN(c2ccc(Cl)c(Cl)c2)c3ccccc13 5.11 CHEMBL1647941 CHEMBL1643512 N[C@@H]1CCN(c2ccc(Cl)c(Cl)c2)c3ccccc13 5.46 CHEMBL1647941 CHEMBL1643513 CN[C@@H]1CCN(c2ccc(Cl)c(Cl)c2)c3ccccc13 5.49 CHEMBL1647941 CHEMBL1643514 CN(C)[C@@H]1CCN(c2ccc(Cl)c(Cl)c2)c3ccccc13 5.07 CHEMBL1647941 CHEMBL1644183 OC(=O)CCNC(=O)c1ccc(Cn2nc(cc2c3ccc(OC(F)(F)F)cc3)c4cc(Cl)cc(Cl)c4)cc1 5.29 CHEMBL1648772 CHEMBL1645164 COC(=O)c1coc(CN2CCN(CC2)C(=O)CC(c3ccc(F)cc3)c4ccc(Br)cc4)n1 5.65 CHEMBL1646507 CHEMBL1645167 COC(=O)c1coc(CN2CCN(CC2)C(=O)CC(c3ccc(F)cc3)c4ccc(cc4)C(F)(F)F)n1 5.42 CHEMBL1646507 CHEMBL1645172 Cc1ccc2nc(CN3CCN(CC3)C(=O)CC(c4ccccc4)c5ccc(F)cc5)oc2c1 5.64 CHEMBL1646507 CHEMBL1645184 COc1ccc(cc1)C(CC(=O)N2CCN(Cc3oc4cc(C)ccc4n3)CC2)c5ccccc5 5.94 CHEMBL1646507 CHEMBL1645462 Cc1c(NC(=O)OC[C@@H]2COCCN2)cn3ncnc(Nc4ccc5c(cnn5Cc6cccc(F)c6)c4)c13 5.4 CHEMBL1054528 CHEMBL1649910 COC(=O)N1CCc2c(C1)nc(C)n2[C@H]3C[C@H]4CC[C@@H](C3)N4CC[C@H](NC(=O)C)c5cccc(F)c5 5.7 CHEMBL1657597 CHEMBL1649911 CC(=O)N[C@@H](CCN1[C@@H]2CC[C@H]1C[C@H](C2)n3c(C)nc4CN(CCc34)C(=O)C)c5cccc(F)c5 5.3 CHEMBL1657597 CHEMBL1649912 CC(C)c1nc(C)nn1[C@H]2C[C@H]3CC[C@@H](C2)N3CC[C@H](NC(=O)C4CCC(F)(F)CC4)c5ccccc5 5.37 CHEMBL1657597 CHEMBL1649913 CC(=O)N[C@@H](CCN1[C@@H]2CC[C@H]1C[C@H](C2)n3c(C)nc4ccccc34)c5ccccc5 5.82 CHEMBL1657597 CHEMBL1649928 CC(=O)N[C@@H](CCN1[C@@H]2CC[C@H]1C[C@H](C2)n3c(C)nc4CN(CCc34)c5ccncn5)c6cccc(F)c6 8 CHEMBL1657597 CHEMBL1649929 CC(=O)N[C@@H](CCN1[C@@H]2CC[C@H]1C[C@H](C2)n3c(C)nc4CN(CCc34)c5cnccn5)c6cccc(F)c6 6 CHEMBL1657597 CHEMBL1649930 CCC(=O)N1CCc2c(C1)nc(C)n2[C@H]3C[C@H]4CC[C@@H](C3)N4CC[C@H](NC(=O)C)c5cccc(F)c5 5.3 CHEMBL1657597 CHEMBL1649931 CC(C)C(=O)N1CCc2c(C1)nc(C)n2[C@H]3C[C@H]4CC[C@@H](C3)N4CC[C@H](NC(=O)C)c5cccc(F)c5 4.92 CHEMBL1657597 CHEMBL1649932 CCCC(=O)N1CCc2c(C1)nc(C)n2[C@H]3C[C@H]4CC[C@@H](C3)N4CC[C@H](NC(=O)C)c5cccc(F)c5 5.22 CHEMBL1657597 CHEMBL1649933 CC(=O)N[C@@H](CCN1[C@@H]2CC[C@H]1C[C@H](C2)n3c(C)nc4CN(CCc34)C(=O)C(C)(C)C)c5cccc(F)c5 5.3 CHEMBL1657597 CHEMBL1650511 FC(F)(F)c1ccccc1c2cc(c3[nH]c(nc3c2)C4=NOC5(CCCCC5)C4)C(F)(F)F 4.8 CHEMBL1656176 CHEMBL1651456 CN1CCN(CC1)c2ccc(cc2)c3nc4c(N5CCN(Cc6cc(C)on6)CC5)c(Cl)cnc4[nH]3 5.64 CHEMBL2214095 CHEMBL1651717 OC(=O)C1CN(Cc2ccc(c(F)c2)c3oc4ccc(Cc5ccccc5)cc4c3)C1 4.77 CHEMBL1657555 CHEMBL1668238 Fc1cc2nc(c3ccc(Cl)cc3)n([C@@H](C4CCCCC4)C(=O)NC5CCCCC5)c2cc1F 5.85 CHEMBL1670716 CHEMBL1668239 O[C@@H]1CC[C@H](CC1)NC(=O)[C@H](C2CCCCC2)n3c(nc4cc(F)c(F)cc34)c5ccc(Cl)cc5 5.14 CHEMBL1670716 CHEMBL1668240 OC(=O)[C@@H]1CC[C@H](CC1)NC(=O)[C@H](C2CCCCC2)n3c(nc4cc(F)c(F)cc34)c5ccc(Cl)cc5 5.12 CHEMBL1670716 CHEMBL1668243 OC(=O)c1ccc(NC(=O)[C@H](C2CCCCC2)n3c(nc4cc(F)c(F)cc34)c5ccc(Cl)cc5)c(Cl)c1 5.11 CHEMBL1670716 CHEMBL1671884 C1CN(CCC1C2C(=Nc3ccccc23)c4ccccc4)c5ccccc5 7.1 CHEMBL1676103 CHEMBL1671885 CCCCCCCCC(=O)NCc1ccc(CC(O)CO)c(OC)c1 7 CHEMBL1676103 CHEMBL1671887 CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C(=O)C(C)C(O)C1(C)O 4.14 CHEMBL1676103 CHEMBL1671888 CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)\C(=N\OCOCCOC)\C(C)C(O)C1(C)O 4.44 CHEMBL1676103 CHEMBL1671889 Brc1cncc(c1)C(=O)N2CCC(NCc3cncn3Cc4ccc(cc4)C#N)C2=O 5.22 CHEMBL1676103 CHEMBL1671890 CC\N=C(\N1CCCc2cc(ccc12)C3=NNC(=O)SC3C)/c4ccc(OC)c(OC)c4 5.18 CHEMBL1676103 CHEMBL1671892 OCCNC(=O)C1CCC(CC1)c2ncc([nH]2)c3cccc(c3)C(F)(F)F 6.3 CHEMBL1676103 CHEMBL1671893 COc1ccc(cc1OC)C2CCN(CCN3CCOc4ccccc34)CC2 6.6 CHEMBL1676103 CHEMBL1671894 C1CC2CC(CC1N2c3ccccc3)c4c([nH]c5ccccc45)c6ccccc6 7.75 CHEMBL1676103 CHEMBL1671897 COc1ccc(CC(=O)NCc2ccccc2c3ccccc3C(=O)NCCc4cccnc4)cc1 5 CHEMBL1676103 CHEMBL1671898 CC(C)CN1CCC(CNC(=O)c2cc(Cl)c(N)n3cc(C)nc23)CC1 5.59 CHEMBL1676103 CHEMBL1671900 CCOP(=O)(Sc1ccccc1)Sc2ccccc2 4.3 CHEMBL1676103 CHEMBL1671901 CC(C)(CN1CCC(=C2c3ccc(F)cc3COc4ccccc24)CC1)C(=O)O 5 CHEMBL1676103 CHEMBL1671902 COC(=O)C1=C(C)NC(=C(C1c2cccc3NONc23)C(=O)OC(C)C)C 4.3 CHEMBL1676103 CHEMBL1671904 CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(CC(C)C(=O)C(C)C(O)C1(C)O)OC 4.48 CHEMBL1676103 CHEMBL1671905 CN1CC(=O)N2C(Cc3c([nH]c4ccccc34)C2c5ccc6OCOc6c5)C1=O 4 CHEMBL1676103 CHEMBL1671906 COc1cc2nc(nc(C)c2cc1OC)N(C)CCCNC(=O)C3CCCO3 4.08 CHEMBL1676103 CHEMBL1671908 CCC1=C(C)CC(C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCC(C)CC3)C1=O 4.13 CHEMBL1676103 CHEMBL1671910 COc1ccc(CC(=O)Nc2cc3[C@H](NC4CC4)[C@@H](O)C(C)(C)Oc3cc2[N+](=O)[O-])cc1 4.36 CHEMBL1676103 CHEMBL1673437 CCCC1NC(C)C2N1NC(=NC2=O)c3cc(ccc3OCC)S(=O)(=O)N4CCN(CC)CC4 4.89 CHEMBL1676103 CHEMBL1673438 CC(C)Oc1cc(ccc1OC(F)F)C(C2=CCC(=O)N=C2)c3ccc(nc3)C(C)(C)O 4.25 CHEMBL1676103 CHEMBL1673440 CC1N=CN=C1CN2CCc3c(C2=O)c4ccccc4n3C 5.5 CHEMBL1676103 CHEMBL1673442 Fc1ccc(cc1)C(=O)N2CCN(CCN3C(=O)Nc4ccccc4C3=O)CC2 6.97 CHEMBL1676103 CHEMBL1673443 CC(=O)NC(=O)C1CCC(CC1)C2N=CC(=N2)c3cccc(Br)c3 6.3 CHEMBL1676103 CHEMBL167779 CCN(CC)CCOc1ccc(cc1)\C(=C(/Cl)\c2ccccc2)\c3ccccc3 6.74 CHEMBL1676103 CHEMBL1682748 CC(C)Oc1ccc(F)cc1c2ccc(nc2)N3CCC(CNC(=O)c4ccc(cc4)c5oc6c(cc(cc6n5)C#N)C(C)C)CC3 7.25 CHEMBL1772211 CHEMBL1683073 CO[C@@H]1COCC[C@@H]1N[C@@H]2CC[C@](C2)(C(C)C)C(=O)N3CCN(CC3)c4cccc(n4)C(F)(F)F 5.41 CHEMBL1786160 CHEMBL1683074 CO[C@@H]1COCC[C@@H]1N[C@@H]2CC[C@](C2)(C(C)C)C(=O)N3CCN(CC3)c4cc(ccn4)C(F)(F)F 5.77 CHEMBL1685790 CHEMBL1683075 CO[C@@H]1COCC[C@@H]1N[C@@H]2CC[C@](C2)(C(C)C)C(=O)N3CCN(CC3)c4nccc(n4)C(F)(F)F 5.31 CHEMBL1786160 CHEMBL1683351 OC(=O)C1=CC(=C2C=CC=CN2C1=O)CN3CCN(CC3)c4ccc(cc4)C#N 5.13 CHEMBL2044730 CHEMBL1683443 C[C@@H](C[C@@H](CS(=O)(=O)N1CCN(CC1)c2ccc(F)cc2)N(O)C=O)c3ncc(F)cn3 4.59 CHEMBL1686219 CHEMBL1683444 C[C@@H](C[C@@H](CS(=O)(=O)N1CCC(CC1)OCc2ccc(Cl)cc2Cl)N(O)C=O)c3ncc(F)cn3 5.3 CHEMBL1686219 CHEMBL1683445 C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCN(CC1)c2ccc(F)cc2)N(O)C=O)c3ncc(F)cn3 4.68 CHEMBL1686219 CHEMBL1683577 Cc1c(ncn1Cc2cccc(c2)C(F)(F)F)C(=O)Nc3ccn(C)n3 4.54 CHEMBL1685382 CHEMBL1684045 CNC(C)C1(CCCCC1)c2ccc(Cl)c(Cl)c2 4.64 CHEMBL1686824 CHEMBL1684047 CC(N(C)C)C1(CCCCC1)c2ccc(Cl)c(Cl)c2 4.4 CHEMBL1686824 CHEMBL1684055 CC(N(C)C)C1(CCCCC1)c2ccc3ccccc3c2 5.37 CHEMBL1686824 CHEMBL1684057 Cl.CNC(C)C1(CCCCC1)c2ccc(Cl)c(Cl)c2 4.64 CHEMBL1686824 CHEMBL1684058 Cl.CC(N(C)C)C1(CCCCC1)c2ccc(Cl)c(Cl)c2 4.4 CHEMBL1686824 CHEMBL1684059 Cl.CC(N(C)C)C1(CCCCC1)c2ccc3ccccc3c2 5.37 CHEMBL1686824 CHEMBL1684585 Nc1nc(CC(=O)Nc2ccc(C[C@@H]3CC[C@@H](N3)[C@H](O)c4ccccc4)cc2)cs1 4.72 CHEMBL3767769 CHEMBL1688243 CCO[C@@H]1Cc2cc(ccc2[C@H]1N3CCN(C[C@@H]3C)C4(C)CCN(CC4)C(=O)c5c(C)ncnc5C)C(F)(F)F 5.35 CHEMBL1695229 CHEMBL16900 FC(F)(F)CN1C(=O)[C@H](NC(=O)Cc2ccc(cc2C(F)(F)F)C(F)(F)F)N=C(c3ccccc3)c4ccccc14 5.22 CHEMBL686879 CHEMBL1712 Cl.Clc1cc2NC(=O)Cc2cc1CCN3CCN(CC3)c4nsc5ccccc45 6.92 CHEMBL766814 CHEMBL171377 COc1ccc(cc1)[C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(CC3)(c4ccccc4)c5ccc(OC)nc5)C(C)(C)C2 6.28 CHEMBL1053229 CHEMBL17157 CC(C)(C)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4 6.51 CHEMBL1048091 CHEMBL1716297 CCOC(=O)N1CCN(Cc2onc(n2)c3cccc(Cl)c3)CC1 4.81 CHEMBL2072927 CHEMBL172 O[C@H]([C@H]1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F 5.59 CHEMBL3407223 CHEMBL1726 COC(=O)C1=C(C)NC(=C(C1c2ccccc2[N+](=O)[O-])C(=O)OCC(C)C)C 4.64 CHEMBL827807 CHEMBL1729 COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c3cc(Cl)c(N)cc3OC 6.77 CHEMBL1909190 CHEMBL1734 O=C(O[C@H]1CN2CCC1CC2)N3CCc4ccccc4[C@@H]3c5ccccc5 5.8 CHEMBL3430717 CHEMBL17350 C[C@@H]([C@@H](O)c1ccc(O)cc1)N2CCC(O)(CC2)c3ccccc3 5 CHEMBL940929 CHEMBL1738705 Cc1c2CCCN3CCC[C@@H]3CNc4cc(ccc4C(=O)N)n2c5CC(C)(C)CC(=O)c15 5.59 CHEMBL1780626 CHEMBL1741 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O)OC 4.23 CHEMBL766814 CHEMBL17423 COc1ccc(cc1OC)C(=O)N2CCN(CC2)c3ccc4NC(=O)CCc4c3 4.75 CHEMBL827807 CHEMBL1760003 COc1ccc(cc1)[C@H]2CN(CCCC3CCOCC3)C[C@@H]2CNC(=O)c4cccc(Cl)c4 5.99 CHEMBL1764797 CHEMBL1760059 COc1ccc(cc1)[C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CNC(=O)c4cccc(Cl)c4 6.8 CHEMBL1764797 CHEMBL1760222 COc1ccc(cc1)[C@H]2CN(Cc3ccc(OC)c(OC)c3)C[C@@H]2CNC(=O)c4cccc(Cl)c4 6.22 CHEMBL1764797 CHEMBL1760223 COc1ccc(cc1)[C@H]2CN(CCCc3ccc(OC)c(OC)c3)C[C@@H]2CNC(=O)c4cccc(Cl)c4 6.7 CHEMBL1764797 CHEMBL1760226 COc1ccc(cc1)[C@H]2CN(CCc3cccc(OC)c3)C[C@@H]2CNC(=O)c4cccc(Cl)c4 7.33 CHEMBL1764797 CHEMBL1760227 COc1ccc(CCN2C[C@H](CNC(=O)c3cccc(Cl)c3)[C@H](C2)c4ccc(OC)cc4)cc1 7.55 CHEMBL1764797 CHEMBL1760229 COc1ccc(cc1)[C@H]2CN(CCC3CCOCC3)C[C@@H]2CNC(=O)c4cccc(Cl)c4 5.71 CHEMBL1764797 CHEMBL1760230 COc1ccc(cc1)[C@H]2CN(CCCC3CCNCC3)C[C@@H]2CNC(=O)c4cccc(Cl)c4 4.69 CHEMBL1764797 CHEMBL1760234 COc1ccc(cc1)[C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CC(=O)Nc4cccc(Cl)c4 7.18 CHEMBL1764797 CHEMBL1760235 COc1ccc(cc1)[C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CC(=O)N(C)c4cccc(Cl)c4 7.54 CHEMBL1764797 CHEMBL1760236 COc1ccc(cc1)[C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CC(=O)NCc4cccc(Cl)c4 7.47 CHEMBL1764797 CHEMBL1760237 COc1ccc(cc1)[C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CCNC(=O)c4cccc(Cl)c4 7.25 CHEMBL1764797 CHEMBL1760242 COc1ccc(cc1)[C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2Cc4nc5ccc(Cl)cc5[nH]4 7.55 CHEMBL1764797 CHEMBL1760243 COc1ccc(cc1)[C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CCc4nc5ccc(Cl)cc5[nH]4 7.8 CHEMBL1764797 CHEMBL1760244 COc1ccc(cc1)[C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CCc4cc5ccc(Cl)cc5[nH]4 7.35 CHEMBL1764797 CHEMBL1760245 COc1ccc(cc1)[C@H]2CN(CCCC3CCOCC3)C[C@@H]2CC(=O)Nc4cccc(Cl)c4 6.43 CHEMBL1764797 CHEMBL1760246 COc1ccc(cc1)[C@H]2CN(CCC3CCOCC3)C[C@@H]2CC(=O)Nc4cccc(Cl)c4 6.92 CHEMBL1764797 CHEMBL1760247 COc1ccc(cc1)[C@H]2CN(CCC3CCS(=O)(=O)CC3)C[C@@H]2CC(=O)Nc4cccc(Cl)c4 6.54 CHEMBL1764797 CHEMBL1760248 COc1ccc(cc1)[C@H]2CN(CCC3(O)CCOCC3)C[C@@H]2CC(=O)Nc4cccc(Cl)c4 5.08 CHEMBL1764797 CHEMBL1760249 COc1ccc(cc1)[C@H]2CN(CCCN(C)S(=O)(=O)C)C[C@@H]2CC(=O)Nc3cccc(Cl)c3 5.34 CHEMBL1764797 CHEMBL1760250 COc1ccc(cc1)[C@H]2CN(CCCN(C)S(=O)(=O)c3ccccc3)C[C@@H]2CC(=O)Nc4cccc(Cl)c4 6.85 CHEMBL1764797 CHEMBL1760251 COc1ccc(cc1)[C@H]2CN(CCCN3CCCC3=O)C[C@@H]2CC(=O)Nc4cccc(Cl)c4 5.9 CHEMBL1764797 CHEMBL1760318 CO[C@H](C[C@H](CCCCNCc1ccc(F)cc1)C(=O)NO)c2ccc(F)cc2 5.7 CHEMBL2013523 CHEMBL1760322 Cc1cc(O[C@H](CCCCNCc2ccc(F)cc2)C(=O)NO)cc(C)c1F 6.1 CHEMBL2013523 CHEMBL1760324 Cc1cc(C[C@H](CCCCNCc2ccc(F)cc2)C(=O)NO)cc(C)c1F 5.33 CHEMBL2013523 CHEMBL1761103 CC(=O)Nc1cccc(c1)C2CCN(CCCn3c(nc4ccccc34)c5ccc(Cl)cc5)CC2 8.52 CHEMBL1764027 CHEMBL1762472 Cl.CNCC[C@@H](Oc1cc(Cl)ccc1C#N)c2ccccc2 5 CHEMBL1763073 CHEMBL1766528 CN1CCN(CC1)c2cnc3cc(cc(NCc4cccc(c4)[N+](=O)[O-])c3c2)C(F)(F)F 7.31 CHEMBL3226599 CHEMBL1766529 CC(=O)N1CCN(CC1)c2cnc3cc(cc(NCc4cccc(c4)[N+](=O)[O-])c3c2)C(F)(F)F 6.34 CHEMBL3226599 CHEMBL1767136 CN1CCC[C@@H]1CN2N=C(Cc3ccc(Cl)cc3)c4ccccc4C2=O 6.7 CHEMBL2150564 CHEMBL1767164 Clc1ccc(CC2=NN(C[C@H]3CCCN3CCCCc4ccc(OCCCN5CCCCCC5)cc4)C(=O)c6ccccc26)cc1 7.3 CHEMBL1769661 CHEMBL1770720 Fc1cccc([C@@H]2CC[C@@H](NC(=O)N3CCC4(CC3)OC(=O)Nc5ncccc45)c6ncc(CC(F)(F)F)n6C2)c1F 5.48 CHEMBL1772125 CHEMBL1771093 Cc1cc(nc(n1)C#N)N2CCC(CC2)C3CCN(CC3)c4ncc(Cl)cn4 6.56 CHEMBL1771845 CHEMBL1771094 Cc1cnc(nc1)N2CCC(CC2)C3CCN(CC3)c4cc(nc(C)n4)C#N 5.75 CHEMBL1771845 CHEMBL1771095 Cc1cnc(cn1)N2CCC(CC2)C3CCN(CC3)c4cc(nc(C)n4)C#N 5.27 CHEMBL1771845 CHEMBL1771096 Cc1cnc(cn1)N2CCC(CC2)C3CCN(CC3)c4cc(C)nc(n4)C#N 4.98 CHEMBL1771845 CHEMBL1771097 Fc1cc(OCC2CC2C3CCN(CC3)c4ncc(Cl)cn4)ccc1C(=O)NC5CC5 5.72 CHEMBL1771845 CHEMBL1771098 Fc1cc(OCCC2CC2C3CCN(CC3)c4ncc(Cl)cn4)ccc1C(=O)NC5CC5 5.59 CHEMBL1771845 CHEMBL1771099 Fc1cc(OCC2CC2CC3CCN(CC3)c4ncc(Cl)cn4)ccc1C(=O)NC5CC5 5.92 CHEMBL1771845 CHEMBL1771100 CS(=O)(=O)c1ccc(OCC[C@@H]2C[C@@H]2C3CCN(CC3)c4ncc(Cl)cn4)nc1 4.72 CHEMBL1771850 CHEMBL1771101 Clc1cnc(nc1)N2CCC(CC2)[C@H]3C[C@H]3CCOc4ccc(cc4)n5ccnn5 4.72 CHEMBL1771850 CHEMBL1771102 Clc1cnc(nc1)N2CCC(CC2)[C@H]3C[C@H]3CCOc4ccc(cn4)n5ccnn5 4.36 CHEMBL1771850 CHEMBL1771103 Cc1cnc(nc1)N2CCC(CC2)[C@H]3C[C@H]3CCOc4nc(C)cc(n4)C#N 5.4 CHEMBL1771850 CHEMBL1771127 CC(C)c1cc(cc2nc(oc12)c3ccc(cc3)C(=O)NC[C@@H]4CC[C@@H](CC4)c5cccc(c5)C(F)(F)F)C#N 5.63 CHEMBL1772211 CHEMBL1771129 CC(C)c1cc(cc2nc(oc12)c3ccc(cc3)C(=O)NC[C@@H]4CC[C@@H](CC4)c5cccc(C)c5)C#N 4.95 CHEMBL1772211 CHEMBL1771136 CC(C)c1cc(cc2nc(oc12)c3ccc(cc3)C(=O)NCC4CN(C(=O)O4)c5ccc(cn5)c6ccccc6C#N)C#N 5.93 CHEMBL1772211 CHEMBL1771138 CC(C)c1cc(cc2nc(oc12)c3ccc(cc3)C(=O)NCC4CN(C(=O)O4)c5ccc(cn5)c6ccc(C)s6)C#N 4.9 CHEMBL1772211 CHEMBL1771145 CC(C)c1cc(cc2nc(oc12)c3ccc(cc3)C(=O)NC[C@H]4CN(C(=O)O4)c5ccc(cn5)c6ccccc6OC(F)(F)F)C#N 5.45 CHEMBL1772211 CHEMBL1775179 CC(C)OC(=O)N1CCC(CC1)Oc2ncnc3c2cnn3c4ccc(cc4F)S(=O)(=O)C 5.52 CHEMBL1775806 CHEMBL1777855 CC#CC(CC(=O)O)c1ccc(Oc2ccc(cc2OC(F)F)C(F)(F)F)cc1F 4.6 CHEMBL1780458 CHEMBL1777878 CC#C[C@H]([C@H]1OC(=O)NC1=O)c2ccc(Oc3ccc(cc3OC(F)F)C(F)(F)F)cc2 5.47 CHEMBL1780458 CHEMBL1778033 CCN1C(=O)c2nc(Cc3ccccc3)n(Cc4ccccc4)c2N5CC6(CCc7ccccc67)N=C15 5.64 CHEMBL1781387 CHEMBL1778052 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@](C)(C[C@H](C)O2)OC)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C(C)C)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 4.52 CHEMBL1781403 CHEMBL1778190 C[C@@H]1CNc2cc(ccc2C(=O)N)n3c(CCCN1)c(C)c4C(=O)CC(C)(C)Cc34 5.5 CHEMBL1781362 CHEMBL1778865 COc1cc(F)ccc1c2cncc(CNCC3CC3)n2 5.72 CHEMBL1781193 CHEMBL1778867 COc1cc(F)ccc1c2cncc(CNC3CCCC3)n2 4.8 CHEMBL1781193 CHEMBL1779003 COc1cc(F)ccc1c2cncc(CNC3CCCC3)c2 5.72 CHEMBL1781193 CHEMBL1779004 COc1cc(F)ccc1c2cccc(CNC3CCCC3)c2 5.67 CHEMBL1781193 CHEMBL1779005 COc1cc(F)ccc1c2cccc(CNC3CCCC3)n2 5.21 CHEMBL1781193 CHEMBL1779006 COc1cc(F)ccc1c2cc(CNC3CCCC3)ccn2 5.42 CHEMBL1781193 CHEMBL1779007 COc1cc(F)ccc1c2cncc(CNC3CCCCC3)c2 5.66 CHEMBL1781193 CHEMBL1779008 COc1cc(F)ccc1c2cncc(CNC(C)C)c2 5.18 CHEMBL1781193 CHEMBL1779009 COc1cc(F)ccc1c2cncc(c2)C3CCCN3 5.06 CHEMBL1781193 CHEMBL1779010 COc1cc(F)ccc1c2cncc(NCc3ccccc3)c2 5.28 CHEMBL1781193 CHEMBL1779011 COc1cc(F)ccc1c2cncc(NC3CCCOC3)c2 5.03 CHEMBL1781193 CHEMBL1779012 COc1cc(F)ccc1c2cncc(CNC(=O)c3cnccn3)c2 5.15 CHEMBL1781193 CHEMBL1779013 COc1cc(F)ccc1c2cncc(CNC(=O)c3ccccn3)c2 4.57 CHEMBL1781193 CHEMBL1779014 COc1cc(F)ccc1c2cncc(CNC(=O)c3ccccc3)c2 4.73 CHEMBL1781193 CHEMBL1779016 COc1cc(F)ccc1c2cncc(CNC(=O)C3CCC3)c2 4.73 CHEMBL1781193 CHEMBL1779532 Cc1c2CCCN3CCCC[C@@H]3CNc4cc(ccc4C(=O)N)n2c5CC(C)(C)CC(=O)c15 6.05 CHEMBL1780626 CHEMBL1779533 Cc1c2CCCN3CCOC[C@@H]3CNc4cc(ccc4C(=O)N)n2c5CC(C)(C)CC(=O)c15 4.9 CHEMBL1780626 CHEMBL1779535 CC(=O)N1CCN2CCCc3c(C)c4C(=O)CC(C)(C)Cc4n3c5ccc(C(=O)N)c(NC[C@H]2C1)c5 4.61 CHEMBL1780626 CHEMBL1779536 Cc1c2CCCN3CC[C@H](CNc4cc(ccc4C(=O)N)n2c5CC(C)(C)CC(=O)c15)C3 6.36 CHEMBL1780626 CHEMBL1779539 Cc1c2CCCN3C[C@@H](F)C[C@@H]3CNc4cc(ccc4C(=O)N)n2c5CC(C)(C)CC(=O)c15 4.79 CHEMBL1780626 CHEMBL1779545 C[C@@H]1Nc2cc(ccc2C(=O)N)n3c(CCCN4CCCC[C@H]14)c(C)c5C(=O)CC(C)(C)Cc35 5.82 CHEMBL1780626 CHEMBL1779547 Cc1c2CCCN3CCC[C@@H](C3)Nc4cc(ccc4C(=O)N)n2c5CC(C)(C)CC(=O)c15 5.47 CHEMBL1780626 CHEMBL1779710 CC(C)(C)OC[C@H]1N(CCNC1=O)C(=O)C[C@H](N)Cc2cc(F)c(F)cc2F 4.1 CHEMBL1781167 CHEMBL1782081 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)c6cc(NS(=O)(=O)C)c(F)cc6Cl)c7cccc(F)c7 4.5 CHEMBL1788065 CHEMBL1782375 CC(C)[C@@]1(CC[C@H](C1)N2CCC3COCCC23)C(=O)N4CCN(CC4)c5cc(ccn5)C(F)(F)F 5.96 CHEMBL1786160 CHEMBL1782376 CC(C)[C@@]1(CC[C@H](C1)NC2C3CCCC2COC3)C(=O)N4CCN(CC4)c5cc(ccn5)C(F)(F)F 5.89 CHEMBL1786160 CHEMBL1782377 CO[C@@H]1COCC[C@@H]1N(C)[C@@H]2CC[C@](C2)(C(C)C)C(=O)N3CCN(CC3)c4cc(ccn4)C(F)(F)F 4.77 CHEMBL1786160 CHEMBL1782378 CO[C@@H]1COCC[C@@H]1N(C)[C@@H]2CC[C@](C2)(C(C)C)C(=O)N3CCN(CC3)c4cc(cnn4)C(F)(F)F 4.28 CHEMBL1786160 CHEMBL1782566 CO[C@@H]1COCC[C@@H]1N[C@@H]2CC[C@](C2)(C(C)C)C(=O)N3CCN(CC3)c4cncc(c4)C(F)(F)F 5.68 CHEMBL1786160 CHEMBL1782568 CO[C@@H]1COCC[C@@H]1N[C@@H]2CC[C@](C2)(C(C)C)C(=O)N3CCN(CC3)c4cncc(n4)C(F)(F)F 5.12 CHEMBL1786160 CHEMBL1782569 CO[C@@H]1COCC[C@@H]1N[C@@H]2CC[C@](C2)(C(C)C)C(=O)N3CCN(CC3)c4ccnc(n4)C(F)(F)F 4.45 CHEMBL1786160 CHEMBL1782570 CO[C@@H]1COCC[C@@H]1N[C@@H]2CC[C@](C2)(C(C)C)C(=O)N3CCN(CC3)c4cc(ncn4)C(F)(F)F 4.37 CHEMBL1786160 CHEMBL1782571 CO[C@@H]1COCC[C@@H]1N[C@@H]2CC[C@](C2)(C(C)C)C(=O)N3CCN(CC3)c4nncc(n4)C(F)(F)F 5.05 CHEMBL1786160 CHEMBL1782572 CO[C@@H]1COCC[C@@H]1N[C@@H]2CC[C@](C2)(C(C)C)C(=O)N3CCN(CC3)c4cc(cnn4)C(F)(F)F 4.5 CHEMBL1786160 CHEMBL1782576 CCO[C@H]1COCC[C@H]1N[C@@H]2CC[C@](C2)(C(C)C)C(=O)N3CCN(CC3)c4cc(ccn4)C(F)(F)F 5.19 CHEMBL1786160 CHEMBL1782577 CCO[C@@H]1COCC[C@@H]1N[C@@H]2CC[C@](C2)(C(C)C)C(=O)N3CCN(CC3)c4cc(ccn4)C(F)(F)F 5.07 CHEMBL1786160 CHEMBL1782578 CCC1COCC[C@@H]1N[C@@H]2CC[C@](C2)(C(C)C)C(=O)N3CCN(CC3)c4cc(ccn4)C(F)(F)F 5.92 CHEMBL1786160 CHEMBL1782580 CC(C)[C@@]1(CC[C@H](C1)N[C@H]2CCOC[C@H]2O)C(=O)N3CCN(CC3)c4cc(ccn4)C(F)(F)F 6.52 CHEMBL1786160 CHEMBL1783876 COc1ccc(cc1)N2C=Nc3c(sc4nccc(NCC#C)c34)C2=O 4.51 CHEMBL3361668 CHEMBL1784384 Cc1nc2ccccc2n1[C@H]3C[C@H]4CC[C@@H](C3)N4CCC5(CCN(CC5)C(=O)c6ccccc6)c7ccccc7 5.7 CHEMBL1788065 CHEMBL1784385 Cc1nc2ccccc2n1[C@H]3C[C@H]4CC[C@@H](C3)N4CCC5(CCN(CC5)C(=O)C(C)(C)C)c6ccccc6 6 CHEMBL1788065 CHEMBL1784405 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C(C)(C)C)c6cccc(F)c6 5.8 CHEMBL1788065 CHEMBL1784406 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C(C)(C)C(=O)O)c6cccc(F)c6 4.25 CHEMBL1788065 CHEMBL1784407 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C6(CCC6)C(=O)O)c7cccc(F)c7 4.35 CHEMBL1788065 CHEMBL1784409 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)c6cccc(c6)C(=O)O)c7ccccc7 4.3 CHEMBL1788065 CHEMBL1784464 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)c6cccc(c6)C(=O)N)c7ccccc7 4.6 CHEMBL1788065 CHEMBL1784465 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C(C)(C)c6nnn[nH]6)c7ccccc7 4.74 CHEMBL1788065 CHEMBL1784466 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C(C)(C)C(=O)NS(=O)(=O)C)c6ccccc6 4.6 CHEMBL1788065 CHEMBL1784467 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)c6cccc(c6)c7nnn[nH]7)c8ccccc8 4.5 CHEMBL1788065 CHEMBL1784468 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)c6cccc(c6)C(=O)NO)c7ccccc7 4.1 CHEMBL1788065 CHEMBL1784471 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C(C)(C)CO)c6ccccc6 5.22 CHEMBL1788065 CHEMBL1784472 COC(=O)c1cccc(c1)C(=O)N2CCC(CCN3C4CCC3CC(C4)n5c(C)nc6ccccc56)(CC2)c7ccccc7 6.1 CHEMBL1788065 CHEMBL1784473 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)c6cccc(c6)S(=O)(=O)N)c7ccccc7 4.2 CHEMBL1788065 CHEMBL1784475 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)c6ccc(cc6)S(=O)(=O)N)c7ccccc7 4.6 CHEMBL1788065 CHEMBL1784476 CNS(=O)(=O)c1cccc(c1)C(=O)N2CCC(CCN3C4CCC3CC(C4)n5c(C)nc6ccccc56)(CC2)c7ccccc7 4.2 CHEMBL1788065 CHEMBL1784477 CN(C)S(=O)(=O)c1cccc(c1)C(=O)N2CCC(CCN3C4CCC3CC(C4)n5c(C)nc6ccccc56)(CC2)c7ccccc7 5.7 CHEMBL1788065 CHEMBL1784511 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)c6cc(ccc6F)S(=O)(=O)N)c7cccc(F)c7 4.38 CHEMBL1788065 CHEMBL1784513 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)c6c(Cl)ccc(c6Cl)S(=O)(=O)N)c7cccc(F)c7 4.28 CHEMBL1788065 CHEMBL1784515 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)c6cc(c(F)cc6Cl)S(=O)(=O)NC7CCCC7)c8cccc(F)c8 4.51 CHEMBL1788065 CHEMBL1784516 CCNS(=O)(=O)c1cc(C(=O)N2CCC(CCN3C4CCC3CC(C4)n5c(C)nc6ccccc56)(CC2)c7cccc(F)c7)c(Cl)cc1F 4.52 CHEMBL1788065 CHEMBL1784517 CC(C)NS(=O)(=O)c1cc(C(=O)N2CCC(CCN3C4CCC3CC(C4)n5c(C)nc6ccccc56)(CC2)c7cccc(F)c7)c(Cl)cc1F 4.89 CHEMBL1788065 CHEMBL1784518 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)c6cc(c(F)cc6Cl)S(=O)(=O)NC7CC7)c8cccc(F)c8 4.92 CHEMBL1788065 CHEMBL1784519 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)c6cc(c(F)cc6Cl)S(=O)(=O)NCC(F)(F)F)c7cccc(F)c7 5.1 CHEMBL1788065 CHEMBL1784520 CCCNS(=O)(=O)c1cc(C(=O)N2CCC(CCN3C4CCC3CC(C4)n5c(C)nc6ccccc56)(CC2)c7cccc(F)c7)c(Cl)cc1F 5.05 CHEMBL1788065 CHEMBL1784521 CNS(=O)(=O)c1cc(C(=O)N2CCC(CCN3C4CCC3CC(C4)n5c(C)nc6ccccc56)(CC2)c7cccc(F)c7)c(Cl)cc1F 4.72 CHEMBL1788065 CHEMBL1784522 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)c6ccc(NS(=O)(=O)C)cc6Cl)c7cccc(F)c7 5 CHEMBL1788065 CHEMBL1784523 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)c6cc(NS(=O)(=O)C)c(F)cc6F)c7cccc(F)c7 4 CHEMBL1788065 CHEMBL1784524 Cc1nc2ccccc2n1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)c6c(F)ccc(NS(=O)(=O)C)c6F)c7cccc(F)c7 4.44 CHEMBL1788065 CHEMBL1784526 CC(C)S(=O)(=O)Nc1cc(C(=O)N2CCC(CCN3C4CCC3CC(C4)n5c(C)nc6ccccc56)(CC2)c7cccc(F)c7)c(F)cc1F 5.05 CHEMBL1788065 CHEMBL1788206 CN1Cc2ccccc2[C@H](N=C1OCc3ccc(NS(=O)(=O)C)cc3)c4ccccc4.OC(=O)\C=C\C(=O)O 4.42 CHEMBL687333 CHEMBL1788304 Cl.CN1Cc2ccccc2[C@@H](N=C1CCc3ccc(NS(=O)(=O)C)cc3)c4ccc(F)cc4F 4.07 CHEMBL684971 CHEMBL1800137 CC(C)(N)C(=O)N1CCn2c(C1)nc(c3ccc(F)cc3)c2Nc4ccc(F)cc4 5.25 CHEMBL1803471 CHEMBL1800168 CCS(=O)(=O)c1ccc2c(c1)nc(n2CC3CC3)C(C)(C)C 5.59 CHEMBL1803284 CHEMBL1800768 CC(C)(N)C(=O)N1CCn2c(C1)nc(c3cccc(F)c3)c2Nc4ccc(F)cc4 5.24 CHEMBL1803471 CHEMBL1800769 Cc1ccc(Nc2c(nc3CN(CCn23)C(=O)CN)c4ccc(F)cc4)cc1 4.96 CHEMBL1803471 CHEMBL1800770 Cc1ccc(Nc2c(nc3CN(CCn23)C(=O)C(C)(C)N)c4ccc(F)cc4)cc1 5.82 CHEMBL1803471 CHEMBL1800772 CC(C)(N)C(=O)N1CCn2c(C1)nc(c3ccc(F)cc3)c2Nc4ccc(Cl)cc4 5.64 CHEMBL1803471 CHEMBL1800774 CC(C)(N)C(=O)N1CCn2c(C1)nc(c2Nc3ccc(F)c(F)c3)c4ccc(F)cc4 5.32 CHEMBL1803471 CHEMBL1800775 NCC(=O)N1CCn2c(C1)nc(c3ccc(F)cc3)c2Nc4ccc(Cl)c(F)c4 4.68 CHEMBL1803471 CHEMBL1800776 CC(C)(N)C(=O)N1CCn2c(C1)nc(c2Nc3ccc(Cl)c(F)c3)c4ccc(F)cc4 5.25 CHEMBL1803471 CHEMBL1801188 Cc1nnc(N2CC[C@@H](F)C2)c3nn(c(C)c13)c4ccc(OCC(F)(F)F)cc4 6.5 CHEMBL1804921 CHEMBL1801191 COC1CN(C1)c2nnc(C)c3c(C)n(nc23)c4ccc(Cl)cc4OC(F)(F)F 5.4 CHEMBL1804921 CHEMBL1801192 CCOc1ccc(c(F)c1)n2nc3c(nnc(C)c3c2C)N4CC(C4)OC 5.22 CHEMBL1804921 CHEMBL1801204 COc1ccc(cc1CO)c2ccc3c(nc(nc3n2)N4CCOC[C@@H]4C)N5CCOC[C@@H]5C 4.52 CHEMBL2338825 CHEMBL1802360 Fc1ccc(OCCCN2CCC(CC2)N3C(=O)Nc4ccccc34)cc1 7.1 CHEMBL2149604 CHEMBL1802602 Cn1cc(cn1)c2cnc3C=Cc4ccc(NS(=O)(=O)C)cc4C(=O)c3c2 5 CHEMBL1803706 CHEMBL1802906 Cn1cc(cn1)c2cnc3C=Cc4ccc(NS(=O)(=O)N)cc4C(=O)c3c2 5.37 CHEMBL1803706 CHEMBL1802909 CN(Cc1cnccn1)S(=O)(=O)Nc2ccc3C=Cc4ncc(cc4C(=O)c3c2)c5cnn(C)c5 5.15 CHEMBL1803706 CHEMBL1803004 CS(=O)(=O)Nc1ccc2C=Cc3ncc(cc3C(=O)c2c1)c4ccccc4 6.54 CHEMBL1803706 CHEMBL180672 CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N 6.71 CHEMBL832717 CHEMBL1808642 ONC(=O)\C=C\c1ccc2CN(Cc3ccccc3)Cc2c1 4.56 CHEMBL1810945 CHEMBL1808643 ONC(=O)\C=C\c1ccc2CN(CCC3CCCCC3)Cc2c1 4.66 CHEMBL1810945 CHEMBL1808645 ONC(=O)\C=C\c1ccc2CN(CCc3cnn4ccccc34)Cc2c1 5.28 CHEMBL1810945 CHEMBL1809045 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)C5CCN(CC5)C(=O)C 4.92 CHEMBL1810388 CHEMBL1809046 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)C5CCNCC5 5.04 CHEMBL1810388 CHEMBL1809048 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCCN(CC5)C(=O)C 4.96 CHEMBL1810388 CHEMBL1809049 COc1cc(OC2CCN(CC2)C(=O)C)ccc1Nc3ncc(Cl)c(n3)c4cnc5ccccn45 5 CHEMBL1810388 CHEMBL1809050 COc1cc(OC2CCNCC2)ccc1Nc3ncc(Cl)c(n3)c4cnc5ccccn45 5.32 CHEMBL1810388 CHEMBL1809052 COc1cc(OC2CNC2)ccc1Nc3ncc(Cl)c(n3)c4cnc5ccccn45 5.23 CHEMBL1810388 CHEMBL1809053 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCOCC5 5.5 CHEMBL1810388 CHEMBL1809054 COc1cc(CN2CCOCC2)ccc1Nc3ncc(Cl)c(n3)c4cnc5ccccn45 5 CHEMBL1810388 CHEMBL1809055 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)C(=O)N5CCOCC5 5.57 CHEMBL1810388 CHEMBL1809056 COc1cc(CC(=O)N2CCOCC2)ccc1Nc3ncc(Cl)c(n3)c4cnc5ccccn45 5.06 CHEMBL1810388 CHEMBL1809058 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CC6CNCC(C5)O6 5.28 CHEMBL1810388 CHEMBL1809059 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CC6CN(CCO)CC(C5)O6 5.82 CHEMBL1810388 CHEMBL1809060 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CC6COCC(C5)N6 5 CHEMBL1810388 CHEMBL1809061 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCNCC5 5.34 CHEMBL1810388 CHEMBL1809062 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCN(CCO)CC5 5.43 CHEMBL1810388 CHEMBL1809063 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCN(CC(=O)N(C)C)CC5 4.92 CHEMBL1810388 CHEMBL1809064 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCN(CCS(=O)(=O)C)CC5 5.03 CHEMBL1810388 CHEMBL1809068 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCN(CC5)C(=O)N(C)C 4.8 CHEMBL1810388 CHEMBL1809069 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCN(CC5)C(=O)CO 4.85 CHEMBL1810388 CHEMBL1809070 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCN(CC5)C(=O)[C@H](C)O 5.09 CHEMBL1810388 CHEMBL1809071 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCN(CC5)C(=O)[C@@H](C)O 4.82 CHEMBL1810388 CHEMBL1809072 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCN(CC5)C(=O)CN 4.8 CHEMBL1810388 CHEMBL1809073 CNCC(=O)N1CCN(CC1)c2ccc(Nc3ncc(Cl)c(n3)c4cnc5ccccn45)c(OC)c2 5.02 CHEMBL1810388 CHEMBL1809074 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCN(CC5)C(=O)[C@H](C)N 5.03 CHEMBL1810388 CHEMBL1809075 COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCN(CC5)C(=O)[C@@H](C)N 4.85 CHEMBL1810388 CHEMBL1809076 COc1ccc(cc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCN(CC5)C(=O)C 5.37 CHEMBL1810388 CHEMBL1809077 COc1ccc(cc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCNCC5 5.32 CHEMBL1810388 CHEMBL1809078 COc1ccc(cc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCOCC5 5.29 CHEMBL1810388 CHEMBL1809079 COc1ccc(cc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)C(=O)N5CCOCC5 5.89 CHEMBL1810388 CHEMBL1813015 CC(=O)Nc1cccc(Nc2ncnc(n2)N3CCc4ccccc4C3)c1 5.42 CHEMBL1816132 CHEMBL1813043 CC(=O)Nc1cccc(Nc2ncnc(n2)N3CCC(CC3)OCc4ccc(C)cc4)c1C 5.71 CHEMBL1816132 CHEMBL1813044 CC(C)c1ccc(COC2CCN(CC2)c3ncnc(Nc4cccc(NC(=O)C)c4C)n3)cc1 6.36 CHEMBL1816132 CHEMBL1813049 CC(=O)Nc1cccc(Nc2ncnc(n2)N3CCC(CC3)Oc4ccc(cc4)C(F)(F)F)c1C 5.39 CHEMBL1816132 CHEMBL1813050 CC(=O)Nc1cccc(Nc2ncnc(n2)N3CCC(CC3)Oc4ccc(OC(F)(F)F)cc4)c1C 5.59 CHEMBL1816132 CHEMBL1813057 C[C@@H]1CCCN1CCCOc2ccc(cc2)C3=NN(C)C(=O)C=C3 4.89 CHEMBL1816830 CHEMBL1813065 C[C@@H]1CCCN1CCCOc2ccc(cc2)C3=CC(=O)NN=C3 5 CHEMBL2038956 CHEMBL1813314 CN1C[C@H]2CCCC[C@]2(C1)c3ccc(Cl)c(Cl)c3 5.38 CHEMBL1816746 CHEMBL1813315 CN1C[C@@H]2CCCC[C@@]2(C1)c3ccc(Cl)c(Cl)c3 5.64 CHEMBL1816746 CHEMBL1813316 CCN1C[C@H]2CCCC[C@]2(C1)c3ccc(Cl)c(Cl)c3 5.33 CHEMBL1816746 CHEMBL1813317 CCN1C[C@@H]2CCCC[C@@]2(C1)c3ccc(Cl)c(Cl)c3 5.36 CHEMBL1816746 CHEMBL1813471 Clc1ccc(cc1Cl)[C@]23CCCC[C@H]2CNC3 5.19 CHEMBL1816746 CHEMBL1813472 Clc1ccc(cc1Cl)[C@@]23CCCC[C@@H]2CNC3 5.44 CHEMBL1816746 CHEMBL1813474 Clc1ccc(cc1Cl)[C@]23CCC[C@H]2CNC3 5.19 CHEMBL1816746 CHEMBL1813475 Clc1ccc(cc1Cl)[C@@]23CCC[C@@H]2CNC3 5.28 CHEMBL1816746 CHEMBL1813478 CN1C[C@@H]2CCC[C@@]2(C1)c3ccc(Cl)c(Cl)c3 5.25 CHEMBL1816746 CHEMBL1813484 CN1C[C@H]2CCC[C@]2(C1)c3ccc(Cl)c(Cl)c3 5.27 CHEMBL1816746 CHEMBL181350 CCN(CC)c1ccc(NC(=O)C2(CCc3cccc(OC)c3C2)N(C)C(=O)OCC(C)C)cc1 5.22 CHEMBL914485 CHEMBL1814154 CCc1c(nn(c2ccc(Cl)cc2Cl)c1c3ccc(Br)cc3)C(=O)NC(C)(C)c4nnnn4C 4.64 CHEMBL1816994 CHEMBL1818218 CC(C)CNc1nc(ncc1C(=O)NCc2ccccc2)N3CCN(CC4CCCOC4)CC3 6.24 CHEMBL1820160 CHEMBL1818303 CN(C)CCC1CCN(CC1)c2cc(C(=O)NC[C@@H]3CC[C@@H](CNC(=O)OCC(C)(C)C)CC3)c4ccccc4n2 4.85 CHEMBL1820828 CHEMBL1818341 CC(C)CNCc1ccc(cc1)c2ccccc2S(=O)(=O)N3CCCC3 5.62 CHEMBL3269792 CHEMBL1818821 COc1cc(ccc1n2cnc(C)c2)c3cn(Cc4ccccc4F)nn3 5.6 CHEMBL1820233 CHEMBL1818822 COc1cc(ccc1n2cnc(C)c2)c3cn(Cc4cccc(F)c4)nn3 5.57 CHEMBL1820233 CHEMBL1818823 COc1cc(ccc1n2cnc(C)c2)c3cn(Cc4ccc(F)cc4)nn3 5.66 CHEMBL1820233 CHEMBL1818824 COc1cc(ccc1n2cnc(C)c2)c3cn(Cc4cccc(c4)C(F)(F)F)nn3 5.9 CHEMBL1820233 CHEMBL1818825 COc1cc(ccc1n2cnc(C)c2)c3cn(Cc4cccc(OC(F)(F)F)c4)nn3 6.14 CHEMBL1820233 CHEMBL1818826 COc1cc(ccc1n2cnc(C)c2)c3cn(Cc4cc(cc(c4)C(C)(C)C)C(C)(C)C)nn3 6.5 CHEMBL1820233 CHEMBL1818827 COc1cc(ccc1n2cnc(C)c2)c3cn(Cc4cc(Br)cc(Br)c4)nn3 7 CHEMBL1820233 CHEMBL1818828 COc1cc(ccc1n2cnc(C)c2)c3cn(Cc4cc(cc(c4)C(F)(F)F)C(F)(F)F)nn3 6.41 CHEMBL1820233 CHEMBL1818829 COc1cc(ccc1n2cnc(C)c2)c3cn(Cc4ccc(cc4)C(C)(C)C)nn3 6.41 CHEMBL1820233 CHEMBL1818830 COc1cc(ccc1n2cnc(C)c2)c3cn(Cc4cccc5cccnc45)nn3 5.27 CHEMBL1820233 CHEMBL1818833 COc1cc(ccc1n2cnc(C)c2)c3cn(Cc4ccc(cc4)c5noc(C)n5)nn3 5.09 CHEMBL1820233 CHEMBL1818835 COc1cc(ccc1n2cnc(C)c2)c3cn(Cc4csc5ccccc45)nn3 5.67 CHEMBL1820233 CHEMBL1819090 CN1C(=O)N(C)c2cc(N3CCC[C@@](C)(N)C3)n(Cc4cc(F)ccc4C#N)c2C1=O 4.52 CHEMBL1821020 CHEMBL1819137 CCN(CCc1c[nH]c2ccccc12)Cc3ccc(\C=C\C(=O)NO)cc3 5.23 CHEMBL1820401 CHEMBL1819138 Cc1[nH]c2ccccc2c1CCN(CCF)Cc3ccc(\C=C\C(=O)NO)cc3 5.24 CHEMBL1820401 CHEMBL1819141 CCCN(CCc1c[nH]c2ccccc12)Cc3ccc(\C=C\C(=O)NO)cc3 5.18 CHEMBL1820401 CHEMBL1819255 ONC(=O)\C=C\c1ccc(CNCCc2c([nH]c3ccccc23)c4ccccc4)cc1 5.83 CHEMBL1820401 CHEMBL1819256 ONC(=O)\C=C\c1ccc(CNCCc2c([nH]c3ccccc23)c4ccccn4)cc1 5.81 CHEMBL1820401 CHEMBL1819257 COc1ccncc1c2[nH]c3ccccc3c2CCNCc4ccc(\C=C\C(=O)NO)cc4 5.07 CHEMBL1820401 CHEMBL1819258 ONC(=O)\C=C\c1ccc(CNCCc2c([nH]c3ccccc23)c4cccs4)cc1 6.32 CHEMBL1820401 CHEMBL1819259 Cc1onc(C)c1c2[nH]c3ccccc3c2CCNCc4ccc(\C=C\C(=O)NO)cc4 4.51 CHEMBL1820401 CHEMBL1819260 CC(C)(C)c1[nH]c2ccccc2c1CCNCc3ccc(\C=C\C(=O)NO)cc3 5.13 CHEMBL1820401 CHEMBL1819272 ONC(=O)\C=C\c1ccc(CNCCc2c(nn3ccccc23)c4ccccc4)cc1 4.98 CHEMBL1820401 CHEMBL1819273 CC(C)N(CCc1c(C)nn2ccccc12)Cc3ccc(\C=C\C(=O)NO)cc3 5 CHEMBL1820401 CHEMBL1819274 CCc1nn2ccccc2c1CCN(Cc3ccc(\C=C\C(=O)NO)cc3)C(C)C 5.12 CHEMBL1820401 CHEMBL1819275 CC(C)N(CCc1c(nn2ccccc12)c3ccccc3)Cc4ccc(\C=C\C(=O)NO)cc4 5.09 CHEMBL1820401 CHEMBL182223 NC(CC(=O)N1CCC[C@H]1C(=O)NCc2ccc(cc2)C(=O)O)Cc3ccc(F)c(F)c3.OC(=O)C(F)(F)F 4.1 CHEMBL829261 CHEMBL1822294 O=C(NCC1(CCCC1)N2CCOCC2)N3CCC(CC3)c4onc(n4)c5ccc6ccccc6n5 5 CHEMBL1827211 CHEMBL1822301 CC(C)(CNC(=O)N1CCC(CC1)c2onc(n2)c3ccc4ccccc4n3)N5CCOCC5 4.55 CHEMBL1827211 CHEMBL1822302 O=C(NCC1(CCCCC1)N2CCOCC2)N3CCC(CC3)c4onc(n4)c5ccc6ccccc6n5 5.37 CHEMBL1827211 CHEMBL1822304 O=C(NCC1(CCCC1)N2CCCC2)N3CCC(CC3)c4onc(n4)c5ccc6ccccc6n5 5.15 CHEMBL1827211 CHEMBL1822442 O=C(NCC1(CCCC1)N2CCCCC2)N3CCC(CC3)c4onc(n4)c5ccc6ccccc6n5 5.24 CHEMBL1827211 CHEMBL1822443 CCN(CC)C1(CNC(=O)N2CCC(CC2)c3onc(n3)c4ccc5ccccc5n4)CCCC1 5.03 CHEMBL1827211 CHEMBL1822444 CN(C)C1(CNC(=O)N2CCC(CC2)c3onc(n3)c4ccc5ccccc5n4)CCCC1 4.42 CHEMBL1827211 CHEMBL1822446 CCNC1(CNC(=O)N2CCC(CC2)c3onc(n3)c4ccc5ccccc5n4)CCCC1 4.62 CHEMBL1827211 CHEMBL1822458 CC(C)N1CCCC1CNC(=O)N2CCC(CC2)c3onc(n3)c4ccc5ccccc5n4 4.77 CHEMBL1827211 CHEMBL1822525 COc1cc(ccc1Nc2ncc3ccc(c4ccccc4N(C)S(=O)(=O)C)n3n2)N5CCN(C[C@H](C)O)CC5 5.04 CHEMBL1826008 CHEMBL1822863 CC1CCCN1CCc2ccc3nc(ccc3c2)c4cc(C#N)c(C)nc4C 5.08 CHEMBL1827362 CHEMBL1822864 CC1CCCN1CCc2ccc3nc(ccc3c2)c4cc(C(=O)N)c(C)nc4C 4.4 CHEMBL1827362 CHEMBL1822865 COC(=O)c1c(C)noc1c2ccc3cc(CCN4CCC[C@H]4C)ccc3n2 5.22 CHEMBL1827362 CHEMBL1822866 COC(=O)c1cc(on1)c2ccc3cc(CCN4CCC[C@H]4C)ccc3n2 4.78 CHEMBL1827362 CHEMBL1822867 CC1CCCN1CCc2ccc3nc(ccc3c2)c4cocc4 5.08 CHEMBL1827362 CHEMBL1822868 CC1CCCN1CCc2ccc3nc(ccc3c2)c4ccsc4 5.32 CHEMBL1827362 CHEMBL1822869 CC1CCCN1CCc2ccc3nc(ccc3c2)c4cccs4 5.61 CHEMBL1827362 CHEMBL1823042 Fc1cccc(OC2CNC(C2)C(=O)N3CCCN(CC3)C4CCC4)c1 5 CHEMBL1827362 CHEMBL1823043 Clc1cccc(OC2CNC(C2)C(=O)N3CCCN(CC3)C4CCC4)c1 5.14 CHEMBL1827362 CHEMBL1823044 Fc1ccc(OC2CNC(C2)C(=O)N3CCCN(CC3)C4CCC4)cc1 5 CHEMBL1827362 CHEMBL1823045 Clc1ccc(OC2CNC(C2)C(=O)N3CCCN(CC3)C4CCC4)cc1 5.7 CHEMBL1827362 CHEMBL1823046 O=C(C1CC(CN1)Oc2ccc(cc2)C#N)N3CCCN(CC3)C4CCC4 5 CHEMBL1827362 CHEMBL1823047 O=C(C1CC(CN1)Oc2ccc(cc2)C#N)N3CCCN(CC3)C4CCCC4 5.54 CHEMBL1827362 CHEMBL1823048 Fc1ccc(OC2CNC(C2)C(=O)N3CCCN(CC3)C4CCCC4)cc1 5.34 CHEMBL1827362 CHEMBL1823049 COC(=O)N1CC(CC1C(=O)N2CCCN(CC2)C3CCC3)Oc4cccc(F)c4 5 CHEMBL1827362 CHEMBL1823050 COC(=O)N1CC(CC1C(=O)N2CCCN(CC2)C3CCC3)Oc4ccc(F)cc4 5 CHEMBL1827362 CHEMBL1823051 CCCNS(=O)(=O)c1ccc(cc1)c2ccc(CCN3CCC[C@H]3C)cc2 5.85 CHEMBL1827362 CHEMBL1823052 CCC(CO)NS(=O)(=O)c1ccc(cc1)c2ccc(CCN3CCC[C@H]3C)cc2 5.29 CHEMBL1827362 CHEMBL1823053 C[C@@H]1CCCN1CCc2ccc(cc2)c3ccc(cc3)S(=O)(=O)N4CCC(O)C4 5.16 CHEMBL1827362 CHEMBL1823054 COCC1CCCN1S(=O)(=O)c2ccc(cc2)c3ccc(CCN4CCC[C@H]4C)cc3 5.72 CHEMBL1827362 CHEMBL1823180 C[C@H]1[C@@H](Oc2ccccc2S1(=O)=O)c3ccc(OCCCN4CCCC4)cc3 6.36 CHEMBL1827362 CHEMBL1823339 CC(C)N1CCN(CC1)C(=C)N(C)Cc2ccc(cc2)c3ccccc3 5.09 CHEMBL1827362 CHEMBL1823340 C(COc1ccc(cc1)c2ccccc2)CN3CCCCC3 6.38 CHEMBL1827362 CHEMBL1824031 Brc1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1 5.55 CHEMBL1826877 CHEMBL1824034 COC(=O)c1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1 4.83 CHEMBL1826877 CHEMBL1824036 CS(=O)(=O)c1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1 4.3 CHEMBL1826877 CHEMBL1824037 [O-][N+](=O)c1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1 4.61 CHEMBL1826877 CHEMBL1824039 FC(F)(F)Oc1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1 5.85 CHEMBL1826877 CHEMBL1824040 CC(=O)c1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1 4.31 CHEMBL1826877 CHEMBL1824041 O=C1COc2ccc(CNC3CCN(CCN4C(=O)COc5ccc(cc45)C#N)CC3)nc2N1 4.39 CHEMBL1919743 CHEMBL1824042 Clc1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1 5.52 CHEMBL1826877 CHEMBL1824043 Fc1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1 5.05 CHEMBL1919743 CHEMBL1824044 COc1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1 4.89 CHEMBL1826877 CHEMBL1824045 O=C1COc2ccc(CNC3CCN(CCN4C(=O)COc5ccc(cc45)c6occc6)CC3)nc2N1 5.89 CHEMBL1826877 CHEMBL182646 COc1ccc(CCN(C)CCCN(C(=O)c2ccc(cc2)[N+](=O)[O-])c3ccc(OC)c(OC)c3)cc1OC 7.7 CHEMBL827807 CHEMBL1829335 C[C@@H]1CCCN1CCCOc2ccc(cc2)C3=NNC(=O)C=C3 4.86 CHEMBL1816830 CHEMBL1829603 O[C@@]1(CC[C@@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4cccnc4 4.46 CHEMBL1831617 CHEMBL1829604 FC(F)(F)c1cccc(c1)C(=O)NCC(=O)NC2CN(C2)C3CCC(CC3)c4c[nH]c5ccccc45 5.62 CHEMBL1831617 CHEMBL1829605 FC(F)(F)c1cccc(c1)C(=O)NCC(=O)NC2CN(C2)[C@@H]3CC[C@@H](CC3)c4ccc5OCOc5c4 5.55 CHEMBL1831617 CHEMBL1829609 FC(F)(F)c1cccc(c1)C(=O)NCC(=O)NC2CN(C2)[C@@H]3CC[C@H](CC3)c4ccccc4 5.4 CHEMBL1831617 CHEMBL1829610 O=C(CNC(=O)c1ccccc1)NC2CN(C2)[C@@H]3CC[C@H](CC3)c4ccc5OCOc5c4 5.55 CHEMBL1831617 CHEMBL1829611 FC(F)(F)c1ccc(cc1)C(=O)NCC(=O)NC2CN(C2)[C@@H]3CC[C@H](CC3)c4ccc5OCOc5c4 5.82 CHEMBL1831617 CHEMBL1829612 COc1ccc(cc1)[C@@H]2CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 5.52 CHEMBL1831617 CHEMBL1829613 Oc1ccc(cc1)[C@@H]2CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 5.39 CHEMBL1831617 CHEMBL1829614 COC(=O)c1ccc(cc1)[C@@H]2CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 5.89 CHEMBL1831617 CHEMBL1829615 OC(=O)c1ccc(cc1)[C@@H]2CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.64 CHEMBL1831617 CHEMBL1829616 FC(F)(F)c1cccc(c1)C(=O)NCC(=O)NC2CN(C2)[C@@H]3CC[C@H](CC3)c4ccc(cc4)N5CCCC5 5.1 CHEMBL1831617 CHEMBL1829617 FC(F)(F)c1cccc(c1)C(=O)NCC(=O)NC2CN(C2)[C@@H]3CC[C@H](CC3)c4ccc5[nH]cnc5c4 5.6 CHEMBL1831617 CHEMBL1829618 FC(F)(F)c1cccc(c1)C(=O)NCC(=O)NC2CN(C2)[C@@H]3CC[C@H](CC3)c4cccnc4 5.42 CHEMBL1831617 CHEMBL1829619 COc1ccc(cn1)[C@@H]2CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 5.55 CHEMBL1831617 CHEMBL1829620 COc1cnccc1[C@@H]2CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 5.09 CHEMBL1831617 CHEMBL1829621 COc1cc(ccn1)[C@@H]2CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 5.21 CHEMBL1831617 CHEMBL1829622 FC(F)(F)c1cccc(c1)C(=O)NCC(=O)NC2CN(C2)[C@@H]3CC[C@H](CC3)c4cnccn4 4.92 CHEMBL1831617 CHEMBL1829623 CN(C)c1ncc(cn1)[C@@H]2CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 5.01 CHEMBL1831617 CHEMBL1829624 Oc1ccc(nc1)[C@@H]2CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 5 CHEMBL1831617 CHEMBL1829625 Oc1cnccc1[C@@H]2CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.64 CHEMBL1831617 CHEMBL1829626 Nc1cccnc1[C@@H]2CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.36 CHEMBL1831617 CHEMBL1829627 Nc1ccc(nc1)[C@@H]2CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.43 CHEMBL1831617 CHEMBL1829628 O[C@@]1(CC[C@@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4ccccc4 5 CHEMBL1831617 CHEMBL1829629 O[C@@]1(CC[C@@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4ccc(F)cc4 5.55 CHEMBL1831617 CHEMBL1829630 O[C@@]1(CC[C@@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4cccc(c4)C#N 5.82 CHEMBL1831617 CHEMBL1829631 CN(C)c1cccc(c1)[C@@]2(O)CC[C@@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.6 CHEMBL1831617 CHEMBL1829632 COc1ccc(cc1)[C@@]2(O)CC[C@@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 5.05 CHEMBL1831617 CHEMBL1829633 O[C@@]1(CC[C@@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4ccc5OCOc5c4 4.87 CHEMBL1831617 CHEMBL1829634 O[C@@]1(CC[C@@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4ccc5CCOc5c4 4.93 CHEMBL1831617 CHEMBL1829635 Cc1cccc(C)c1[C@@]2(O)CC[C@@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 5.12 CHEMBL1831617 CHEMBL1829636 FC(F)(F)c1cccc(c1)C(=O)NCC(=O)NC2CN(C2)[C@@H]3CC[C@](F)(CC3)c4ccccc4 5.48 CHEMBL1831617 CHEMBL1829637 N[C@@]1(CC[C@@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4ccccc4 5.21 CHEMBL1831617 CHEMBL182977 CCCCCCCN(CC)CCCCc1ccc(cc1)[N+](=O)[O-] 8 CHEMBL827807 CHEMBL1830042 CN1CC(C1)c2c[nH]c3cc(ccc23)N4C=CC(=CC4=O)OCc5ccccc5 4.92 CHEMBL1833187 CHEMBL1830693 N(c1ccccn1)c2nc(cs2)c3cn[nH]c3 4.48 CHEMBL1831776 CHEMBL1830698 C1Cc2sc(Nc3ccccn3)nc2c4c[nH]nc14 4.77 CHEMBL1831776 CHEMBL1830707 C1Cc2n[nH]cc2c3nc(Nc4ccccn4)sc3C1 4.55 CHEMBL1831776 CHEMBL1830711 C1Cc2n[nH]cc2c3nc(Nc4ncccn4)sc3C1 4.52 CHEMBL1831776 CHEMBL1833986 NC(=O)c1cnc(NC(C2CC2)C3CC3)c4c5ccc(cc5[nH]c14)c6cnc(N)nc6 5.09 CHEMBL1840125 CHEMBL1834350 CCN\C(=N/S(=O)(=O)c1cccc(Cl)c1)\N2CC3(CCNCC3)C=N2 5.1 CHEMBL1839299 CHEMBL1834631 FC(F)(F)c1ccc2[nH]nc(NCC(=O)NC3CN(C3)[C@@H]4CC[C@@H](CC4)c5ccccc5)c2c1 5.92 CHEMBL1837909 CHEMBL1834632 FC(F)(F)c1ccc2[nH]nc(NCC(=O)NC3CN(C3)[C@@H]4CC[C@@H](CC4)c5ccc6OCOc6c5)c2c1 5.96 CHEMBL1837909 CHEMBL1834633 NC(=O)Cc1ccc(cc1)[C@@H]2CC[C@@H](CC2)N3CC(C3)NC(=O)CNc4n[nH]c5ccc(cc45)C(F)(F)F 5.02 CHEMBL1837909 CHEMBL1834634 COc1ccc(cn1)[C@@H]2CC[C@@H](CC2)N3CC(C3)NC(=O)CNc4n[nH]c5ccc(cc45)C(F)(F)F 5.6 CHEMBL1837909 CHEMBL1834635 Cn1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@@H](CC3)c4ccc5OCOc5c4)c6cc(ccc16)C(F)(F)F 6.08 CHEMBL1837909 CHEMBL1834636 FC(F)(F)c1ccc2[nH]nc(NCC(=O)NC3CN(C3)[C@@H]4CC[C@@H](CC4)N5C=CC=CC5=O)c2c1 4.47 CHEMBL1837909 CHEMBL1834637 CC(C)[C@@H]1CC[C@@H](CC1)N2CC(C2)NC(=O)CNc3n[nH]c4ccc(cc34)C(F)(F)F 5.21 CHEMBL1837909 CHEMBL1834638 Cn1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@@H](CC3)C#N)c4cc(ccc14)C(F)(F)F 4.62 CHEMBL1837909 CHEMBL1834639 Cn1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@@H](CC3)C4CCCCC4)c5cc(ccc15)C(F)(F)F 5.51 CHEMBL1837909 CHEMBL1834640 CCOC(=O)[C@@H]1CC[C@@H](CC1)N2CC(C2)NC(=O)CNc3nn(C)c4ccc(cc34)C(F)(F)F 5.1 CHEMBL1837909 CHEMBL1834641 Cn1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@@H](CC3)C(=O)O)c4cc(ccc14)C(F)(F)F 4.6 CHEMBL1837909 CHEMBL1834642 Cn1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@@H](CC3)C(=O)N)c4cc(ccc14)C(F)(F)F 4.5 CHEMBL1837909 CHEMBL1834643 Cn1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@H](CO)CC3)c4cc(ccc14)C(F)(F)F 4.5 CHEMBL1837909 CHEMBL1834644 CCOC[C@@H]1CC[C@@H](CC1)N2CC(C2)NC(=O)CNc3nn(C)c4ccc(cc34)C(F)(F)F 5.25 CHEMBL1837909 CHEMBL1834645 Cn1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@H](COCC=C)CC3)c4cc(ccc14)C(F)(F)F 5.3 CHEMBL1837909 CHEMBL1834646 O[C@@H]1CC[C@@H](CC1)N2CC(C2)NC(=O)CNc3n[nH]c4ccc(cc34)C(F)(F)F 4.52 CHEMBL1837909 CHEMBL1834647 CCO[C@@H]1CC[C@@H](CC1)N2CC(C2)NC(=O)CNc3n[nH]c4ccc(cc34)C(F)(F)F 5.35 CHEMBL1837909 CHEMBL1834648 FC(F)(F)c1ccc2[nH]nc(NCC(=O)NC3CN(C3)[C@@H]4CC[C@@H](CC4)OCC=C)c2c1 5.13 CHEMBL1837909 CHEMBL1834650 CS(=O)(=O)N[C@@H]1CC[C@@H](CC1)N2CC(C2)NC(=O)CNc3n[nH]c4ccc(cc34)C(F)(F)F 4.64 CHEMBL1837909 CHEMBL1834651 FC(F)(F)c1ccc2onc(NCC(=O)NC3CN(C3)[C@@H]4CC[C@@H](CC4)c5ccc6OCOc6c5)c2c1 5.72 CHEMBL1837909 CHEMBL1834652 OCCn1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@@H](CC3)c4ccc5OCOc5c4)c6cc(ccc16)C(F)(F)F 5.12 CHEMBL1837909 CHEMBL1834717 CC(C)(C)NC(=O)n1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@@H](CC3)c4ccc5OCOc5c4)c6cc(ccc16)C(F)(F)F 5.33 CHEMBL1837909 CHEMBL1834718 NC(=O)n1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@@H](CC3)c4ccc5OCOc5c4)c6cc(ccc16)C(F)(F)F 4.92 CHEMBL1837909 CHEMBL1834719 CCOC(=O)[C@@H]1CC[C@@H](CC1)N2CC(C2)NC(=O)CNc3n[nH]c4ccc(cc34)C(F)(F)F 5.04 CHEMBL1837909 CHEMBL1834720 CCOC(=O)[C@@H]1CC[C@@H](CC1)N2CC(C2)NC(=O)CNc3noc4ccc(cc34)C(F)(F)F 5.25 CHEMBL1837909 CHEMBL1834721 CCOC(=O)[C@@H]1CC[C@@H](CC1)N2CC(C2)NC(=O)CNc3nn(CC)c4ccc(cc34)C(F)(F)F 5.12 CHEMBL1837909 CHEMBL1834757 Cc1cccc(Nc2nc(N[C@@H]3CCCNC3)ncc2C(=O)N)c1 5.6 CHEMBL1838283 CHEMBL1834758 Cc1cccc(Nc2nc(N[C@H]3CCCNC3)ncc2C(=O)N)c1 5.8 CHEMBL1838283 CHEMBL1834779 CCOC(=O)[C@@H]1CC[C@@H](CC1)N2CC(C2)NC(=O)CNc3nn(CC=C)c4ccc(cc34)C(F)(F)F 5.43 CHEMBL1837909 CHEMBL1834780 CCOC(=O)[C@@H]1CC[C@@H](CC1)N2CC(C2)NC(=O)CNc3nn(CC(F)(F)F)c4ccc(cc34)C(F)(F)F 5.6 CHEMBL1837909 CHEMBL1834781 CCOC(=O)[C@@H]1CC[C@@H](CC1)N2CC(C2)NC(=O)CNc3nn(C(=O)N)c4ccc(cc34)C(F)(F)F 4.7 CHEMBL1837909 CHEMBL1834782 CCOC(=O)[C@@H]1CC[C@@H](CC1)N2CC(C2)NC(=O)CNc3nn(c4ccc(cc34)C(F)(F)F)S(=O)(=O)C 4.6 CHEMBL1837909 CHEMBL1834783 CCOC(=O)[C@@H]1CC[C@@H](CC1)N2CC(C2)NC(=O)CNC3=NC(Cc4ccccc4)c5ccc(cc35)C(F)(F)F 5.85 CHEMBL1837909 CHEMBL1834784 CCOC(=O)[C@@H]1CC[C@@H](CC1)N2CC(C2)NC(=O)CNc3nn(C4CCCC4)c5ccc(cc35)C(F)(F)F 5.39 CHEMBL1837909 CHEMBL1834785 Cn1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@@H](CC3)c4ccccc4)c5cc(ccc15)C(F)(F)F 5 CHEMBL1837909 CHEMBL1834786 CN(C)c1cccc(c1)[C@@H]2CC[C@@H](CC2)N3CC(C3)NC(=O)CNc4nn(C)c5ccc(cc45)C(F)(F)F 4.92 CHEMBL1837909 CHEMBL1834787 FC(F)(F)c1ccc2[nH]nc(NCC(=O)NC3CN(C3)[C@@H]4CC[C@@H](CC4)c5cccnc5)c2c1 4.44 CHEMBL1837909 CHEMBL1834788 Cc1ccc(cn1)[C@@H]2CC[C@@H](CC2)N3CC(C3)NC(=O)CNc4n[nH]c5ccc(cc45)C(F)(F)F 4.57 CHEMBL1837909 CHEMBL1834789 Cn1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@@H](CC3)c4cccnc4)c5cc(ccc15)C(F)(F)F 4.62 CHEMBL1837909 CHEMBL1834790 COc1ccc(cn1)[C@@H]2CC[C@@H](CC2)N3CC(C3)NC(=O)CNc4nn(C)c5ccc(cc45)C(F)(F)F 4.92 CHEMBL1837909 CHEMBL1834791 Cc1ccc(cn1)[C@@H]2CC[C@@H](CC2)N3CC(C3)NC(=O)CNc4nn(C)c5ccc(cc45)C(F)(F)F 4.75 CHEMBL1837909 CHEMBL1834793 Cn1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@@H](CC3)c4cncs4)c5cc(ccc15)C(F)(F)F 4.36 CHEMBL1837909 CHEMBL1834794 Cn1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@@H](CC3)c4nccs4)c5cc(ccc15)C(F)(F)F 4.57 CHEMBL1837909 CHEMBL1834795 NC(=O)n1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@@H](CC3)c4nccs4)c5cc(ccc15)C(F)(F)F 4.51 CHEMBL1837909 CHEMBL1834797 Cc1ncc(s1)[C@@H]2CC[C@@H](CC2)N3CC(C3)NC(=O)CNc4nn(C)c5ccc(cc45)C(F)(F)F 4.6 CHEMBL1837909 CHEMBL1834798 CCc1ncc(s1)[C@@H]2CC[C@@H](CC2)N3CC(C3)NC(=O)CNc4nn(C)c5ccc(cc45)C(F)(F)F 4.64 CHEMBL1837909 CHEMBL1834799 CC(C)c1ncc(s1)[C@@H]2CC[C@@H](CC2)N3CC(C3)NC(=O)CNc4nn(C)c5ccc(cc45)C(F)(F)F 4.77 CHEMBL1837909 CHEMBL1834852 COc1ccc(cn1)[C@@H]2CC[C@@H](CC2)N3CC(C3)NC(=O)CNc4noc5ccc(cc45)C(F)(F)F 8.06 CHEMBL1837909 CHEMBL1834853 FC(F)(F)c1ccc2onc(NCC(=O)NC3CN(C3)[C@@H]4CC[C@@H](CC4)c5cncs5)c2c1 7.8 CHEMBL1837909 CHEMBL1834854 FC(F)(F)c1ccc2onc(NCC(=O)NC3CN(C3)[C@@H]4CC[C@@H](CC4)c5nccs5)c2c1 7.96 CHEMBL1837909 CHEMBL1835035 Cn1cc(cn1)c2ccc3c(c2)[nH]c4c(ccc(NC5CCCCC5)c34)C(=O)N 6.21 CHEMBL1840125 CHEMBL1835039 C[C@H](Nc1ccc(C(=O)N)c2[nH]c3cc(ccc3c12)c4cnn(C)c4)C(C)(C)C 4.54 CHEMBL1840125 CHEMBL1835057 Cc1cccc(Nc2nc(N[C@@H]3CCNC3)ncc2C(=O)N)c1 6.3 CHEMBL1838283 CHEMBL1835058 Cc1cccc(Nc2nc(N[C@H]3CCNC3)ncc2C(=O)N)c1 5.6 CHEMBL1838283 CHEMBL1835059 Cc1cccc(Nc2nc(NC3CNC3)ncc2C(=O)N)c1 5.8 CHEMBL1838283 CHEMBL1835060 Cc1cccc(Nc2nc(NCC3CCCCN3)ncc2C(=O)N)c1 5.6 CHEMBL1838283 CHEMBL1835061 Cc1cccc(Nc2nc(NC[C@@H]3CCCN3)ncc2C(=O)N)c1 6 CHEMBL1838283 CHEMBL1835062 Cc1cccc(Nc2nc(NC[C@H]3CCCN3)ncc2C(=O)N)c1 5.6 CHEMBL1838283 CHEMBL1835063 N[C@H]1CCCN(C1)c2ncc(C(=O)N)c(Nc3cccc(c3)C(F)(F)F)n2 6.1 CHEMBL1838283 CHEMBL1835064 Cc1cccc(Nc2nc(N[C@H]3CCCC[C@H]3N)ncc2C(=O)N)c1 5.2 CHEMBL1838283 CHEMBL1835065 Cc1cccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(=O)N)c1 5.4 CHEMBL1838283 CHEMBL1835066 Cc1cccc(Nc2nc(N[C@@H]3COCC[C@@H]3N)ncc2C(=O)N)c1 5.1 CHEMBL1838283 CHEMBL1835067 Cc1cccc(Nc2nc(N[C@@H]3COC[C@@H]3N)ncc2C(=O)N)c1 5.4 CHEMBL1838283 CHEMBL1835068 Cc1cccc(Nc2nc(N[C@@H]3CCC(F)(F)C[C@@H]3N)ncc2C(=O)N)c1 5.5 CHEMBL1838283 CHEMBL1835069 Cc1cccc(Nc2nc(N[C@@H]3CC(F)(F)CC[C@@H]3N)ncc2C(=O)N)c1 5.1 CHEMBL1838283 CHEMBL1835070 Cc1ccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(=O)N)cc1 4.6 CHEMBL1838283 CHEMBL1835071 Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(=O)N)cc1 4.7 CHEMBL1838283 CHEMBL1835141 Cn1cc(cn1)c2ccc3c(c2)[nH]c4c(cnc(NC(C5CC5)C6CC6)c34)C(=O)N 5.77 CHEMBL1840125 CHEMBL1835142 Cn1cc(cn1)c2ccc3c(c2)[nH]c4c(cnc(N[C@H](C5CC5)C(F)(F)F)c34)C(=O)N 5.47 CHEMBL1840125 CHEMBL1835146 NC(=O)c1cnc(NC(C2CC2)C3CC3)c4c5ccc(cc5[nH]c14)c6cn[nH]c6 6 CHEMBL1840125 CHEMBL1835148 NC(=O)c1cnc(NC(C2CC2)C3CC3)c4c5ccc(cc5[nH]c14)c6cnc(N)cn6 6.14 CHEMBL1840125 CHEMBL1835149 NC(=O)c1cnc(N[C@H](C2CC2)C(F)(F)F)c3c4ccc(cc4[nH]c13)c5cn[nH]c5 5.52 CHEMBL1840125 CHEMBL1835150 NC(=O)c1cnc(N[C@H](C2CC2)C(F)(F)F)c3c4ccc(cc4[nH]c13)c5ccc(N)nc5 6.13 CHEMBL1840125 CHEMBL1835153 NC(=O)c1cnc(N[C@H](C2CC2)C(F)(F)F)c3c4ccc(cc4[nH]c13)c5cnc(N)nc5 4.66 CHEMBL1840125 CHEMBL1835999 CN([C@@H]1CCN(C1)C2CCC2)C(=O)c3ccc(cc3)n4cccn4 4.6 CHEMBL1839633 CHEMBL1836035 CC(C)N1CC[C@H](C1)N(C)C(=O)c2ccc(cc2)n3c(C)nc4ccccc34 4.35 CHEMBL1839633 CHEMBL1836039 CN([C@@H]1CCN(C1)C2CCCC2)C(=O)c3ccc(cc3)n4c(C)nc5ccccc45 5.64 CHEMBL1839633 CHEMBL1836040 CN([C@@H]1CCN(C1)C2CCCCC2)C(=O)c3ccc(cc3)n4c(C)nc5ccccc45 5.55 CHEMBL1839633 CHEMBL1836146 COc1cc(OC)cc(c1)C(=O)NCC2(CCN(Cc3ccccc3OC)CC2)C#N 6.04 CHEMBL1839504 CHEMBL1836147 COc1cccc(CN2CCC(CNC(=O)c3cc(OC)cc(OC)c3)(CC2)C#N)c1 5.82 CHEMBL1839504 CHEMBL1836148 COc1ccc(CN2CCC(CNC(=O)c3cc(OC)cc(OC)c3)(CC2)C#N)cc1 5.49 CHEMBL1839504 CHEMBL1836149 COc1cc(OC)cc(c1)C(=O)NCC2(CCN(Cc3ccccc3C(F)(F)F)CC2)C#N 5.32 CHEMBL1839504 CHEMBL1836152 COc1cc(OC)cc(c1)C(=O)NCC2(CCN(CC3=Cc4ccccc4OC3(C)C)CC2)C#N 5.33 CHEMBL1839504 CHEMBL1836153 COc1cc(OC)cc(c1)C(=O)NCC2(CCN(CCc3ccccc3)CC2)C#N 5.8 CHEMBL1839504 CHEMBL1836161 Clc1cc(Cl)cc(c1)C(=O)NCC2(CCN(CCc3ccccc3)CC2)C#N 6.44 CHEMBL1839504 CHEMBL1836162 COC(=O)C1(CNC(=O)c2cc(OC)cc(OC)c2)CCN(Cc3ccccc3OC)CC1 5.72 CHEMBL1839504 CHEMBL1836163 COC(=O)C1(CNC(=O)c2cc(OC)cc(OC)c2)CCN(Cc3cccc(OC)c3)CC1 6.51 CHEMBL1839504 CHEMBL1836164 COC(=O)C1(CNC(=O)c2cc(OC)cc(OC)c2)CCN(Cc3ccc(OC)cc3)CC1 6.32 CHEMBL1839504 CHEMBL1836165 COC(=O)C1(CNC(=O)c2cc(OC)cc(OC)c2)CCN(Cc3ccccc3C(F)(F)F)CC1 5.3 CHEMBL1839504 CHEMBL1836166 COC(=O)C1(CNC(=O)c2cc(OC)cc(OC)c2)CCN(Cc3cccc(c3)C(F)(F)F)CC1 5.55 CHEMBL1839504 CHEMBL1836167 COC(=O)C1(CNC(=O)c2cc(OC)cc(OC)c2)CCN(Cc3ccc(cc3)C(F)(F)F)CC1 5.63 CHEMBL1839504 CHEMBL1836168 COC(=O)C1(CNC(=O)c2cc(OC)cc(OC)c2)CCN(CC3=Cc4ccccc4OC3(C)C)CC1 5.89 CHEMBL1839504 CHEMBL1836170 CC(C)Oc1ncc(cc1C#N)c2onc(n2)c3ccc4CCNCCc4c3 5.5 CHEMBL1839209 CHEMBL1836172 CC(C)Oc1ccc(cc1C#N)c2onc(n2)c3ccc4CCN(CCc4c3)C(CO)CO 4.75 CHEMBL1839209 CHEMBL1836212 CC(C)Oc1ccc(cc1C#N)c2onc(n2)c3cccc4CN(CCOc34)C(CO)CO 5.17 CHEMBL1839209 CHEMBL1836213 CC(C)Oc1ccc(cc1C#N)c2onc(n2)c3cnc4CN(CCc4c3C)C(CO)CO 4.9 CHEMBL1839209 CHEMBL1836214 CC(C)Oc1ccc(cc1C#N)c2onc(n2)c3ccc4CN(CCc4c3)C(CO)CO 4.7 CHEMBL1839209 CHEMBL1836215 CC(C)Oc1ccc(cc1C#N)c2onc(n2)c3ccc4CN(CCc4c3C)C(CO)CO 4.89 CHEMBL1839209 CHEMBL1836247 COC(=O)C1(CNC(=O)c2cc(Cl)cc(Cl)c2)CCN(Cc3ccccc3OC)CC1 6.8 CHEMBL1839504 CHEMBL1836248 COC(=O)C1(CNC(=O)c2cc(Cl)cc(Cl)c2)CCN(Cc3cccc(OC)c3)CC1 6.44 CHEMBL1839504 CHEMBL1836249 COC(=O)C1(CNC(=O)c2cc(Cl)cc(Cl)c2)CCN(Cc3ccc(OC)cc3)CC1 6.89 CHEMBL1839504 CHEMBL1836250 COC(=O)C1(CNC(=O)c2cc(Cl)cc(Cl)c2)CCN(Cc3ccccc3C(F)(F)F)CC1 6.34 CHEMBL1839504 CHEMBL1836251 COC(=O)C1(CNC(=O)c2cc(Cl)cc(Cl)c2)CCN(Cc3cccc(c3)C(F)(F)F)CC1 6.05 CHEMBL1839504 CHEMBL1836252 COC(=O)C1(CNC(=O)c2cc(Cl)cc(Cl)c2)CCN(Cc3ccc(cc3)C(F)(F)F)CC1 6.54 CHEMBL1839504 CHEMBL1836253 COC(=O)C1(CNC(=O)c2cc(Cl)cc(Cl)c2)CCN(CC3=Cc4ccccc4OC3(C)C)CC1 4.86 CHEMBL1839504 CHEMBL1836255 COc1ccccc1CN2CCC(CNC(=O)c3cc(CC(C)C)n(n3)c4ccccc4)(CC2)C#N 6.04 CHEMBL1839504 CHEMBL1836256 COc1cccc(CN2CCC(CNC(=O)c3cc(CC(C)C)n(n3)c4ccccc4)(CC2)C#N)c1 5.82 CHEMBL1839504 CHEMBL1836257 COc1ccc(CN2CCC(CNC(=O)c3cc(CC(C)C)n(n3)c4ccccc4)(CC2)C#N)cc1 5.49 CHEMBL1839504 CHEMBL1836258 CC(C)Cc1cc(nn1c2ccccc2)C(=O)NCC3(CCN(Cc4ccccc4C(F)(F)F)CC3)C#N 5.32 CHEMBL1839504 CHEMBL1836261 CC(C)Cc1cc(nn1c2ccccc2)C(=O)NCC3(CCN(CC4=Cc5ccccc5OC4(C)C)CC3)C#N 5.33 CHEMBL1839504 CHEMBL1836262 CC(C)Cc1cc(nn1c2ccccc2)C(=O)NCC3(CCN(CCc4ccccc4)CC3)C#N 5.8 CHEMBL1839504 CHEMBL1836263 Cl.COc1cc(OC)cc(c1)C(=O)NCC2(CCN(Cc3ccc(cc3)C(F)(F)F)CC2)C(=O)O 4.92 CHEMBL1839504 CHEMBL1837037 CN1Cc2cc(Cl)ccc2n3c(C1)nnc3C4CCN(CC4)c5ccccn5 4.75 CHEMBL1837361 CHEMBL1837038 COC(=O)N1Cc2cc(Cl)ccc2n3c(C1)nnc3C4CCN(CC4)c5ccccn5 4.33 CHEMBL1837361 CHEMBL1837040 CC(=O)N1Cc2cc(Cl)ccc2n3c(C1)nnc3C4CCN(CC4)c5ccccn5 4.45 CHEMBL1837361 CHEMBL1837041 CS(=O)(=O)N1Cc2cc(Cl)ccc2n3c(C1)nnc3C4CCN(CC4)c5ccccn5 4.51 CHEMBL1837361 CHEMBL184014 COc1ccc(CCNC(C)COc2c(C)cccc2C)cc1OC 5.22 CHEMBL827807 CHEMBL184412 CCCCN(CCCC)CCCOc1ccc(cc1)C(=O)c2c(CCCC)oc3ccc(NS(=O)(=O)C)cc23 5.52 CHEMBL827807 CHEMBL184461 COc1ccc(CCNCCCNC(=O)c2ccc(cc2)[N+](=O)[O-])cc1OC 6.38 CHEMBL827807 CHEMBL185434 CCN(CC)CC#CCOC(=O)[C@@](O)(C1CCCCC1)c2ccccc2 4.92 CHEMBL827807 CHEMBL186482 COC(=O)Cc1ccc(CNC(=O)[C@@H]2CSCN2C(=O)CC(N)Cc3ccccc3F)cc1.OC(=O)C(F)(F)F 5.01 CHEMBL829261 CHEMBL186730 NCc1ccc(F)c(c1)C2CCN(CC2)C(=O)c3cccc(c3)c4onc(n4)c5cccs5 6.1 CHEMBL827842 CHEMBL186873 COc1ccc2CC3N(CCc4cc(OC)c(OC)cc34)C(Cc5ccccc5)c2c1OC 4.85 CHEMBL827807 CHEMBL188068 NCc1ccc(F)c(c1)C2CCN(CC2)C(=O)c3cc(cc(c3)c4onc(n4)c5cccs5)C(=O)O 4.12 CHEMBL827842 CHEMBL188678 O=C1C=C(Oc2c1cccc2c3cccc4c5ccccc5sc34)N6CCOCC6 4.85 CHEMBL2423441 CHEMBL189881 C[C@H]([C@H](N)C(=O)N1CC[C@H](F)C1)c2ccc(cc2)c3ccc(F)cc3.OC(=O)C(F)(F)F 5.96 CHEMBL829377 CHEMBL1909986 Cc1nc2cn(Cc3ccccc3)cc2c(c1CN)c4ccc(Cl)cc4Cl 4.85 CHEMBL1913068 CHEMBL1910126 Cc1nc2C(=O)N(CC(=O)NCc3cccnc3)Cc2c(c1CN)c4ccc(Cl)cc4Cl 4.1 CHEMBL1913194 CHEMBL1910292 COCCCc1cc(CN(C2CC2)C(=O)[C@H]3CNCC[C@]3(O)c4ccc(F)c(F)c4)cc(OCCOC)c1 5.35 CHEMBL1924167 CHEMBL191054 C[C@@H]1CNC[C@@H]2Cc3ccc(Cl)c(C)c3N12 5.6 CHEMBL865567 CHEMBL191067 CN(C)C(=O)[C@H]([C@H](N)C(=O)N1CC[C@H](F)C1)c2ccc(cc2)c3ccc(F)cc3.OC(=O)C(F)(F)F 5.34 CHEMBL887127 CHEMBL1914480 COc1ccc2N=CC(=O)N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2n1 4.51 CHEMBL1919743 CHEMBL1914835 Cl.OC(COc1ccccc1C(=O)CCc2ccccc2)CN3CCC(CC3)c4ccccc4 5.46 CHEMBL1918925 CHEMBL1914844 Cl.Cc1ccc(cc1)N2CCN(CC(O)COc3ccccc3C(=O)CCc4ccccc4)CC2 5.37 CHEMBL1918925 CHEMBL1915083 Cl.OC(COc1ccccc1C(=O)CCc2ccccc2)CN3CCN(CC3)C(c4ccccc4)c5ccccc5 5.59 CHEMBL1918925 CHEMBL1915364 Cl.OC(COc1ccc(F)cc1C(=O)CCc2ccccc2)CN3CCN(CC3)C(c4ccccc4)c5ccccc5 5.32 CHEMBL1918925 CHEMBL1915619 CC(=O)NC[C@@H]1OC(=O)N2[C@H]1COc3cc(ccc23)c4ccc(nc4)C#N 5.56 CHEMBL2329729 CHEMBL1916532 COc1ccc2ncc(F)c(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2n1 4.82 CHEMBL1931724 CHEMBL1916533 COc1ccc2ncc(F)c(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2n1 5.4 CHEMBL1919743 CHEMBL1916534 COc1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2c1 4.89 CHEMBL1919743 CHEMBL1916535 O=C1COc2ccccc2N1CCN3CCC(CC3)NCc4cc5OCCOc5cn4 4.7 CHEMBL1919743 CHEMBL1916536 COc1ccc2SCC(=O)N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2c1 5.22 CHEMBL1919743 CHEMBL1916537 COc1ccc2CCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1 4.54 CHEMBL1919743 CHEMBL1916538 COc1ccc2COC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1 4.38 CHEMBL1919743 CHEMBL1916539 COc1ccc2C=CC(=O)N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2c1 4.47 CHEMBL1919743 CHEMBL1916540 COc1ccc2C(=CC(=O)N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2c1)C 4.64 CHEMBL1919743 CHEMBL1916542 COc1ccc2N=CC(=O)N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2c1 4.72 CHEMBL1919743 CHEMBL1916544 COc1ncc2N=CC(=O)N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2n1 4.09 CHEMBL1919743 CHEMBL1916545 COc1ccc2C=CC(=O)N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2n1 4.4 CHEMBL1919743 CHEMBL1917511 CC(C)(C)c1cc(C(=O)Nc2nc(CN)cs2)n(Cc3ccccc3)n1 5.43 CHEMBL1919559 CHEMBL192 CCCc1nn(C)c2C(=O)NC(=Nc12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(C)CC4 4 CHEMBL691014 CHEMBL1922270 C[C@@H]1[C@H]2CN(CCCC3CCOCC3)CC[C@@H]2Cc4[nH]c5ccc(cc5c14)C(F)(F)F 7.52 CHEMBL2032591 CHEMBL19224 COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC 5.14 CHEMBL1676103 CHEMBL1922933 CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(=O)O)C(=O)c2cc3cc(Cl)ccc3n2c4cccc(c4)C(F)(F)F 5.43 CHEMBL1925825 CHEMBL1924014 FC(F)(F)c1cc(ccc1Cl)S(=O)(=O)Nc2cc(Cl)cnc2Oc3ccc(cc3)C(=O)NCCN4CCCCC4 5.3 CHEMBL1925760 CHEMBL1924024 COc1cc(ccc1Oc2ccc(Cl)cc2NS(=O)(=O)c3ccc(Cl)c(c3)C(F)(F)F)C(=O)NCCN4CCCC4 4.6 CHEMBL1925760 CHEMBL1926762 COc1ccc2nccc(NC(=O)[C@@H]3CC[C@H](CC3)NCc4ccc5OCCOc5c4)c2c1 4.6 CHEMBL1932121 CHEMBL1926763 COc1ccc2nccc(NC(=O)[C@@]3(O)CC[C@@H](CC3)NCc4cc5OCCOc5cn4)c2n1 4.62 CHEMBL1932121 CHEMBL1926765 COc1ccc2nccc(NC(=O)[C@@]3(O)CC[C@@H](CC3)NCc4ccc5OCCOc5c4)c2n1 4.6 CHEMBL1932121 CHEMBL1926766 COc1ccc2nccc(NC(=O)[C@@]3(O)CC[C@@H](CC3)NCc4cnc5OCCOc5c4)c2n1 4.28 CHEMBL1932121 CHEMBL1926864 COc1ccc2nccc(NC(=O)[C@@H]3CC[C@H](CC3)NCc4cc5OCCOc5cn4)c2n1 4.54 CHEMBL1932121 CHEMBL1926867 Cc1ccc2cccc(NC(=O)[C@@]3(O)CC[C@@H](CC3)NCc4cc5OCCOc5cn4)c2n1 5.7 CHEMBL1932121 CHEMBL1926893 COc1ccc(cc1)N(Cc2cnccc2C)C3CCN(CC3)[C@H](C)CCNC(=O)c4c(C)cc(Cl)nc4C 6.6 CHEMBL1930402 CHEMBL1927161 COc1ccc2nccc([C@@H](O)CN3CCC(CC3)NCc4cc5OCCOc5cn4)c2n1 4.6 CHEMBL1931724 CHEMBL1927162 COc1ccc2ncc(F)c(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2c1 5.22 CHEMBL1931723 CHEMBL1927163 COc1ccc2ncc(Cl)c(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2n1 5.7 CHEMBL1931723 CHEMBL1927164 COc1ccc2ncc(C#N)c(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2n1 5.1 CHEMBL1931724 CHEMBL1927165 COc1ccc2ncc(F)c([C@@H](O)CN3CCC(CC3)NCc4cc5OCCOc5cn4)c2n1 4.1 CHEMBL1931724 CHEMBL1927166 COc1ccc2ncc(F)c([C@H](O)CN3CCC(CC3)NCc4cc5OCCOc5cn4)c2n1 4.2 CHEMBL1931724 CHEMBL1927167 COc1ccc2ncc(F)c(CCN3CC[C@H](NCc4cc5OCCOc5cn4)[C@H](O)C3)c2n1 5.1 CHEMBL1931724 CHEMBL1927168 COc1ccc2ncc(F)c(CCN3CC[C@@H](NCc4cc5OCCOc5cn4)[C@@H](O)C3)c2n1 5.31 CHEMBL1931724 CHEMBL1927170 COc1ccc2ncc(F)c(CCN3CC[C@@H](NCc4cc5OCCOc5cn4)[C@H](O)C3)c2n1 4.53 CHEMBL1931724 CHEMBL1928705 C[C@H](CN(C)C)Oc1nc(Nc2cc3cccc(Cl)c3cn2)cnc1C#N 5.3 CHEMBL2216275 CHEMBL193 COC(=O)C1=C(C)NC(=C(C1c2ccccc2[N+](=O)[O-])C(=O)OC)C 4.3 CHEMBL766814 CHEMBL1934130 CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4c(c3)c5ccccc5n4C(=O)N)CC2)c6ccccc16 5.7 CHEMBL1936822 CHEMBL1934520 COCCS(=O)(=O)c1ccc(cc1)c2ccc(CCN3CCC[C@H]3C)cc2 5.13 CHEMBL1936097 CHEMBL1934521 C[C@@H]1CCCN1CCc2ccc(cc2)c3ccc(cc3)S(=O)(=O)CCO 5.11 CHEMBL1936097 CHEMBL1934523 COCCCS(=O)(=O)c1ccc(cc1)c2ccc(CCN3CCC[C@H]3C)cc2 4.96 CHEMBL1936097 CHEMBL1934525 C[C@@H]1CCCN1CCc2ccc(cc2)c3ccc(cc3)S(=O)(=O)CC4CCOCC4 5.51 CHEMBL1936097 CHEMBL1934835 CC(=O)Nc1cccc(c1)C2CCN(CCCN3N=C(c4ccc(F)c(F)c4)c5ccccc5C3=O)CC2 4.8 CHEMBL1937279 CHEMBL1935114 C[C@@H]1CCCN1CCCOc2ccc(cc2)C3=NNC(=O)C(C)(C)C3 4.7 CHEMBL1937493 CHEMBL1935425 O=S1(=O)CCC(CC1)Oc2ccc3OC4(CCN(CC4)C5CCC5)CCc3c2 5.16 CHEMBL1938176 CHEMBL1935439 CN(C)C(=O)CN1CCCC(C1)c2nc3ccccc3n2CCOc4ccccc4 6.35 CHEMBL1938199 CHEMBL193544 CN1CCC(CC1)Oc2cccc3ncnc(Nc4ccc(OCc5ccccn5)c(Cl)c4)c23 5.3 CHEMBL930660 CHEMBL1935441 Cc1ccc(Cn2c(nc3ccccc23)[C@H]4CNCCO4)cc1 5.64 CHEMBL1938199 CHEMBL1935442 Fc1ccc(Cn2c(nc3ccccc23)[C@H]4CNCCO4)cc1 5.47 CHEMBL1938199 CHEMBL1935443 Cc1ccc(Cn2c(nc3ccccc23)C4CNCCO4)cc1C 5.68 CHEMBL1938199 CHEMBL1935444 Cc1ccc(Cn2c(nc3ccccc23)C4CNCCS4)cc1 6.03 CHEMBL1938199 CHEMBL1935446 Fc1ccc(Cn2c(nc3ccccc23)[C@H]4CNCCS4)cc1 6.05 CHEMBL1938199 CHEMBL1935447 COc1ccc(Cn2c(nc3ccccc23)[C@H]4CNCCS4)cc1 5.82 CHEMBL1938199 CHEMBL1935590 Fc1cccc(c1)S(=O)(=O)c2ccc3c4CCNCc4oc3c2 6 CHEMBL1936933 CHEMBL1935594 CC1(C)NCCc2c1oc3cc(ccc23)S(=O)(=O)c4cccc(F)c4 6 CHEMBL1936933 CHEMBL1935601 Fc1cccc(c1)S(=O)(=O)c2ccc3c4CCNC5(CCCOC5)c4oc3c2 4.87 CHEMBL1936933 CHEMBL1938410 CCN(C)C(=O)c1ccc(cc1)[C@@H](N2CCN(Cc3cscn3)CC2)c4cccnc4 4.82 CHEMBL1943910 CHEMBL1938433 ONC(=O)\C=C\c1ccc2OC3(CCN(Cc4ccccc4)CC3)CC(=O)c2c1 5.42 CHEMBL2395207 CHEMBL1939735 CCN(CC)C(=O)c1ccc(cc1)[C@@H](N2CCN(Cc3cccnc3)CC2)c4cccc(NC(=O)OC)c4 4.96 CHEMBL1943910 CHEMBL1939736 CCN(CC)C(=O)c1ccc(cc1)[C@@H](N2CCN(Cc3cncs3)CC2)c4cccc(NC(=O)OC)c4 4.85 CHEMBL1943910 CHEMBL1939737 CCN(CC)C(=O)c1ccc(cc1)[C@@H](N2CCN(Cc3ccc(F)cc3)CC2)c4cccc(NC(=O)C5CC5)c4 4.96 CHEMBL1943910 CHEMBL1939738 CN(CCO)C(=O)c1ccc(cc1)[C@@H](N2CCN(Cc3ccc(F)cc3)CC2)c4cccc(NC(=O)C5CC5)c4 4.82 CHEMBL1943910 CHEMBL1939739 Fc1ccc(CN2CCN(CC2)[C@H](c3ccc(cc3)C(=O)N4CCC4)c5cccc(NC(=O)C6CC6)c5)cc1 5.44 CHEMBL1943910 CHEMBL1939740 CCN(CC)C(=O)c1ccc(cc1)[C@@H](N2CCN(Cc3ccccn3)CC2)c4cccc(NC(=O)C5CC5)c4 4.7 CHEMBL1943910 CHEMBL1939741 CCN(C)C(=O)c1ccc(cc1)[C@@H](N2CCN(Cc3cccnc3)CC2)c4cccc(NC(=O)C5CCC5)c4 4.55 CHEMBL1943910 CHEMBL1939742 CCN(C)C(=O)c1ccc(cc1)[C@@H](N2CCN(Cc3nc(C)cs3)CC2)c4cccc(NC(=O)C5CC5)c4 4.75 CHEMBL1943910 CHEMBL1939744 CCN(C)C(=O)c1ccc(cc1)[C@@H](N2CCN(CCCOC)CC2)c3cccc(NC(=O)C4CC4)c3 4.89 CHEMBL1943910 CHEMBL1939745 CCOC(=O)Nc1ccccc1[C@H](N2CCN(Cc3cscn3)CC2)c4ccc(cc4)C(=O)N(CC)CC 5.06 CHEMBL1943910 CHEMBL1939746 CCOC(=O)Nc1cccc(c1)[C@H](N2CCN(Cc3cscn3)CC2)c4ccc(cc4)C(=O)N(CC)CC 5.27 CHEMBL1943910 CHEMBL1939747 CCOC(=O)Nc1ccc(cc1)[C@H](N2CCN(Cc3cscn3)CC2)c4ccc(cc4)C(=O)N(CC)CC 5.14 CHEMBL1943910 CHEMBL1939748 CCOC(=O)Nc1ccccc1[C@H](N2CCN(Cc3ccccn3)CC2)c4ccc(cc4)C(=O)N(CC)CC 5 CHEMBL1943910 CHEMBL1939751 CCN(C)C(=O)c1ccc(cc1)[C@@H](N2CCN(Cc3cscn3)CC2)c4cccc(NC(=O)OC)c4 4.77 CHEMBL1943910 CHEMBL1939752 CCOC(=O)Nc1cccc(c1)[C@H](N2CCN(Cc3cccnc3)CC2)c4ccc(cc4)C(=O)N5CCC5 4.96 CHEMBL1943910 CHEMBL1939753 CCN(C)C(=O)c1ccc(cc1)[C@@H](N2CCN(Cc3ccccn3)CC2)c4cccnc4 4.89 CHEMBL1943910 CHEMBL1945199 [Br-].C[N+](C)(CCCCNC(=O)Cc1ccc(OCc2ccccc2)cc1)CCNC(=O)c3nc(Cl)c(N)nc3N 4.97 CHEMBL1947997 CHEMBL194564 Clc1ccc2OC(=O)C=C(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 5.65 CHEMBL882589 CHEMBL1945694 Cc1cc2ncn(Cc3ccc(Cl)cc3)c2cc1C 5.16 CHEMBL3706049 CHEMBL1945844 O=C1NN=CC(=C1)c2ccc(OC3CCN(CC3)C4CCC4)cc2 5.7 CHEMBL1948885 CHEMBL1945845 CC1=NNC(=O)C=C1c2ccc(OC3CCN(CC3)C4CCC4)cc2 5.16 CHEMBL1948885 CHEMBL1946016 CCN(CC)C(=O)c1ccc(cc1)C(=C2CCN(Cc3ccc(F)cc3)CC2)c4ccccn4 5.41 CHEMBL1947877 CHEMBL1946017 CCN(CC)C(=O)c1ccc(cc1)C(=C2CCN(Cc3ccc(F)cc3)CC2)c4cccnc4 5.89 CHEMBL1947877 CHEMBL1946019 CCN(C)C(=O)c1ccc(cc1)C(=C2CCN(Cc3ccc(F)cc3)CC2)c4ccccc4NC(=O)C 4.92 CHEMBL1947877 CHEMBL1946020 CCN(CC)C(=O)c1ccc(cc1)C(=C2CCN(Cc3ccc(F)cc3)CC2)c4cccc(NC(=O)C)c4 5.52 CHEMBL1947877 CHEMBL1946021 CCN(CC)C(=O)c1ccc(cc1)C(=C2CCN(Cc3ccc(F)cc3)CC2)c4ccc(NC(=O)C)cc4 5.89 CHEMBL1947877 CHEMBL1946022 CCN(CC)C(=O)c1ccc(cc1)C(=C2CCN(Cc3ccc(F)cc3)CC2)c4ccccc4NC(=O)OC 5.33 CHEMBL1947877 CHEMBL1946023 CCN(CC)C(=O)c1ccc(cc1)C(=C2CCN(Cc3ccc(F)cc3)CC2)c4cccc(NC(=O)OC)c4 5.96 CHEMBL1947877 CHEMBL1946024 CCN(CC)C(=O)c1ccc(cc1)C(=C2CCN(Cc3ccc(F)cc3)CC2)c4ccc(NC(=O)OC)cc4 6.05 CHEMBL1947877 CHEMBL1946619 CCN(CC)C(=O)c1ccc(cc1)C(=C2CCNCC2)c3ccccn3 4.48 CHEMBL1947877 CHEMBL1946620 CCN(CC)C(=O)c1ccc(cc1)C(=C2CCN(Cc3cscn3)CC2)c4ccccn4 4.8 CHEMBL1947877 CHEMBL1946621 CN(C)C(=O)c1ccc(cc1)C(=C2CCN(Cc3cscn3)CC2)c4ccccn4 4.75 CHEMBL1947877 CHEMBL1949693 CN1C(=O)N(Cc2c(cnc3ccccc23)C#N)C(=O)c4c1c(C#N)c(N5CCCNCC5)n4CC=C(C)C 6.05 CHEMBL1954401 CHEMBL1949930 Cl.COc1cc(OC(C)C)cc(c1)S(=O)(=O)c2ccc3[C@@H]4CCNC[C@@H]4Oc3c2 5.48 CHEMBL1953186 CHEMBL1950346 CCCS(=O)(=O)n1c2CCN(Cc2c3cc(ccc13)C(=O)N4CCC(C)CC4)C5CCOCC5 5.7 CHEMBL1954425 CHEMBL1950351 CCS(=O)(=O)n1c2CCN(Cc2c3cc(ccc13)C(=O)N4CCC(C)CC4)C5CCOCC5 5.51 CHEMBL2032798 CHEMBL1950433 COc1cc(\C=C\2/CCCN3C2=NOC3(C)c4ccc(F)cc4)ccc1n5cnc(C)c5 6.13 CHEMBL1954142 CHEMBL1950434 COc1cc(\C=C\2/CCCN3C2=NO[C@]3(CO)c4ccc(F)cc4)ccc1n5cnc(C)c5 5.48 CHEMBL1954142 CHEMBL1950487 CCCS(=O)(=O)n1c2CCN(Cc2c3cc(ccc13)C(=O)N4CCC(C)CC4)C5CCOC5 4.89 CHEMBL1954425 CHEMBL1950488 CCS(=O)(=O)n1c2CCN(Cc2c3cc(ccc13)C(=O)N4CCC(C)CC4)C5CCOC5 4.6 CHEMBL1954425 CHEMBL1950489 CC1CCN(CC1)C(=O)c2ccc3c(c2)c4CN(CCc4n3C)C5CCOCC5 5.59 CHEMBL1954425 CHEMBL1950490 Cn1c2CCN(Cc2c3cc(ccc13)C(=O)N4CCCCC4)C5CCOCC5 4.75 CHEMBL1954425 CHEMBL1950535 COc1cc(\C=C\2/CCCN3[C@H](CON=C23)c4cc(F)c(F)c(F)c4)ccc1n5cnc(C)c5 6 CHEMBL1954142 CHEMBL1950643 O=C1NN=C(C=C1)c2ccc(OC3CCN(CC3)C4CCC4)cc2 5.1 CHEMBL1952486 CHEMBL1950736 O=C1NN=C(C=C1)c2ccc(OC3CCN(CC3)C4CCC4)nc2 5.05 CHEMBL1952486 CHEMBL1950743 CC1(C)CC(=NNC1=O)c2ccc(OC3CCN(CC3)C4CCC4)cc2 4.68 CHEMBL1952486 CHEMBL1950747 C[C@H]1CC(=O)NN=C1c2ccc(OC3CCN(CC3)C4CCC4)cc2 4.57 CHEMBL1952486 CHEMBL1951032 COc1c(Nc2ccc(nc2C)S(=O)(=O)C)ncnc1OC3CCN(CC3)C(=O)OC(C)C 4.89 CHEMBL1952937 CHEMBL1951415 Nc1nccc(n1)c2c(ncn2C3CCCCC3)c4ccc(F)cc4 4.56 CHEMBL2424274 CHEMBL1951416 CC#CCn1c(N2CCCNCC2)c(C#N)c3N(C)C(=O)N(Cc4ncc5ccccc5c4C#N)C(=O)c13 4.92 CHEMBL1954401 CHEMBL1951431 CC(=CCn1c(N2CCC[C@H](N)C2)c(C#N)c3N=CN(Cc4ccnc5ccccc45)C(=O)c13)C 5.38 CHEMBL1954401 CHEMBL1951453 CCCOc1sc(C(=O)N2CCC(CC2)c3cccc(CN)c3)c(C)c1Br 6 CHEMBL1953695 CHEMBL1951595 COc1cccc(c1)C(=O)CN2C(=O)N(C)c3c(C#N)c(N4CCC[C@H](N)C4)n(Cc5ccccc5)c3C2=O 7 CHEMBL1954401 CHEMBL1951596 CN1C(=O)N(Cc2nccc3ccccc23)C(=O)c4c1c(C#N)c(N5CCC[C@H](N)C5)n4Cc6ccccc6 5.55 CHEMBL1954401 CHEMBL1951597 CN1C(=O)N(C)c2c(C#N)c(N3CCC[C@H](N)C3)n(Cc4ccccc4)c2C1=O 5.37 CHEMBL1954401 CHEMBL1951598 COc1cccc(c1)C(=O)CN2C(=O)N(C)c3c(C#N)c(N4CCC[C@H](N)C4)n(CC=C(C)C)c3C2=O 5.8 CHEMBL1954401 CHEMBL1951599 CN1C(=O)N(Cc2nccc3ccccc23)C(=O)c4c1c(C#N)c(N5CCC[C@H](N)C5)n4CC=C(C)C 5.05 CHEMBL1954401 CHEMBL1951600 CN1C(=O)N(Cc2nc(C)c3ccccc3n2)C(=O)c4c1c(C#N)c(N5CCC[C@H](N)C5)n4CC=C(C)C 5.17 CHEMBL1954401 CHEMBL1951601 CN1C(=O)N(Cc2cnc3ccccc3n2)C(=O)c4c1c(C#N)c(N5CCC[C@H](N)C5)n4CC=C(C)C 5.3 CHEMBL1954401 CHEMBL1951602 CN1C(=O)N(Cc2ncccc2C#N)C(=O)c3c1c(C#N)c(N4CCC[C@H](N)C4)n3CC=C(C)C 4.77 CHEMBL1954401 CHEMBL1951603 COc1cccc(c1)C(=O)CN2C(=O)N(C)c3c(C#N)c(N4CCC[C@H](N)C4)n(CC#CC)c3C2=O 5.89 CHEMBL1954401 CHEMBL1951604 CC#CCn1c(N2CCC[C@H](N)C2)c(C#N)c3N(C)C(=O)N(Cc4nccc5ccccc45)C(=O)c13 4.55 CHEMBL1954401 CHEMBL1951605 CC#CCn1c(N2CCC[C@@H](N)C2)c(C#N)c3N(C)C(=O)N(Cc4nc(C)c5ccccc5n4)C(=O)c13 4.66 CHEMBL1954401 CHEMBL1951607 COc1cccc(c1)C(=O)CN2C(=O)N(C)c3c(C#N)c(N4CCCNCC4)n(CC=C(C)C)c3C2=O 5.96 CHEMBL1954401 CHEMBL1951608 CN1C(=O)N(Cc2nccc3ccccc23)C(=O)c4c1c(C#N)c(N5CCCNCC5)n4CC=C(C)C 5.72 CHEMBL1954401 CHEMBL1951609 CN1C(=O)N(Cc2nc(C)c3ccccc3n2)C(=O)c4c1c(C#N)c(N5CCCNCC5)n4CC=C(C)C 5.7 CHEMBL1954401 CHEMBL1951610 CN1C(=O)N(Cc2cn3ccccc3n2)C(=O)c4c1c(C#N)c(N5CCCNCC5)n4CC=C(C)C 5.75 CHEMBL1954401 CHEMBL1951611 CN1C(=O)N(Cc2ncc3ccccc3c2C#N)C(=O)c4c1c(C#N)c(N5CCCNCC5)n4CC=C(C)C 5.75 CHEMBL1954401 CHEMBL1951612 CC#CCn1c(N2CCCNCC2)c(C#N)c3N(C)C(=O)N(Cc4nccc5ccccc45)C(=O)c13 5 CHEMBL1954402 CHEMBL1951613 CC#CCn1c(N2CCCNCC2)c(C#N)c3N(C)C(=O)N(Cc4nc(C)c5ccccc5n4)C(=O)c13 4.92 CHEMBL1954401 CHEMBL1951614 CC#CCn1c(N2CCCNCC2)c(C#N)c3N(C)C(=O)N(Cc4c(cnc5ccccc45)C#N)C(=O)c13 5.36 CHEMBL1954401 CHEMBL1951766 Cc1ccc(cc1)[C@@]2(O)CC[C@H](CC2)N3CC[C@H](C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.88 CHEMBL1953525 CHEMBL1951778 COc1ccc(cn1)[C@@]2(O)CC[C@H](CC2)N3CC[C@H](C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F.CS(=O)(=O)O 4.08 CHEMBL1954009 CHEMBL195180 Clc1ccc(cc1)c2nc(COc3ccccc3CN4CCCCCCC4)cs2 7.52 CHEMBL827704 CHEMBL1951893 CCN(C1CCN(CCC(N2CCN(CC2)c3ccccc3)c4ccccc4)CC1)C(=O)Cc5ccc(cc5)S(=O)(=O)C 4.89 CHEMBL1954529 CHEMBL1951894 CCN(C1CCN(CCC(N2CCN(CC2)c3cccc(F)c3)c4ccccc4)CC1)C(=O)Cc5ccc(cc5)S(=O)(=O)C 5.5 CHEMBL1954529 CHEMBL1951896 CCN(C1CCN(CCC(N2CCN(CC2)S(=O)(=O)C)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C 4.6 CHEMBL1954529 CHEMBL1951898 CCN(C1CCN(CC[C@H](N2CCN(CC2)S(=O)(=O)C(F)(F)F)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C 5.5 CHEMBL1954529 CHEMBL1951899 CCN(C1CCN(CC[C@H](N2CCN(CC2)S(=O)(=O)CC(F)(F)F)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C 5.24 CHEMBL1954529 CHEMBL1951906 CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C 4.6 CHEMBL1954529 CHEMBL1951908 CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C(F)(F)F)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C 5.92 CHEMBL1954529 CHEMBL1951911 CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C)c3cccc(OC)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C 4.5 CHEMBL1954529 CHEMBL1951912 CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C)c3cccc(F)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C 4.46 CHEMBL1954529 CHEMBL1951914 CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C)c3cc(F)cc(F)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C 4.62 CHEMBL1954529 CHEMBL1951915 CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C)c3cc(F)cc(Cl)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C 4.85 CHEMBL1954529 CHEMBL1951916 CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C)c3cc(C)cc(C)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C 5.4 CHEMBL1954529 CHEMBL1951917 CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C)c3cccc(Cl)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C 5.1 CHEMBL1954529 CHEMBL1951918 CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C)c3cccc(c3)C(F)(F)F)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C 5.1 CHEMBL1954529 CHEMBL1952100 CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C)c3cc(Cl)cc(Cl)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C 5.19 CHEMBL1954529 CHEMBL1952113 FC(F)(F)Oc1cccc(c1)n2nnc3ccc(NCC4CCNCC4)nc23 5 CHEMBL1954570 CHEMBL1952141 CN1CCC(CNc2ccc3ncc(c4cccc(OC(F)(F)F)c4)n3n2)CC1.OS(=O)(=O)O 5.5 CHEMBL1954570 CHEMBL1952142 COc1cc(NCC2CCNCC2)nc3c1nnn3c4cccc(OC(F)(F)F)c4 5.5 CHEMBL1954570 CHEMBL1952143 COc1cc(NCC2CCNCC2)nc3c1nnn3c4cccc(c4)N(C)C 4.5 CHEMBL1954570 CHEMBL1952144 FC(F)(F)Oc1cccc(c1)n2nnc3cc(Cl)c(NCC4CCNCC4)nc23 6.4 CHEMBL1954570 CHEMBL195232 CC(=O)N1N=C(C[C@H]1c2cccc(O)c2)c3cc(F)ccc3F 4.58 CHEMBL870149 CHEMBL1952329 CN1CCC(CNc2ccc3ncc(c4cccc(OC(F)(F)F)c4)n3n2)CC1 6.01 CHEMBL2149353 CHEMBL195235 Clc1ccc(cc1)c2nc(COc3ccccc3C(=O)N4CCCC4)cs2 5.01 CHEMBL828432 CHEMBL195378 C[C@H]([C@H](N)C(=O)N1CC[C@H](F)C1)c2ccc(cc2)c3cccc(c3)c4nn[nH]n4.OC(=O)C(F)(F)F 4.23 CHEMBL829377 CHEMBL1956107 CN[C@@H]1CC[C@@H](CC1)N2CCc3ccc(NC(=N)c4cccs4)cc23 4.89 CHEMBL1959635 CHEMBL1956112 CN1CCC[C@H]1CCN2CCCc3cc(NC(=N)c4cccs4)ccc23 5.33 CHEMBL1959635 CHEMBL1956195 CC(Oc1ccccc1CC2CC2)C3=NCCN3 5.05 CHEMBL2091208 CHEMBL1956988 CC(C)N1CCC[C@H](CN2C(=Nc3ccc(Oc4ccc(F)cc4)nc3C2=O)C)C1 5.49 CHEMBL1958785 CHEMBL1956989 CC(C)N1CCC[C@H](CN2C(=Nc3ncc(Oc4ccc(F)cc4)cc3C2=O)C)C1 5.51 CHEMBL1958785 CHEMBL1956990 CC(C)N1CCC[C@H](CN2C(=Nc3ncc(Oc4ccc(Br)cc4F)cc3C2=O)C)C1 5.89 CHEMBL1958785 CHEMBL1956991 CC(C)N1CCC[C@H](CN2C(=Nc3ccc(Oc4ccc(Cl)cc4F)nc3C2=O)C)C1 5.89 CHEMBL1958785 CHEMBL1956992 CC(C)N1CCC[C@H](CN2C(=Nc3ccc(Oc4ccc5OCOc5c4)nc3C2=O)C)C1 4.87 CHEMBL1958785 CHEMBL1956995 COc1ccc2cccc(Oc3ccc4N=C(C)N(C[C@H]5CCCN(C5)C(C)C)C(=O)c4n3)c2n1 4.87 CHEMBL1958785 CHEMBL1956996 CC(C)N1CCC[C@H](CN2C(=Nc3ccc(Oc4ccc(F)c5cccnc45)nc3C2=O)C)C1 6.89 CHEMBL1958785 CHEMBL1956998 CC(C)N1CCC[C@H](CN2C(=Nc3cnc(Oc4ccc(F)cc4)cc3C2=O)C)C1 5.89 CHEMBL1958785 CHEMBL1956999 CC(C)N1CCC[C@H](CN2C(=Nc3cnc(Oc4ccc(Cl)cc4F)cc3C2=O)C)C1 6.89 CHEMBL1958785 CHEMBL1957001 CC(C)N1CCC[C@H](CN2C(=Nc3cnc(Oc4ccc5ncsc5c4)cc3C2=O)C)C1 5.62 CHEMBL1958785 CHEMBL1957002 CC(C)N1CCC[C@H](CN2C(=Nc3cnc(Oc4ccc(F)c5cccnc45)cc3C2=O)C)C1 5.02 CHEMBL1958785 CHEMBL1957004 CC(C)N1CCC[C@H](CN2C(=Nc3ncc(Oc4ccc(F)cc4)nc3C2=O)C)C1 4.79 CHEMBL1958785 CHEMBL1957005 CC(C)N1CCC[C@H](CN2C(=Nc3ncc(Oc4ccc(Cl)cc4F)nc3C2=O)C)C1 4.48 CHEMBL1958785 CHEMBL1957008 CC(C)N1CCC[C@H](CN2C(=Nc3ncc(Oc4ccc(F)c5cccnc45)nc3C2=O)C)C1 4.48 CHEMBL1958785 CHEMBL1957012 CC(C)N1CCC[C@H](CN2C(=Nc3cnc(Oc4cccc5cccnc45)cc3C2=O)C)C1 4.6 CHEMBL1958785 CHEMBL1957287 Fc1ccccc1c2nc3ccn(Cc4ccc(nn4)c5ccc(cc5C(F)(F)F)C(F)(F)F)cc3n2 6.1 CHEMBL3123230 CHEMBL1957497 CS(=O)(=O)N1CCN(Cc2cn3cc(nc(N4CCOCC4)c3n2)c5cccc6[nH]ncc56)CC1 4 CHEMBL1960000 CHEMBL1957676 CC(=O)NCCc1ccccc1c2ccc([C@H]3CNCC[C@@H]3c4ccc(F)c(F)c4)c(Cl)c2 5.96 CHEMBL1961077 CHEMBL1957677 CC(=O)NCCc1ccccc1c2ccc([C@H]3CNCC[C@@H]3c4cccnc4)c(Cl)c2 5.32 CHEMBL1961077 CHEMBL1957718 CC[C@@]1([C@@H]2CN(CC3Cc4ccccc4C3)C[C@H]12)c5cccc(NS(=O)(=O)C)c5 6.49 CHEMBL3225969 CHEMBL1957788 CC(=O)NCCc1ccccc1c2ccc([C@H]3CNCC[C@@]34OCc5cc(F)c(F)cc45)c(C)c2 5.29 CHEMBL1961077 CHEMBL1957789 COCC(F)(F)COCc1ccc(cc1)[C@@]2(O)CCNC[C@@H]2c3ccc(cc3C)c4ccccc4CCNC(=O)C 5.01 CHEMBL1961077 CHEMBL1957790 CN1C=CC(=CC1=O)[C@H]2CCNC[C@@H]2c3ccc(cc3Cl)c4ccccc4CCNC(=O)C 5.24 CHEMBL1961077 CHEMBL1957791 CCC(=O)NCCc1ccccc1c2ccc([C@H]3CNCC[C@@H]3C4=CC(=O)N(C)C=C4)c(Cl)c2 5.55 CHEMBL1961077 CHEMBL1957792 COC(=O)NCCc1ccccc1c2ccc([C@H]3CNCC[C@@H]3C4=CC(=O)N(C)C=C4)c(Cl)c2 4.99 CHEMBL1961077 CHEMBL1957793 CCOC(=O)NCCc1ccccc1c2ccc([C@H]3CNCC[C@@H]3C4=CC(=O)N(C)C=C4)c(Cl)c2 5.5 CHEMBL1961077 CHEMBL1957795 CC(=O)NCCc1ccccc1c2ccc([C@H]3CNCC[C@]3(O)c4ccc(F)c(F)c4)c(C)c2 5.38 CHEMBL1961077 CHEMBL1957796 CC(=O)NCCc1ccccc1c2ccc([C@H]3CNCC[C@@]34OC(=O)c5cc(F)c(F)cc45)c(C)c2 4.89 CHEMBL1961077 CHEMBL1957797 COC[C@H](C)COCc1ccc(cc1)[C@@]2(O)CCNC[C@@H]2c3ccc(cc3C)c4ccccc4CCNC(=O)C 5.05 CHEMBL1961077 CHEMBL1957798 Cl.CC(=O)NCCc1ccccc1c2ccc([C@@H](CN)Cc3ccc(OCCOc4c(Cl)cc(C)cc4Cl)cc3)c(C)c2 8.22 CHEMBL1961077 CHEMBL1957816 Fc1ccc(CCN2CCN(CC2)C(=O)c3cccn4ccnc34)c(F)c1 5.72 CHEMBL1961177 CHEMBL1962378 OC(COc1ccccc1C(=O)CCc2ccccc2)CN3CCN(CC3)C(c4ccccc4)c5ccccc5 5.59 CHEMBL2160405 CHEMBL1963280 OC(COc1ccccc1C(=O)CCc2ccccc2)CN3CCC(CC3)c4ccccc4 5.46 CHEMBL2160405 CHEMBL1963307 OC(COc1ccc(F)cc1C(=O)CCc2ccccc2)CN3CCN(CC3)C(c4ccccc4)c5ccccc5 5.32 CHEMBL2160405 CHEMBL1963594 Cc1ccc(cc1)N2CCN(CC(O)COc3ccccc3C(=O)CCc4ccccc4)CC2 5.37 CHEMBL2160405 CHEMBL196431 C\C=C/1\N(C)C(C)CC1(c2ccccc2)c3ccccc3 4.3 CHEMBL829152 CHEMBL196983 COc1ccc(cc1)[C@@H](O)C[C@@H]2N(C)CCc3cc(OC)c(OC)cc23 6.1 CHEMBL828008 CHEMBL197243 COc1cccc(CN2CCCCCCC2)c1OCc3csc(n3)c4ccccc4 6.75 CHEMBL827704 CHEMBL197304 COc1cccc(CN2CCCCCCC2)c1OCc3csc(n3)c4ccc(Cl)cc4 7.4 CHEMBL827704 CHEMBL197467 COc1cc2CCN(C)[C@@H](C[C@H](O)c3ccc(Cl)cc3)c2cc1OC 6.4 CHEMBL828008 CHEMBL1980297 Nc1ncc(c2cnn(CCO)c2)c3scc(c4ccc(NC(=O)Nc5cccc(F)c5)cc4)c13 6 CHEMBL2024791 CHEMBL198387 CC(C)(C)C1CCC2(CC1)CCN(C(=O)N2Cc3ccc(cc3)C(=O)Nc4nn[nH]n4)c5ccc(OC(F)(F)F)cc5 5.27 CHEMBL882919 CHEMBL2 COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4occc4 4.62 CHEMBL1909190 CHEMBL2010816 Nc1cncc(Nc2ccc(Oc3ccc(OC(F)(F)F)cc3)cc2)n1 5.07 CHEMBL2013364 CHEMBL2010824 CCC(NCCCC[C@@H](Cc1cc(C)c(F)c(C)c1)C(=O)NO)c2ccc(F)cc2 4.88 CHEMBL2013523 CHEMBL2010830 CCN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc3ccc(cc3)S(=O)(=O)C 5.6 CHEMBL2014817 CHEMBL2010831 CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc3ccc(cc3)S(=O)(=O)C 5.52 CHEMBL2014817 CHEMBL2010832 CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc3ccc(cc3F)S(=O)(=O)C 5.59 CHEMBL2014817 CHEMBL2010833 CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc3ccc(c(F)c3)S(=O)(=O)C 5.54 CHEMBL2014817 CHEMBL2010834 CNC(=O)c1ccc(CC(=O)N(C)C2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cc1 5.68 CHEMBL2014817 CHEMBL2010835 CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc3ccc(NC(=O)C)cc3 5.35 CHEMBL2014817 CHEMBL2010836 CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc3ccc(cc3)n4cnnn4 5.92 CHEMBL2014817 CHEMBL2010837 CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc3ccccc3 5.8 CHEMBL2014817 CHEMBL2010838 CN(C1CCN(Cc2ccc(cn2)C(F)(F)F)CC1)C(=O)Cc3ccc(cc3)n4cnnn4 5.38 CHEMBL2014817 CHEMBL2010839 CN(C1CCN(Cc2ccc(nc2)C(F)(F)F)CC1)C(=O)Cc3ccc(cc3)n4cnnn4 4.89 CHEMBL2014817 CHEMBL2010840 CN(C1CCN(Cc2ccc(c(F)c2)C(F)(F)F)CC1)C(=O)Cc3ccc(cc3)n4cnnn4 5.55 CHEMBL2014817 CHEMBL2010841 CN(C1CCN(Cc2ccc(cc2)c3noc(C)n3)CC1)C(=O)Cc4ccc(cc4)n5cnnn5 5.19 CHEMBL2014817 CHEMBL2010842 CN(C1CCN(Cc2nc3cc(F)ccc3s2)CC1)C(=O)Cc4ccc(cc4)n5cnnn5 5.89 CHEMBL2014817 CHEMBL2010843 CN(C1CCN(Cc2nc3CCCCc3s2)CC1)C(=O)Cc4ccc(cc4)n5cnnn5 5.12 CHEMBL2014817 CHEMBL2010844 CN([C@H]1CCN(Cc2ccc(cc2)C(F)(F)F)C[C@H]1F)C(=O)Cc3ccc(cc3)n4cnnn4 5.44 CHEMBL2014817 CHEMBL2010845 CN([C@@H]1CCN(Cc2ccc(cc2)C(F)(F)F)C[C@@H]1F)C(=O)Cc3ccc(cc3)n4cnnn4 5.7 CHEMBL2014817 CHEMBL2010846 CO[C@@H]1CN(Cc2ccc(cc2)C(F)(F)F)CC[C@@H]1N(C)C(=O)Cc3ccc(cc3)n4cnnn4 5.7 CHEMBL2014817 CHEMBL2010847 CO[C@H]1CN(Cc2ccc(cc2)C(F)(F)F)CC[C@H]1N(C)C(=O)Cc3ccc(cc3)n4cnnn4 5.92 CHEMBL2014817 CHEMBL2010848 CN([C@@H]1CCN(Cc2ccc(cn2)C(F)(F)F)C[C@@H]1F)C(=O)Cc3ccc(cc3)n4cnnn4 5 CHEMBL2014817 CHEMBL2010849 CN([C@@H]1CCN(Cc2ccc(nc2)C(F)(F)F)C[C@@H]1F)C(=O)Cc3ccc(cc3)n4cnnn4 4.82 CHEMBL2014817 CHEMBL2010850 CN([C@@H]1CCN(Cc2nc3cc(F)ccc3s2)C[C@@H]1F)C(=O)Cc4ccc(cc4)n5cnnn5 5.33 CHEMBL2014817 CHEMBL2010851 CN([C@@H]1CCN(Cc2ccc(cc2)C(F)(F)F)C[C@@H]1F)C(=O)Cc3ccc(cc3)S(=O)(=O)C 5.38 CHEMBL2014817 CHEMBL2010852 CN([C@@H]1CCN(Cc2nc3ccccc3s2)C[C@@H]1F)C(=O)Cc4ccc(cc4)S(=O)(=O)C 4.8 CHEMBL2014817 CHEMBL2010853 CN([C@@H]1CCN(Cc2nc3cc(F)ccc3s2)C[C@@H]1F)C(=O)Cc4ccc(cc4)S(=O)(=O)C 5.16 CHEMBL2014817 CHEMBL2010872 CC(C)Cn1c2ccc(Nc3ncccn3)cc2c4c5CNC(=O)c5c6c(CCc7nn(C)cc67)c14 4.7 CHEMBL2016219 CHEMBL2011528 N[C@H]1CN(C[C@@H]1c2cc(F)ccc2F)c3ccc(cn3)N4C=CC(=CC4=O)OCc5ccccc5 5.06 CHEMBL2014322 CHEMBL2011534 N[C@H]1CN(C[C@@H]1c2cc(F)c(F)cc2F)c3ccc(cn3)N4C=CC(=CC4=O)OCc5ccccc5 5.22 CHEMBL2014322 CHEMBL2011947 Nc1ncnc(Nc2ccc(Oc3ccc(Cl)cc3)cc2)n1 5.82 CHEMBL2013364 CHEMBL2012178 Cc1c(C)n(Cc2ccccc2)c3ncnc(OC4CCN(Cc5cscn5)CC4)c13 6.29 CHEMBL2013640 CHEMBL2012244 C(N1CCC(CC1)Oc2ncnc3c2ccn3Cc4ccccc4)c5cscn5 6.12 CHEMBL2013640 CHEMBL2012836 CCC(NCCCC[C@@H](Nc1cc(C)c(F)c(C)c1)C(=O)NO)c2ccc(F)cc2 6.02 CHEMBL2013523 CHEMBL2012837 CCC(NCCCC[C@@H](Oc1cc(C)c(F)c(C)c1)C(=O)NO)c2ccc(F)cc2 5.57 CHEMBL2013523 CHEMBL2012838 CCC(NCCCC[C@@H](C[C@@H](OC)c1ccc(F)cc1)C(=O)NO)c2ccc(F)cc2 5 CHEMBL2013523 CHEMBL2012951 Cc1nc2c(OC(F)F)cccc2n1c3ccc(s3)C(=O)NC4CC4 4.54 CHEMBL2014814 CHEMBL2012958 Cc1nc2c(cccc2n1c3ccc(s3)C(=O)NC4CC4)C#N 4.28 CHEMBL2014814 CHEMBL2016588 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCCC(NC4=O)C(C)(C)C 4.36 CHEMBL2021104 CHEMBL2016731 Cc1nc(nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12)N4CCC(CC4)N5CCCC5 6.35 CHEMBL2021018 CHEMBL2016776 Cc1nc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N4CCC(CC4)N5CCCC5=O 5.43 CHEMBL2021018 CHEMBL2017374 Cl.CC(=O)N1CCC(CC1)C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2)c4ccc(C)c(Cl)c4 5.74 CHEMBL2020788 CHEMBL2017408 COc1cc(ccc1n2cnc(C)c2)c3cn(CC(=O)N(c4ccccc4)c5ccccc5)nn3 5.52 CHEMBL2021104 CHEMBL2017409 COc1cc(ccc1n2cnc(C)c2)c3cn(CC(=O)N(C4CCCCC4)c5ccccc5)nn3 6.1 CHEMBL2021104 CHEMBL2017412 COc1cc(ccc1n2cnc(C)c2)c3cn(CC(=O)NC4C5CC6CC(CC4C6)C5)nn3 5.4 CHEMBL2021104 CHEMBL2017413 COc1cc(ccc1n2cnc(C)c2)c3cn(CC(=O)N(Cc4ccc(F)cc4)C5C6CC7CC(CC5C7)C6)nn3 6.6 CHEMBL2021104 CHEMBL2017414 COc1cc(ccc1n2cnc(C)c2)c3cn(CC(=O)N(Cc4ccccc4)Cc5ccccc5)nn3 6.06 CHEMBL2021104 CHEMBL2017415 COc1cc(ccc1n2cnc(C)c2)c3cn(CC(=O)N(Cc4ccccc4)[C@H](C)c5ccccc5)nn3 6.37 CHEMBL2021104 CHEMBL2017416 COc1cc(ccc1n2cnc(C)c2)c3cn(CC(=O)N([C@H](C)c4ccccc4)[C@H](C)c5ccccc5)nn3 6.08 CHEMBL2021104 CHEMBL2017417 COc1cc(ccc1n2cnc(C)c2)c3cn(CC(=O)N(C4CCCCC4)C5CCCCC5)nn3 5.86 CHEMBL2021104 CHEMBL2017562 COc1cc(ccc1n2cnc(C)c2)c3cn(CC(=O)N4CCC(CC4)c5oc6ccccc6n5)nn3 4.99 CHEMBL2021104 CHEMBL2017563 COc1cc(ccc1n2cnc(C)c2)c3cn(CC(=O)N(Cc4ccccc4)CC(F)(F)F)nn3 5.54 CHEMBL2021104 CHEMBL2017564 COc1cc(ccc1n2cnc(C)c2)c3cn(CC(=O)N(CC(F)(F)F)c4ccc5CCCc5c4)nn3 5.83 CHEMBL2021104 CHEMBL2017565 COc1cc(ccc1n2cnc(C)c2)c3cn(CC(=O)N(CC(F)(F)F)c4ccc5OC(F)(F)Oc5c4)nn3 5.72 CHEMBL2021104 CHEMBL2017566 COc1cc(ccc1n2cnc(C)c2)c3cn(CC(=O)N(CC(F)(F)F)c4ccc5ccccc5c4)nn3 6.2 CHEMBL2021104 CHEMBL2017567 COc1cc(ccc1n2cnc(C)c2)c3cn(CC(=O)N(CC(F)(F)F)c4cccc5ccccc45)nn3 6.1 CHEMBL2021104 CHEMBL2017568 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCCCNC4=O 4.36 CHEMBL2021104 CHEMBL2017569 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4C5CCC(C5)NC4=O 5.27 CHEMBL2021104 CHEMBL2017572 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CC(C)(C)CCNC4=O 4.68 CHEMBL2021104 CHEMBL2017573 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CC[C@H]5CCCC[C@@H]5NC4=O 4.68 CHEMBL2021104 CHEMBL2017574 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CC(CCNC4=O)[Si](C)(C)C 5.2 CHEMBL2021104 CHEMBL2017575 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CC(CCNC4=O)C5CCCCC5 5.43 CHEMBL2021104 CHEMBL2017576 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)[C@H]4C[C@H](CCN(CC56CC7CC(CC(C7)C5)C6)C4=O)C(C)(C)C 6.06 CHEMBL2021104 CHEMBL2017577 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)[C@H]4C[C@H](CCN(CC(C)(C)C)C4=O)C(C)(C)C 5.68 CHEMBL2021104 CHEMBL2017579 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)[C@H]4CC[C@@H](CN(Cc5ccccc5)C4=O)c6ccccc6 6.7 CHEMBL2021104 CHEMBL2017580 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)[C@H]4C[C@H](CCN(Cc5ccccc5)C4=O)C(F)(F)F 5.26 CHEMBL2021104 CHEMBL2017581 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)[C@H]4C[C@H](CCN(Cc5ccccc5)C4=O)[Si](C)(C)C 4.39 CHEMBL2021104 CHEMBL2017582 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)[C@H]4C[C@H](CCN(CC(F)(F)F)C4=O)C(F)(F)F 4.5 CHEMBL2021104 CHEMBL2017583 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)[C@H]4C[C@H](CN(CC(F)(F)F)C4=O)C(F)(F)F 4.88 CHEMBL2021104 CHEMBL2017584 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)[C@H]4CCCCN(CC(F)(F)F)C4=O 4.66 CHEMBL2021104 CHEMBL2017585 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)[C@H]4C[C@H](CCN(CC(F)(F)F)C4=O)c5ccccc5 5.65 CHEMBL2021104 CHEMBL2017586 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)[C@H]4C[C@H](CCN(CC(F)(F)F)C4=O)C(C)(C)C 5.27 CHEMBL2021104 CHEMBL2017588 Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N4CCC(O)CC4 5.48 CHEMBL2021111 CHEMBL2017593 Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(Cl)cc3)cc12)N4CCC(O)(CC4)C5CC5 5.25 CHEMBL2021111 CHEMBL2017597 Cc1nc(nc2ccc(NC(=O)\C=C\c3ccc(cc3)C(F)F)cc12)N4CCC(O)(CC4)C5CC5 5.6 CHEMBL2021111 CHEMBL2017760 COCC(=O)NC1CCN(CC1)c2nc(C)c3cc(NC(=O)\C=C\c4ccc(Cl)cc4)ccc3n2 5.92 CHEMBL2021111 CHEMBL2021600 C[C@H](Oc1ccc(cc1C(=O)N2CCN(CC2)c3ncc(cc3F)C(F)(F)F)S(=O)(=O)C)C(C)(C)C 4.77 CHEMBL1177037 CHEMBL2021601 C[C@@H](Oc1ccc(cc1C(=O)N2CCN(CC2)c3ncc(cc3F)C(F)(F)F)S(=O)(=O)C)C(C)(C)C 4.55 CHEMBL1177037 CHEMBL2021936 Fc1ccccc1C(=O)Nc2ccc(cc2)c3oc(NCCCN4CCN5CCC4CC5)nn3 4.9 CHEMBL2026860 CHEMBL2021948 Fc1ccc(cc1)C(=O)Nc2ccc(cc2)c3oc(NCCCN4CCCCC4)nn3 5 CHEMBL2024805 CHEMBL2021969 CCOC(=O)C1CCN(CCCOc2ccc(cc2)S(=O)(=O)NC(=O)Nc3ccccc3)CC1 4.1 CHEMBL2026493 CHEMBL2021974 FC(F)(F)c1ccc(NC(=O)NS(=O)(=O)c2ccc(OCCCCN3CCCC3)cc2)cc1 4.31 CHEMBL2026493 CHEMBL2022495 COc1cc(NC(=O)c2ccccc2F)ccc1c3oc(NCCCN4CCCCC4)nn3 4.77 CHEMBL2024833 CHEMBL2022496 Fc1ccccc1C(=O)Nc2ccc(cc2)c3oc(NCCCN4CCCCC4)nn3 5.1 CHEMBL2026860 CHEMBL2022497 Fc1ccccc1C(=O)Nc2ccc(cc2)c3oc(NCCCN4CCOCC4)nn3 4.5 CHEMBL2024805 CHEMBL2022498 Fc1ccccc1C(=O)Nc2ccc(cc2)c3oc(NCCCN4CCCOCC4)nn3 4.7 CHEMBL2026860 CHEMBL2022499 Fc1ccccc1C(=O)Nc2ccc(cc2)c3oc(NCCCN4CCCC4)nn3 5.1 CHEMBL2026860 CHEMBL2022500 C[C@@H]1CC[C@@H](C)N1CCCNc2oc(nn2)c3ccc(NC(=O)c4ccccc4F)cc3 5.1 CHEMBL2026860 CHEMBL2022501 CN1CCN(CCCNc2oc(nn2)c3ccc(NC(=O)c4ccccc4F)cc3)CC1 4.2 CHEMBL2026860 CHEMBL2022503 FC1CCN(CCCNc2oc(nn2)c3ccc(NC(=O)c4ccccc4F)cc3)CC1 5.1 CHEMBL2026860 CHEMBL2022504 Fc1ccccc1C(=O)Nc2ccc(cc2)c3oc(NCCCN4C[C@@H]5CC[C@H]4C5)nn3 5.2 CHEMBL2026860 CHEMBL2022729 Fc1ccccc1C(=O)Nc2ccc(cc2)c3oc(NCCCCN4CCOCC4)nn3 4.2 CHEMBL2026860 CHEMBL2022730 Fc1ccccc1C(=O)Nc2ccc(cc2)c3oc(NCCCCN4CCCOCC4)nn3 4.9 CHEMBL2026860 CHEMBL2022731 Fc1ccccc1C(=O)Nc2ccc(cc2)c3oc(NCCCCN4CCCC4)nn3 4.9 CHEMBL2026860 CHEMBL2022732 CCN(CC)CCCCNc1oc(nn1)c2ccc(NC(=O)c3ccccc3F)cc2 4.7 CHEMBL2026860 CHEMBL2022733 Fc1ccccc1C(=O)Nc2ccc(cc2)c3oc(NCCCCN4CCCCC4)nn3 4.9 CHEMBL2026860 CHEMBL2022734 O=C(Nc1ccc(cc1)c2oc(NCCCCN3CCCCC3)nn2)c4ccccc4 4.7 CHEMBL2026860 CHEMBL2022735 O=C(Nc1ccc(cc1)c2oc(NCCCCN3CCCCC3)nn2)C4CCCCC4 4.6 CHEMBL2026860 CHEMBL2022736 COc1cc(NC(=O)c2ccccc2F)ccc1c3oc(NCCCCN4CCCCC4)nn3 4.8 CHEMBL2026860 CHEMBL2022737 Fc1ccccc1C(=O)Nc2ccc(c(Cl)c2)c3oc(NCCCCN4CCCCC4)nn3 5.7 CHEMBL2026860 CHEMBL2022739 Fc1ccccc1C(=O)Nc2ccc(c(F)c2)c3oc(NCCCCN4CCOCC4)nn3 4.4 CHEMBL2026860 CHEMBL2022740 Fc1cc(NC(=O)c2ccccc2)ccc1c3oc(NCCCCN4CCOCC4)nn3 4.8 CHEMBL2026860 CHEMBL2022741 FC1CCN(CCCCNc2oc(nn2)c3ccc(NC(=O)c4ccccc4F)cc3)CC1 4.8 CHEMBL2026860 CHEMBL2022867 c1ccc(cc1)n2cc(cn2)c3ccnc4ccccc34 5.6 CHEMBL2025328 CHEMBL2022935 CCN(CC)CCCNc1oc(nn1)c2ccc(NC(=O)c3ccccc3F)cc2 4.9 CHEMBL2024805 CHEMBL2022938 Fc1ccccc1C(=O)Nc2ccc(cc2)c3oc(NCCCN4CCCCCC4)nn3 5.2 CHEMBL2024805 CHEMBL2022939 O=C(Nc1ccc(cc1)c2oc(NCCCN3CCCCC3)nn2)c4ccccc4 4.8 CHEMBL2024805 CHEMBL2022940 Clc1ccccc1C(=O)Nc2ccc(cc2)c3oc(NCCCN4CCCCC4)nn3 4.9 CHEMBL2024805 CHEMBL2022941 Cc1ccccc1C(=O)Nc2ccc(cc2)c3oc(NCCCN4CCCCC4)nn3 5.1 CHEMBL2024805 CHEMBL2022997 Cc1cccc(c1)C(CCCN)(c2ccccc2)c3ccccc3 5.19 CHEMBL2025095 CHEMBL2023457 COc1ccc2c(ccnc2c1)c3cnn(c3)c4ccccc4 5.6 CHEMBL2025328 CHEMBL2023802 CCOc1cc2nccc(Oc3cnc(CC(=O)Nc4n[nH]c(CC)c4C)c(OC)c3)c2cc1OC 4.12 CHEMBL2026445 CHEMBL2023898 COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c2ncc([nH]2)c3ccc(cc3)c4ccc(cc4)c5cnc([nH]5)[C@@H]6CCCN6C(=O)[C@@H](NC(=O)OC)C(C)C 4.54 CHEMBL3123626 CHEMBL2023916 Fc1cccc(c1)C(=O)Nc2ccc(cc2)c3oc(NCCCN4CCCCC4)nn3 5.1 CHEMBL2024805 CHEMBL2023917 Fc1cccc(F)c1C(=O)Nc2ccc(cc2)c3oc(NCCCN4CCCCC4)nn3 5.1 CHEMBL2024805 CHEMBL2023918 O=C(Nc1ccc(cc1)c2oc(NCCCN3CCCCC3)nn2)C4CCCC4 4.6 CHEMBL2024805 CHEMBL2023919 O=C(Nc1ccc(cc1)c2oc(NCCCN3CCCCC3)nn2)C4CCCCC4 4.7 CHEMBL2024805 CHEMBL2023920 O=C(Nc1ccc(cc1)c2oc(NCCCN3CCCCC3)nn2)C4CCCCCC4 4.7 CHEMBL2024805 CHEMBL2023921 Fc1ccccc1C(=O)Nc2ccc(cc2F)c3oc(NCCCN4CCCCC4)nn3 5.2 CHEMBL2024805 CHEMBL2023922 CCc1cc(ccc1NC(=O)c2ccccc2F)c3oc(NCCCN4CCCCC4)nn3 4.6 CHEMBL2024805 CHEMBL2023923 Cc1cc(ccc1NC(=O)c2ccccc2F)c3oc(NCCCN4CCCCC4)nn3 4.8 CHEMBL2024805 CHEMBL2023924 Fc1ccccc1C(=O)Nc2ccc(c(Cl)c2)c3oc(NCCCN4CCCCC4)nn3 5.4 CHEMBL2024805 CHEMBL2023925 Cc1cc(NC(=O)c2ccccc2F)ccc1c3oc(NCCCN4CCCCC4)nn3 5.4 CHEMBL2024805 CHEMBL2023926 COc1cc(NC(=O)c2ccccc2F)ccc1c3oc(NCCCN4CCOCC4)nn3 4.8 CHEMBL2024805 CHEMBL2023927 CCOc1cc(NC(=O)c2ccccc2F)ccc1c3oc(NCCCN4CCCCC4)nn3 4.9 CHEMBL2024805 CHEMBL2023928 Fc1ccccc1C(=O)Nc2ccc(c(F)c2)c3oc(NCCCN4CCCCC4)nn3 5 CHEMBL2024805 CHEMBL2023929 Fc1ccccc1C(=O)Nc2ccc(c3oc(NCCCN4CCCCC4)nn3)c(c2)C(F)(F)F 5.3 CHEMBL2024805 CHEMBL2023930 CCc1cc(NC(=O)c2ccccc2F)ccc1c3oc(NCCCN4CCCCC4)nn3 5.4 CHEMBL2024805 CHEMBL2024309 NS(=O)(=O)c1ccc(OCCN2CCCCC2)cc1 4.62 CHEMBL2026493 CHEMBL2024310 CCOC(=O)C1CCN(CCOc2ccc(cc2)S(=O)(=O)N)CC1 4.64 CHEMBL2026493 CHEMBL2024378 NS(=O)(=O)c1ccc(OCCCN2CCCCC2)cc1 4.03 CHEMBL2026493 CHEMBL2024379 CCOC(=O)C1CCN(CCCOc2ccc(cc2)S(=O)(=O)N)CC1 4.12 CHEMBL2026493 CHEMBL2024382 NS(=O)(=O)c1ccc(OCCCCN2CCCCC2)cc1 4.87 CHEMBL2026493 CHEMBL2024383 CCOC(=O)C1CCN(CCCCOc2ccc(cc2)S(=O)(=O)N)CC1 4.73 CHEMBL2026493 CHEMBL2024389 CC(C)NC(=O)NS(=O)(=O)c1ccc(OCCN2CCCCC2)cc1 4.58 CHEMBL2026493 CHEMBL2024390 O=C(Nc1ccccc1)NS(=O)(=O)c2ccc(OCCN3CCCCC3)cc2 4.56 CHEMBL2026493 CHEMBL202788 CC(C)(C)[C@H](NC(=O)OCCO)C(=O)N1CC(=C[C@H]1c2ccccc2)c3cc(F)ccc3F 4.6 CHEMBL868944 CHEMBL2029180 CN=[S+](C)([O-])c1ccc(Nc2ncc(c(N[C@@H]3CCC[C@H]3N(C)C)n2)C(F)(F)F)cc1 4.69 CHEMBL1787952 CHEMBL2029417 Cc1ccc(nc1)[C@@]2(O)CC[C@H](CC2)N[C@H]3CCN(C3)C(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.62 CHEMBL2032544 CHEMBL2029418 O[C@@]1(CC[C@H](CC1)N[C@H]2CCN(C2)C(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4ccc(cn4)c5cccnc5 4.52 CHEMBL2032544 CHEMBL2029419 O[C@@]1(CC[C@H](CC1)N[C@H]2CCN(C2)C(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4ccc(cn4)c5ccncc5 4.89 CHEMBL2032544 CHEMBL2029422 O[C@@]1(CC[C@H](CC1)N[C@H]2CCN(C2)C(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4ccc(cn4)c5ncccn5 4.7 CHEMBL2032963 CHEMBL2029566 O[C@@]1(CC[C@H](CC1)N[C@H]2CCN(C2)C(=O)C3CCN(CC3)c4cccc(c4)C(F)(F)F)c5ccc(cn5)c6ncccn6 5.05 CHEMBL2032544 CHEMBL2029567 O[C@@]1(CC[C@H](CC1)N[C@H]2CCN(C2)C(=O)C3CCN(CC3)c4cccc(n4)C(F)(F)F)c5ccc(cn5)c6ncccn6 5 CHEMBL2032544 CHEMBL2029568 O[C@@]1(CC[C@H](CC1)N[C@H]2CCN(C2)C(=O)C3CCN(CC3)c4cc(ccn4)C(F)(F)F)c5ccc(cn5)c6ncccn6 4.55 CHEMBL2032544 CHEMBL2029569 O[C@@]1(CC[C@H](CC1)N[C@H]2CCN(C2)C(=O)C3CCN(CC3)c4nccc(n4)C(F)(F)F)c5ccc(cn5)c6ncccn6 4.59 CHEMBL2032544 CHEMBL203045 CC(C)(CN)C(=O)N1CC(=C[C@H]1c2ccccc2)c3cc(F)ccc3F 5.66 CHEMBL868944 CHEMBL2031477 O=C1CC2CCc3cc(OC4CCN(CC4)C5CCC5)ccc3C2=NN1 4.75 CHEMBL2034507 CHEMBL2031760 C[C@@H]1CCCN1CCN2CCc3cc(ccc3C2=O)c4ccc(F)cc4 6.52 CHEMBL2034394 CHEMBL2031762 C[C@@H]1CCCN1CCN2CCc3cc(ccc3C2=O)c4ccc(cc4)C#N 6.85 CHEMBL2034394 CHEMBL2031868 CNC(=O)c1ccc(cc1)c2ccc3C(=O)N(CCN4CCCC4)CCc3c2 4.54 CHEMBL2034394 CHEMBL2031869 CCNC(=O)c1ccc(cc1)c2ccc3C(=O)N(CCN4CCCC4)CCc3c2 4.8 CHEMBL2034394 CHEMBL2031870 CC(C)NC(=O)c1ccc(cc1)c2ccc3C(=O)N(CCN4CCCC4)CCc3c2 5.21 CHEMBL2034394 CHEMBL2031871 O=C(NC1CC1)c2ccc(cc2)c3ccc4C(=O)N(CCN5CCCC5)CCc4c3 4.96 CHEMBL2034394 CHEMBL2031872 O=C(NC1CCC1)c2ccc(cc2)c3ccc4C(=O)N(CCN5CCCC5)CCc4c3 5.6 CHEMBL2034394 CHEMBL2031873 O=C(NC1CCCC1)c2ccc(cc2)c3ccc4C(=O)N(CCN5CCCC5)CCc4c3 5.09 CHEMBL2034394 CHEMBL2031874 CN(C)C(=O)c1ccc(cc1)c2ccc3C(=O)N(CCN4CCCC4)CCc3c2 4.96 CHEMBL2034394 CHEMBL2031875 O=C(N1CCCC1)c2ccc(cc2)c3ccc4C(=O)N(CCN5CCCC5)CCc4c3 5.06 CHEMBL2034394 CHEMBL2031876 C[C@@H]1CCCN1C(=O)c2ccc(cc2)c3ccc4C(=O)N(CCN5CCCC5)CCc4c3 4.98 CHEMBL2034394 CHEMBL2031877 C[C@H]1CCCN1C(=O)c2ccc(cc2)c3ccc4C(=O)N(CCN5CCCC5)CCc4c3 4.92 CHEMBL2034394 CHEMBL2031878 Fc1cc(ccc1c2ccc3C(=O)N(CCN4CCCC4)CCc3c2)C(=O)N5CCCC5 4.95 CHEMBL2034394 CHEMBL2031879 Fc1cc(ccc1C(=O)N2CCCC2)c3ccc4C(=O)N(CCN5CCCC5)CCc4c3 5.06 CHEMBL2034394 CHEMBL2031880 Clc1cc(ccc1C(=O)N2CCCC2)c3ccc4C(=O)N(CCN5CCCC5)CCc4c3 5.03 CHEMBL2034394 CHEMBL2031881 CNC(=O)c1ccc(c(F)c1)c2ccc3C(=O)N(CCN4CCCC4)CCc3c2 5.43 CHEMBL2034394 CHEMBL2031882 CN(C)C(=O)c1ccc(c(F)c1)c2ccc3C(=O)N(CCN4CCCC4)CCc3c2 4.49 CHEMBL2034394 CHEMBL2031883 CNC(=O)c1ccc(cc1)c2ccc3C(=O)N(CCN4CCC[C@H]4C)CCc3c2 4.77 CHEMBL2034394 CHEMBL2031884 CCNC(=O)c1ccc(cc1)c2ccc3C(=O)N(CCN4CCC[C@H]4C)CCc3c2 5.13 CHEMBL2034394 CHEMBL2031885 C[C@@H]1CCCN1CCN2CCc3cc(ccc3C2=O)c4ccc(cc4)C(=O)N5CCCC5 5.02 CHEMBL2034394 CHEMBL2031958 COc1cc(CN2CCN(CCCCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2)cc(OC)c1OC 5.47 CHEMBL3381617 CHEMBL2031961 CC(C)(C)c1cc(CN2CCN(CCCCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2)cc(c1O)C(C)(C)C 7 CHEMBL2033832 CHEMBL2031962 CC(C)(C)c1cc(cc(c1O)C(C)(C)C)C(=O)N2CCN(CCCCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2 6.6 CHEMBL2033832 CHEMBL2031965 COc1c(cc(CN2CCN(CCCCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2)cc1C(C)(C)C)C(C)(C)C 7 CHEMBL2033832 CHEMBL2031966 COc1c(cc(cc1C(C)(C)C)C(=O)N2CCN(CCCCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2)C(C)(C)C 6.18 CHEMBL2033832 CHEMBL2031967 COc1c(cc(CN2CCN(CC2)C(=O)CCCCC(c3ccc(F)cc3)c4ccc(F)cc4)cc1C(C)(C)C)C(C)(C)C 6.89 CHEMBL2033832 CHEMBL2031968 COc1c(cc(cc1C(C)(C)C)C(=O)N2CCN(CC2)C(=O)CCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C(C)(C)C 5.05 CHEMBL2033832 CHEMBL2031969 CC(C)(C)c1cc(CN2CCN(CCCCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2)cc(c1)C(C)(C)C 7 CHEMBL2033832 CHEMBL2031973 COc1c(cc(cc1C(C)(C)C)C(=O)N2CCN([C@@H](C)C2)C(=O)CCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C(C)(C)C 6.05 CHEMBL2033832 CHEMBL2031974 COc1c(cc(cc1C(C)(C)C)C(=O)N2CCN(C[C@@H]2C)C(=O)CCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C(C)(C)C 5.31 CHEMBL2033832 CHEMBL2031975 CC(C)(C)c1ccc(cc1)C(=O)NCC2CCN(C2)C(=O)CCCCC(c3ccc(F)cc3)c4ccc(F)cc4 6.09 CHEMBL2033832 CHEMBL2031976 CC(C)(C)c1cc(cc(c1)C(C)(C)C)C(=O)NCC2CCN(C2)C(=O)CCCCC(c3ccc(F)cc3)c4ccc(F)cc4 5.55 CHEMBL2033832 CHEMBL2031977 COc1c(cc(cc1C(C)(C)C)C(=O)NCC2CCN(C2)C(=O)CCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C(C)(C)C 5.72 CHEMBL2033832 CHEMBL2031978 Fc1ccc(cc1)C(CCCCC(=O)N2CCC(CNC(=O)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)C2)c4ccc(F)cc4 6.16 CHEMBL2033832 CHEMBL2031980 COc1c(cc(cc1C(C)(C)C)C(=O)NCC2CCN(CCCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C2)C(C)(C)C 7 CHEMBL2033832 CHEMBL2031981 COc1cc(cc(OC)c1OC)C(=O)NCC2CCN(CCCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C2 7 CHEMBL2033832 CHEMBL2031982 Fc1ccc(cc1)C(CCCCCN2CCC(CNC(=O)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)C2)c4ccc(F)cc4 7 CHEMBL2033832 CHEMBL2031983 COc1cc(CNCC2CCN(CCCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C2)cc(OC)c1OC 7.4 CHEMBL2033832 CHEMBL2031984 CC(C)(C)c1cc(CNCC2CCN(CCCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C2)cc(c1O)C(C)(C)C 6.06 CHEMBL2033832 CHEMBL2031985 CC(C)(C)c1cc(CNCC2CCN(CCCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C2)cc(c1)C(C)(C)C 6.34 CHEMBL2033832 CHEMBL2031986 CC(C)(C)c1cc(cc(c1)C(C)(C)C)C(=O)NC[C@H]2CCN(C2)C(=O)CCCCC(c3ccc(F)cc3)c4ccc(F)cc4 5.3 CHEMBL2033832 CHEMBL2031987 CC(C)(C)c1cc(cc(c1)C(C)(C)C)C(=O)NC[C@@H]2CCN(C2)C(=O)CCCCC(c3ccc(F)cc3)c4ccc(F)cc4 5.7 CHEMBL2033832 CHEMBL2031988 COc1c(cc(cc1C(C)(C)C)C(=O)NC[C@H]2CCN(C2)C(=O)CCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C(C)(C)C 5.3 CHEMBL2033832 CHEMBL2031989 COc1c(cc(cc1C(C)(C)C)C(=O)NC[C@@H]2CCN(C2)C(=O)CCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C(C)(C)C 5.7 CHEMBL2033832 CHEMBL2031990 Fc1ccc(cc1)C(CCCCC(=O)N2CC[C@H](CNC(=O)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)C2)c4ccc(F)cc4 6.13 CHEMBL2033832 CHEMBL2031991 Fc1ccc(cc1)C(CCCCC(=O)N2CC[C@@H](CNC(=O)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)C2)c4ccc(F)cc4 6.1 CHEMBL2033832 CHEMBL2031996 COc1cc(cc(OC)c1OC)C(=O)N2CCC(CNC(=O)CCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C2 6.13 CHEMBL2033832 CHEMBL2031997 COc1c(cc(cc1C(C)(C)C)C(=O)N2CCC(CNC(=O)CCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C2)C(C)(C)C 6.19 CHEMBL2033832 CHEMBL2031998 COc1cc(CN2CCC(CNCCCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C2)cc(OC)c1OC 7 CHEMBL2033832 CHEMBL2031999 CC(C)(C)c1cc(CN2CCC(CNCCCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C2)cc(c1O)C(C)(C)C 8 CHEMBL2033832 CHEMBL2032000 COc1c(cc(CN2CCC(CNCCCCCC(c3ccc(F)cc3)c4ccc(F)cc4)C2)cc1C(C)(C)C)C(C)(C)C 6.96 CHEMBL2033832 CHEMBL2032047 C[C@@H]1[C@H]2CN(CCCC3(CCOCC3)C(=O)O)CC[C@@H]2Cc4[nH]c5ccc(cc5c14)C(F)(F)F 6.52 CHEMBL2032591 CHEMBL203230 C[C@@H]1CNC[C@H]2Cc3ccc(Cl)nc3N12 4.4 CHEMBL865567 CHEMBL2035000 Clc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C3)C4CC4)CC2)cc1 4.85 CHEMBL2038474 CHEMBL2035052 C(CN1CCCC1)Oc2ccc3Nc4nccc(n4)c5ccnc(OCC\C=C\COCc2c3)c5 5.62 CHEMBL2040132 CHEMBL2035183 C(CN1CCCC1)Oc2ccc3Nc4nccc(n4)c5ccc(COC\C=C\COCc2c3)s5 5.14 CHEMBL2040132 CHEMBL2036234 CC1CN(CC(=O)N[C@@H]2C3CC4CC2C[C@@](C4)(C3)C(=O)N)S(=O)(=O)N(C1)c5c(Cl)cc(Cl)cc5Cl 4.43 CHEMBL3294274 CHEMBL2036268 Cl.CN[C@@H]1CC[C@@H](CC1)c2c[nH]c3ccc(NC(=N)c4cccs4)cc23 4.41 CHEMBL2037696 CHEMBL2036270 Cl.CCN[C@@H]1CC[C@@H](CC1)c2c[nH]c3ccc(NC(=N)c4cccs4)cc23 4.64 CHEMBL2037696 CHEMBL2036273 Cl.CNC1CCCC(C1)c2c[nH]c3ccc(NC(=N)c4cccs4)cc23 4.48 CHEMBL2037696 CHEMBL2036275 Cl.CCN[C@H]1CCC[C@H](C1)c2c[nH]c3ccc(NC(=N)c4cccs4)cc23 4.79 CHEMBL2037696 CHEMBL2036748 CN1CCCC(CN2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3)C1 5.8 CHEMBL2038474 CHEMBL2036749 Clc1ccc(NC(=O)N2CCN(CC3CCCNC3)CC2)cc1Cl 5.8 CHEMBL2038474 CHEMBL2036750 CCN1CCCC(CN2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3)C1 5.37 CHEMBL2038474 CHEMBL2036751 CCN1CCC[C@@H](CN2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3)C1 5.68 CHEMBL2038474 CHEMBL2036753 Clc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(Cc4ccccc4)C3)CC2)cc1Cl 6.25 CHEMBL2038474 CHEMBL2036754 Clc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(CC4CC4)C3)CC2)cc1Cl 6.03 CHEMBL2038474 CHEMBL2036756 Clc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(CCCc4ccccc4)C3)CC2)cc1Cl 6.4 CHEMBL2038474 CHEMBL2036757 Clc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C3)C4CC4)CC2)cc1Cl 5.7 CHEMBL2038474 CHEMBL2036758 CC(C)N1CCC[C@@H](CN2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3)C1 5.89 CHEMBL2038474 CHEMBL2036759 Fc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C3)C4CC4)CC2)cc1Cl 4.85 CHEMBL2038474 CHEMBL2036760 FC(F)(F)c1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C3)C4CC4)CC2)cc1Cl 6.05 CHEMBL2038474 CHEMBL2036761 FC(F)(F)c1cc(NC(=O)N2CCN(C[C@@H]3CCCN(C3)C4CC4)CC2)ccc1Cl 5.2 CHEMBL2038474 CHEMBL2036762 Cc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C3)C4CC4)CC2)cc1Cl 5.15 CHEMBL2038474 CHEMBL2036763 Clc1cccc(NC(=O)N2CCN(C[C@@H]3CCCN(C3)C4CC4)CC2)c1 4.55 CHEMBL2038474 CHEMBL2036764 Brc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C3)C4CC4)CC2)cc1 5.15 CHEMBL2038474 CHEMBL2036766 FC(F)(F)c1cccc(NC(=O)N2CCN(C[C@@H]3CCCN(C3)C4CC4)CC2)c1 4.89 CHEMBL2038474 CHEMBL2036767 FC(F)(F)c1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C3)C4CC4)CC2)cc1 5.2 CHEMBL2038474 CHEMBL2036773 CCN1CCO[C@@H](CN2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3)C1 5.1 CHEMBL2038474 CHEMBL2036774 Clc1ccc(NC(=O)N2CCN(C[C@H]3CN(CCO3)C4CC4)CC2)cc1Cl 4.8 CHEMBL2038474 CHEMBL2036775 CC(C)N1CCO[C@@H](CN2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3)C1 5.2 CHEMBL2038474 CHEMBL2036776 CCN1CCNC(CN2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3)C1 5.05 CHEMBL2038474 CHEMBL2036777 CC(C)N1CCN[C@@H](CN2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3)C1 5.25 CHEMBL2038474 CHEMBL2036778 CCN1CCC[C@H](C1)C(=O)N2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3 5.3 CHEMBL2038474 CHEMBL2036779 CCN1CCOC(C1)C(=O)N2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3 5.3 CHEMBL2038474 CHEMBL2036780 CCN1CCN[C@H](C1)C(=O)N2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3 5 CHEMBL2038474 CHEMBL2036781 Clc1ccc(NC(=O)N2CCN(CC2)C(=O)[C@H]3CN(CCN3)C4CC4)cc1Cl 4.72 CHEMBL2038474 CHEMBL2036782 CC(C)N1CCN[C@H](C1)C(=O)N2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3 4.22 CHEMBL2039631 CHEMBL2036783 CN1CCN[C@H](C1)C(=O)N2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3 4.7 CHEMBL2038474 CHEMBL2036784 CN1CCN(C)C(C1)C(=O)N2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3 4.89 CHEMBL2038474 CHEMBL2040854 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(nc4)c5ccc(cc5C)C(=O)O)c6cc(O)ncn6 4.7 CHEMBL2045992 CHEMBL2040894 COCc1onc(n1)c2ccc(cc2)N3C(=O)N(c4cc(O)ncn4)C5(CCN(Cc6ncccc6C)CC5)C3=O 5.11 CHEMBL2045992 CHEMBL2040895 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)n5cccn5)c6cc(O)ncn6 5.05 CHEMBL2045992 CHEMBL2040896 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)c5oncc5)c6cc(O)ncn6 4.66 CHEMBL2045992 CHEMBL2040897 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)c5sc(C)nc5C)c6cc(O)ncn6 6.02 CHEMBL2045992 CHEMBL2041010 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc(s6)C(=O)O 4.92 CHEMBL2045992 CHEMBL2041164 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6csc(c6)C(=O)O 5.1 CHEMBL2045992 CHEMBL2041168 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc(cc6)c7ccn[nH]7 5.7 CHEMBL2045992 CHEMBL2041169 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)c5ccc(cc5)c6ccn[nH]6)c7cc(O)ncn7 5.09 CHEMBL2045992 CHEMBL2041170 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)c5ccc(cc5)N6CCOCC6)c7cc(O)ncn7 4.89 CHEMBL2045992 CHEMBL2041171 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc(cc6)C7=CC(=O)NN7 4.77 CHEMBL2045992 CHEMBL2041172 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc7cn[nH]c7c6 6.14 CHEMBL2045992 CHEMBL2041173 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc7[nH]ncc7c6 5.33 CHEMBL2045992 CHEMBL2041174 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc7nc[nH]c7c6 4.82 CHEMBL2045992 CHEMBL2041175 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)c5ccc6scnc6c5)c7cc(O)ncn7 5.82 CHEMBL2045992 CHEMBL2041176 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc(cc6)C#N 6.43 CHEMBL2045992 CHEMBL2041177 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc(cc6)C(=O)N 6.19 CHEMBL2045992 CHEMBL2041178 CNC(=O)c1ccc(cc1)c2ccc(cc2)N3C(=O)N(c4cc(OC)ncn4)C5(CCN(Cc6ncccc6C)CC5)C3=O 5.07 CHEMBL2045992 CHEMBL2041179 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc(cc6)C(=O)N(C)C 5.05 CHEMBL2045992 CHEMBL2041180 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(nc5)c6ccc(cc6)C(=O)O 4.34 CHEMBL2045992 CHEMBL2041181 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(nc5)c6ccc(cc6C)C(=O)O 5.15 CHEMBL2045992 CHEMBL2041182 Cc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc(cc6C)C(=O)O 4.42 CHEMBL2045992 CHEMBL2041183 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)c5ccc(cc5C)C(=O)O)c6cc(ncn6)C(F)(F)F 4.68 CHEMBL2045992 CHEMBL2041184 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)c5ccc(cc5C)C(=O)O)c6ccnc(C)n6 4.66 CHEMBL2045992 CHEMBL2041185 COc1nccnc1N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc(cc6C)C(=O)O 5.85 CHEMBL2045992 CHEMBL2041186 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)c5ccc(cc5C)C(=O)O)c6nccnc6C 5.11 CHEMBL2045992 CHEMBL2041187 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)c5ccc(cc5)C(=O)O)c6ncccn6 4.72 CHEMBL2045992 CHEMBL2041188 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)c5ccc(cc5C)C(=O)O)c6ncccn6 4.64 CHEMBL2045992 CHEMBL2041189 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)c5ccc(cc5)C(=O)O)c6cnccn6 4.8 CHEMBL2045992 CHEMBL2041190 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)c5ccc(cc5C)C(=O)O)c6cnccn6 5.14 CHEMBL2045992 CHEMBL2041191 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(nc4)c5ccc(cc5C)C(=O)O)c6cnccn6 5.6 CHEMBL2045992 CHEMBL2041192 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)c5ccc(cc5)C(=O)O)c6ccncn6 4.51 CHEMBL2045992 CHEMBL2041193 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)c5ccc(cc5C)C(=O)O)c6ccncn6 4.66 CHEMBL2045992 CHEMBL2041933 NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)c3cccc(F)c3 4.82 CHEMBL2072706 CHEMBL2041980 CS(=O)(=O)c1ccc(cc1)c2cnc(N)c(c2)c3ccc(nc3)C(F)(F)F 5.33 CHEMBL2043698 CHEMBL2042321 CC(C)(C)Oc1cccc2nc(N)nc(N)c12 4.7 CHEMBL2044716 CHEMBL2042691 OC(=O)C1=CC(=C2C=CC=CN2C1=O)CN3CCN(CC3)c4ccc(Br)cc4 5.68 CHEMBL2044730 CHEMBL2042692 OC(=O)C1=CC(=C2C=CC=CN2C1=O)CN3CCN(CC3)c4ccc(cc4)C(F)(F)F 7 CHEMBL2044730 CHEMBL2043004 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)c5ccccc5)c6cc(O)ncn6 6.66 CHEMBL2045992 CHEMBL2043168 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc(cc6)C(=O)O 5.19 CHEMBL2045992 CHEMBL2043169 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6cccc(c6)C(=O)O 5.16 CHEMBL2045992 CHEMBL2043170 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccccc6C(=O)O 5.62 CHEMBL2045992 CHEMBL2043172 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc(C(=O)O)c(Cl)c6 5.24 CHEMBL2045992 CHEMBL2043324 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc(cc6F)C(=O)O 4.27 CHEMBL2045992 CHEMBL2043325 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc(cc6C)C(=O)O 4.89 CHEMBL2045992 CHEMBL2043326 COc1cc(ncn1)N2C(=O)N(C(=O)C23CCN(Cc4ncccc4C)CC3)c5ccc(cc5)c6ccc(C(=O)O)c(C)c6 4.64 CHEMBL2045992 CHEMBL2043327 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)C5CCCCC5)c6cc(O)ncn6 6 CHEMBL2045992 CHEMBL2043328 Cc1cccnc1CN2CCC3(CC2)N(C(=O)N(C3=O)c4ccc(cc4)N5CCC5=O)c6cc(O)ncn6 4.57 CHEMBL2045992 CHEMBL204408 CC(C)(C)[C@H](N)C(=O)N1CC(=C[C@H]1c2ccccc2)c3cc(F)ccc3F 5.82 CHEMBL868944 CHEMBL204459 N[C@@H](C1CC1)C(=O)N2CC(=C[C@H]2c3ccccc3)c4cc(F)ccc4F 5.19 CHEMBL868945 CHEMBL2046888 C(CC(c1ccccc1)c2ccccc2)NCCc3ccccc3 5.5 CHEMBL2051179 CHEMBL2046889 C(CNCCC(c1ccccc1)c2ccccc2)Cc3ccccc3 7.77 CHEMBL2051179 CHEMBL2046890 C(CN(c1ccccc1)c2ccccc2)NCCc3ccccc3 7.2 CHEMBL2051179 CHEMBL2046891 C(CNCCN(c1ccccc1)c2ccccc2)Cc3ccccc3 6.2 CHEMBL2051179 CHEMBL2046892 Fc1ccc(cc1)N(CCNCCc2ccccc2)c3ccc(F)cc3 7.36 CHEMBL2051179 CHEMBL2046893 Fc1ccc(cc1)N(CCNCCCc2ccccc2)c3ccc(F)cc3 8.6 CHEMBL2051179 CHEMBL2046894 O=C(Cc1ccccc1)NCCN(c2ccccc2)c3ccccc3 5.1 CHEMBL2051179 CHEMBL2046895 Fc1ccc(cc1)N(CCNC(=O)CCc2ccccc2)c3ccc(F)cc3 6.7 CHEMBL2051179 CHEMBL204828 Clc1cc2OC(=CC(=O)c2cc1Cl)C(=O)NC3CCN(Cc4ccc5OCOc5c4)CC3 8.85 CHEMBL909940 CHEMBL2048870 CC(C)COc1cccc(\C=C\2/SC(=O)NC2=O)c1N3CCC[C@@H](N)C3 4.64 CHEMBL2049748 CHEMBL205285 CN1CCN(CCCN([C@@H]2CC[C@@]3(C[C@H]23)c4ccc(cc4)C#N)C(=O)Nc5ccc(F)c(c5)C(F)(F)F)CC1 7.28 CHEMBL869841 CHEMBL205437 CN(C1CCNCC1)C(=O)N2CC(=C[C@H]2c3ccccc3)c4cc(F)ccc4F 5.89 CHEMBL868944 CHEMBL205710 COC[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C 4.75 CHEMBL859790 CHEMBL2058831 CC(C)[C@H]1N(CCn2c(Nc3ccc(F)c(Cl)c3)c(nc12)c4ccc(F)cc4)C(=O)CN 4.87 CHEMBL2060804 CHEMBL2058833 CC1(C)N(CCn2c(Nc3ccc(F)cc3)c(nc12)c4ccc(F)cc4)C(=O)CN 4.87 CHEMBL2060804 CHEMBL2058837 CC(C)(N)C(=O)N1CCn2c(Nc3ccc(F)cc3)c(nc2C1(C)C)c4ccc(F)cc4 4.66 CHEMBL2060804 CHEMBL2059304 O=C1Nc2ccccc2N1C3CCN(CCOc4ccccc4)CC3 5.68 CHEMBL2060137 CHEMBL2059305 O=C1CCc2ccccc2N1CCCN3CCC(CC3)c4ccc5[nH]ccc5c4 5.36 CHEMBL2060137 CHEMBL2059306 O=C1CCc2ccccc2N1CCCN3CCC(CC3)N4C(=O)Nc5ccccc45 5.14 CHEMBL2060137 CHEMBL2059310 O=C1CCc2cccnc2N1CCCN3CCC(CC3)N4C(=O)Nc5ccccc45 5.2 CHEMBL2060137 CHEMBL2059311 O=C1COc2ccccc2N1CCCN3CCC(CC3)N4C(=O)Nc5ccccc45 5.18 CHEMBL2060137 CHEMBL2059312 O=C1CCc2ccccc2N1OCCN3CCC(CC3)N4C(=O)Nc5ccccc45 5.03 CHEMBL2060137 CHEMBL2059313 O=C1COc2ccccc2N1CCCN3CCC(CC3)N4C(=O)Nc5cccnc45 4.89 CHEMBL2060137 CHEMBL2059315 O=C1COc2ccccc2N1CCCN3CCC(CC3)N4C(=O)Nc5cnccc45 4.34 CHEMBL2060137 CHEMBL2059316 O=C1COc2ccccc2N1CCCN3CCC(CC3)N4C(=O)Nc5ncccc45 4.66 CHEMBL2060137 CHEMBL2059317 Fc1cccc2N(CCCN3CCC(CC3)N4C(=O)Nc5ccccc45)C(=O)CCc12 5.28 CHEMBL2060137 CHEMBL2059318 Fc1ccc2N(CCCN3CCC(CC3)N4C(=O)Nc5ccccc45)C(=O)CCc2c1 5.47 CHEMBL2060137 CHEMBL2059319 Fc1ccc2CCC(=O)N(CCCN3CCC(CC3)N4C(=O)Nc5ccccc45)c2c1 5.24 CHEMBL2060137 CHEMBL2059320 Fc1cccc2CCC(=O)N(CCCN3CCC(CC3)N4C(=O)Nc5ccccc45)c12 5.1 CHEMBL2060137 CHEMBL2059321 Fc1cccc2NC(=O)N(C3CCN(CCCN4C(=O)COc5ccccc45)CC3)c12 5.2 CHEMBL2060137 CHEMBL2059322 Fc1ccc2NC(=O)N(C3CCN(CCCN4C(=O)COc5ccccc45)CC3)c2c1 5.36 CHEMBL2060137 CHEMBL2059323 Fc1ccc2N(C3CCN(CCCN4C(=O)COc5ccccc45)CC3)C(=O)Nc2c1 5.72 CHEMBL2060137 CHEMBL2059324 Fc1cccc2N(C3CCN(CCCN4C(=O)COc5ccccc45)CC3)C(=O)Nc12 5.47 CHEMBL2060137 CHEMBL206081 COc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5OCOc5c4)CC3 7.94 CHEMBL909940 CHEMBL206115 N[C@@H](C1CC1)C(=O)N2CC(=C[C@H]2c3cccc(O)c3)c4cc(F)ccc4F 5.25 CHEMBL869626 CHEMBL206249 CN(C1CCNCC1)C(=O)N2CC(=CC2c3cccc(O)c3)c4cc(F)ccc4F 5.18 CHEMBL869626 CHEMBL2062563 CC(=O)Nc1ccc2ccn(c3cc(NC4CC4)n5ncc(C#N)c5n3)c2c1 5.07 CHEMBL2065451 CHEMBL2064645 CNC(=O)[C@@]12C[C@@H]1[C@H]([C@H](O)[C@@H]2O)n3cnc4c(NC)nc(nc34)C#Cc5ccc(F)c(F)c5 4.57 CHEMBL3414402 CHEMBL2064657 CNC(=O)[C@@]12C[C@@H]1[C@H]([C@H](O)[C@@H]2O)n3cnc4c(NCc5cccc(Cl)c5)nc(nc34)C#Cc6ccc(F)c(F)c6 4.91 CHEMBL3414402 CHEMBL206798 CN(CCO)C(=O)N1CC(=C[C@H]1c2cccc(O)c2)c3cc(F)ccc3F 4.82 CHEMBL869626 CHEMBL206845 C[C@@H]1CNC[C@H]2Cc3ccc(C)nc3N12 4.68 CHEMBL865567 CHEMBL2069324 O=C(NC1(CC1)C#N)[C@@H]2CCCC[C@H]2C(=O)N3CCN(CC3)c4nc(cs4)c5ccccc5 4.6 CHEMBL2073369 CHEMBL2069397 Fc1ccc(cc1)N2CC(CC2=O)c3onc(n3)c4cccc(Cl)c4 5.4 CHEMBL2072739 CHEMBL2069398 Cc1cccc(c1)c2noc(n2)C3CN(C(=O)C3)c4ccc(F)cc4 5.1 CHEMBL2072739 CHEMBL2069399 CCCCOc1ccc(cc1)C(=O)N[C@@H]2COc3cccc(N4CCN(C)CC4)c3C2 5.2 CHEMBL2072752 CHEMBL2069400 CN1CCN(CC1)c2cccc3OC[C@H](Cc23)NC(=O)c4ccc(OC(F)(F)F)cc4 5.1 CHEMBL2072752 CHEMBL2069401 CN1CCN(CC1)c2cccc3OC[C@H](Cc23)NC(=O)c4ccc(OCC(F)(F)F)nc4 5.1 CHEMBL2072752 CHEMBL2069402 CN1CCN(CC1)c2cccc3OC[C@H](Cc23)NC(=O)c4ccc(OCCC(F)(F)F)nc4 4.9 CHEMBL2072752 CHEMBL2069403 CN1CCN(CC1)c2cccc3OC[C@H](Cc23)NC(=O)c4nn(nc4C)c5ccccc5 5.1 CHEMBL2072752 CHEMBL2069404 CN1CCN(CC1)c2cccc3OC[C@H](Cc23)NC(=O)c4nn(nc4C)c5ccc(C)cc5C 5 CHEMBL2072752 CHEMBL2069407 FC(F)(F)Oc1ccc(cc1)C(=O)N[C@@H]2COc3cccc(c3C2)c4ccncc4 5.6 CHEMBL2072752 CHEMBL2069408 FC(F)(F)COc1ccc(cn1)C(=O)N[C@@H]2COc3cccc(c3C2)c4cccnc4 4.6 CHEMBL2072752 CHEMBL2069409 FC(F)(F)COc1ccc(cn1)C(=O)N[C@@H]2COc3cccc(c3C2)c4ccncc4 5.2 CHEMBL2072752 CHEMBL2069410 COc1ncc(cc1F)c2cccc3OC[C@H](Cc23)NC(=O)c4ccc(OCC(F)(F)F)nc4 4.6 CHEMBL2072752 CHEMBL2069411 OCc1ccc(cn1)c2cccc3OC[C@H](Cc23)NC(=O)c4ccc(OCC(F)(F)F)nc4 5 CHEMBL2072752 CHEMBL2069412 OCc1cc(ccn1)c2cccc3OC[C@H](Cc23)NC(=O)c4ccc(OCC(F)(F)F)nc4 4.8 CHEMBL2072752 CHEMBL2069413 OCc1ccc(cn1)c2cccc3OC[C@H](Cc23)NC(=O)c4ccc(OCCOCC(F)(F)F)nc4 4.8 CHEMBL2072752 CHEMBL2069416 Cc1nn(nc1C(=O)N[C@@H]2COc3cccc(c3C2)c4ccncc4)c5ccccc5 5.4 CHEMBL2072752 CHEMBL2069420 FC(F)(F)CCOc1ccc(cn1)C(=O)N[C@@H]2COc3cccc(c3C2)c4cncnc4 5.2 CHEMBL2072752 CHEMBL2069421 COc1ncc(cn1)c2cccc3OC[C@H](Cc23)NC(=O)c4ccc(OCC(F)(F)F)nc4 5.1 CHEMBL2072752 CHEMBL2069422 COc1ncc(cn1)c2cccc3OC[C@H](Cc23)NC(=O)c4ccc(OCCC(F)(F)F)nc4 4.9 CHEMBL2072752 CHEMBL2069423 COc1ncc(cn1)c2cccc3OC[C@H](Cc23)NC(=O)c4ccc(COCC(F)(F)F)nc4 4.8 CHEMBL2072752 CHEMBL2069424 Cc1ncc(cn1)c2cccc3OC[C@H](Cc23)NC(=O)c4ccc(OCC(F)(F)F)nc4 5 CHEMBL2072752 CHEMBL2069427 COc1cnc(cn1)c2cccc3OC[C@H](Cc23)NC(=O)c4ccc(COCC(F)(F)F)nc4 4.9 CHEMBL2072752 CHEMBL2069499 CCCCC1(CCCC)N[C@H](Cc2c1[nH]c3ccccc23)c4nc(c[nH]4)c5ccccc5 6.82 CHEMBL2072491 CHEMBL2069500 C1CCC(CC1)C2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccc6 7.11 CHEMBL2072491 CHEMBL2069501 CCOCC1(COCC)N[C@H](Cc2c1[nH]c3ccccc23)c4nc(c[nH]4)c5ccccc5 6.75 CHEMBL2072491 CHEMBL2069502 C1CC(CCO1)[C@H]2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccc6 6.42 CHEMBL2072491 CHEMBL2069503 C1CC(CCO1)[C@@H]2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccc6 6.14 CHEMBL2072491 CHEMBL2069504 C1CC(CO1)C2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccc6 7.19 CHEMBL2072491 CHEMBL2069505 C1CC(CCS1)C2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccc6 6.92 CHEMBL2072491 CHEMBL2069506 [O-][S+]1CCC(CC1)C2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccc6 7 CHEMBL2072491 CHEMBL2069507 O=S1(=O)CCC(CC1)C2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccc6 7 CHEMBL2072491 CHEMBL2069509 C1CC(CCN1)C2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccc6 5.29 CHEMBL2072491 CHEMBL2069510 CC(=O)N1CCC(CC1)C2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccc6 5.01 CHEMBL2072491 CHEMBL2069511 CS(=O)(=O)N1CCC(CC1)C2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccc6 5.46 CHEMBL2072491 CHEMBL2069512 COC(=O)N1CCC(CC1)C2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccc6 6.16 CHEMBL2072491 CHEMBL2069513 CNC(=O)N1CCC(CC1)C2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccc6 6.62 CHEMBL2072491 CHEMBL2069921 C(N1CCN(Cc2onc(n2)c3ccccc3)CC1)c4ccccc4 4.9 CHEMBL2072927 CHEMBL2069922 CN(CC1=Nc2ccccc2C(=O)N1)Cc3onc(n3)c4ccccc4 4.58 CHEMBL2072927 CHEMBL2069924 C(N1CCN(Cc2nc3ccccc3s2)CC1)c4onc(n4)c5ccccc5 4.89 CHEMBL2072927 CHEMBL2069925 C(N1CCN(Cc2nc3ccccc3s2)CC1)c4oc(nn4)c5ccccc5 4.52 CHEMBL2072927 CHEMBL2069926 C[C@@H](Oc1nnc(c2ccncc2)n1C)c3noc(n3)c4cccc(Cl)c4 4.94 CHEMBL2072927 CHEMBL2069927 C[C@@H](Oc1nnc(c2ccncc2)n1C)c3oc(nn3)c4cccc(Cl)c4 4.67 CHEMBL2072927 CHEMBL2069928 C1CN2CCC1C(C2)c3onc(n3)c4oc(cc4)c5cccnc5 5.19 CHEMBL2072927 CHEMBL2069929 C1CN2CCC1C(C2)c3oc(nn3)c4oc(cc4)c5cccnc5 4.7 CHEMBL2072927 CHEMBL2069930 CCOC(=O)N1CCN(Cc2noc(n2)c3cc(Cl)ccc3F)CC1 4.51 CHEMBL2072927 CHEMBL2070936 Fc1ccc(cc1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N 4.5 CHEMBL2073369 CHEMBL2070937 O=C(NC1(CC1)C#N)[C@@H]2CCCC[C@H]2C(=O)N3CCN(CC3)c4nc5ccccc5s4 5.1 CHEMBL2073369 CHEMBL2070942 CC(C)(C)c1csc(n1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N 5.2 CHEMBL2073369 CHEMBL2070943 FC(F)(F)c1csc(n1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N 4.6 CHEMBL2073369 CHEMBL2070944 Cc1sc(nc1C(F)(F)F)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N 4.8 CHEMBL2073369 CHEMBL2070945 FC(F)(F)c1nc(sc1Cl)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N 4.6 CHEMBL2073369 CHEMBL207220 CN(CCCCN1CCN(CC1)c2cccc(NC(=O)C)c2)S(=O)(=O)CC3CCCCC3 5.4 CHEMBL853270 CHEMBL207478 CC(C)CS(=O)(=O)N(C)CCCCN1CCN(CC1)c2cccc(NC(=O)C)c2 5.66 CHEMBL853270 CHEMBL2086582 COc1ccc(cc1)c2cc(NC(=O)CCCCN3CCCN(CC3)C(=O)C)[nH]n2 4.62 CHEMBL2091635 CHEMBL2086687 C[C@@H]1CN(CCN1c2ncc(OCc3ccncc3C#N)cn2)C(=O)OCC(F)(F)F 4.92 CHEMBL2384313 CHEMBL2086690 CC(C)c1onc(n1)N2CCN([C@H](C)C2)c3ncc(OCc4ccncc4C#N)cn3 5 CHEMBL2089933 CHEMBL2086693 C[C@@H]1CN(CCN1c2ncc(OCc3ccncc3C#N)cn2)c4noc(n4)C(F)(F)F 5.12 CHEMBL3226215 CHEMBL2086760 CCN1CCC(CC1)Nc2ccc3NC(=O)C(=C(c4ccc(Cl)cc4)c5ncc[nH]5)c3c2 5.47 CHEMBL2091838 CHEMBL2087084 CC(C)c1noc(n1)N2CCN([C@H](C)C2)c3ncc(OCc4ccncc4C#N)cn3 4.94 CHEMBL3226215 CHEMBL2087086 C[C@@H]1CN(CCN1c2ncc(OCc3ccncc3C#N)cn2)c4onc(n4)C(F)(F)F 5.23 CHEMBL3226215 CHEMBL2092884 COc1ccc(cn1)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNc4n[nH]c5ccc(cc45)C(F)(F)F 4.5 CHEMBL1837909 CHEMBL2092889 CN1Cc2ccccc2[C@@H](N=C1OCc3ccc(NS(=O)(=O)C)cc3)c4ccccc4.OC(=O)\C=C\C(=O)O 4.54 CHEMBL684971 CHEMBL2092890 Cl.CN1Cc2ccccc2[C@H](N=C1CCc3ccc(NS(=O)(=O)C)cc3)c4ccc(F)cc4F 4.42 CHEMBL684971 CHEMBL209324 COc1ccccc1N2CCN(CCCCNS(=O)(=O)c3ccc(C)cc3)CC2 5.3 CHEMBL1027667 CHEMBL2093896 Cl.CSc1ccc(cc1)[C@H]2N=C(OCc3ccc(NS(=O)(=O)C)cc3)N(C)Cc4ccccc24 4.68 CHEMBL684971 CHEMBL2096837 O=C1NC[C@@H](c2ccccc2)C13CCN(CC3)C4CCCCC4c5ccccc5 5.85 CHEMBL854582 CHEMBL209821 CC(=O)Nc1cccc(c1)N2CCN(CCCCNS(=O)(=O)CC3CCCCC3)CC2 5.42 CHEMBL853270 CHEMBL209964 CN1CCN(CCCN([C@@H]2CC[C@@]3(C[C@H]23)c4ccc5c(N)noc5c4)C(=O)Nc6ccc(F)c(c6)C(F)(F)F)CC1 6.16 CHEMBL869841 CHEMBL210537 CC(=O)Nc1cccc(c1)N2CCN(CCCCNS(=O)(=O)c3ccc(C)cc3)CC2 6.52 CHEMBL853270 CHEMBL2105617 CCC1C2CC3C4N(C)c5ccccc5C46CC(C2[C@H]6O)N3C1O 5.98 CHEMBL3430627 CHEMBL2105762 CS(=O)(=O)n1cc2CN(Cc2n1)[C@H]3CO[C@@H]([C@@H](N)C3)c4cc(F)ccc4F 4.41 CHEMBL3738365 CHEMBL210829 CN(C)C(=O)[C@H]([C@H](N)C(=O)N1CCC(F)(F)C1)c2ccc(cc2)c3ccn4ncnc4c3.OC(=O)C(F)(F)F 4.8 CHEMBL868204 CHEMBL211012 CC(=O)Nc1cccc(c1)N2CCN(CC3CCN(CC3)S(=O)(=O)CC4CCCCC4)CC2 5.7 CHEMBL853270 CHEMBL2112075 Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N 5.52 CHEMBL939877 CHEMBL2113086 OC(=O)[C@@H](CC1CCC1)N2C[C@H](CN3CCC(CC3)c4cnc5ccccn45)[C@H](C2)c6cccc(F)c6 5.57 CHEMBL827855 CHEMBL212689 CCN(C1CCN(CC[C@H](c2ccc(cc2)S(=O)(=O)C)c3cc(F)cc(F)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C 5.14 CHEMBL870536 CHEMBL213715 FC(F)Oc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5OCOc5c4)CC3 8.44 CHEMBL909940 CHEMBL213754 CCCOc1ccccc1CC(N2CCNCC2)c3ccccc3 5.23 CHEMBL1120514 CHEMBL213761 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccccc4)CC3 7.7 CHEMBL909940 CHEMBL214021 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5OCOc5c4)CC3 5.8 CHEMBL908898 CHEMBL214122 OC1(CCCCC1N2CCC3(CC2)C(CNC3=O)c4ccccc4)c5ccc(F)cc5 5.75 CHEMBL854582 CHEMBL214323 CCN(CC)Cc1ccc2C[C@H](CCc2c1)N3CCN(CCc4cccc(c4)C(F)(F)F)CC3=O 5.77 CHEMBL854894 CHEMBL214335 COc1ccccc1CC(N2CCNCC2)c3ccccc3 4.39 CHEMBL1120514 CHEMBL214377 CCc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5OCOc5c4)CC3 8.13 CHEMBL909940 CHEMBL214432 CN(CC(=O)N(C)C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c3ccc(cc3)c4ccc(F)cc4 5.75 CHEMBL854892 CHEMBL214553 COc1ccc2C(=O)N(CC(CO)NCc3cccnc3)C(=C(c4ccccc4)c2c1)C#N 5 CHEMBL908975 CHEMBL214585 Fc1ccc2OC(=CC(=O)c2c1)C(=O)NC3CCN(CC3)C4CCc5cc6OCOc6cc45 4.95 CHEMBL854891 CHEMBL214629 CCN(CC)Cc1ccc2C[C@H](CCc2c1)N3CCN(CCc4ccc(F)cc4)CC3=O 5.09 CHEMBL854894 CHEMBL2146484 CN1CCC[C@@H]1CN2N=C(Cc3ccc(Cl)cc3)c4cccnc4C2=O 5.6 CHEMBL2150564 CHEMBL2146599 Cc1ccc2NC(=O)N(C3CCN(CC3)C4CCOCC4)c2c1 4.6 CHEMBL2149604 CHEMBL2146754 [O-][N+](=O)c1ccc(CCN2CCNCC2)cc1 6.72 CHEMBL2148626 CHEMBL2146755 [O-][N+](=O)c1ccc(CCN2CCN(CCc3ccc(cc3)[N+](=O)[O-])CC2)cc1 8.3 CHEMBL2148626 CHEMBL2146757 [O-][N+](=O)c1ccc(CCN2CCN(CCc3ccc(cc3)C#N)CC2)cc1 8.05 CHEMBL2148626 CHEMBL2146801 COCCN1CCC[C@@H]1CN2N=C(Cc3ccc(Cl)cc3)c4cnccc4C2=O 5.9 CHEMBL2150564 CHEMBL2146802 CCCCN1CCC[C@@H]1CN2N=C(Cc3ccc(Cl)cc3)c4ccccc4C2=O 7.8 CHEMBL2150564 CHEMBL2146803 COCCN1CCC[C@@H]1CN2N=C(Cc3ccc(Cl)cc3)c4ccccc4C2=O 6.6 CHEMBL2150564 CHEMBL2146804 CN1CCC[C@@H]1CN2N=C(Cc3ccc(Cl)cc3)c4ccncc4C2=O 5.9 CHEMBL2150564 CHEMBL2146805 CN1CCC[C@@H]1CN2N=C(Cc3ccc(Cl)cc3)c4cnccc4C2=O 5.6 CHEMBL2150564 CHEMBL2146806 CCCCN1CCC[C@@H]1CN2N=C(Cc3ccc(Cl)cc3)c4cnccc4C2=O 7.3 CHEMBL2150564 CHEMBL2146807 CCCCN1CCC[C@@H]1CN2N=C(Cc3ccc(Cl)cc3)c4cccnc4C2=O 7.1 CHEMBL2150564 CHEMBL2146808 COCCN1CCC[C@@H]1CN2N=C(Cc3ccc(Cl)cc3)c4cccnc4C2=O 5.3 CHEMBL2150564 CHEMBL2146809 CN1CCC[C@@H]1CN2N=C(Cc3ccc(Cl)cc3)c4ncccc4C2=O 6.8 CHEMBL2150564 CHEMBL2146810 CCCCN1CCC[C@@H]1CN2N=C(Cc3ccc(Cl)cc3)c4ncccc4C2=O 8.4 CHEMBL2150564 CHEMBL2146811 COCCN1CCC[C@@H]1CN2N=C(Cc3ccc(Cl)cc3)c4ncccc4C2=O 7.2 CHEMBL2150564 CHEMBL2146812 CN1CCC[C@@H]1CN2N=C(Cc3ccc(Cl)cc3)c4nccnc4C2=O 5.9 CHEMBL2150564 CHEMBL2146813 Clc1ccc(CC2=NN(C[C@H]3CCCN3CCCCc4ccc(OCCCN5CCCCCC5)cc4)C(=O)c6ccncc26)cc1 6.8 CHEMBL2150564 CHEMBL2146851 N#Cc1ccc(CCN2CCN(CCc3ccc4nonc4c3)CC2)cc1 7.38 CHEMBL2148626 CHEMBL2146852 [O-][N+](=O)c1ccc(CCN2CCN(CCc3cccc(c3)C#N)CC2)cc1 7.66 CHEMBL2148626 CHEMBL2146853 [O-][N+](=O)c1ccc(CCN2CCN(CCc3ccc4nonc4c3)CC2)cc1 7.6 CHEMBL2148626 CHEMBL2146854 [O-][N+](=O)c1ccc(CCN2CCN(CCc3ccc(cc3)c4occn4)CC2)cc1 7.33 CHEMBL2148626 CHEMBL2146856 [O-][N+](=O)c1ccc(CCN2CCN(CCc3ccc(cc3)c4cccc5C(=O)OCc45)CC2)cc1 6.82 CHEMBL2148626 CHEMBL2146857 CCOC(=O)c1ccc(CCN2CCN(CCc3ccc(cc3)[N+](=O)[O-])CC2)cc1 7.72 CHEMBL2148626 CHEMBL2146858 [O-][N+](=O)c1ccc(CCN2CCN(CCc3ccc(F)cc3)CC2)cc1 7.64 CHEMBL2148626 CHEMBL2146861 COc1ccc(CCN2CCN(CCc3ccc(cc3)[N+](=O)[O-])CC2)cc1 8.16 CHEMBL2148626 CHEMBL2146862 CS(=O)(=O)c1ccc(CCN2CCN(CCc3ccc(cc3)[N+](=O)[O-])CC2)cc1 6.82 CHEMBL2148626 CHEMBL2146865 CC(CN1CCN(CCc2ccc(cc2)[N+](=O)[O-])CC1)c3ccc(cc3)[N+](=O)[O-] 8.51 CHEMBL2148626 CHEMBL2146866 CC(Cc1ccc(cc1)[N+](=O)[O-])N2CCN(CCc3ccc(cc3)[N+](=O)[O-])CC2 8.41 CHEMBL2148626 CHEMBL2146867 CC1CN(CCc2ccc(cc2)[N+](=O)[O-])CCN1CCc3ccc(cc3)[N+](=O)[O-] 9.12 CHEMBL2148626 CHEMBL2146868 N#Cc1ccc(CCN2CCN(CCc3ccc(cc3)C#N)CC2)cc1 7.92 CHEMBL2148626 CHEMBL2146869 C(Cc1ccc2nonc2c1)N3CCN(CCc4ccc5nonc5c4)CC3 7.17 CHEMBL2148626 CHEMBL2146870 O=C1OCc2cc(CCN3CCN(CCc4ccc5C(=O)OCc5c4)CC3)ccc12 5.72 CHEMBL2148626 CHEMBL2146871 O=C1OCc2cc(CCN3CCN(CCc4ccc(cc4)C#N)CC3)ccc12 6.37 CHEMBL2148626 CHEMBL2146872 O=C1OCc2cc(CCN3CCN(CCc4ccc5nonc5c4)CC3)ccc12 6.55 CHEMBL2148626 CHEMBL2146873 Fc1cc(CCN2CCN(CCc3ccc4C(=O)OCc4c3)CC2)ccc1C#N 6.77 CHEMBL2148626 CHEMBL2146874 Clc1cc(CCN2CCN(CCc3ccc4C(=O)OCc4c3)CC2)ccc1C#N 6.92 CHEMBL2148626 CHEMBL2146875 Brc1cc(CCN2CCN(CCc3ccc4C(=O)OCc4c3)CC2)ccc1C#N 6.25 CHEMBL2148626 CHEMBL2146876 COc1cc(CCN2CCN(CCc3ccc4C(=O)OCc4c3)CC2)ccc1C#N 5.8 CHEMBL2148626 CHEMBL2146877 CCOc1cc(CCN2CCN(CCc3ccc4C(=O)OCc4c3)CC2)ccc1C#N 6.17 CHEMBL2148626 CHEMBL2146878 FC(F)(F)Oc1cc(CCN2CCN(CCc3ccc4C(=O)OCc4c3)CC2)ccc1C#N 6.96 CHEMBL2148626 CHEMBL2146879 O=C1OCc2cc(CCN3CCN(CCc4ccc(C#N)c(OC5CC5)c4)CC3)ccc12 6.33 CHEMBL2148626 CHEMBL2146880 CSc1cc(CCN2CCN(CCc3ccc4C(=O)OCc4c3)CC2)ccc1C#N 6.34 CHEMBL2148626 CHEMBL2146881 CNc1cc(CCN2CCN(CCc3ccc4C(=O)OCc4c3)CC2)ccc1C#N 6.17 CHEMBL2148626 CHEMBL2146882 CS(=O)(=O)c1cc(CCN2CCN(CCc3ccc4C(=O)OCc4c3)CC2)ccc1C#N 5.33 CHEMBL2148626 CHEMBL2147020 Cc1cc(ccc1c2ccnc(NCc3n[nH]c4ncccc34)c2)C#N 5.72 CHEMBL2150640 CHEMBL2147021 Cc1cc(ccc1c2ccnc(NCc3n[nH]c4nc(F)ccc34)c2)C#N 5.57 CHEMBL2150640 CHEMBL2147022 Cc1cc(ccc1c2ccnc(NCc3n[nH]c4nc(N)ccc34)c2)C#N 5.37 CHEMBL2150640 CHEMBL2147023 Cc1cc(ccc1c2ccnc(NCc3n[nH]c(c3Cl)c4ccccc4)c2)C#N 4.52 CHEMBL2150640 CHEMBL2147024 Cc1cc(ccc1c2ccnc(NCc3cc([nH]n3)c4ccccn4)c2)C#N 5.96 CHEMBL2150640 CHEMBL2147072 CN1C(=O)c2c(nc(N3CCC[C@@H](N)C3)n2Cc4ccccc4Cl)c5ccc(cc15)C#N 5.92 CHEMBL2149440 CHEMBL2147194 Cl.COCc1ccc2c(c1)N(C)C(=O)c3c2nc(N4CCC[C@@H](N)C4)n3Cc5ccccc5Cl 5.74 CHEMBL2149440 CHEMBL2147210 COc1ncc(cn1)c2ccccc2CCNC(=O)c3ccc(OCCC(F)(F)F)nc3 5 CHEMBL2149459 CHEMBL2147211 COc1cnc(cn1)c2ccccc2CCNC(=O)c3ccc(OCCC(F)(F)F)nc3 4.7 CHEMBL2149459 CHEMBL2147212 FC(F)Oc1cnc(cn1)c2ccccc2CCNC(=O)c3ccc(OCCC(F)(F)F)nc3 5.2 CHEMBL2149459 CHEMBL2147213 FC(F)(F)CCOc1ccc(cn1)C(=O)NCCc2ccccc2c3cccnc3 5.2 CHEMBL2149459 CHEMBL2147214 Cc1ncc(cn1)c2ccccc2CCNC(=O)c3ccc(OCCC(F)(F)F)nc3 4.9 CHEMBL2149459 CHEMBL2147217 Cc1ncc(cn1)c2ccccc2CCNC(=O)c3ccc(OCCOCC(F)(F)F)nc3 4.5 CHEMBL2149459 CHEMBL2147219 Cc1ncc(cn1)c2ccccc2CCNC(=O)c3ccc(nc3)C(=O)NCCCC(F)(F)F 4.7 CHEMBL2149459 CHEMBL2147221 COc1ncc(cn1)c2cccc(C)c2CCNC(=O)c3ccc(OCCC(F)(F)F)nc3 5.2 CHEMBL2149459 CHEMBL2147222 COc1ncc(cn1)c2cccc(F)c2CCNC(=O)c3ccc(OCCC(F)(F)F)nc3 5.1 CHEMBL2149459 CHEMBL2147223 COc1ncc(cn1)c2cccc(Cl)c2CCNC(=O)c3ccc(OCCC(F)(F)F)nc3 5.4 CHEMBL2149459 CHEMBL2147225 COc1ccc(CCNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(c1)c3cnc(OC)nc3 5.2 CHEMBL2149459 CHEMBL2147303 COc1ncc(cn1)c2ccccc2C(F)(F)CNC(=O)c3ccc(COCC(F)(F)F)nc3 4.7 CHEMBL2149459 CHEMBL2147304 COc1ncc(cn1)c2cccc(OC(F)F)c2CCNC(=O)c3ccc(OCCC(F)(F)F)nc3 5.4 CHEMBL2149459 CHEMBL2147306 COc1ncc(cn1)c2c(C)ccc(F)c2CCNC(=O)c3ccc(OCC(F)(F)F)nc3 4.9 CHEMBL2149459 CHEMBL2147307 COc1cnc(cn1)c2c(C)ccc(F)c2CCNC(=O)c3ccc(COCC(F)(F)F)nc3 4.7 CHEMBL2149459 CHEMBL2147308 COc1cnc(cn1)c2c(F)ccc(F)c2CCNC(=O)c3ccc(COCC(F)(F)F)nc3 4.7 CHEMBL2149459 CHEMBL214731 Fc1ccc2OC(=CC(=O)c2c1)C(=O)NC3CCN(Cc4ccc5OCOc5c4)CC3 4.82 CHEMBL854891 CHEMBL2147316 COc1cnc(cn1)c2ccccc2C(F)(F)CNC(=O)c3ccc(COCC(F)(F)F)nc3 4.6 CHEMBL2149459 CHEMBL2147317 COc1cnc(cn1)c2cccc(F)c2C(F)(F)CNC(=O)c3ccc(COCC(F)(F)F)nc3 4.7 CHEMBL2149459 CHEMBL214742 COc1ccc2C(=O)N(C)C(=C(c3ccccc3)c2c1)CN(C)C 5.28 CHEMBL908975 CHEMBL214767 O=C(NC1CCN(Cc2ccc3OCOc3c2)CC1)C4=CC(=O)c5ccccc5O4 8.17 CHEMBL909940 CHEMBL214768 COc1ccc(CN2CCC(CC2)NC(=O)C3=CC(=O)c4ccc(F)cc4O3)cc1F 5.08 CHEMBL886903 CHEMBL214808 CN1CCN(Cc2ccc3cc(ccc3n2)N4C=Nc5cc(sc5C4=O)c6ccc(Cl)cc6)CC1 4.66 CHEMBL908401 CHEMBL214876 COc1ccc2c(NC[C@H](O)CO)nc(C#N)c(c3ccccc3)c2c1 4.82 CHEMBL908975 CHEMBL214957 COc1cc(ccc1OCCN2CCCC2)N3C=Nc4cc(sc4C3=O)c5ccc(Cl)cc5 5.93 CHEMBL993708 CHEMBL214969 COc1ccc2C(=O)N(CCO)C(=C(c3cccc(F)c3)c2c1)C#N 4.21 CHEMBL908975 CHEMBL214983 Fc1ccc(CCN2CCN([C@H]3CCc4cc(Cn5ccnc5)ccc4C3)C(=O)C2)cc1 5.4 CHEMBL854894 CHEMBL215023 COc1ccc2C(=O)N(CC(O)CO)C(=C(c3cccc(F)c3)c2c1)C#N 4.48 CHEMBL908975 CHEMBL215050 COCCN(C)CCN1C(=O)c2ccc(OC)cc2C(=C1C#N)c3cccc(F)c3 5.78 CHEMBL908975 CHEMBL2151164 COc1nc(Nc2cccc3c2nc(c4ccc(F)cc4)n3C)ccc1n5cnc(C)c5 5.07 CHEMBL2186754 CHEMBL2151218 COc1cc(Nc2cccc3c2nc(c4ccc(F)cc4)n3C)ccc1n5cnc(C)c5 5.7 CHEMBL2186754 CHEMBL2151322 CC(C)Oc1cc(n[nH]1)n2cnc3ccc(N[C@@H](CO)c4ccc(F)cn4)nc23 4.28 CHEMBL2154697 CHEMBL2151325 CCOc1cc(Nc2nc3c(cc2F)ncn3[C@@H](CO)c4ccc(F)cn4)n[nH]1 4.5 CHEMBL2154697 CHEMBL2151438 C1CN2CCC1[C@@]3(C2)Cc4cc(cnc4O3)c5cocc5 5.8 CHEMBL2157810 CHEMBL2152252 CNC(=O)c1nc(cnc1N)c2ccc(Cl)c(c2)S(=O)(=O)Nc3cccc(F)c3F 4.76 CHEMBL2156882 CHEMBL2152522 C1CCN(CC1)[C@H]([C@@H](N2CCCCC2)c3ccccc3)c4ccccc4 4.5 CHEMBL2153967 CHEMBL2152523 C1CCN(CC1)[C@@H]([C@H](N2CCCCC2)c3ccccc3)c4ccccc4 4.6 CHEMBL2153967 CHEMBL2152524 C1CCN(C1)[C@H]([C@@H](N2CCCC2)c3ccccc3)c4ccccc4 4.5 CHEMBL2153967 CHEMBL2152525 C1CCN(C1)[C@@H]([C@H](N2CCCC2)c3ccccc3)c4ccccc4 4.5 CHEMBL2153967 CHEMBL215278 CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c3ccc(cn3)c4ccc(Cl)cc4 5.59 CHEMBL854892 CHEMBL2152903 CCN1C=C(C=C(C)C1=O)[C@@]2(N=C(N)c3c(F)cccc23)c4cccc(c4)c5cncc(c5)C#CC 5.55 CHEMBL2182706 CHEMBL2153098 CN(C)c1ccc(\C=C\c2c(F)cccc2F)cc1 4.49 CHEMBL3378079 CHEMBL215457 CCc1oc2cc(CN3CCC(CC3)NC(=O)C4=CC(=O)c5ccc(F)cc5O4)ccc2n1 4.57 CHEMBL854890 CHEMBL215526 CCN(CC)Cc1ccc2C[C@H](CCc2c1)N3CCN(CCC4CCCS4)CC3=O 4.88 CHEMBL854894 CHEMBL215631 Oc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5OCOc5c4)CC3 7.2 CHEMBL909940 CHEMBL215660 CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c3ccc(cn3)c4ccc(F)cc4 5.28 CHEMBL854892 CHEMBL215661 CC(=O)Nc1ccc2CCC(N3CCC(CC3)NC(=O)C4=CC(=O)c5ccc(F)cc5O4)c2c1 4.46 CHEMBL854891 CHEMBL2158050 COc1ccc2ncc(F)c([C@@H](O)CC[C@@H]3CCN(CCSc4cccs4)C[C@@H]3C(=O)O)c2c1 4.63 CHEMBL2384768 CHEMBL215818 COc1ccc2c(nc(C#N)c(c3cccc(F)c3)c2c1)n4cnc(C)c4 4.68 CHEMBL908975 CHEMBL2158224 O=C(Nc1ccc(cc1C2=CCCCC2)C3CCN(Cc4ccccn4)CC3)c5nc(c[nH]5)C#N 5.11 CHEMBL2160981 CHEMBL2158563 CCN(CC)CCOc1cc(c(Cl)cc1Cl)c2nc(SCC(=O)NC)nc3[nH]cc(C#N)c23 4.75 CHEMBL2162323 CHEMBL2158564 CCN(CC)CCSc1nc(c2cc(OC)c(cc2Cl)C#N)c3c(c[nH]c3n1)C#N 5.97 CHEMBL2162322 CHEMBL2158625 CSc1nc(c2cc(OCCN3CCCC3)c(Cl)cc2Cl)c4c(c[nH]c4n1)C#N 5.44 CHEMBL2162322 CHEMBL2158626 CCN(CC)CCOc1cc(c(Cl)cc1Cl)c2nc(SC)nc3[nH]cc(C#N)c23 5.77 CHEMBL2162322 CHEMBL2158629 CCN(CC)CCSc1nc(c2cc(OC)c(Cl)cc2Cl)c3c(c[nH]c3n1)C#N 5.85 CHEMBL2162322 CHEMBL2158769 OC(=O)[C@H](Cc1ccccc1C#N)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 4.6 CHEMBL2160723 CHEMBL2158770 OC(=O)[C@H](Cc1cccc(c1)C#N)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 4.9 CHEMBL2160723 CHEMBL2158771 OC(=O)[C@H](Cc1ccc(cc1)C#N)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 5.3 CHEMBL2160723 CHEMBL2158773 Cc1cccc(C[C@H](N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2)C(=O)O)c1 5.2 CHEMBL2160723 CHEMBL2158774 Cc1ccc(C[C@H](N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2)C(=O)O)cc1 5.2 CHEMBL2160723 CHEMBL2158775 COc1ccccc1C[C@H](N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2)C(=O)O 5 CHEMBL2160723 CHEMBL2158776 COc1ccc(C[C@H](N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2)C(=O)O)cc1 5 CHEMBL2160723 CHEMBL2158777 OC(=O)[C@H](Cc1cccc(c1)C(F)(F)F)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 5.2 CHEMBL2160723 CHEMBL2158785 Cc1c(Cl)c(ccc1OC2CCN(CC3CCN(CC3)[C@@H](Cc4ccc(F)cc4)C(=O)O)CC2)C#N 4.8 CHEMBL2160723 CHEMBL2158791 Cc1cc(Cl)ccc1OC2CCN(CC3CCN(CC3)[C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC2 4.5 CHEMBL2160723 CHEMBL2158814 Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4 4.6 CHEMBL2160723 CHEMBL2158815 OC(=O)C(N1CCC(CC1)N2CCC(CC2)Oc3ccc(Cl)c(Cl)c3)c4ccccc4 5.3 CHEMBL2160726 CHEMBL2158816 OC(=O)C(N1CCCC(CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3)C1)c4ccccc4 4.6 CHEMBL2160723 CHEMBL2158820 OC(=O)[C@@H](N1CCC(CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3)CC1)c4ccccc4 4.6 CHEMBL2160723 CHEMBL2158821 OC(=O)[C@H](N1CCC(CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3)CC1)c4ccccc4 4.8 CHEMBL2160723 CHEMBL2158822 OC(=O)c1ccccc1N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 5.8 CHEMBL2160723 CHEMBL2158823 OC(=O)c1cccc(c1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 4.5 CHEMBL2160723 CHEMBL2158824 OC(=O)c1ccc(cc1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 4.5 CHEMBL2160723 CHEMBL2158825 OC(=O)Cc1ccccc1N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 4.9 CHEMBL2160723 CHEMBL2158826 OC(=O)Cc1cccc(c1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 4.5 CHEMBL2160723 CHEMBL2158827 OC(=O)Cc1ccc(cc1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 4.5 CHEMBL2160723 CHEMBL2158828 OC(=O)COc1ccccc1N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 4.5 CHEMBL2160723 CHEMBL2158829 OC(=O)COc1cccc(c1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 5 CHEMBL2160723 CHEMBL2158830 OC(=O)COc1ccc(cc1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 5 CHEMBL2160723 CHEMBL2158831 OC(=O)c1ccccc1CN2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 4.9 CHEMBL2160723 CHEMBL2158832 OC(=O)c1cccc(CN2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2)c1 4.7 CHEMBL2160723 CHEMBL2158833 OC(=O)c1ccc(CN2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2)cc1 4.5 CHEMBL2160723 CHEMBL2158834 OC(=O)c1cccnc1N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 4.5 CHEMBL2160723 CHEMBL2158835 OC(=O)[C@H](Cc1ccccc1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 4.8 CHEMBL2160723 CHEMBL2158836 OC(=O)[C@@H](Cc1ccccc1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 5.2 CHEMBL2160723 CHEMBL2158838 OC(=O)[C@H](Cc1ccc(Cl)cc1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2 5.4 CHEMBL2160723 CHEMBL2159347 COc1ccc2cc(ccc2c1)c3cc(nn3[C@@H](C)c4ccc(cc4)C(=O)NCCC(=O)O)c5cc(Cl)ccc5Cl 5.01 CHEMBL2160806 CHEMBL2159976 COc1ccc2nccc([C@@H](O)CC[C@@H]3CCN(CCSc4cccs4)C[C@@H]3C(=O)O)c2c1 4.68 CHEMBL2161976 CHEMBL216104 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5sccc5c4)CC3 5.86 CHEMBL854890 CHEMBL216168 COc1ccc2C(=O)N(CC(O)CO)C(=C(c3cccc(c3)C(F)(F)F)c2c1)C#N 4.8 CHEMBL908975 CHEMBL216180 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5[nH]ccc5c4)CC3 5.22 CHEMBL854890 CHEMBL216225 Fc1cccc(CN2CCC(CC2)NC(=O)C3=CC(=O)c4ccc(F)cc4O3)c1 7.67 CHEMBL909940 CHEMBL216228 Cc1nc(nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12)N4CCCC4 5 CHEMBL854889 CHEMBL216314 CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c3ccc(nc3)c4ccc(F)cc4 5 CHEMBL854892 CHEMBL216323 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5OC(=O)Oc5c4)CC3 4.07 CHEMBL854890 CHEMBL2163364 COc1ccc2N=CC(=O)N(CCN3CC[C@H](NCc4ccc5OCC(=O)Nc5n4)[C@H](F)C3)c2c1 4.6 CHEMBL2166761 CHEMBL2164037 COc1cccc2C(=O)N(CCc3ccccn3)C(C(=O)NCc4ccc(OC(F)(F)F)cc4)c12 5.44 CHEMBL2168489 CHEMBL2164039 Fc1cccc2C(N(CCc3ccccn3)C(=O)c12)C(=O)NCc4ccc(OC(F)(F)F)cc4 5.09 CHEMBL2168489 CHEMBL2164042 Fc1cnc(CCN2C(C(=O)NCc3cccc(OC(F)(F)F)c3)c4ccccc4C2=O)nc1 4.62 CHEMBL2168489 CHEMBL2164046 FC(F)(F)Oc1ccc(CNC(=O)C2N(CCc3ccncc3)C(=O)c4ccccc24)cc1 5.29 CHEMBL2168489 CHEMBL2164047 Fc1ccc(CCN2C(C(=O)NCc3ccc(OC(F)(F)F)cc3)c4ccccc4C2=O)nc1 5.28 CHEMBL2168489 CHEMBL216406 CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c3ccc(cn3)c4ccccc4 4.7 CHEMBL854892 CHEMBL2164203 CNC(=O)N(Cc1ccsc1)C2CCN(CC2)[C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C 5.8 CHEMBL2168044 CHEMBL2164206 CONC(=O)N(Cc1ccsc1)C2CCN(CC2)[C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C 5.26 CHEMBL2168044 CHEMBL2164207 CONC(=O)N(Cc1ccsc1)C2CCN(CC2)[C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3Cl 6.52 CHEMBL2168044 CHEMBL2164208 CONC(=O)N(Cc1ccsc1)C2CCN(CC2)[C@H](C)CCNC(=O)c3c(C)cc(nc3C)C(=O)NC(C)C 4.48 CHEMBL2168044 CHEMBL2164210 CONC(=O)N(Cc1ccsc1)C2CCN(CC2)[C@H](C)CCNC(=O)c3c(C)cc(nc3Cl)C#N 4.97 CHEMBL2168044 CHEMBL2164219 COCC(=O)N(Cc1ccsc1)C2CCN(CC2)[C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C 5.08 CHEMBL2168044 CHEMBL2164220 C[C@H](CCNC(=O)c1c(C)cc(Cl)nc1C)N2CCC(CC2)N(Cc3ccsc3)C(=O)CC#N 4.8 CHEMBL2168044 CHEMBL2164356 Cc1cccc(CCN2C(C(=O)NCc3ccc(OC(F)(F)F)cc3)c4ccccc4C2=O)n1 5.18 CHEMBL2168489 CHEMBL2164358 FC(F)(F)Oc1ccc(CNC(=O)C2N(CCOc3ccccn3)C(=O)c4ccccc24)cc1 5.31 CHEMBL2168489 CHEMBL2164359 FC(F)(F)Oc1ccc(CNC(=O)C2N(Cc3ccc(cn3)C(F)(F)F)C(=O)c4ccccc24)cc1 5.48 CHEMBL2168489 CHEMBL2164360 CC(Cc1ccccn1)N2C(C(=O)NCc3ccc(OC(F)(F)F)cc3)c4ccccc4C2=O 5.07 CHEMBL2168489 CHEMBL2164361 CC(C)(Cc1ccccn1)N2C(C(=O)NCc3ccc(OC(F)(F)F)cc3)c4ccccc4C2=O 5.37 CHEMBL2168489 CHEMBL2164363 FC(F)(F)Oc1ccc(CNC(=O)C2N(CC(F)(F)c3ccccn3)C(=O)c4ccccc24)cc1 5.01 CHEMBL2168489 CHEMBL2164364 FC(F)(F)Oc1ccc(CNC(=O)C2N(CCc3ncccn3)C(=O)c4ccccc24)cc1 4.8 CHEMBL2168489 CHEMBL2164365 FC(F)(F)Oc1ccc(CNC(=O)C2N(CCc3cnccn3)C(=O)c4ccccc24)cc1 5.04 CHEMBL2168489 CHEMBL2164366 Fc1cnc(CCN2C(C(=O)NCc3ccc(OC(F)(F)F)cc3)c4ccccc4C2=O)nc1 5.26 CHEMBL2168489 CHEMBL2164367 CC1(N(CCc2ccccn2)C(=O)c3ccccc13)C(=O)NCc4ccc(OC(F)(F)F)cc4 4.96 CHEMBL2168489 CHEMBL2164368 Fc1cccc2C(=O)N(CCc3ccccn3)C(C(=O)NCc4ccc(OC(F)(F)F)cc4)c12 5.25 CHEMBL2168489 CHEMBL2164369 Cc1cccc2C(=O)N(CCc3ccccn3)C(C(=O)NCc4ccc(OC(F)(F)F)cc4)c12 5.25 CHEMBL2168489 CHEMBL2164372 FC(F)(F)Oc1ccc(CNC(=O)C2N(C[C@@H]3CCCO3)C(=O)c4ccccc24)cc1 4.77 CHEMBL2168489 CHEMBL2164373 FC(F)(F)Oc1ccc(CNC(=O)C2N(C3CCC(F)(F)CC3)C(=O)c4ccccc24)cc1 4.85 CHEMBL2168489 CHEMBL2164374 CC(C)(C)OC(=O)N1CCC(CC1)N2C(C(=O)NCc3ccc(OC(F)(F)F)cc3)c4ccccc4C2=O 4.85 CHEMBL2168489 CHEMBL2164375 CC(C)(C)OC(=O)N1CC(C1)N2C(C(=O)NCc3ccc(OC(F)(F)F)cc3)c4ccccc4C2=O 4.96 CHEMBL2168489 CHEMBL2164376 FC(F)(F)Oc1ccc(CNC(=O)C2N(C3CC(F)(F)C3)C(=O)c4ccccc24)cc1 4.64 CHEMBL2168489 CHEMBL2164380 CC(CC#N)N1C(C(=O)NCc2ccc(OC(F)(F)F)cc2)c3ccccc3C1=O 4.51 CHEMBL2168489 CHEMBL2164381 FC(F)(F)Oc1ccc(CNC(=O)C2N(CCC#N)C(=O)c3ccccc23)cc1 4.59 CHEMBL2168489 CHEMBL2164382 FC(F)(F)Oc1ccc(CNC(=O)C2N(CCc3cccnc3)C(=O)c4ccccc24)cc1 5.26 CHEMBL2168489 CHEMBL2164384 Brc1ccc(CNC(=O)C2N(CCc3ccccn3)C(=O)c4ccccc24)cc1 5.03 CHEMBL2168489 CHEMBL2164387 FC(F)(F)c1ccc(CNC(=O)C2N(CCc3ccccn3)C(=O)c4ccccc24)cc1 5.07 CHEMBL2168489 CHEMBL2164389 FC(F)(F)Oc1ccc(CNC(=O)C2N(CCc3ccccn3)C(=O)c4ccccc24)cc1 5.11 CHEMBL2168489 CHEMBL2164390 FC(F)(F)Oc1cccc(CNC(=O)C2N(CCc3ccccn3)C(=O)c4ccccc24)c1 4.68 CHEMBL2168489 CHEMBL2164391 FC(F)(F)Cc1ccc(CNC(=O)C2N(CCc3ccccn3)C(=O)c4ccccc24)cc1 4.85 CHEMBL2168489 CHEMBL2164392 FC(F)(F)COc1ccc(CNC(=O)C2N(CCc3ccccn3)C(=O)c4ccccc24)cc1 5.05 CHEMBL2168489 CHEMBL2164393 CC(NC(=O)C1N(CCc2ccccn2)C(=O)c3ccccc13)c4ccc(OCC(F)(F)F)cc4 5.14 CHEMBL2168489 CHEMBL2164395 FC(F)(F)COc1ccc(CNC(=O)C2N(CCc3ccccn3)C(=O)c4ccccc24)cn1 4.8 CHEMBL2168489 CHEMBL2164396 FC(F)(F)CCOc1ccc(CNC(=O)C2N(CCc3ccccn3)C(=O)c4ccccc24)cn1 4.7 CHEMBL2168489 CHEMBL2164397 FC(F)(F)Oc1ccc(CNC(=O)C2N(CCC3CCOCC3)C(=O)c4ccccc24)cc1 4.66 CHEMBL2168489 CHEMBL2164443 CS(=O)(=O)c1ccc(cc1F)C(CC2CCCC2)C(=O)Nc3nccs3 4.64 CHEMBL2167265 CHEMBL2164552 Fc1cc(cc(c1)c2onc(n2)c3ccc(cn3)C#N)C#N 5.2 CHEMBL2168561 CHEMBL2164565 CCN(CCO)C(=O)c1cc2cccnn2c1c3cccc(c3)C(F)(F)F 4.63 CHEMBL2168569 CHEMBL2164739 COc1ccc2N=CC(=O)N(CCN3CC[C@H](NCc4ccc5OCC(=O)Nc5n4)[C@@H](F)C3)c2c1 4.72 CHEMBL2166761 CHEMBL2164745 COc1ccc2N=CC(=O)N(CCN3CC[C@@H](NCc4cc5OCCOc5cn4)[C@@H](O)C3)c2c1 4.82 CHEMBL2166761 CHEMBL2164761 CS(=O)(=O)c1ccc(cc1Cl)[C@@H](CC2CCCC2)C(=O)Nc3cnccn3 5.14 CHEMBL2167265 CHEMBL216482 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5C=CC(=O)Nc5c4)CC3 4.07 CHEMBL854890 CHEMBL216486 Fc1ccc(CCN2CCN([C@H]3CCc4cc(CN5CCC(CC5)C(F)(F)F)ccc4C3)C(=O)C2)cc1 5.7 CHEMBL854894 CHEMBL2164887 OCC1CCCCN1C(=O)c2cc3ccccn3c2c4cccc(c4)C#N 4.61 CHEMBL2168569 CHEMBL2165056 CO[C@H]1CN(CCN2C(=O)C=Nc3ccc(OC)cc23)CC[C@H]1NCc4cc5OCCOc5cn4 4.13 CHEMBL2166761 CHEMBL2165057 CO[C@H]1CN(CCN2C(=O)C=Nc3ccc(OC)cc23)CC[C@H]1NCc4ccc5OCC(=O)Nc5n4 4.06 CHEMBL2166761 CHEMBL2165060 CO[C@H]1CN(CCN2C(=O)C=Nc3ccc(OC)cc23)CC[C@@H]1NCc4cc5OCCOc5cn4 4.03 CHEMBL2166761 CHEMBL2165061 CO[C@@H]1CN(CCN2C(=O)C=Nc3ccc(OC)cc23)CC[C@H]1NCc4ccc5OCC(=O)Nc5n4 4.57 CHEMBL2166761 CHEMBL2165062 O=C1C=Cc2ccc(cc2N1CCN3CCC(CC3)NCc4cc5OCCOc5cn4)C#N 4.36 CHEMBL2166761 CHEMBL2165063 COc1ccc2N=CC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1 4.46 CHEMBL2166761 CHEMBL2165067 COc1ccc2N=CC(=O)N(CCN3CC[C@@H](NCc4ccc5OCC(=O)Nc5n4)[C@@H](F)C3)c2c1 4.5 CHEMBL2166761 CHEMBL2165068 F[C@H]1CN(CCN2C(=O)C=Cc3ccc(cc23)C#N)CC[C@@H]1NCc4cc5OCCOc5cn4 4.24 CHEMBL2166760 CHEMBL2165069 COc1ccc2N=CC(=O)N(CCN3CC[C@H](NCc4cc5OCCOc5cn4)[C@@H](F)C3)c2c1 4.13 CHEMBL2166761 CHEMBL216524 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5ncoc5c4)CC3 4.46 CHEMBL854890 CHEMBL216554 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5occc5c4)CC3 5.28 CHEMBL854890 CHEMBL216666 CN(Cc1ccc(cc1)c2ccccc2)C(=O)N3CCC[C@H]3CN4CCCC4 5.29 CHEMBL1827362 CHEMBL216680 CC(=O)Nc1ccc(CN2CCC(CC2)NC(=O)C3=CC(=O)c4ccc(F)cc4O3)cc1 4.32 CHEMBL854890 CHEMBL216741 CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c3ccc(cc3)c4ccc(Cl)cn4 4.85 CHEMBL854892 CHEMBL216821 CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c3ccc(cc3)c4ccc(F)cc4 5.75 CHEMBL854892 CHEMBL216959 Fc1ccc(CCN2CCN([C@H]3CCc4cc(CN5CCS(=O)(=O)CC5)ccc4C3)C(=O)C2)cc1 4.62 CHEMBL854894 CHEMBL2170070 C[C@@H]1CN(CCOc2cc(C)n(n2)c3ccc4ccccc4c3)C[C@H](C)O1 5.13 CHEMBL2173630 CHEMBL2170213 CC(=O)C1CCN(CCOc2ccn(n2)c3ccc(Cl)c(Cl)c3)CC1 5.35 CHEMBL2173630 CHEMBL2170225 Cc1cc(OCCN2CCOCC2)nn1c3ccc(Cl)c(Cl)c3 5.46 CHEMBL2173630 CHEMBL2170231 CN1CCN(CCOc2cc(C)n(n2)c3ccc(Cl)c(Cl)c3)CC1 5.13 CHEMBL2173630 CHEMBL2170232 CCOC(=O)N1CCN(CCOc2cc(C)n(n2)c3ccc(Cl)c(Cl)c3)CC1 5.39 CHEMBL2173630 CHEMBL2170605 CC(C)(C)C(=O)N1CCC(CC1)c2ccc(cc2C(F)(F)F)C(=O)NC(=N)N 4.57 CHEMBL2173338 CHEMBL2170611 CC(=O)N1CCC(CC1)c2cc(C)c(cc2C(F)(F)F)C(=O)NC(=N)N 5.16 CHEMBL2173338 CHEMBL2170629 NC(=N)NC(=O)c1ccc(C2CCN(CC2)C(=O)c3ccc(cc3)C#N)c(c1)C(F)(F)F 5.4 CHEMBL2173338 CHEMBL2171013 CN(C(=O)N1CCC(CC1)N2CCC(CC2)Oc3ccc(Cl)c(Cl)c3)S(=O)(=O)c4ccc(C)cc4 6.5 CHEMBL2173968 CHEMBL2171015 Clc1ccc(OC2CCN(CC2)C3CCN(CC3)S(=O)(=O)NC(=O)c4ccccc4)cc1Cl 5.2 CHEMBL2173974 CHEMBL2171016 Cc1c(Cl)ccc(OC2CCN(CC2)C3CCN(CC3)S(=O)(=O)NC(=O)c4ccccc4)c1Cl 5.4 CHEMBL2173974 CHEMBL2171033 Clc1ccc(OC2CCN(CC2)C3CCN(CC3)C(=O)NS(=O)(=O)c4ccccc4)cc1Cl 5 CHEMBL2173974 CHEMBL2171035 Clc1ccc(cc1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4 4.9 CHEMBL2173974 CHEMBL217105 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4cc5OCOc5cc4Cl)CC3 7.87 CHEMBL909940 CHEMBL217133 CCc1c(C)[nH]c2CCC\C(=N/NC(=O)Nc3ccccc3)\c12 4.68 CHEMBL907676 CHEMBL2171415 Cl.CCCOC(C1CNC1)c2ccc(Cl)c(Cl)c2 5.66 CHEMBL2176358 CHEMBL2171416 Cl.CCCOC(C1CNC1)c2ccc3ccccc3c2 6.01 CHEMBL2176358 CHEMBL2171417 Cl.C1NCC1C(Oc2ccccc2)c3ccc4ccccc4c3 6.08 CHEMBL2176358 CHEMBL2171418 Cl.Clc1ccc(OC(C2CNC2)c3ccc4ccccc4c3)cc1Cl 6.75 CHEMBL2176358 CHEMBL2171419 Cl.Fc1cc(ccc1Cl)C(Oc2ccccc2)C3CNC3 5.81 CHEMBL2176358 CHEMBL2172186 CNc1nn2c3CCN(C)Cc3cnc2c1S(=O)(=O)c4ccccc4 4.27 CHEMBL2176468 CHEMBL2172192 CNc1nn2cc3CN(C)CCc3nc2c1S(=O)(=O)c4ccccc4 6.3 CHEMBL2176468 CHEMBL217233 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5OCC(=O)Nc5c4)CC3 5.24 CHEMBL854890 CHEMBL217400 COc1cccc(CN2CCC(CC2)NC(=O)C3=CC(=O)c4ccc(F)cc4O3)c1 7.98 CHEMBL909940 CHEMBL217435 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5OC(=O)Nc5c4)CC3 4.6 CHEMBL854890 CHEMBL217442 COc1cc2OC(=CC(=O)c2cc1F)C(=O)NC3CCN(Cc4ccc5OCOc5c4)CC3 7.8 CHEMBL909940 CHEMBL217571 COc1ccc2C(=O)N(C[C@@H](O)CO)C(=C(c3ccccc3)c2c1)C#N 4.12 CHEMBL908975 CHEMBL217593 COc1ccc(CN2CCC(CC2)NC(=O)C3=CC(=O)c4ccc(F)cc4O3)cc1 8.27 CHEMBL909940 CHEMBL217706 Brc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5OCOc5c4)CC3 8.6 CHEMBL909940 CHEMBL217707 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5OC(F)(F)Oc5c4)CC3 8.25 CHEMBL909940 CHEMBL2177113 NC1=NC(c2cccc(c2)c3cncnc3)(c4ccnc(c4)C5CC5)c6cccc(F)c16 5.46 CHEMBL2182706 CHEMBL2177301 CCN1C=C(C=C(C)C1=O)C2(N=C(N)c3c(F)cccc23)c4cccc(c4)c5cncc(F)c5 5.57 CHEMBL2182706 CHEMBL2177303 CCN1C=C(C=C(C)C1=O)[C@@]2(N=C(N)c3c(F)cc(F)cc23)c4cccc(c4)c5cncc(c5)C#CC 5.51 CHEMBL2182706 CHEMBL2177304 CCN1C=C(C=C(C)C1=O)[C@@]2(N=C(N)c3c(F)cccc23)c4cccc(c4)C#CC5CC5 5.07 CHEMBL2182706 CHEMBL2177305 CCN1C=C(C=C(C)C1=O)[C@@]2(N=C(N)c3c(F)cccc23)c4cccc(NC(=O)c5ccc(Cl)cn5)c4 5.89 CHEMBL2182706 CHEMBL2177307 NC1=NC(c2ccncc2)(c3cccc(c3)c4cncnc4)c5ccccc15 4.8 CHEMBL2182706 CHEMBL2177308 NC1=NC(c2cccc(c2)c3cncnc3)(c4ccnc(c4)C(F)(F)F)c5ccccc15 5.26 CHEMBL2182706 CHEMBL2177309 NC1=NC(c2ccncc2)(c3cccc(c3)c4cncnc4)c5cccc(F)c15 5.24 CHEMBL2182706 CHEMBL2177582 CN1C[C@@H]([C@H](C1)c2ccc(\C=C\C(=O)Nc3ccccc3N)cc2F)C(=O)Nc4ccc(Cl)cc4 5.16 CHEMBL2188943 CHEMBL2177587 CN1C[C@@H]([C@H](C1)c2ccc(\C=C\C(=O)Nc3ccccc3N)cc2)C(=O)Nc4ccc(Cl)cc4 5 CHEMBL2188943 CHEMBL2177588 CN1C[C@H]([C@@H](C1)c2ccc(\C=C\C(=O)Nc3ccccc3N)cc2)C(=O)Nc4ccc(Cl)cc4 5.3 CHEMBL2188943 CHEMBL2177736 N[C@H]1CCCC[C@H]1Nc2ncc(C(=O)N)c(Nc3cccc(c3)n4nccn4)n2 5 CHEMBL3419366 CHEMBL217789 Clc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5OCOc5c4)CC3 8.44 CHEMBL909940 CHEMBL2177904 NC1=N[C@](c2ccncc2)(c3cccc(c3)c4cncnc4)c5cccc(F)c15 5.51 CHEMBL2182706 CHEMBL2177905 NC1=NC(c2ccncc2)(c3cccc(c3)c4cncc(F)c4)c5cccc(F)c15 5.8 CHEMBL2182706 CHEMBL2177906 NC1=NC(c2cccc(c2)c3cncnc3)(c4ccnc(c4)C(F)(F)F)c5cccc(F)c15 4.96 CHEMBL2182706 CHEMBL2177907 NC1=NC(c2cccc(c2)c3cncc(c3)C#N)(c4ccnc(c4)C(F)(F)F)c5cccc(F)c15 5.77 CHEMBL2182706 CHEMBL2177908 NC1=NC(c2ccnc(c2)C(F)(F)F)(c3ccc(F)c(c3)c4cncnc4)c5cccc(F)c15 4.8 CHEMBL2182706 CHEMBL2177909 NC1=N[C@](c2ccnc(c2)C(F)(F)F)(c3ccc(F)c(c3)c4cncnc4)c5cccc(F)c15 5.1 CHEMBL2182706 CHEMBL2177910 Cc1cc(cc(C)n1)C2(N=C(N)c3c(F)cccc23)c4cccc(c4)c5cncnc5 5.19 CHEMBL2182706 CHEMBL2177911 COc1cc(ccn1)C2(N=C(N)c3c(F)cccc23)c4cccc(c4)c5cncnc5 5.66 CHEMBL2182706 CHEMBL2177912 NC1=NC(c2cccc(c2)c3cncnc3)(c4ccnc(c4)C(F)F)c5cccc(F)c15 5.14 CHEMBL2182706 CHEMBL2177913 NC1=N[C@@](c2cccc(c2)c3cncnc3)(c4ccnc(c4)C(F)F)c5cccc(F)c15 5.32 CHEMBL2182706 CHEMBL2177914 NC1=N[C@@](c2cccc(c2)c3cncnc3)(c4ccnc(c4)C(F)F)c5cc(F)cc(F)c15 4.72 CHEMBL2182706 CHEMBL2177915 CC#Cc1cncc(c1)c2cccc(c2)C3(N=C(N)c4c(F)cccc34)c5ccnc(c5)C(F)F 5.54 CHEMBL2182706 CHEMBL2177916 COc1ccc(cc1)C2(N=C(N)c3c(F)cccc23)c4cccc(c4)c5cncnc5 6.3 CHEMBL2182706 CHEMBL2177917 COc1c(C)cc(nc1C)C2(N=C(N)c3c(F)cccc23)c4cccc(c4)c5cncnc5 5.42 CHEMBL2182706 CHEMBL2177918 COc1c(C)cc(cc1C#N)C2(N=C(N)c3c(F)cccc23)c4cccc(c4)c5cncnc5 5.68 CHEMBL2182706 CHEMBL2177920 CCN1C=C(C=C(C)C1=O)C2(N=C(N)c3c(F)cccc23)c4cccc(c4)c5cncnc5 4.82 CHEMBL2182706 CHEMBL217820 CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c3ccc(nc3)c4ccc(Cl)cc4 5.29 CHEMBL854892 CHEMBL2178221 Nc1ccccc1NC(=O)\C=C\c2ccc(cc2)[C@H]3CN(CCO)C[C@@H]3C(=O)Nc4ccc(Cl)cc4 4.82 CHEMBL2188943 CHEMBL2178521 COc1cc(Nc2cccc3c2nc(c4ccc(F)cc4)n3C)cnc1n5cnc(C)c5 5.75 CHEMBL2186754 CHEMBL2178522 Cc1cn(cn1)c2ccc(Nc3cccc4c3nc(c5ccc(F)cc5)n4C)nc2 5.28 CHEMBL2186754 CHEMBL217875 Fc1ccc(CCN2CCN([C@H]3CCc4cc(CN5CCOCC5)ccc4C3)C(=O)C2)cc1 4.96 CHEMBL854894 CHEMBL2179670 CC(=O)Nc1ccc(CCN2CCC(COc3nc4ccccc4c5cn(C)cc35)CC2)cc1 7.7 CHEMBL2184356 CHEMBL2179671 COCc1ccc(CCN2CCC(COc3nc4ccccc4c5cn(C)cc35)CC2)cc1 7.7 CHEMBL2184356 CHEMBL2179672 Cn1cc2c(OCC3CCN(CCc4ccc(CO)cc4)CC3)nc5ccccc5c2c1 8 CHEMBL2184356 CHEMBL2179674 Cn1cc2c(OCC3CCN(CCc4ccc(cc4)C(=O)O)CC3)nc5ccccc5c2c1 5 CHEMBL2184356 CHEMBL2179675 Cl.Cn1cc2c(OCC3CCN(CCc4ccc(N)cc4)CC3)nc5ccccc5c2c1 7.3 CHEMBL2184356 CHEMBL2179676 Cl.Cn1cc2c(OCC3CCN(CCN4CCOCC4)CC3)nc5ccccc5c2c1 5.91 CHEMBL2184356 CHEMBL2179702 Cl.CC(C)n1nc(C(=O)NCC2CCN(CCNS(=O)(=O)C)CC2)c3ccccc13 5.58 CHEMBL2184356 CHEMBL2179804 CC(C)c1ccc(NC(=O)c2cccc(c2)c3nn([C@@H]4CCCN(C4)C(=O)C=C)c5ncnc(N)c35)cc1 5.96 CHEMBL2184102 CHEMBL2179805 CC(C)c1ccc(NC(=O)c2cccc(c2)c3nn([C@@H]4CCCN(C4)C(=O)C=C)c5ncnc(N)c35)cc1C 6.52 CHEMBL2184102 CHEMBL2179806 CC(C)(C)c1ccc(CNC(=O)c2cccc(c2)c3nn([C@@H]4CCCN(C4)C(=O)C=C)c5ncnc(N)c35)cc1 5.75 CHEMBL2184102 CHEMBL2180014 CC#Cc1cncc(c1)c2cc(ccc2O)C3(N=C(C)C(=N3)N)C4CC4 4.61 CHEMBL2186062 CHEMBL2180018 COc1cccc(c1)c2cccc(c2)C3(C)N=C(C)C(=N3)N 4.78 CHEMBL2186062 CHEMBL2180021 COc1ccc(cc1)C2(N=C(N)C(=N2)C(C)C)c3cccc(c3)c4cncnc4 4.57 CHEMBL2186062 CHEMBL2180026 COc1ccc(cc1)C2(N=C(C)C(=N2)N)c3cccc(c3)c4cccnc4 4.72 CHEMBL2186062 CHEMBL2180031 COc1c(C)cc(cc1C)C2(N=C(C)C(=N2)N)c3cccc(c3)c4cncc(c4)C#CC 4.76 CHEMBL2186062 CHEMBL2180033 CC1=NC(N=C1N)(C2CC2)c3cccc(c3)c4cncc(Cl)c4 4.91 CHEMBL2186062 CHEMBL2180034 CC1=NC(N=C1N)(C2CCCCC2)c3cccc(c3)c4cccnc4 4.54 CHEMBL2186062 CHEMBL2180035 COc1cccc(c1)c2cccc(c2)C3(N=C(C)C(=N3)N)C4CCOCC4 4.68 CHEMBL2186062 CHEMBL2180037 CC#Cc1cncc(c1)c2cccc(c2)C3(N=C(C)C(=N3)N)C4CC4 4.84 CHEMBL2186062 CHEMBL2180070 C[C@@H](N1CC(C1)c2ncccn2)C3=Nc4c(cnn4C5CCCC5)C(=O)N3 4.27 CHEMBL2184696 CHEMBL2180528 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N2CCC(CC2)c3ccc(Cl)cc3 5.16 CHEMBL2184930 CHEMBL2180835 COc1ccc(cc1)c2cc(NC(=O)CCCN3CCCCC3)[nH]n2 5.34 CHEMBL2187242 CHEMBL2180840 COc1cccc(c1)c2cc(NC(=O)CCCN3CCCCC3)[nH]n2 5.51 CHEMBL2187242 CHEMBL2180841 Fc1cccc(c1)c2cc(NC(=O)CCCN3CCCCC3)[nH]n2 5.89 CHEMBL2187242 CHEMBL2180842 Fc1cncc(c1)c2cc(NC(=O)CCCN3CCCCC3)[nH]n2 4.8 CHEMBL2187242 CHEMBL2181207 CCCN1CNc2cc(Nc3ccnc4cc(Cl)ccc34)ccc2C1 7.66 CHEMBL2186404 CHEMBL2181296 CN1CCN(CC1)C(=O)c2ccc(cc2)c3cnc(N)c(c3)c4ccc(cc4)C(F)(F)F 4.79 CHEMBL2188959 CHEMBL2181297 Nc1ncc(cc1c2ccc(nc2)C(F)(F)F)c3ccc(cc3)C(=O)N4CCNCC4 4.71 CHEMBL2188959 CHEMBL2181298 Nc1ncc(cc1c2ccc(cc2)C(F)(F)F)c3ccc(cc3)C(=O)N4CCNCC4 5.26 CHEMBL2188959 CHEMBL2181486 COc1ccc(cn1)c2cc(cnc2N)c3ccc(cc3)C(=O)N4CCN(C)CC4 4.69 CHEMBL2188959 CHEMBL2181488 Nc1ncc(cc1c2ccc(nc2)C(F)(F)F)c3ccc(cc3)C(=O)N4CCOCC4 4.7 CHEMBL2188959 CHEMBL2181489 Nc1ncc(cc1c2ccc(cc2)C(F)(F)F)c3ccc(cc3)C(=O)N4CCOCC4 5.52 CHEMBL2188959 CHEMBL2181490 CN1CCN(CC1)C(=O)c2ccc(cc2)c3cnc(N)c(c3)c4ccc(nc4)C(F)(F)F 5.09 CHEMBL2188959 CHEMBL2181492 COc1ccc(cn1)c2cc(cnc2N)c3ccc(cc3)S(=O)(=O)N(C)C 5.01 CHEMBL2188959 CHEMBL2181495 COc1ccc(cn1)c2cc(cnc2N)c3ccc(cc3)S(=O)(=O)NC4CC4 5.68 CHEMBL2188959 CHEMBL2181497 COc1ccc(cn1)c2cc(cnc2N)c3ccc(cc3)S(=O)(=O)N4CCN(C)CC4 4.98 CHEMBL2188959 CHEMBL2181880 CO[C@H](C)C(=O)N[C@@H](Cc1ccc2OCOc2c1)[C@H](O)CN[C@H]3CC4(CCC4)Oc5ncc(CC(C)(C)C)cc35 4.63 CHEMBL2187047 CHEMBL218790 FC(F)(F)c1ccc(\C=C\C(=O)N2CCC[C@H]2CN3CCCC3)cc1 5.43 CHEMBL1827362 CHEMBL218836 FC(F)(F)c1ccc(CNC(=O)N2CCC[C@H]2CN3CCCC3)cc1 4.4 CHEMBL1827362 CHEMBL219074 CC(C)N1CCN(CC1)C(=O)N2CCC(Cc3ccccc3)CC2 4.43 CHEMBL1827362 CHEMBL219128 CC(C)N1CCN(CC1)C(=O)N2CCC(CC2)C(C)(C)C 4.17 CHEMBL1827362 CHEMBL219592 CC(C)N1CCN(CC1)C(=O)N2Cc3ccccc3C2 4.71 CHEMBL1827362 CHEMBL219916 Clc1ccc2N(C3CCN(CCCN4C(=O)Nc5ccccc45)CC3)C(=O)Nc2c1 6.79 CHEMBL691014 CHEMBL2203585 O[C@H]1CCCC[C@@H]1NC(=O)C2=CC(=C3C=CC=CN3C2=O)CN4CCC(CC4)(C#N)c5ccccn5 4.79 CHEMBL2211966 CHEMBL2203589 O[C@H]1CCCC[C@@H]1NC(=O)C2=CC(=C3C=CC=CN3C2=O)CN4CCC(CC4)(C#N)c5ccccc5 5.29 CHEMBL2211966 CHEMBL220360 C[C@H](NC(=O)C(C)(C)Oc1ccc(cn1)C(F)(F)F)[C@@H](Cc2ccc(Cl)cc2)c3cccc(c3)C#N 4.85 CHEMBL1227232 CHEMBL2203713 N=C(Nc1ccc2N(CCc2c1)C3CCNCC3)c4cccs4 4.89 CHEMBL2215015 CHEMBL2203764 Cc1onc(CN2CCN(CC2)c3c(Cl)cnc4[nH]c(nc34)c5cn(C)nc5C6CC6)c1 5.6 CHEMBL2214095 CHEMBL2203775 CN1CCN(CC1)c2cccc(c2)c3nc4c(N5CCN(Cc6cc(C)on6)CC5)c(Cl)cnc4[nH]3 5.02 CHEMBL2214095 CHEMBL2203841 CNc1cc(Nc2cnc(C#N)c(O[C@@H]3CCN(C)C3)n2)ncc1c4cnn(C)c4 4.62 CHEMBL2216275 CHEMBL2203842 CNc1cc(Nc2cnc(C#N)c(O[C@H]3CCN(C)C3)n2)ncc1c4cnn(C)c4 4.72 CHEMBL2216275 CHEMBL2203843 COc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1c3cnn(C)c3 5.3 CHEMBL2216275 CHEMBL2203845 COc1cc(Nc2cnc(C#N)c(O[C@@H]3CCN(C)C3)n2)ncc1c4cnn(C)c4 4.8 CHEMBL2216275 CHEMBL2203846 CSc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1c3cnn(C)c3 5.1 CHEMBL2216275 CHEMBL2203847 CNc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1C(=O)OC 5.3 CHEMBL2216275 CHEMBL2203848 CNc1cc(Nc2cnc(C#N)c(O[C@@H]3CCNC3)n2)ncc1C(=O)OC 4.8 CHEMBL2216275 CHEMBL2204242 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4ccc(nc4)C#N 4.9 CHEMBL2216324 CHEMBL2204243 Cc1ccc(cn1)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.46 CHEMBL2216324 CHEMBL2204244 COc1ccc(cn1)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.43 CHEMBL2216324 CHEMBL2204245 CN(C)c1ccc(cn1)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.65 CHEMBL2216324 CHEMBL2204246 COc1ncc(cc1C)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.67 CHEMBL2216324 CHEMBL2204247 COc1cccc(n1)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.76 CHEMBL2216324 CHEMBL2204248 COc1ccc(nc1)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.6 CHEMBL2216324 CHEMBL2204249 CCOc1ccc(cn1)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.84 CHEMBL2216324 CHEMBL2204250 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4ccc(OCC(F)(F)F)nc4 5.16 CHEMBL2216324 CHEMBL2204251 CC(C)Oc1ccc(cn1)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.95 CHEMBL2216324 CHEMBL2204252 CC(C)(C)Oc1ccc(cn1)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 5.26 CHEMBL2216324 CHEMBL2204253 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4ccc(OC5CCC5)nc4 5.01 CHEMBL2216324 CHEMBL2204255 Cn1ccnc1[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.82 CHEMBL2216324 CHEMBL2204258 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4cccs4 4.57 CHEMBL2216324 CHEMBL2204259 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4nccs4 4.5 CHEMBL2216324 CHEMBL2204260 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4ccns4 4.62 CHEMBL2216324 CHEMBL2204261 Cc1cnc(s1)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.55 CHEMBL2216324 CHEMBL2204262 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4nc5ccccc5s4 5.21 CHEMBL2216324 CHEMBL2204266 CC(C)Oc1ncc(s1)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 4.55 CHEMBL2216324 CHEMBL2204267 CSc1ncc(s1)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F 5.22 CHEMBL2216324 CHEMBL2204269 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4cncnc4 4.36 CHEMBL2216324 CHEMBL2204270 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNC(=O)c3cccc(c3)C(F)(F)F)c4ccc(F)nc4 5 CHEMBL2216324 CHEMBL2204275 O[C@H]1CCCC[C@@H]1NC(=O)C2=CC(=C3C=CC=CN3C2=O)CN4CCN(CC4)c5ccc(cc5)C#N 6.41 CHEMBL2211966 CHEMBL2204276 Cc1ccc(nc1)N2CCN(CC3=C4C=CC=CN4C(=O)C(=C3)C(=O)N[C@H]5CCCC[C@@H]5O)CC2 4.94 CHEMBL2211966 CHEMBL2204277 O[C@H]1CCCC[C@@H]1NC(=O)C2=CC(=C3C=CC=CN3C2=O)CN4CCN(CC4)c5cc6ccccc6cn5 5.7 CHEMBL2211966 CHEMBL2204278 O[C@H]1CCCC[C@@H]1NC(=O)C2=CC(=C3C=CC=CN3C2=O)CN4CCN(CC4)c5cc6scnc6cn5 4.88 CHEMBL2211966 CHEMBL2204583 COC(=O)c1cnc(Nc2cnc(C#N)c(O[C@@H]3CCNC3)n2)cc1N(C)C 4.52 CHEMBL2216275 CHEMBL2204586 CNc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1Cl 6 CHEMBL2216275 CHEMBL2204587 CNc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1C(F)(F)F 6 CHEMBL2216275 CHEMBL2204588 CNc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1C3CC3 5.22 CHEMBL2216275 CHEMBL2204589 CNc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1C#C 5.1 CHEMBL2216275 CHEMBL2204592 CNc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1c3cnn(C)c3 4.92 CHEMBL2216275 CHEMBL2204935 Cc1onc(n1)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cc6)c7cnn(C)c7 5.47 CHEMBL3378638 CHEMBL2204941 Fc1ccc(cc1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 6.42 CHEMBL3779605 CHEMBL2206790 COCC[C@H](Oc1ncnc2c1cnn2c3ccccc3Cl)C(=O)Nc4ccc(C)cn4 4.66 CHEMBL2215193 CHEMBL2206791 COCC[C@H](Oc1ncnc2c1cnn2c3ccccc3C(F)(F)F)C(=O)Nc4ccc(C)cn4 4.59 CHEMBL2215193 CHEMBL2207276 Cc1cc(Cl)ccc1OC2CCN(C[C@H](O)CNC(=O)C3=CNC(=O)c4cc(ccc34)S(=O)(=O)C)CC2 5.7 CHEMBL2215146 CHEMBL2207280 O[C@H](CNC(=O)C1=CNC(=O)c2ccc(F)cc12)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4 5.9 CHEMBL2215146 CHEMBL2207281 OCCNS(=O)(=O)c1ccc2C(=CNC(=O)c2c1)C(=O)NC[C@@H](O)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4 5.3 CHEMBL2215146 CHEMBL2207284 CNS(=O)(=O)c1ccc2C(=CNC(=O)c2c1)C(=O)NC[C@@H](O)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4 5.7 CHEMBL2215146 CHEMBL2207285 O[C@H](CNC(=O)C1=CNC(=O)c2cc(ccc12)S(=O)(=O)NC3CC3)CN4CCC(CC4)Oc5ccc(Cl)c(Cl)c5 6.1 CHEMBL2215146 CHEMBL2207286 CN(C)S(=O)(=O)c1ccc2C(=CNC(=O)c2c1)C(=O)NC[C@@H](O)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4 6 CHEMBL2215146 CHEMBL2207500 Cc1nn(C)cc1c2nc3c(N4CCN(Cc5nocn5)CC4)c(Cl)cnc3[nH]2 4.96 CHEMBL2214095 CHEMBL2207501 Cc1onc(CN2CCN(CC2)c3c(Cl)cnc4[nH]c(nc34)c5cn(C)nc5C)n1 5.02 CHEMBL2214095 CHEMBL2207518 Cc1onc(CN2CCN(CC2)c3c(Cl)cnc4[nH]c(nc34)c5cn(C)nc5C)c1 5.2 CHEMBL2214095 CHEMBL2207654 O[C@H](CNC(=O)C1=CNC(=O)c2cc(ccc12)S(=O)(=O)N3CCC3)CN4CCC(CC4)Oc5ccc(Cl)c(Cl)c5 6 CHEMBL2215146 CHEMBL2207655 CC1(O)CN(C1)S(=O)(=O)c2ccc3C(=CNC(=O)c3c2)C(=O)NC[C@@H](O)CN4CCC(CC4)Oc5ccc(Cl)c(Cl)c5 5.5 CHEMBL2215146 CHEMBL2207656 O[C@H](CNC(=O)C1=CNC(=O)c2c(F)cccc12)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4 5.7 CHEMBL2215146 CHEMBL2207658 O[C@H](CNC(=O)c1c[nH]nc1C(F)(F)F)CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3 5.5 CHEMBL2215143 CHEMBL2207659 Cc1cc(Cl)ccc1OC2CCN(C[C@H](O)CNC(=O)c3c[nH]nc3C(F)(F)F)CC2 5.5 CHEMBL2215146 CHEMBL2207660 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]nc3C(F)(F)F)CC2)c1Cl 5.7 CHEMBL2215146 CHEMBL2207661 O[C@H](CNC(=O)c1c[nH]nc1C2CC2)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4 5.6 CHEMBL2215146 CHEMBL2207662 O[C@H](CNC(=O)C1=CNC(=O)C=C1C(F)(F)F)CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3 5 CHEMBL2215143 CHEMBL2207663 Cc1cc(Cl)ccc1OC2CCN(C[C@H](O)CNC(=O)C3=CNC(=O)C=C3C(F)(F)F)CC2 5 CHEMBL2215143 CHEMBL2207664 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)C3=CNC(=O)C=C3C(F)(F)F)CC2)c1Cl 5.3 CHEMBL2215146 CHEMBL2207665 CN1C=C(C(=O)NC[C@@H](O)CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3)C(=CC1=O)C(F)(F)F 4.9 CHEMBL2215146 CHEMBL2207666 O[C@H](CNC(=O)C1=CNC(=O)c2ccccc12)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4 5.1 CHEMBL2215806 CHEMBL2207671 CS(=O)(=O)c1ccc2C(=CNC(=O)c2c1)C(=O)NC[C@@H](O)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4 5.2 CHEMBL2215146 CHEMBL2207733 Cc1ccnc2nc(Oc3ccc(CN4CCCCC4)cc3)sc12 5.09 CHEMBL2210904 CHEMBL2207738 O=C1CCCN1C2CCN(CCOc3ccc(Oc4nc5ncccc5s4)cc3)CC2 5.6 CHEMBL2210902 CHEMBL2207744 O=C1CCCN1C2CCN(CCc3ccc(Oc4nc5ncccc5s4)cc3)CC2 5.55 CHEMBL2210902 CHEMBL2207747 CC(=O)NC1CC2CCC(C1)N2CCc3ccc(Oc4nc5ncccc5s4)cc3 5.08 CHEMBL2210904 CHEMBL2207752 NC(=O)C1CCN(Cc2ccc(Oc3nc4ncccc4s3)cc2)CC1 5.05 CHEMBL2210904 CHEMBL2208427 COc1cc(ccc1N)C(=O)NC[C@@H](O)CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3 6.6 CHEMBL2215806 CHEMBL2208429 O[C@H](CNC(=O)c1n[nH]c2ccccc12)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4 6.6 CHEMBL2215806 CHEMBL2208430 O[C@H](CNC(=O)c1c[nH]c2ccccc12)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4 5.7 CHEMBL2215806 CHEMBL2208431 O[C@H](CNC(=O)C1=NNC(=O)c2ccccc12)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4 6.4 CHEMBL2215806 CHEMBL2208432 O[C@H](CNC(=O)N1C(=O)Nc2ccccc12)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4 6.3 CHEMBL2215806 CHEMBL2208433 CN(C[C@@H](O)CN1CCC(CC1)Oc2ccc(Cl)c(Cl)c2)C(=O)C3=CNC(=O)c4ccccc34 5.7 CHEMBL2215806 CHEMBL2208435 O[C@H](CNC(=O)c1cnnc2ccccc12)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4 5.2 CHEMBL2215806 CHEMBL2216904 COc1cc2CCN(C)[C@H](Cc3ccc(O)c(Oc4ccc(C[C@H]5N(C)CCc6cc(OC)c(OC)cc56)cc4)c3)c2cc1O 5.02 CHEMBL2217332 CHEMBL221753 [Cl-].CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 6.97 CHEMBL1909190 CHEMBL221906 CN(C)C(=N)c1ccc(cc1)C(=O)Nc2ccc(Cl)cc2C(=O)Nc3ccc(Cl)cn3 6.48 CHEMBL968701 CHEMBL223219 CN1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCOc6cccnc6)c2)CC1 5.47 CHEMBL914755 CHEMBL223943 CC#Cc1cc(cs1)c2n[nH]c3c2Cc4cc(CN5CCN(C)CC5)ccc34 5.85 CHEMBL914755 CHEMBL223971 COCCOCC#Cc1cc(cs1)c2n[nH]c3c2Cc4ccc(Cn5cncn5)cc34 4.94 CHEMBL914758 CHEMBL223997 CCCC#Cc1cc(cs1)c2n[nH]c3c2Cc4cc(CN5CCN(C)CC5)ccc34 5.75 CHEMBL914755 CHEMBL223998 CN1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCCc6ccccc6)c2)CC1 5.32 CHEMBL914755 CHEMBL223999 CN1CCC(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCOc6ccccc6)c2)CC1 5.68 CHEMBL914755 CHEMBL224497 CN1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCOc6ccc(C)c(C)c6)c2)CC1 5.6 CHEMBL914755 CHEMBL224547 CN1CCN(CC1)c2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCOc6ccccc6)c2 5.76 CHEMBL914755 CHEMBL224834 C(Oc1ccccc1)C#Cc2cc(cs2)c3n[nH]c4c3Cc5cc(Cn6ccnc6)ccc45 5.85 CHEMBL914755 CHEMBL224918 C(Oc1ccccc1)C#Cc2cc(cs2)c3n[nH]c4c3Cc5cc(Cn6cncn6)ccc45 5.77 CHEMBL914758 CHEMBL224968 CN1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCNC(=O)Oc6ccccc6)c2)CC1 5.56 CHEMBL914755 CHEMBL225036 COCC#Cc1cc(cs1)c2n[nH]c3c2Cc4cc(CN5CCN(C)CC5)ccc34 5.29 CHEMBL914755 CHEMBL225090 CN1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCCOc6ccccc6)c2)CC1 6.35 CHEMBL914755 CHEMBL225193 COCCOCC#Cc1cc(cs1)c2n[nH]c3c2Cc4cc(CN5CCN(C)CC5)ccc34 5.04 CHEMBL914755 CHEMBL225240 CN1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCOc6ccc(CN7CCOCC7)cc6)c2)CC1 5.59 CHEMBL914755 CHEMBL225261 NC(=O)N1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCOc6ccccc6)c2)CC1 5.27 CHEMBL914755 CHEMBL225311 CN1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCNC(=O)c6ccccc6)c2)CC1 5.13 CHEMBL914755 CHEMBL225318 CN1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCOc6ccccc6Cl)c2)CC1 6.1 CHEMBL914755 CHEMBL225319 CN1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCOc6cccc(Cl)c6)c2)CC1 5.59 CHEMBL914755 CHEMBL225334 CN1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCOc6ccccc6)c2)C(=O)C1 4.28 CHEMBL914758 CHEMBL225336 CN1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCNC(=O)Nc6ccccc6)c2)CC1 5.1 CHEMBL914755 CHEMBL227000 CC1(C)C2=C3CC4C(CC[N+]5=C4C(C)(C)c6cc(ccc56)S(=O)(=O)[O-])OC3CCN2c7ccc(CC(=O)NCCCCCCN(CCOc8ccc(NS(=O)(=O)C)cc8)CCc9ccc(NS(=O)(=O)C)cc9)cc17 6.51 CHEMBL889312 CHEMBL228814 CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3cc(Cl)ccc3C(=O)N2Cc4ccccc4 5.32 CHEMBL2025095 CHEMBL229008 CCN1CCN(CC1)c2ccc(cn2)C(C)(C)NC(=O)c3cc4Nc5ccccc5C(=O)c4cc3F 4.6 CHEMBL890380 CHEMBL23 COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(=O)C 4.76 CHEMBL691014 CHEMBL230984 N[C@H]1CN(CC[C@@H]1c2cc(F)c(F)cc2F)c3ccncn3.OC(=O)C(F)(F)F 4.58 CHEMBL888509 CHEMBL231196 N[C@H]1CN(CC[C@@H]1c2cc(F)c(F)cc2F)c3cnc4nccnc4n3.OC(=O)C(F)(F)F 5 CHEMBL888509 CHEMBL2312142 COc1cc(Nc2cc(ccn2)c3cccc(c3)C#N)ccc1N4CCN(C)CC4 5.89 CHEMBL2317008 CHEMBL2312146 COc1cc(Nc2cc(ccn2)c3cccc(c3)C#N)ccc1N4CCOCC4 5.11 CHEMBL2317008 CHEMBL2312148 COc1ccc(cc1c2ccnc(Nc3ccc(N4CCOCC4)c(OC)c3)c2)C#N 5.33 CHEMBL2317008 CHEMBL2312150 COc1ccc(Cl)cc1c2ccnc(Nc3ccc(N4CCOCC4)c(OC)c3)c2 4.7 CHEMBL2317008 CHEMBL231293 N[C@H]1CN(CC[C@@H]1c2cc(F)c(F)cc2F)c3ccc4nc(nn4n3)C(F)(F)F.OC(=O)C(F)(F)F 5.09 CHEMBL888509 CHEMBL231294 N[C@H]1CN(CC[C@@H]1c2cc(F)c(F)cc2F)c3ccn4cnnc4n3.OC(=O)C(F)(F)F 4 CHEMBL888509 CHEMBL2313767 COC1COCCC1N[C@@H]2C[C@H]3CCC[C@]3(C2)C(=O)N4CCc5ccc(cc5C4)C#N 4.47 CHEMBL2318190 CHEMBL2313768 COC1COCCC1N[C@@H]2C[C@H]3CCC[C@]3(C2)C(=O)N4CCc5ccc(OC(F)(F)F)cc5C4 5.13 CHEMBL2318190 CHEMBL2313782 COC1COCCC1N[C@@H]2C[C@H]3CCC[C@]3(C2)C(=O)N4CCc5ncc(Cl)cc5C4 4.48 CHEMBL2318190 CHEMBL2313783 COC1COCCC1N[C@@H]2C[C@H]3CCC[C@]3(C2)C(=O)N4CCc5ncc(Br)cc5C4 4.31 CHEMBL2318190 CHEMBL2313786 COC1COCCC1N[C@@H]2C[C@H]3CCC[C@]3(C2)C(=O)N4CCc5ncc(OC)cc5C4 4.33 CHEMBL2318190 CHEMBL231396 N[C@H]1CN(CC[C@@H]1c2cc(F)c(F)cc2F)C3=NN4C=CC(=O)N=C4C=C3.OC(=O)C(F)(F)F 4 CHEMBL888509 CHEMBL231397 CC1=CC(=O)N2N=C(C=CC2=N1)N3CC[C@@H]([C@@H](N)C3)c4cc(F)c(F)cc4F.OC(=O)C(F)(F)F 4.48 CHEMBL888509 CHEMBL2314050 COC1COCCC1N[C@@H]2C[C@H]3CCC[C@]3(C2)C(=O)N4CCc5ncc(OC(C)C)cc5C4 4.33 CHEMBL2318190 CHEMBL2314051 COC1COCCC1N[C@@H]2C[C@H]3CCC[C@]3(C2)C(=O)N4CCc5ccc(F)cc5C4 4.63 CHEMBL2318190 CHEMBL2314052 COC1COCCC1N[C@@H]2C[C@H]3CCC[C@]3(C2)C(=O)N4CCc5ccc(Cl)cc5C4 4.37 CHEMBL2318190 CHEMBL2314053 COC1COCCC1N[C@@H]2C[C@H]3CCC[C@]3(C2)C(=O)N4CCc5ccc(Br)cc5C4 4.69 CHEMBL2318190 CHEMBL2314054 COC1COCCC1N[C@@H]2C[C@H]3CCC[C@]3(C2)C(=O)N4CCc5ccc(cc5C4)C(F)(F)F 4.56 CHEMBL2318190 CHEMBL2314056 FC(F)(F)c1cnc2CCN(Cc2c1)C(=O)[C@@]34CCC[C@@H]3C[C@H](C4)NC5CCCC5 4.48 CHEMBL2318190 CHEMBL2314057 FC(F)(F)c1cnc2CCN(Cc2c1)C(=O)[C@@]34CCC[C@@H]3C[C@H](C4)NC5CCCCC5 4.47 CHEMBL2318190 CHEMBL2314058 FC(F)(F)c1cnc2CCN(Cc2c1)C(=O)[C@@]34CCC[C@@H]3C[C@H](C4)NC5CCCCCC5 4.83 CHEMBL2318190 CHEMBL2314059 FC(F)(F)c1cnc2CCN(Cc2c1)C(=O)[C@@]34CCC[C@@H]3C[C@H](C4)NC5CCSCC5 4.64 CHEMBL2318190 CHEMBL2314061 FC(F)(F)c1cnc2CCN(Cc2c1)C(=O)[C@@]34CCC[C@@H]3C[C@H](C4)NC5CCOCC5 4.59 CHEMBL2318190 CHEMBL2314062 FC(F)(F)c1cnc2CCN(Cc2c1)C(=O)[C@@]34CCC[C@@H]3C[C@H](C4)NCC5CCOCC5 4.33 CHEMBL2318190 CHEMBL2314064 FC(F)(F)c1cnc2CCN(Cc2c1)C(=O)[C@@]34CCCC[C@@H]3C[C@H](C4)NC5CCOCC5 4.41 CHEMBL2318190 CHEMBL2314065 COC1COCCC1N[C@@H]2C[C@H]3CCCC[C@]3(C2)C(=O)N4CCc5ncc(cc5C4)C(F)(F)F 4.39 CHEMBL2318190 CHEMBL231497 Cc1nnc2ccc(nn12)N3CC[C@@H]([C@@H](N)C3)c4cc(F)c(F)cc4F.OC(=O)C(F)(F)F 4.69 CHEMBL888509 CHEMBL2315920 FC(F)(F)c1ccc2ncnc(NCC(=O)NC3CN(C3)[C@@H]4CC[C@@H](CC4)c5ccccc5)c2c1 5.28 CHEMBL2320519 CHEMBL2315921 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNc3ncnc4ccc(cc34)C(F)(F)F)c5ccccc5 4.77 CHEMBL2320519 CHEMBL2315923 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNc3ncnc4ccc(cc34)C(F)(F)F)c5ccns5 4.55 CHEMBL2320519 CHEMBL2315926 CC(C)c1ncc(s1)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNc4ncnc5ccc(cc45)C(F)(F)F 4.43 CHEMBL2320519 CHEMBL2315927 COc1ccc(cn1)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNc4ncnc5ccc(cc45)C(F)(F)F 4.55 CHEMBL2320519 CHEMBL2315928 COc1cccc(n1)[C@@]2(O)CC[C@H](CC2)N3CC(C3)NC(=O)CNc4ncnc5ccc(cc45)C(F)(F)F 4.87 CHEMBL2320519 CHEMBL2315929 Nc1cnccc1[C@@H]2CC[C@@H](CC2)N3CC(C3)NC(=O)CNc4ncnc5ccc(cc45)C(F)(F)F 4.34 CHEMBL2320519 CHEMBL2315930 COc1cnccc1[C@@H]2CC[C@@H](CC2)N3CC(C3)NC(=O)CNc4ncnc5ccc(cc45)C(F)(F)F 4.7 CHEMBL2320519 CHEMBL2315931 FC(F)(F)c1ccc2ncnc(NCC(=O)NC3CN(C3)[C@@H]4CC[C@@H](CC4)c5cccnc5)c2c1 4.8 CHEMBL2320519 CHEMBL2315932 Oc1ccc(nc1)[C@@H]2CC[C@@H](CC2)N3CC(C3)NC(=O)CNc4ncnc5ccc(cc45)C(F)(F)F 4.89 CHEMBL2320519 CHEMBL2315933 Nc1cccnc1[C@@H]2CC[C@@H](CC2)N3CC(C3)NC(=O)CNc4ncnc5ccc(cc45)C(F)(F)F 5.08 CHEMBL2320519 CHEMBL2315934 FC(F)(F)c1ccc2ncnc(NCC(=O)NC3CN(C3)[C@@H]4CC[C@@H](CC4)c5ccccn5)c2c1 5.13 CHEMBL2320519 CHEMBL2315935 Oc1ccccc1[C@@H]2CC[C@@H](CC2)N3CC(C3)NC(=O)CNc4ncnc5ccc(cc45)C(F)(F)F 5.18 CHEMBL2320519 CHEMBL2315936 FC(F)(F)c1ccc2ncnc(NCC(=O)NC3CN(C3)[C@@H]4CC[C@@H](CC4)c5ccccc5C#N)c2c1 5.68 CHEMBL2320519 CHEMBL2315937 Cc1nc(NCC(=O)NC2CN(C2)[C@@H]3CC[C@@](O)(CC3)c4cncs4)c5cc(ccc5n1)C(F)(F)F 4.59 CHEMBL2320519 CHEMBL2315938 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNc3nc(nc4ccc(cc34)C(F)(F)F)C(F)(F)F)c5cncs5 4.49 CHEMBL2320519 CHEMBL2315939 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNc3cc(nc4ccc(cc34)C(F)(F)F)C(F)(F)F)c5cncs5 4.44 CHEMBL2320519 CHEMBL2315940 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNc3cc(nc4ccc(cc34)C(F)(F)F)C#N)c5cncs5 4.46 CHEMBL2320519 CHEMBL2315941 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNc3ccnc4ccc(cc34)C(F)(F)F)c5cncs5 4.95 CHEMBL2320519 CHEMBL2316209 O[C@@]1(CC[C@H](CC1)N2CC(C2)NC(=O)CNc3nccc4ccc(cc34)C(F)(F)F)c5cncs5 4.48 CHEMBL2320519 CHEMBL2316378 COc1ccc(NC(=O)c2ccc(Cn3ccnn3)c4ccccc24)c(n1)C(=O)NCC5CCOCC5 4.96 CHEMBL2320190 CHEMBL2316385 C[S+]([O-])Cc1ccc(C(=O)Nc2nccnc2C(=O)NCC3CCC3)c4ccccc14 4.77 CHEMBL2320190 CHEMBL2321995 CN1CC=CCC(C1)c2ccc(Cl)c(Cl)c2 5.12 CHEMBL2327304 CHEMBL2321996 CN1CC=CC[C@@H](C1)c2ccc(Cl)c(Cl)c2 5 CHEMBL2327304 CHEMBL2321998 Clc1ccc(cc1Cl)C2CNCC=CC2 4.96 CHEMBL2327304 CHEMBL2321999 Clc1ccc(cc1Cl)[C@@H]2CNCC=CC2 4.68 CHEMBL2327304 CHEMBL2322000 Clc1ccc(cc1Cl)[C@H]2CNCC=CC2 4.86 CHEMBL2327304 CHEMBL2322001 C1NCC(CC=C1)c2ccc3ccccc3c2 4.81 CHEMBL2327304 CHEMBL2322611 Cl.COCCCOc1cc(ccc1OC)C(=O)N(C[C@@H]2CNC[C@H]2Cc3ccccc3)C(C)C 4.84 CHEMBL2330862 CHEMBL2322875 COc1cc(ccc1Cl)N2CCN(CC2)C(=O)Cn3nc(c(Cl)c3C)C(F)(F)F 4.8 CHEMBL2328652 CHEMBL2323191 OC[C@@H]1OC(=O)N2[C@H]1COc3cc(ccc23)c4ccc(nc4)C#N 4.74 CHEMBL2329729 CHEMBL2324239 C[n+]1c(cccc1C#CCOc2ccc(Cl)cc2)C#CCOc3ccc(Cl)cc3 4.51 CHEMBL2330781 CHEMBL2324242 C[n+]1c(CCCOc2ccccc2)cccc1CCCOc3ccccc3 6.68 CHEMBL2330781 CHEMBL2324243 COc1ccc(OCCCc2cccc(CCCOc3ccc(OC)cc3)[n+]2C)cc1 6.8 CHEMBL2330781 CHEMBL2324244 C[n+]1c(CCCOc2ccc(Cl)cc2)cccc1CCCOc3ccc(Cl)cc3 7.85 CHEMBL2330781 CHEMBL2324245 C[n+]1c(CCCOc2cccc(Cl)c2)cccc1CCCOc3cccc(Cl)c3 7.22 CHEMBL2330781 CHEMBL2324246 C[n+]1c(CCCOc2ccccc2Cl)cccc1CCCOc3ccccc3Cl 7.13 CHEMBL2330781 CHEMBL2324247 C(Oc1ccccc1)c2cccc(COc3ccccc3)n2 7.13 CHEMBL2330781 CHEMBL2324248 C[n+]1c(COc2ccccc2)cccc1COc3ccccc3 6.12 CHEMBL2330781 CHEMBL2324250 C(Cc1cccc(CCc2ccccc2)n1)c3ccccc3 5.79 CHEMBL2330781 CHEMBL2324251 C[n+]1c(CCc2ccccc2)cccc1CCc3ccccc3 6.33 CHEMBL2330781 CHEMBL2324254 CN(CCOc1ccc(C)cc1)CCc2ccc(C)cc2 8.29 CHEMBL2330781 CHEMBL2324256 Cc1ccc(OCCCc2cc(N)cc(CCCOc3ccc(C)cc3)n2)cc1 6.77 CHEMBL2330781 CHEMBL2324257 Clc1ccc(OCCCc2cccc(CCCOc3ccc(Cl)cc3)n2)cc1 8 CHEMBL2330781 CHEMBL2324261 Cc1ccc(Cc2cc[n+](C)c(COc3ccc(C)cc3)c2)cc1.[O-]S(=O)(=O)C(F)(F)F 6.46 CHEMBL2330781 CHEMBL2324262 Cc1ccc(OCc2cccc(COc3ccc(C)cc3)[n+]2C)cc1 7.28 CHEMBL2330781 CHEMBL2324263 Cc1ccc(COCc2cccc(COCc3ccc(C)cc3)[n+]2C)cc1 6.97 CHEMBL2330781 CHEMBL2324264 Cc1ccc(CCOCc2cccc(COCCc3ccc(C)cc3)[n+]2C)cc1 6.87 CHEMBL2330781 CHEMBL2324510 Fc1cc(ccc1N2CCC(=CC#N)CC2)N3C[C@H](Cn4ccnn4)OC3=O 4.31 CHEMBL2327767 CHEMBL2324511 Fc1cn(C[C@H]2CN(C(=O)O2)c3ccc(N4CCC(=CC#N)CC4)c(F)c3)nn1 5.63 CHEMBL2327767 CHEMBL2324520 CC(=C1CCN(CC1)c2ccc(cc2F)N3C[C@H](Cn4cc(F)nn4)OC3=O)C#N 4.68 CHEMBL2327767 CHEMBL2325199 Cc1ccc(CCCOCc2cccc(COCCCc3ccc(C)cc3)[n+]2C)cc1 6.71 CHEMBL2330743 CHEMBL2325200 Cc1ccc(cc1)C#CCOCc2cccc(COCC#Cc3ccc(C)cc3)[n+]2C 6.67 CHEMBL2330743 CHEMBL2325201 Cc1ccc(cc1)C#Cc2cccc(C#Cc3ccc(C)cc3)[n+]2C 6.55 CHEMBL2330781 CHEMBL2325203 Cc1ccc(CCOCC#Cc2cccc(C#CCOCCc3ccc(C)cc3)[n+]2C)cc1 4.84 CHEMBL2330781 CHEMBL2325204 Cc1ccc(CCc2cccc(CCc3ccc(C)cc3)[n+]2C)cc1 7.62 CHEMBL2330781 CHEMBL2325205 Cc1ccc(OCCCc2cccc(CCCOc3ccc(C)cc3)[n+]2C)cc1 6.02 CHEMBL2330743 CHEMBL2325206 Cc1ccc(CCOCCCc2cccc(CCCOCCc3ccc(C)cc3)[n+]2C)cc1 6.43 CHEMBL2330781 CHEMBL2325207 CCCCCCC#Cc1cccc(C#CCCCCCC)[n+]1C 5.7 CHEMBL2330781 CHEMBL2325208 CCCCCCCCc1cccc(CCCCCCCC)[n+]1C 7.82 CHEMBL2330781 CHEMBL2325209 Cc1ccc(OCCCc2cccc(C#CCOc3ccc(C)cc3)[n+]2C)cc1 5.54 CHEMBL2330781 CHEMBL2325210 C[n+]1c(cccc1C#Cc2ccccc2)C#Cc3ccccc3 6.26 CHEMBL2330781 CHEMBL2325211 C[n+]1c(cccc1C#CC2CCCCC2)C#CC3CCCCC3 5.36 CHEMBL2330781 CHEMBL2325212 C[n+]1c(cccc1C#Cc2ccc(cc2)c3ccccc3)C#Cc4ccc(cc4)c5ccccc5 6.53 CHEMBL2330781 CHEMBL2325213 COc1ccc(cc1)C#Cc2cccc(C#Cc3ccc(OC)cc3)[n+]2C 6.42 CHEMBL2330781 CHEMBL2325214 C[n+]1c(cccc1C#Cc2ccc(Cl)cc2)C#Cc3ccc(Cl)cc3 5.94 CHEMBL2330781 CHEMBL2325215 C[n+]1c(cccc1C#Cc2cccc(Cl)c2)C#Cc3cccc(Cl)c3 5.4 CHEMBL2330781 CHEMBL2325216 C[n+]1c(cccc1C#Cc2ccccc2Cl)C#Cc3ccccc3Cl 5.41 CHEMBL2330781 CHEMBL2325217 C[n+]1c(cccc1C#CCOc2ccccc2)C#CCOc3ccccc3 4.85 CHEMBL2330781 CHEMBL2325429 CC(C)[C@@H](N(CCCN)C(=O)c1ccc(C)cc1)C2=C(Cc3ccccc3)C(=O)c4ccc(Cl)cc4O2 5.8 CHEMBL2327410 CHEMBL2325436 COc1ccc(cc1)C(CCCN)(c2ccccc2)c3ccccc3 5.18 CHEMBL2327410 CHEMBL2325697 C[C@@H]1COCCN1c2cc(nc(n2)c3cccc4[nH]ccc34)C5(CC5)S(=O)(=O)C 4.3 CHEMBL2330583 CHEMBL2325728 NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)N[C@@H](CCN4CCCC4)c5ccc(Cl)cc5 4.68 CHEMBL2330875 CHEMBL2325729 NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)N[C@@H](CCN4CCCCC4)c5ccc(Cl)cc5 4.53 CHEMBL2330875 CHEMBL2325736 CS(=O)(=O)NCCC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4 4.1 CHEMBL2330875 CHEMBL2325739 NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)NC(CCCO)c4ccc(Cl)cc4 4.24 CHEMBL2330875 CHEMBL2325740 COCCC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4 5.03 CHEMBL2330875 CHEMBL2325742 C[C@@H](NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4 5.04 CHEMBL2330875 CHEMBL2325743 C[C@H](NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4 5.17 CHEMBL2330875 CHEMBL2325982 CCC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4 5.19 CHEMBL2330875 CHEMBL2325983 NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)NC(C4CC4)c5ccc(Cl)cc5 5.59 CHEMBL2330875 CHEMBL2325984 NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)NC(c4ccccc4)c5ccc(Cl)cc5 5.8 CHEMBL2330875 CHEMBL2325985 NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)NC(Cc4ccccc4)c5ccc(Cl)cc5 5.46 CHEMBL2330875 CHEMBL2325987 CC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(F)cc4 4.57 CHEMBL2330875 CHEMBL2325995 NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)NC(CCCN4CCOCC4)c5ccc(Cl)cc5 4.13 CHEMBL2330875 CHEMBL2325997 CC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4 5.14 CHEMBL2330875 CHEMBL2326469 Nc1nc2cc3CCN(Cc4cscn4)CCc3cc2s1 4.82 CHEMBL2328742 CHEMBL2326476 Nc1nc2cc3CCN(Cc4ccccc4)CCc3cc2s1 5.11 CHEMBL2328742 CHEMBL2326477 Nc1nc2cc3CCN(Cc4ccc(F)cc4)CCc3cc2s1 5.44 CHEMBL2328742 CHEMBL2326478 Nc1nc2cc3CCN(Cc4cccc(F)c4)CCc3cc2s1 5.17 CHEMBL2328742 CHEMBL2326479 COc1ccc(CN2CCc3cc4nc(N)sc4cc3CC2)cc1 5.48 CHEMBL2328742 CHEMBL2326480 COc1cccc(CN2CCc3cc4nc(N)sc4cc3CC2)c1 5.18 CHEMBL2328742 CHEMBL2326481 CN(C)C(=O)c1ccc(CN2CCc3cc4nc(N)sc4cc3CC2)cc1 4.92 CHEMBL2328742 CHEMBL2326483 Nc1nc2cc3CCN(Cc4ccccn4)CCc3cc2s1 4.89 CHEMBL2328742 CHEMBL2326484 Nc1nc2cc3CCN(Cc4cccnc4)CCc3cc2s1 4.68 CHEMBL2328742 CHEMBL2326489 CCN1CCc2cc3nc(N)sc3cc2CC1 4.54 CHEMBL2328742 CHEMBL2326490 Nc1nc2cc3CCN(CCc3cc2s1)C4CC4 4.89 CHEMBL2328742 CHEMBL2326684 CN1CC=CCC(C1)c2ccc(Cl)c(C)c2 4.59 CHEMBL2327304 CHEMBL2326685 Cc1cc(ccc1Cl)C2CNCC=CC2 4.59 CHEMBL2327304 CHEMBL2326686 Fc1ccc(cc1Cl)C2CNCC=CC2 4.64 CHEMBL2327304 CHEMBL2326689 CN1CC=CCC(C1)c2oc3ccccc3c2 4.82 CHEMBL2327304 CHEMBL2326690 C1NCC(CC=C1)c2oc3ccccc3c2 4.72 CHEMBL2327304 CHEMBL2326691 CN1CCCCC(C1)c2ccc(Cl)c(Cl)c2 5 CHEMBL2327304 CHEMBL2326692 Clc1ccc(cc1Cl)C2CCCCNC2 5.22 CHEMBL2327304 CHEMBL2326693 OCCN1CC=CC[C@@H](C1)c2ccc(Cl)c(Cl)c2 5 CHEMBL2327304 CHEMBL2326694 COCCN1CC=CC[C@@H](C1)c2ccc(Cl)c(Cl)c2 5.28 CHEMBL2327304 CHEMBL233047 N.CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1 6.52 CHEMBL890046 CHEMBL2331605 C[C@@H]1CN(C[C@H](C)O1)c2nc(N3CCOC[C@@H]3C)c4ncc(nc4n2)c5ccccc5 4.88 CHEMBL2338825 CHEMBL2331648 CCNc1nc2CCN(Cc2c(n1)C(=O)N)C(=O)CCc3ccc(OC(F)(F)F)cc3 5.34 CHEMBL2339897 CHEMBL2331678 CCNC(=O)Nc1ccc(cc1)c2nc3CN(CCc3c(n2)N4CCOC[C@@H]4C)C(C)C 5.07 CHEMBL2344471 CHEMBL2331747 CC1=CN([C@H]2CCCN(C2)S(=O)(=O)c3ccc(O)c(Oc4cccc(Cl)c4)c3)C(=O)NC1=O 4.57 CHEMBL2342062 CHEMBL2333604 CN1CCC(COCc2cc(cc(n2)C3CC3)C(F)(F)F)(CC1)c4ccccc4 5.05 CHEMBL2342727 CHEMBL2333605 FC(F)(F)c1cc(COCC2(CCNCC2)c3ccccc3)nc(c1)C4CC4 5.26 CHEMBL2342727 CHEMBL2333606 CC1CC1c2cc(cc(COCC3(CCN(C)CC3)c4ccc(F)cc4)n2)C(F)(F)F 4.47 CHEMBL2342727 CHEMBL2333607 CN1CCC(COCc2cc(cc(n2)C3CC3(C)C)C(F)(F)F)(CC1)c4ccc(F)cc4 5.05 CHEMBL2342727 CHEMBL2333608 CN1CCC(COCc2cc(cc(n2)C3(F)CC3)C(F)(F)F)(CC1)c4ccc(F)cc4 5.37 CHEMBL2342727 CHEMBL2333609 CN1CCC(COCc2cc(cc(n2)C3(F)CC3)C(F)(F)F)(CC1)c4ccccc4 4.92 CHEMBL2342727 CHEMBL2333610 CN1CCC(COCc2cc(cc(n2)C3CCCC3)C(F)(F)F)(CC1)c4ccc(F)cc4 4.92 CHEMBL2342727 CHEMBL2333611 CN1CCC(COCc2cc(cc(n2)C3CC3)C4CC4)(CC1)c5ccc(F)cc5 4.77 CHEMBL2342727 CHEMBL2333612 CN1CCC(COCc2cc(cc(n2)C3CC3)C#N)(CC1)c4ccc(F)cc4 4.77 CHEMBL2342727 CHEMBL2333613 CN1CCC(COCc2cc(cc(n2)C3CC3)C(F)(F)F)(CC1)c4ccc(Cl)cc4 5.51 CHEMBL2342727 CHEMBL2333614 CN1CCC(COCc2cc(cc(n2)C3CC3)C(F)(F)F)(CC1)c4cccc(Cl)c4 5.04 CHEMBL2342727 CHEMBL2333615 CN1CCC(COCc2cc(cc(n2)C3CC3)C(F)(F)F)(CC1)c4cccc(F)c4 5.05 CHEMBL2342727 CHEMBL2333616 CN1CCC(COCc2cc(Cl)cc(n2)C(F)(F)F)(CC1)c3ccccc3 4.92 CHEMBL2342727 CHEMBL2333617 CN(C)c1cc(cc(COCC2(CCNCC2)c3ccc(F)cc3)n1)C(F)(F)F 5.08 CHEMBL2342727 CHEMBL2333618 CCN(CC)c1cc(cc(COCC2(CCN(C)CC2)c3ccc(F)cc3)n1)C(F)(F)F 4.85 CHEMBL2342727 CHEMBL2333619 CCNc1cc(cc(COCC2(CCN(C)CC2)c3ccc(F)cc3)n1)C(F)(F)F 4.1 CHEMBL2342727 CHEMBL2333620 CCC(CC)Nc1cc(cc(COCC2(CCN(C)CC2)c3ccc(F)cc3)n1)C(F)(F)F 5.15 CHEMBL2342727 CHEMBL2333621 CCN(C)c1cc(cc(COCC2(CCN(C)CC2)c3ccc(F)cc3)n1)C(F)(F)F 5.22 CHEMBL2342727 CHEMBL2333622 CC(C)CN(CC(C)C)c1cc(cc(COCC2(CCN(C)CC2)c3ccc(F)cc3)n1)C(F)(F)F 5.02 CHEMBL2342727 CHEMBL2333623 FC(F)(F)c1cc(COCC2(CCNCC2)c3ccccc3)nc(c1)N4CCCC4 5.64 CHEMBL2342727 CHEMBL2333624 CN1CCC(COCc2cc(cc(n2)N3CCCC3)C(F)(F)F)(CC1)c4ccccc4 5.13 CHEMBL2342727 CHEMBL2333625 CN1CCC(COCc2cc(cc(n2)N3CCC4CC34)C(F)(F)F)(CC1)c5ccc(F)cc5 4.92 CHEMBL2342727 CHEMBL2333626 CN1CCC(COCc2cc(cc(n2)N3CC=CC3)C(F)(F)F)(CC1)c4ccc(F)cc4 5.06 CHEMBL2342727 CHEMBL2333627 CN1CCC(COCc2cc(cc(n2)N3CCC(C3)C#N)C(F)(F)F)(CC1)c4ccc(F)cc4 5.08 CHEMBL2342727 CHEMBL2333628 CN1CCN(CC1)c2cc(cc(COCC3(CCNCC3)c4ccccc4)n2)C(F)(F)F 4.8 CHEMBL2342727 CHEMBL2333629 CN1CCC(COCc2cc(cc(n2)N3CCC(CC3)C#N)C(F)(F)F)(CC1)c4ccc(F)cc4 5.11 CHEMBL2342727 CHEMBL2333630 CN1CCC(COCc2cc(ccn2)C(F)(F)F)(CC1)c3ccc(F)cc3 4.54 CHEMBL2342727 CHEMBL2333631 CN1CCC(COCc2cc(cc(n2)C#N)C(F)(F)F)(CC1)c3ccccc3 4.48 CHEMBL2342727 CHEMBL2333632 COc1cc(cc(COCC2(CCN(C)CC2)c3ccc(F)cc3)n1)C(F)(F)F 5 CHEMBL2342727 CHEMBL2333633 CC(C)c1cc(cc(COCC2(CCN(C)CC2)c3ccc(F)cc3)n1)C(F)(F)F 4.59 CHEMBL2342727 CHEMBL2333634 CC(C)Cc1cc(cc(COCC2(CCN(C)CC2)c3ccc(F)cc3)n1)C(F)(F)F 4.92 CHEMBL2342727 CHEMBL2333635 C\C=C\c1cc(cc(COCC2(CCN(C)CC2)c3ccc(F)cc3)n1)C(F)(F)F 4.89 CHEMBL2342727 CHEMBL2333636 CN1CCC(COCc2cc(cc(C=C(C)C)n2)C(F)(F)F)(CC1)c3ccc(F)cc3 4.75 CHEMBL2342727 CHEMBL2333637 CN1CCC(COCc2cc(cc(n2)C3CC3)C(F)(F)F)(CC1)c4ccc(F)cc4 4.89 CHEMBL2342727 CHEMBL2333638 FC(F)(F)c1cc(Cl)cc(COCC2(CCNCC2)c3ccccc3)c1 5.14 CHEMBL2342727 CHEMBL2333639 FC(F)(F)c1cc(Cl)nc(COCC2(CCNCC2)c3ccccc3)c1 4.55 CHEMBL2342727 CHEMBL2333640 CN1CCC(COCc2cc(cc(Cl)n2)C(F)(F)F)(CC1)c3ccccc3 4.6 CHEMBL2342727 CHEMBL2333641 CN1CCC(COCc2cc(cc(Cl)n2)C(F)(F)F)(CC1)c3ccc(Cl)cc3 4.64 CHEMBL2342727 CHEMBL2333642 Fc1ccc(cc1)C2(COCc3cc(cc(Cl)n3)C(F)(F)F)CCNCC2 4.7 CHEMBL2342727 CHEMBL2333643 CN1CCC(COCc2cc(cc(Cl)n2)C(F)(F)F)(CC1)c3ccc(F)cc3 5.22 CHEMBL2342727 CHEMBL2333644 CN1CCC(COCc2cc(cc(Cl)n2)C(F)(F)F)(CC1)c3ccccc3F 4.37 CHEMBL2342727 CHEMBL2333645 Brc1cncc(COCC2(CCNCC2)c3ccccc3)c1 4.82 CHEMBL2342727 CHEMBL2333646 CN1CCC(COCc2cncc(Br)c2)(CC1)c3ccccc3 4.89 CHEMBL2342727 CHEMBL2333647 Clc1cc(COCC2(CCNCC2)c3ccccc3)cc(Cl)n1 4.48 CHEMBL2342727 CHEMBL2333648 FC(F)(F)c1cc(Cl)cc(COCC2(CCNCC2)c3ccccc3)n1 4.6 CHEMBL2342727 CHEMBL2334264 O[C@H](COc1ccc(F)cc1)CN2CCN(Cc3ccc(Cl)cc3)CC2 5.87 CHEMBL2339143 CHEMBL2334265 O[C@H](COc1ccc(F)cc1)CN2CCN(Cc3ccc(Cl)c(Cl)c3)CC2 6.54 CHEMBL2339143 CHEMBL2334271 COc1cccc(c1)N2CCN(C[C@H](O)COc3ccc(cc3)C(F)(F)F)CC2 5.39 CHEMBL2339143 CHEMBL2334275 O[C@H](COc1ccc(cc1)C(F)(F)F)CN2CCN(Cc3c(F)cccc3Cl)CC2 4.86 CHEMBL2339143 CHEMBL2334601 O[C@@H](COc1ccc(F)cc1)CN2CCN(Cc3ccc(Cl)c(Cl)c3)CC2 6.06 CHEMBL2339143 CHEMBL2334606 COc1ccccc1N2CCN(C[C@@H](O)COc3ccc(cc3)C(F)(F)F)CC2 5.4 CHEMBL2339143 CHEMBL2334610 O[C@@H](COc1ccc(cc1)C(F)(F)F)CN2CCN(Cc3ccc(Cl)c(Cl)c3)CC2 5.04 CHEMBL2339143 CHEMBL2334618 O[C@H](COc1ccc(Cl)cc1)CN2CCN(Cc3ccc(Cl)cc3)CC2 6.5 CHEMBL2339143 CHEMBL2334620 O[C@H](COc1ccc(Cl)cc1)CN2CCN(Cc3c(F)cccc3Cl)CC2 5.68 CHEMBL2339143 CHEMBL2335279 COc1cccc2nc(ccc12)C#Cc3ccccc3 4.21 CHEMBL2345730 CHEMBL2335285 COc1cccc2nc(ccc12)C#Cc3cccnc3 4.19 CHEMBL2345730 CHEMBL2335291 c1ccc(nc1)C#Cc2ccc3ccccc3n2 4.69 CHEMBL2345730 CHEMBL2335295 Brc1cccc2nc(ccc12)C#Cc3ccccn3 4.64 CHEMBL2345730 CHEMBL2336055 CCOC(=O)N1CCC(CN2CC[C@@H](C2)N3C(=O)Cc4ccccc34)CC1 6.1 CHEMBL2343015 CHEMBL2336056 CCOC(=O)N1CCC(C)(CN2CC[C@@H](C2)N3C(=O)Cc4ccccc34)CC1 5.46 CHEMBL2343015 CHEMBL2336057 CCOC(=O)N1CCC(O)(CN2CC[C@@H](C2)N3C(=O)Cc4ccccc34)CC1 5.41 CHEMBL2343015 CHEMBL2336059 CCOC(=O)N1[C@@H]2CC[C@H]1C[C@H](CN3CC[C@@H](C3)N4C(=O)Cc5ccccc45)C2 5.62 CHEMBL2343015 CHEMBL2336323 CNC(=O)c1cc(ccc1OC(F)F)c2ccc3c(nc(nc3n2)N4CCOC[C@@H]4C)N5CCOC[C@@H]5C 4.62 CHEMBL2338825 CHEMBL2336325 CNC(=O)c1cccc(c1)c2ccc3c(nc(nc3n2)N4CCOC[C@@H]4C)N5CCOC[C@@H]5C 4.32 CHEMBL2338825 CHEMBL2336327 COc1ccc(cc1CNCCO)c2ccc3c(nc(nc3n2)N4C[C@@H](C)O[C@@H](C)C4)N5CCOCC5 4.56 CHEMBL2338825 CHEMBL2336328 C[C@@H]1CN(C[C@H](C)O1)c2nc(N3CCOCC3)c4ccc(nc4n2)c5cccc(CNCCO)c5 4.89 CHEMBL2338825 CHEMBL2336329 CNCc1cccc(c1)c2ccc3c(nc(nc3n2)N4C[C@@H](C)O[C@@H](C)C4)N5CCOCC5 4.76 CHEMBL2338825 CHEMBL2336331 C[C@@H]1CN(C[C@H](C)O1)c2nc(N3CCOC[C@@H]3C)c4ccc(nc4n2)c5ccccc5 5.4 CHEMBL2338825 CHEMBL2336332 COc1ccc(cc1CO)c2ccc3c(nc(nc3n2)N4CC[C@@H](O)C4)N5CCOC[C@@H]5C 5.1 CHEMBL2338825 CHEMBL2336334 COCC(C)Nc1nc(N2CCOC[C@@H]2C)c3ccc(nc3n1)c4ccc(OC)c(CO)c4 4.77 CHEMBL2338825 CHEMBL2337725 COc1cc(ccc1OCCN2CCCC2)N3Cc4ccc(Sc5ccc(F)cc5)nc4C3=O 4.6 CHEMBL2342858 CHEMBL233781 NC(=O)CNC[C@@H]1CC[C@@]2(CC1)OO[C@]3(O2)C4CC5CC(CC3C5)C4 5.57 CHEMBL895925 CHEMBL2337977 CC(C)(C)NC(=O)NCCN1CC(C1)NC(=O)c2cc(Cl)cc(Cl)c2 4.89 CHEMBL2344015 CHEMBL2337978 CC(C)(C)NC(=O)NCCN1CCC(C1)NC(=O)c2cc(Cl)cc(Cl)c2 5.18 CHEMBL2344015 CHEMBL2337979 CC(C)(C)NC(=O)NCCN1CCCC(C1)NC(=O)c2cc(Cl)cc(Cl)c2 5.39 CHEMBL2344015 CHEMBL2338347 CS(=O)(=O)c1ccc(cc1Cl)[C@@H](CC2CCCC2)C(=O)Nc3cnc(cn3)[C@H](O)CO 4.16 CHEMBL2346000 CHEMBL2338405 CC(C)(C)NC(=O)NCCN1CCN(CC(=O)Nc2cc(Cl)cc(Cl)c2)CC1 5.8 CHEMBL2344015 CHEMBL2338406 CC(C)(C)NC(=O)NCCN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 4.89 CHEMBL2344015 CHEMBL2338407 CC(C)(C)NC(=O)NCCN1CCCC(CNC(=O)c2cc(Cl)cc(Cl)c2)C1 5.28 CHEMBL2344015 CHEMBL2338409 CC(C)(C)NC(=O)NCCN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)C1 5.24 CHEMBL2344015 CHEMBL2346967 FC(F)(F)c1nnc2ccc(nn12)N3CCN(Cc4ccc(cc4)C#N)CC3 5.65 CHEMBL2352672 CHEMBL2346968 Fc1ccc(CN2CCN(CC2)c3ccc4nnc(n4n3)C(F)(F)F)cc1 4.97 CHEMBL2352672 CHEMBL2346970 OC1(CCN(CC1)c2ccc3nnc(n3n2)C(F)(F)F)c4ccc(F)cc4 4.74 CHEMBL2352672 CHEMBL2346971 OC1(CCN(CC1)c2ccc3nnc(n3n2)C(F)(F)F)c4cccnc4 4.02 CHEMBL2352672 CHEMBL2346972 Fc1ccc(CN2CCN(CC2)C3=Nn4c(CC3)nnc4C(F)(F)F)cc1 4.53 CHEMBL2352672 CHEMBL2346973 Cn1nccc1CCOc2ccc(cc2)C3CCN(CC3)c4ccc5nnc(n5n4)C(F)(F)F 4.75 CHEMBL2352672 CHEMBL2346974 CC(=O)N1CCN(CCOc2ccc(cc2)C3CCN(CC3)c4ccc5nnc(n5n4)C(F)(F)F)CC1 4.95 CHEMBL2352672 CHEMBL2347416 CN1CC(Cn2nc(c3cnc4[nH]cc(C(=O)NC(C)(C)C)c4n3)c5cc(OC(F)F)ccc25)C1 6.53 CHEMBL2350555 CHEMBL2347417 CC(C)(C)NC(=O)c1c[nH]c2ncc(nc12)c3nn(CCCN4CC(C4)C#N)c5ccc(OC(F)F)cc35 6.38 CHEMBL2350555 CHEMBL2347418 CC(C)(C)NC(=O)c1c[nH]c2ncc(nc12)c3nn(CCCN4CCOCC4)c5ccc(OC(F)F)cc35 5.84 CHEMBL2350555 CHEMBL2347419 CN(C)CCCn1nc(c2cnc3[nH]cc(C(=O)NC(C)(C)CO)c3n2)c4cc(OC(F)F)ccc14 5.2 CHEMBL2350555 CHEMBL2347420 CC(C)(C)NC(=O)c1c[nH]c2ncc(nc12)c3nn(CCCS(=O)(=O)C)c4ccc(OC(F)F)cc34 6.37 CHEMBL2350555 CHEMBL2347988 CC(C)(C)NC(=O)c1c[nH]c2ncc(nc12)c3nn(CCC(O)CO)c4ccc(OC(F)F)cc34 5.38 CHEMBL2350555 CHEMBL2347996 CC(C)(C)NC(=O)c1c[nH]c2ncc(nc12)c3ncn4CCCCc34 5.39 CHEMBL2350555 CHEMBL2348780 C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@@]1(O)C(=O)CO 4.7 CHEMBL2351330 CHEMBL2368925 O=C(O[C@@H]1C[C@@H]2C[C@H]3C[C@H](C1)N2CC3=O)c4c[nH]c5ccccc45 4.92 CHEMBL766814 CHEMBL237119 CN(C)C(=O)[C@H]([C@H](N)C(=O)N1CC[C@H](F)C1)c2ccc(cc2)c3ccc(F)cc3 5.34 CHEMBL898851 CHEMBL237191 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cnc(nc4C)N5CCCC5 4.98 CHEMBL1827362 CHEMBL237336 C[C@H]([C@H](N)C(=O)N1CC[C@H](F)C1)c2ccc(cc2)c3ccc(F)cc3 5.96 CHEMBL898851 CHEMBL237337 CN(C)C(=O)[C@H]([C@H](N)C(=O)N1CC[C@H](F)C1)c2ccc(cc2)c3ccc4ncnn4c3 4.07 CHEMBL898851 CHEMBL237394 CCOc1ccc(nn1)n2ncc(c2C)c3ccc4cc(CCN5CCC[C@H]5C)ccc4n3 4.98 CHEMBL1827362 CHEMBL237793 O[C@@H](CN1CCC(O)(CC1)c2cccc(F)c2)c3ccc4NC(=O)CCc4c3 5.96 CHEMBL899624 CHEMBL2380438 CC1(Oc2ccccc2C(=N1)N)c3cccc(c3)c4cccnc4 5.55 CHEMBL2382572 CHEMBL2380439 CCC1(Oc2ccccc2C(=N1)N)c3cccc(c3)c4cncnc4 5.8 CHEMBL2382572 CHEMBL2380440 CC1(Oc2cccc(F)c2C(=N1)N)c3cccc(c3)c4cncnc4 5.05 CHEMBL2382572 CHEMBL2380442 CC1(Sc2ccccc2C(=N1)N)c3cccc(c3)c4cncnc4 5.22 CHEMBL2382572 CHEMBL2380444 CC1(OCCC(=N1)N)c2cccc(c2)c3cccc(Cl)c3 5.21 CHEMBL2382572 CHEMBL2380446 COc1cccc(c1)c2cccc(c2)C3(C)SCCC(=N3)N 4.96 CHEMBL2382572 CHEMBL2380447 COc1cccc(c1)c2cccc(c2)C3(C)COCC(=N3)N 5.1 CHEMBL2382572 CHEMBL2380448 COc1cccc(c1)c2cccc(c2)C3(C)CSCC(=N3)N 5.05 CHEMBL2382572 CHEMBL2380449 COc1cccc(c1)c2cccc(c2)C3(C)CCSC(=N3)N 5.12 CHEMBL2382572 CHEMBL2380450 COc1ccc(cc1)C2(N=C(N)c3nc(C)sc23)c4cccc(c4)c5cncnc5 5.82 CHEMBL2382572 CHEMBL2380451 COc1ccc(cc1)C2(N=C(N)n3nc(C)cc23)c4cccc(c4)c5cncnc5 5.07 CHEMBL2382572 CHEMBL2380454 COc1cccc(c1)c2cccc(c2)C3(C)SCC(=N3)N 5.04 CHEMBL2382572 CHEMBL2380455 COc1ccc(cc1)C2(SCC(=N2)N)c3cccc(c3)c4cccnc4 5 CHEMBL2382572 CHEMBL2380456 COc1cccc(c1)c2cccc(c2)C3(SCC(=N3)N)c4ccncc4 4.92 CHEMBL2382572 CHEMBL2380458 COc1ccc(cc1)C2(CCC(=N2)N)c3cccc(c3)c4cncnc4 4.64 CHEMBL2382572 CHEMBL2380459 COC1CC(N=C1N)(c2ccc(OC)cc2)c3cccc(c3)c4cccnc4 5.5 CHEMBL2382572 CHEMBL2380461 CC1(Oc2ccccc2C(=N1)N)c3cccc(c3)c4cncnc4 5.24 CHEMBL2382572 CHEMBL2381898 CN(C)Cc1ccccc1c2ccc(NC(=O)Nc3cccnc3Oc4ccccc4C(C)(C)C)c(F)c2 5.27 CHEMBL2384079 CHEMBL2381908 CC(C)CN1CCC(COc2ccc(NC(=O)Nc3cccnc3Oc4ccccc4C(C)(C)C)c(F)c2)CC1 5.43 CHEMBL2384079 CHEMBL2382287 COc1ccc2nccc([C@@H](O)CC[C@@H]3CCN(C[C@@H]3C(=O)O)C4CC(C4)c5ccccc5)c2c1 4.6 CHEMBL2384768 CHEMBL2382341 COc1ccc2nccc([C@@H](O)CC[C@@H]3CCN(C[C@@H]3C(=O)O)C4CC(C4)c5ccccc5F)c2c1 4.91 CHEMBL2384768 CHEMBL2382342 COc1ccc2nccc([C@@H](O)CC[C@@H]3CCN(C[C@@H]3C(=O)O)C4CC(C4)c5cccc(F)c5)c2c1 4.99 CHEMBL2384768 CHEMBL2382343 COc1ccc2nccc([C@@H](O)CC[C@@H]3CCN(C[C@@H]3C(=O)O)C4CC(C4)c5c(F)cccc5F)c2c1 4.32 CHEMBL2384768 CHEMBL2382345 COc1ccc2nccc([C@@H](O)CC[C@@H]3CCN(C[C@@H]3C(=O)O)C4CC(C4)c5cc(F)ccc5F)c2c1 5 CHEMBL2384768 CHEMBL2382364 COc1ccc2nccc([C@@H](O)CC[C@@H]3CCN(C[C@@H]3C(=O)O)C4CC(C4)c5cc(F)cc(F)c5)c2c1 5.14 CHEMBL2384768 CHEMBL2382372 COc1ccc2nccc([C@@H](O)CC[C@@H]3CCN(C[C@@H]3C(=O)O)C4CC(C4)c5cc(F)cc(F)c5F)c2c1 4.51 CHEMBL2384768 CHEMBL2382414 FC(F)(F)COC(=O)N1CCN(CC1)c2ncc(OCc3ccncc3C#N)cn2 5 CHEMBL2384313 CHEMBL2382415 FC(F)(F)COC(=O)N1C2CCC1CN(C2)c3ncc(OCc4ccncc4C#N)cn3 4.89 CHEMBL2384313 CHEMBL2385102 CC1=C(C)c2ccc(OCCCCN3CCC(CC3)c4noc5cc(F)ccc45)cc2OC1=O 6.71 CHEMBL2390223 CHEMBL2386558 CN(C)C(=O)[C@H]1C[C@@H]1c2ccc(cc2)c3ncn(C)c3Sc4ccc(Cl)cn4 4.43 CHEMBL2388893 CHEMBL2386636 C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@@H]4CC[C@@H](CCC#N)CC4 4.7 CHEMBL2390363 CHEMBL2387229 CC1=CC(=O)Oc2c(Cl)c(OCCCCN3CCC(CC3)c4noc5cc(F)ccc45)ccc12 5.8 CHEMBL2390223 CHEMBL2387230 CC1=CC(=O)Oc2c(C)c(OCCCCN3CCC(CC3)c4noc5cc(F)ccc45)ccc12 6.65 CHEMBL2390223 CHEMBL2387253 COc1ccccc1N2CCN(CCCCOc3ccc4C(=CC(=O)Oc4c3)C)CC2 7.51 CHEMBL2390223 CHEMBL2387260 CC1=CC(=O)Oc2cc(OCCCCN3CCC(CC3)c4noc5cc(F)ccc45)ccc12 6.8 CHEMBL2390223 CHEMBL2387265 Fc1ccc2c(noc2c1)C3CCN(CCCCOc4ccc5C(=CC(=O)Oc5c4)c6ccccc6)CC3 6.09 CHEMBL2390223 CHEMBL2387464 F[C@H]1CNCC[C@@H]1CNc2ccn3ncc(C(=O)Nc4c[nH]c5ncc(cc45)c6ccccc6F)c3n2 5.3 CHEMBL2387962 CHEMBL238870 OC=O.Fc1ccc(cc1)C(=O)N2CCN(C(=O)C2)c3ccc(OCCCN4CCCCCC4)cc3 4.9 CHEMBL903096 CHEMBL238871 OC=O.Fc1cc(F)cc(c1)C(=O)N2CCN(C(=O)C2)c3ccc(OCCCN4CCCCCC4)cc3 4.9 CHEMBL903096 CHEMBL238872 OC=O.Fc1ccc(C(=O)N2CCN(C(=O)C2)c3ccc(OCCCN4CCCCCC4)cc3)c(F)c1 4.3 CHEMBL903096 CHEMBL239081 C[C@@H]1CCCN1CCCOc2ccc(cc2)N3CCN(CC3=O)C(=O)c4cc(F)cc(F)c4.OC=O 6.3 CHEMBL903096 CHEMBL239099 OC=O.O=C(N1CCN(C(=O)C1)c2ccc(OC3CCN(CC3)C4CCC4)cc2)c5ccc(cc5)C#N 5.03 CHEMBL903096 CHEMBL2390995 ONC(=O)\C=C\c1ccc2OC3(CCN(Cc4ccc(F)cc4)CC3)CC(=O)c2c1 5.62 CHEMBL2395207 CHEMBL2391166 CC1CCCN1C2CCN(C2)c3ccc(NC(=O)c4ccccc4F)c(C)c3 6 CHEMBL2394849 CHEMBL2391167 CC1CCCN1C2CCN(C2)c3ccc(NC(=O)c4cc(F)ccc4C)c(C)c3 6.32 CHEMBL2394849 CHEMBL2391795 O[C@H](COc1cc(O)ccc1C(=O)NC2CC2)CN3CCC4(CC3)Cc5cc(Cl)ccc5O4 6.52 CHEMBL2396019 CHEMBL2391800 O[C@H](COc1cc(F)ccc1C(=O)N2CC[C@H](O)C2)CN3CCC4(CC3)Cc5cc(Cl)ccc5O4 6.16 CHEMBL2396019 CHEMBL2391803 O[C@H](COc1cc(O)c(Cl)cc1C(=O)N2CC[C@H](O)C2)CN3CCC4(CC3)Cc5cc(Cl)ccc5O4 5.08 CHEMBL2396019 CHEMBL2391804 O[C@H](COc1cc(O)ccc1C(=O)N2CC[C@H](O)C2)CN3CCC4(CC3)Cc5cc(Cl)ccc5O4 4.64 CHEMBL2396019 CHEMBL2391810 O[C@H](COc1cc(O)ccc1C(=O)N2CCC(O)CC2)CN3CCC4(CC3)Cc5cc(Cl)ccc5O4 5.8 CHEMBL2396019 CHEMBL2391935 CC(=O)NCCNC(=O)c1ccc(O)cc1OC[C@@H](O)CN2CCC3(CC2)Cc4cc(Cl)ccc4O3 5.92 CHEMBL2396019 CHEMBL2391939 O[C@H](COc1cc(F)ccc1C(=O)NC2CC2)CN3CCC4(CC3)Cc5cc(Cl)ccc5O4 7.42 CHEMBL2396019 CHEMBL2391994 CC(C)(C(=O)O)c1ccc(CN2CCC(COC(=O)c3c4OCCCn4c5ccccc35)CC2)cc1 4.16 CHEMBL2395380 CHEMBL239299 C[C@@H]1CCCN1CCCOc2ccc(cc2)N3CCN(CC3=O)C(=O)c4ccc(F)cc4F.OC=O 5.8 CHEMBL903096 CHEMBL239300 C[C@H]1CCCN1CCCOc2ccc(cc2)N3CCN(CC3=O)C(=O)c4ccc(F)cc4.OC=O 4.6 CHEMBL903096 CHEMBL2393431 COc1cccc(COC(=O)c2c(N)scc2c3ccc(OC)c(OC)c3)c1 6 CHEMBL2393913 CHEMBL239724 C[C@H]1CCCN1CCCOc2ccc(cc2)N3CCN(CC3=O)C(=O)c4ccc(F)cc4F.OC=O 4.5 CHEMBL903096 CHEMBL239744 OC=O.Clc1ccc(cc1)C(=O)N2CCN(C(=O)C2)c3ccc(OC4CCN(CC4)C5CCCC5)cc3 5.4 CHEMBL903096 CHEMBL239963 OC=O.Fc1ccc(cc1)C(=O)N2CCN(C(=O)C2)c3ccc(OC4CCN(CC4)C5CCCC5)cc3 4.7 CHEMBL903096 CHEMBL240185 OC=O.Fc1ccc(cc1)C(=O)N2CCN(C(=O)C2)c3ccc(OCCCN4CCCCC4)cc3 4.3 CHEMBL903096 CHEMBL2403108 CC(C)Oc1cc(C2CCNCC2)c(C)cc1Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3 4.34 CHEMBL2406353 CHEMBL2403316 Fc1cc(F)c(CN2C=NC(=O)c3cc(Oc4ccccc4)ccc23)c(F)c1 5.43 CHEMBL2405371 CHEMBL2403327 Cc1ccc(CN2C=NC(=O)c3cc(Oc4ncccc4C(F)(F)F)ccc23)cc1 4.77 CHEMBL2405371 CHEMBL2403338 Cc1ccc(CN2C=NC(=O)c3cc(Oc4ncccc4C(F)(F)F)ccc23)c(F)c1 4.85 CHEMBL2405371 CHEMBL2403549 C[C@H]1CCCN1[C@@H]2CCN(C2)c3ccc(NC(=O)c4cc(F)ccc4C)c(C)c3 5.75 CHEMBL2404993 CHEMBL2403550 C[C@H]1CCCN1[C@H]2CCN(C2)c3ccc(NC(=O)c4cc(F)ccc4C)c(C)c3 5.96 CHEMBL2404993 CHEMBL2403831 CC(C)Oc1nc(ncc1Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)C4CCNCC4 6.4 CHEMBL2406355 CHEMBL2403836 CC(C)Oc1cc(C2CCN(CCO)CC2)c(C)cc1Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3 5.58 CHEMBL2406355 CHEMBL2403842 CC(C)Oc1cc(C2CCN(CC2)C(=O)CN(C)C)c(C)cc1Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3 4.61 CHEMBL2406355 CHEMBL2403843 CC(C)Oc1cc(C2CCN(C)CC2)c(C)cc1Nc3ncc(C)c(Nc4ccccc4S(=O)(=O)C(C)C)n3 4.7 CHEMBL2406353 CHEMBL2403845 CC(C)Oc1cc(ccc1Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)C4CCNCC4 5.28 CHEMBL2406355 CHEMBL2403848 CC(C)S(=O)(=O)c1ccccc1Nc2nc(Nc3cc(C)c(cc3OC4CCC4)C5CCNCC5)ncc2Cl 5.52 CHEMBL2406355 CHEMBL2403849 CC(C)Oc1cc(C2CCN(C)CC2)c(C)cc1Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3 5.48 CHEMBL2406355 CHEMBL2403858 CC(C)(O)c1nc2cc(Cl)ccc2n1[C@@H]3CC[C@@H](CC3)NCC4Cc5ccc(Cl)cc5C4 6.38 CHEMBL2406366 CHEMBL2403861 CC(C)(O)c1nc2cc(Cl)ccc2n1[C@@H]3CC[C@@H](CC3)NC[C@H]4Cc5ccc(cc5C4)C#N 7.22 CHEMBL2406366 CHEMBL2403866 Cc1nc2cc(F)ccc2n1[C@@H]3CC[C@@H](CC3)NC[C@H]4Cc5ccc(cc5C4)C#N 7.52 CHEMBL2406366 CHEMBL240394 OC=O.Fc1cc(F)cc(c1)C(=O)N2CCN(C(=O)C2)c3ccc(OCCCN4CCCCC4)cc3 4.4 CHEMBL903096 CHEMBL240567 OC=O.Fc1cc(F)cc(c1)C(=O)N2CCN(C(=O)C2)c3ccc(OC4CCN(CC4)C5CCCC5)cc3 5.1 CHEMBL903096 CHEMBL2407170 CCOC(=O)N1CCC(CN2CCC3(CC2)OC(=O)N(C)c4ncccc34)CC1 5.83 CHEMBL2411862 CHEMBL2407171 CCOC(=O)N1CCC(CN2CCC3(CC2)OC(=O)Nc4ncccc34)CC1 6.04 CHEMBL2411862 CHEMBL2407172 CCOC(=O)N1CCC(CN2CCC3(CC2)CC(=O)Nc4ncccc34)CC1 5.55 CHEMBL2411862 CHEMBL2407173 CCOC(=O)N1CCC(CN2CCC3(CC2)CC(=O)N(C)c4ncccc34)CC1 5.6 CHEMBL2411862 CHEMBL2407174 CCOC(=O)N1CCC(CN2CCC3(CC2)CC(=O)N(CC)c4ncccc34)CC1 5.54 CHEMBL2411862 CHEMBL2407175 CCCN1C(=O)CC2(CCN(CC3CCN(CC3)C(=O)OCC)CC2)c4cccnc14 6.17 CHEMBL2411862 CHEMBL24072 CC(Cc1ccccc1)NCCC(c2ccccc2)c3ccccc3 7.19 CHEMBL3430647 CHEMBL2409175 CC(=O)Nc1cc(Nc2cc(NC3CC3)n4ncc(C#N)c4n2)ccc1C 4.68 CHEMBL2411100 CHEMBL2409177 CC(=O)Nc1cc(Nc2cc(NC3CC3)n4ncc(C#N)c4n2)ccc1C5CC5 4.72 CHEMBL2411100 CHEMBL2409178 CC(=O)Nc1cc(Nc2cc(NC3CC3)n4ncc(C#N)c4n2)c(F)cc1C 4.8 CHEMBL2411100 CHEMBL2409180 CC(=O)Nc1cc(Nc2cc(NC3CC3)n4ncc(C#N)c4n2)ncc1C 4.72 CHEMBL2411100 CHEMBL2409181 CC(=O)Nc1cc(Nc2cc(NC3CCC3)n4ncc(C#N)c4n2)ccc1C 4.96 CHEMBL2411100 CHEMBL2409182 CC(=O)Nc1cc(Nc2cc(NC3CCC3)n4ncc(C#N)c4n2)c(F)cc1C 4.8 CHEMBL2411100 CHEMBL240923 CN(C)C(=O)N1CC(=C[C@@]1(CC[C@@H](N)C(F)F)c2ccccc2)c3cc(F)ccc3F 4.8 CHEMBL1020033 CHEMBL2409309 CCOc1cc2ncc(C(=O)N)c(Nc3ccc(F)cc3F)c2cc1C4CCN(C)CC4 4.96 CHEMBL2411831 CHEMBL2409310 CCOc1cc2ncc(C(=O)N)c(Nc3cccc(Cl)c3Cl)c2cc1C4CCN(C)CC4 5.4 CHEMBL2411831 CHEMBL2409311 COCCOc1cc2ncc(C(=O)N)c(Nc3ccc(C)cc3F)c2cc1N4CCOCC4 5.05 CHEMBL2411831 CHEMBL2409397 COc1cc2nnc(C(=O)N)c(Nc3ccc(C)cc3F)c2cc1N4CCN(CC4)C(C)C 4.77 CHEMBL2411831 CHEMBL2409398 COc1cc2nnc(C(=O)N)c(Nc3ccc(C)cc3F)c2cc1N4CCCN(C)CC4 5.22 CHEMBL2411831 CHEMBL2409399 COc1cc2nnc(C(=O)N)c(Nc3ccc(C)cc3F)c2cc1N4C[C@@H](C)N[C@@H](C)C4 4.7 CHEMBL2411831 CHEMBL2409400 COc1cc2nnc(C(=O)N)c(Nc3ccc(C)cc3F)c2cc1N4CCC(CC4)N(C)C 4.68 CHEMBL2411831 CHEMBL2409401 COCCN1CCN(CC1)c2cc3c(Nc4ccc(C)cc4F)c(nnc3cc2OC)C(=O)N 4.64 CHEMBL2411831 CHEMBL2409402 COc1cc2nnc(C(=O)N)c(Nc3ccc(C)cc3F)c2cc1N4CCCN(CCO)CC4 4.85 CHEMBL2411831 CHEMBL2409405 COc1cc2nnc(C(=O)N)c(Nc3ccc(C)cc3F)c2cc1N4CCS(=O)(=O)CC4 4.8 CHEMBL2411831 CHEMBL2409409 COc1cc2nnc(C(=O)N)c(Nc3ccc(C)cc3F)c2cc1C4CCN(CC4)C(C)C 4.96 CHEMBL2411831 CHEMBL2409410 COc1cc2nnc(C(=O)N)c(Nc3ccc(C)cc3F)c2cc1C4CCN(CCO)CC4 4.85 CHEMBL2411831 CHEMBL2409676 C[C@]1(CS(=O)(=O)N2CCN(CC2)c3ncc(OCc4oc(cc4)C(F)(F)F)cn3)NC(=O)NC1=O 4.36 CHEMBL2410296 CHEMBL2409707 C[C@]1(CS(=O)(=O)N2CCC(CC2)Oc3ccc(OC(F)(F)C(F)F)cc3)NC(=O)NC1=O 4.4 CHEMBL2410296 CHEMBL241330 CCOc1cc(CN2CCC(CC2)NC(=O)c3cccc(c3)S(=O)(=O)C)ccc1Cl 5.89 CHEMBL902587 CHEMBL2415095 COc1cc(ccc1n2cnc(C)c2)c3nc4[C@@H](CCCn4n3)c5ccc(F)cc5C 5.1 CHEMBL2417298 CHEMBL2415096 COc1cc(ccc1n2cnc(C)c2)c3nc4[C@H](CCCn4n3)c5ccc(F)cc5C 6.1 CHEMBL2417298 CHEMBL2419601 CC(C)(C)n1cc2OC3(CCN(CC3)C(=O)c4ccc5[nH]ncc5c4)CC(=O)c2n1 4.47 CHEMBL3385491 CHEMBL2420702 CNCc1cc(ccn1)c2cn(C)nc2c3ccc(F)cc3 4.42 CHEMBL2424274 CHEMBL2420703 Cn1cc(c2ccnc3CNCCOc23)c(n1)c4ccc(F)cc4 4.59 CHEMBL2424465 CHEMBL2420704 Cn1cc(c2ccnc(c2)C3COCCN3)c(n1)c4ccc(F)cc4 4.59 CHEMBL2424274 CHEMBL2424930 Fc1cnc2C=CC(=O)N3C[C@@](F)(CN4CCC(CC4)NCc5cc6OCCOc6cn5)c1c23 4.8 CHEMBL2427861 CHEMBL2424931 Fc1cnc2C=CC(=O)N3C[C@@H](CN4CCC(CC4)NCc5cc6OCCOc6cn5)c1c23 4.24 CHEMBL2427861 CHEMBL2425059 N[C@H]1C[C@H](CC[C@@H]1c2cc(F)c(F)cc2F)N3Cc4cnc(nc4C3)C(F)(F)F 5.32 CHEMBL2429418 CHEMBL2425060 N[C@H]1C[C@H](CO[C@@H]1c2cc(F)c(F)cc2F)N3Cc4cnc(nc4C3)C(F)(F)F 4.64 CHEMBL2429418 CHEMBL2425893 CC#CCN1C(=O)N(Cc2ccc3ccc(Cl)cc3n2)C(=O)C=C1N4CCC[C@@H](N)C4 4 CHEMBL2429187 CHEMBL2425952 CCC1=Nc2c(Cc3ccc(cc3)C(=O)NO)cccc2C(=O)N1CCc4ccccc4 5.33 CHEMBL2429415 CHEMBL242598 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(C5CCOCC5)n4C)CCc3c2 5.4 CHEMBL895464 CHEMBL242600 COc1ccc(cc1)c2nnc(SCCCN3CCc4ccc(cc4CC3)c5cc(C)on5)n2C 7.4 CHEMBL895464 CHEMBL242601 Cc1cnc(cn1)c2nnc(SCCN3CCc4ccc(cc4CC3)c5cc(C)nn5C)n2C 5.7 CHEMBL895464 CHEMBL242602 Cc1cc(c2ccc3CCN(CCSc4nnc(c5ccc(F)c(F)c5)n4C)CCc3c2)n(C)n1 6.3 CHEMBL895464 CHEMBL242603 CC(CCSc1nnc(c2cccc3nc(C)ccc23)n1C)N4CCc5ccc(cc5CC4)c6cc(C)nn6C 5.9 CHEMBL895464 CHEMBL2426277 COc1cc(N2CCN(C)CC2)c(NC(=O)C=C)cc1Nc3ncc(Cl)c(n3)c4cnn5ccccc45 5.15 CHEMBL3389028 CHEMBL2426279 COc1cc(N2CCN(C)CC2)c(NC(=O)C=C)cc1Nc3nccc(n3)c4c[nH]c5ccccc45 5.04 CHEMBL3389028 CHEMBL2426288 COc1ccc(NC(=O)\C=C\CN(C)C)cc1Nc2ncc(Cl)c(n2)c3cnn4ccccc34 5.38 CHEMBL2427694 CHEMBL2426677 COc1ccc(CC(=O)N2CCC3(CC2)CN(C3)[C@@H]4CCc5cc(ccc45)c6ncccn6)cc1 5.54 CHEMBL3295453 CHEMBL243001 CC(C)N1CCC[C@H](CN2C(=Nc3ccc(Oc4ccc(F)cc4)cc3C2=O)C)C1 5.79 CHEMBL1958785 CHEMBL2431809 CC1(C)N(CCn2c(Nc3ccc(Cl)cc3)c(nc12)c4ccc(F)cc4)C(=O)CN 5.14 CHEMBL2433139 CHEMBL243474 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(n4C)C(C)(C)C)CCc3c2 6.4 CHEMBL895464 CHEMBL2435853 Cc1nc(Oc2ccc(cc2)C(=O)O)ccc1CN3CCC(CC3)N4[C@@H](CN(C5CCOCC5)C4=O)c6cccc(Cl)c6 5 CHEMBL2439735 CHEMBL2435858 Cc1nc(Oc2ccc(cc2)C(=O)N)ccc1CN3CCC(CC3)N4[C@@H](CN(C5CCOCC5)C4=O)c6ccccc6 4.75 CHEMBL2439735 CHEMBL2436226 Cl.CN[C@@H](C)C(=O)N[C@H]1[C@H](C)N(C(=O)C)c2cc(ccc2N(Cc3c(C)ccc4ccccc34)C1=O)C#N 4.45 CHEMBL2439936 CHEMBL2436978 CN1CCN(Cc2ccc(cc2)c3cnc4[nH]cc(c5ccc6[nH]ccc6c5)c4c3)CC1 4.68 CHEMBL2439896 CHEMBL243707 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3c2 6.3 CHEMBL895464 CHEMBL243708 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(c5ccc6nc(C)c(C)nc6c5)n4C)CCc3c2 6.5 CHEMBL895464 CHEMBL243709 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(c5ccccc5)n4C)CCc3c2 5.7 CHEMBL895464 CHEMBL243859 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(C5CCCC5)n4C)CCc3c2 6.1 CHEMBL895464 CHEMBL243860 CC1CCC(CC1)c2nnc(SCCCN3CCc4ccc(cc4CC3)c5cc(C)on5)n2C 6.9 CHEMBL895464 CHEMBL243896 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(c5ccc(cc5)C#N)n4C)CCc3c2 7.7 CHEMBL895464 CHEMBL243897 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(c5ccc(cc5)C(F)(F)F)n4C)CCc3c2 7.2 CHEMBL895464 CHEMBL243898 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(c5ccccn5)n4C)CCc3c2 6.6 CHEMBL895464 CHEMBL243899 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(C)n4C)CCc3c2 6.1 CHEMBL895464 CHEMBL243900 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(n4C)C(F)(F)F)CCc3c2 6.5 CHEMBL895464 CHEMBL243901 CC(C)c1nnc(SCCCN2CCc3ccc(cc3CC2)c4cc(C)on4)n1C 5.9 CHEMBL895464 CHEMBL2440383 Cc1ccc(cc1)S(=O)(=O)N\N=C\c2cn(CC(=O)Nc3ccccc3Cl)c4ccccc24 4.73 CHEMBL2444347 CHEMBL2440384 Cc1ccc(cc1)S(=O)(=O)N\N=C\c2cn(CC(=O)Nc3ccc(F)cc3F)c4ccccc24 4.37 CHEMBL2444347 CHEMBL2440392 CCCCOc1ccc(cc1)S(=O)(=O)NCCc2c[nH]c3ccccc23 5.5 CHEMBL2444347 CHEMBL2440395 COc1ccc(NC(=O)Cn2cc(CCNS(=O)(=O)c3ccc(OC)cc3)c4ccccc24)cc1 4.99 CHEMBL2444347 CHEMBL2440396 COc1ccc(cc1)S(=O)(=O)NCCc2cn(CC(=O)Nc3ccc(Cl)cc3)c4ccccc24 4.94 CHEMBL2444347 CHEMBL2440398 Cc1ccc(cc1)S(=O)(=O)N\N=C\c2cn(CC(=O)Nc3ccccc3)c4ccccc24 4.36 CHEMBL2444347 CHEMBL2440407 COC(=O)C(Cc1c[nH]c2ccccc12)NS(=O)(=O)c3ccc(OC4CCCC4)cc3 5.02 CHEMBL2444347 CHEMBL2440410 COC(=O)C(Cc1c[nH]c2ccccc12)NS(=O)(=O)c3ccc(Br)cc3 5.33 CHEMBL2444347 CHEMBL2440456 O=C(OCC1CCN(Cc2ccc(cc2)c3ccccc3c4nnn[nH]4)CC1)c5c6OCCCn6c7ccccc57 4.56 CHEMBL2447591 CHEMBL2440459 COC(=O)c1ccccc1c2ccc(CN3CCC(COC(=O)c4c5OCCCn5c6ccccc46)CC3)cc2.CS(=O)(=O)O 6.88 CHEMBL2447591 CHEMBL2440460 CS(=O)(=O)O.OC(=O)c1ccccc1c2ccc(CN3CCC(COC(=O)c4c5OCCCn5c6ccccc46)CC3)cc2 4.32 CHEMBL2447591 CHEMBL244083 Cc1onc(n1)c2cccc(c2)C(=O)N[C@@H]3CC[C@@H](CCN4CCc5ccc(cc5CC4)S(=O)(=O)C)CC3 5.6 CHEMBL895464 CHEMBL244084 Cc1oc(nc1)c2ccc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3c2 6.1 CHEMBL895464 CHEMBL244085 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(c5ccncc5)n4C)CCc3c2 6.1 CHEMBL895464 CHEMBL244086 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(c5cccs5)n4C)CCc3c2 6.9 CHEMBL895464 CHEMBL244087 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(c5ccccc5Cl)n4C)CCc3c2 7.2 CHEMBL895464 CHEMBL2441408 O=C(Cc1ccc(cc1)n2cnnn2)N3CCN(CCc4ccc5C(=O)OCCc5c4)CC3 4.37 CHEMBL2443482 CHEMBL2441409 Fc1cc(CC(=O)N2CCN(CCc3ccc4C(=O)OCc4c3)CC2)ccc1n5cnnn5 4.57 CHEMBL2443482 CHEMBL2441410 COc1cc(CC(=O)N2CCN(CCc3ccc4C(=O)OCc4c3)CC2)ccc1n5cnnn5 5.09 CHEMBL2443482 CHEMBL2441411 O=C(Cc1ccc(c(c1)C#N)n2cnnn2)N3CCN(CCc4ccc5C(=O)OCc5c4)CC3 5.15 CHEMBL2443482 CHEMBL2441412 FC(F)(F)c1cc(CC(=O)N2CCN(CCc3ccc4C(=O)OCc4c3)CC2)ccc1n5cnnn5 5.29 CHEMBL2443482 CHEMBL2441414 Cc1cc(ccc1CC(=O)N2CCN(CCc3ccc4C(=O)OCc4c3)CC2)n5cnnn5 5.85 CHEMBL2443482 CHEMBL2441415 O=C(Cc1ccc(cc1C2CC2)n3cnnn3)N4CCN(CCc5ccc6C(=O)OCc6c5)CC4 5.52 CHEMBL2443482 CHEMBL2441416 FC(F)(F)c1cc(ccc1CC(=O)N2CCN(CCc3ccc4C(=O)OCc4c3)CC2)n5cnnn5 5.16 CHEMBL2443482 CHEMBL2441417 Cc1c(CCN2CCN(CC2)C(=O)Cc3ccc(cc3)n4cnnn4)ccc5C(=O)OCc15 4.7 CHEMBL2443482 CHEMBL2441418 CCc1c(CCN2CCN(CC2)C(=O)Cc3ccc(cc3)n4cnnn4)ccc5C(=O)OCc15 4.57 CHEMBL2443482 CHEMBL2441419 O=C(Cc1ccc(cc1)n2cnnn2)N3CCN(CCc4ccc5C(=O)OCc5c4C6CC6)CC3 4.92 CHEMBL2443482 CHEMBL2441420 Fc1c(CCN2CCN(CC2)C(=O)Cc3ccc(cc3)n4cnnn4)ccc5C(=O)OCc15 4.51 CHEMBL2443482 CHEMBL2441421 Clc1c(CCN2CCN(CC2)C(=O)Cc3ccc(cc3)n4cnnn4)ccc5C(=O)OCc15 4.77 CHEMBL2443482 CHEMBL2441422 COc1c(CCN2CCN(CC2)C(=O)Cc3ccc(cc3)n4cnnn4)ccc5C(=O)OCc15 4.4 CHEMBL2443482 CHEMBL2441423 Cc1cc2C(=O)OCc2cc1CCN3CCN(CC3)C(=O)Cc4ccc(cc4)n5cnnn5 4.85 CHEMBL2443482 CHEMBL2441424 Fc1cc2C(=O)OCc2cc1CCN3CCN(CC3)C(=O)Cc4ccc(cc4)n5cnnn5 4.59 CHEMBL2443482 CHEMBL2441425 COc1cc2C(=O)OCc2cc1CCN3CCN(CC3)C(=O)Cc4ccc(cc4)n5cnnn5 5.25 CHEMBL2443482 CHEMBL2441426 Cc1cc(CCN2CCN(CC2)C(=O)Cc3ccc(cc3)n4cnnn4)cc5COC(=O)c15 5 CHEMBL2443482 CHEMBL2441427 Fc1cc(CCN2CCN(CC2)C(=O)Cc3ccc(cc3)n4cnnn4)cc5COC(=O)c15 4.89 CHEMBL2443482 CHEMBL2441428 Clc1cc(CCN2CCN(CC2)C(=O)Cc3ccc(cc3)n4cnnn4)cc5COC(=O)c15 5.47 CHEMBL2443482 CHEMBL2441429 [O-][N+](=O)c1ccc(CCN2CCN(CCc3ccc(cc3)n4cnnn4)CC2)cc1 7.96 CHEMBL2443482 CHEMBL2441430 [O-][N+](=O)c1ccc(CCN2CCN(CC2)C(=O)Cc3ccc(cc3)[N+](=O)[O-])cc1 7.34 CHEMBL2443482 CHEMBL2441431 [O-][N+](=O)c1ccc(CCN2CCN(CC2)C(=O)Cc3ccc4C(=O)OCc4c3)cc1 5.89 CHEMBL2443482 CHEMBL2441433 [O-][N+](=O)c1ccc(CCN2CCN(CC2)C(=O)Cc3ccc(cc3)n4cnnn4)cc1 6.8 CHEMBL2443482 CHEMBL2441434 O=C(Cc1ccc(cc1)n2cnnn2)N3CCN(CCc4ccc(cc4)C#N)CC3 6.38 CHEMBL2443482 CHEMBL2441435 O=C(Cc1ccc(cc1)n2cnnn2)N3CCN(CCc4cccc(c4)C#N)CC3 5.57 CHEMBL2443482 CHEMBL2441436 O=C(Cc1ccc(cc1)n2cnnn2)N3CCN(CCc4ccc5nonc5c4)CC3 5.89 CHEMBL2443482 CHEMBL2441437 O=C(Cc1ccc(cc1)n2cnnn2)N3CCN(CCc4ccc5C(=O)OCc5c4)CC3 4.85 CHEMBL2443482 CHEMBL2441438 O=C(Cc1ccc(cc1)n2cnnn2)N3CCN(CCc4ccc5COC(=O)c5c4)CC3 4.5 CHEMBL2443482 CHEMBL2441440 O=C(Cc1ccc(cc1)n2cnnn2)N3CCN(CCc4ccc5COCc5c4)CC3 5.6 CHEMBL2443482 CHEMBL2441441 O=C(Cc1ccc(cc1)n2cnnn2)N3CCN(CCc4ccc5C(=O)CCc5c4)CC3 5.19 CHEMBL2443482 CHEMBL2441636 C[C@H]1CCCN1[C@H]2CCN(C2)c3ccc(NC(=O)C4CCOCC4)c(C)c3 4.72 CHEMBL2443511 CHEMBL244275 Cc1oc(nc1)c2ccc3CCN(CCCSc4nnc(c5cccs5)n4C)CCc3c2 6.5 CHEMBL895464 CHEMBL244276 Cc1oc(nc1)c2ccc3CCN(CCCSc4nnc(c5ccc6[nH]ccc6c5)n4C)CCc3c2 7.4 CHEMBL895464 CHEMBL244277 Cc1oc(nc1)c2ccc3CCN(CCCSc4nnc(c5cccn5C)n4C)CCc3c2 6.3 CHEMBL895464 CHEMBL244278 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(c5cccc(Cl)c5)n4C)CCc3c2 7.1 CHEMBL895464 CHEMBL244279 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(c5ccc(Cl)cc5)n4C)CCc3c2 7.6 CHEMBL895464 CHEMBL244280 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(c5cccc(F)c5)n4C)CCc3c2 6.6 CHEMBL895464 CHEMBL2443262 COc1ccsc1CNCC[C@]2(CCOC3(CCCC3)C2)c4ccccn4 5.21 CHEMBL2445978 CHEMBL2443278 C(C[C@]1(CCOC2(CCCC2)C1)c3ccccn3)NCc4cccs4 5.64 CHEMBL2445978 CHEMBL244347 CN(C1CCCCC1)C(=O)CC[C@@H](C2CCCCC2)N3Cc4cc(Oc5ccccc5)ccc4N=C3N 6.85 CHEMBL895731 CHEMBL2447962 Cl.CCCCN1CCCC[C@@H]1C(=O)Nc2c(C)cccc2C 4.08 CHEMBL1820248 CHEMBL244945 COc1ccc(cn1)c2nnc(SCCCN3CCc4ccc(cc4CC3)c5cc(C)on5)n2C 6.8 CHEMBL895464 CHEMBL244946 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5ccc(cc5CC4)c6cc(C)nn6C)n3C 5.7 CHEMBL895464 CHEMBL245118 Cc1cc(c2ccc3CCN(CCCSc4nnc(c5ccc(F)c(F)c5)n4C)CCc3c2)n(C)n1 6.6 CHEMBL895464 CHEMBL245119 Cc1cc(c2ccc3CCN(CCCSc4nnc(c5ocnc5C)n4C)CCc3c2)n(C)n1 5.6 CHEMBL895464 CHEMBL245120 Cc1ccc2c(cccc2n1)c3nnc(SCCN4CCc5ccc(cc5CC4)c6cc(C)nn6C)n3C 5.7 CHEMBL895464 CHEMBL245379 Cl.C[C@H]([C@H](N)C(=O)N1CC[C@H](F)C1)C2CCC(CC2)N(C)C(=O)c3cccc(F)c3 4.11 CHEMBL887127 CHEMBL245492 Fc1cccc(CN(C2CCOCC2)[C@H]3CCNC3)c1C(F)(F)F 5.8 CHEMBL903477 CHEMBL245568 COc1ccc2nccc([C@@H]3CN(C4CCN(Cc5cc6ccccc6[nH]5)CC4)C(=O)O3)c2c1 5.8 CHEMBL903467 CHEMBL245642 CO\N=C\COc1ccc(CN2CCC(CC2)NC(=O)C3=CC(=O)c4ccc(F)cc4O3)cc1F 5.5 CHEMBL886903 CHEMBL245844 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc(OCCCN5C(=O)CSC5=O)c(F)c4)CC3 5.07 CHEMBL886903 CHEMBL246050 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc(cc4)C(=O)NCCN5CCCCC5)CC3 4.18 CHEMBL886903 CHEMBL246051 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc(cc4)C(=O)NCCN5CCC(F)(F)CC5)CC3 5.2 CHEMBL886903 CHEMBL246258 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc(cc4Cl)C(=O)NCCN5CCCC5)CC3 4.96 CHEMBL886903 CHEMBL246259 COc1cc(ccc1CN2CCC(CC2)NC(=O)C3=CC(=O)c4ccc(F)cc4O3)C(=O)NCCN5CCCC5 5.18 CHEMBL886903 CHEMBL246464 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc(NC(=O)CCN5CCCCC5)c(F)c4)CC3 5.04 CHEMBL886903 CHEMBL246519 Fc1ccc(CN(C2CCOCC2)[C@H]3CCNC3)c(F)c1F 5.92 CHEMBL903477 CHEMBL246634 CC(C(O)c1ccc2NC(=O)Oc2c1)N3CCC(O)(CC3)c4ccc(F)cc4 5.59 CHEMBL940929 CHEMBL246635 CC(C(O)c1ccc2NC(=O)COc2c1)N3CCC(O)(CC3)c4ccc(F)cc4 5.8 CHEMBL940929 CHEMBL246815 CC(C(O)c1ccc2NC(=O)NCc2c1)N3CCC(O)(CC3)c4ccc(F)cc4 5.13 CHEMBL940929 CHEMBL246816 CC(C(O)c1ccc2NC(=O)N(C)Cc2c1)N3CCC(O)(CC3)c4ccc(F)cc4 5.51 CHEMBL940929 CHEMBL246817 CC(C(O)c1ccc2NC(=O)CCc2c1)N3CCC(O)(CC3)c4ccc5CCOCc5c4 4.8 CHEMBL940929 CHEMBL246818 COc1cccc(c1)C2(O)CCN(CC2)C(C)C(O)c3ccc4NC(=O)CCc4c3 4.96 CHEMBL940929 CHEMBL246819 OC(CN1CCC(O)(CC1)c2cccc(F)c2)c3ccc4NC(=O)CCc4c3 4.68 CHEMBL940929 CHEMBL247044 CN(C)CCC[C@]1(CN(N=C1C(=O)C)c2cc(C)ccc2F)c3ccccc3 5.52 CHEMBL940958 CHEMBL247688 COC(C)(C)CCOc1ccc(CN2CCC(CC2)NC(=O)C3=CC(=O)c4ccc(F)cc4O3)cc1 5.37 CHEMBL886903 CHEMBL247689 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc(OCC(F)(F)F)c(F)c4)CC3 5.8 CHEMBL886903 CHEMBL247690 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc(OCCCN5CCOCC5)c(F)c4)CC3 4.47 CHEMBL886903 CHEMBL24778 C[C@H](Cc1cc2CCN(CCCO)c2c(c1)C(=O)N)NCCOc3ccccc3OCC(F)(F)F 4.6 CHEMBL3430715 CHEMBL247840 CC(C(O)c1ccc2NC(=O)CCc2c1)N3CCC(O)(CC3)c4ccc(C)cc4 5.48 CHEMBL940929 CHEMBL247891 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc(OCCCN(C5CC5)C6CC6)c(F)c4)CC3 6.13 CHEMBL886903 CHEMBL248296 CN(C)CCCOc1ccc(CN2CCC(CC2)NC(=O)C3=CC(=O)c4ccc(F)cc4O3)cc1F 4.19 CHEMBL886903 CHEMBL248297 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc(OCCCN5CCCCC5)c(F)c4)CC3 4.38 CHEMBL886903 CHEMBL249601 CC(N1C[C@H](N)[C@@H](C1)C(=O)N2CCC[C@H]2C#N)c3ccc(cc3)C#N 5 CHEMBL943040 CHEMBL249854 CC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@@H](C1)NC(=O)Nc4nc(C)c(s4)C(=O)C 5.22 CHEMBL925077 CHEMBL250125 CC(=O)N1CCN(CCC[C@]2([C@@H]3COc4ccc(F)cc4N3N=C2C(=O)C)c5ccccc5)CC1 5 CHEMBL940958 CHEMBL250126 CC(=O)N1CCN(CCC[C@]2([C@@H]3COc4ccc(Cl)cc4N3N=C2C(=O)C)c5ccccc5)CC1 5.25 CHEMBL941016 CHEMBL250127 CC(=O)C1=NN2[C@@H](COc3ccc(F)cc23)[C@@]1(CCCN)c4ccccc4 6.03 CHEMBL941016 CHEMBL250328 CN(C)CCC[C@]1([C@@H]2COc3ccc(F)cc3N2N=C1C(=O)C)c4ccccc4 5.23 CHEMBL941016 CHEMBL250481 Cc1[nH]nc2c3cc(C4CCCCC4)c(cc3N(CCCN)C(=O)c12)C5CCCCC5 5.28 CHEMBL941012 CHEMBL250532 CN(C)CCC[C@]1([C@@H]2COc3ccc(C)cc3N2N=C1C(=O)C)c4ccccc4 5.62 CHEMBL941016 CHEMBL250533 CC(=O)C1=NN2[C@@H](COc3ccc(Cl)cc23)C1(CCCN4CCOCC4)c5ccccc5 5.48 CHEMBL941016 CHEMBL250689 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN3CCC[C@@H](Cc4ccc(F)cc4)C3)c1 6.4 CHEMBL925077 CHEMBL250743 CC(=O)C1=NN2[C@@H](COc3ccc(F)cc23)[C@@]1(CCCO)c4ccccc4 4.75 CHEMBL941016 CHEMBL250877 CN1CCCc2cc(NC(=O)c3oc(cc3)c4ccc(Cl)cc4)ccc12 5.28 CHEMBL944718 CHEMBL251142 CN1CCN(CCC[C@]2([C@@H]3COc4ccc(F)cc4N3N=C2C(=O)C)c5ccccc5)CCC1=O 5.02 CHEMBL941016 CHEMBL251241 C[C@@H](NC(=O)c1oc(cc1)c2ccc(Cl)cc2)C(=O)N3CCN(CCCOc4ccc(cc4)C(=O)C5CC5)CC3 6.1 CHEMBL944718 CHEMBL253868 Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2)c4ccccc4 5.52 CHEMBL927770 CHEMBL253869 Nc1ccc(cc1NC(=O)c2ccc(CNC(=O)CCc3cccnc3)cc2)c4ccccc4 5.43 CHEMBL927770 CHEMBL255158 Cc1ncccc1c2nnc(SCCCN3CCc4ccc5oc(nc5c4CC3)C(F)(F)F)n2C 5.4 CHEMBL931097 CHEMBL255220 Cc1nc2ccc3CCN(CCCSc4nnc(c5ocnc5C)n4C)CCc3c2s1 4.9 CHEMBL931097 CHEMBL255245 Nc1ccccc1NC(=O)c2ccc(cc2)c3ncc(CN4CCC4)cc3Cl 4.65 CHEMBL927950 CHEMBL255312 CC(C)[C@@]1(CC[C@H](C1)N2CCC(CC2)c3cccc(O)c3)C(=O)NCc4cc(cc(c4)C(F)(F)F)C(F)(F)F 7.17 CHEMBL944859 CHEMBL255389 Cc1oc(nc1CCOc2cccc(C[C@H]3[C@H](N(C3=O)c4ccc(cc4)C(C)(C)C)C(=O)O)c2)c5ccccc5 5.21 CHEMBL933193 CHEMBL255417 CCc1oc2c(Br)c3CCN(CCc3cc2n1)C(C)CCSc4nnc(c5cccc6nc(C)ccc56)n4C 5.5 CHEMBL948183 CHEMBL255431 Cc1cccnc1C(=O)N2CCC(C)(CC2)N3CCC(CC3)N(c4ccccc4)c5cccnc5 6.39 CHEMBL928561 CHEMBL255511 CC(C)[C@@]1(CC[C@H](C1)N2CCC(CC2)c3cccc(c3)C(=O)O)C(=O)NCc4cc(cc(c4)C(F)(F)F)C(F)(F)F 5.56 CHEMBL944859 CHEMBL255513 CC(C)[C@@]1(CC[C@H](C1)N2CCC(CC2)c3cccnc3)C(=O)NCc4cc(cc(c4)C(F)(F)F)C(F)(F)F 6.65 CHEMBL944859 CHEMBL255566 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6nc(oc6c(Br)c5CC4)C(C)(C)C)n3C 6.4 CHEMBL948183 CHEMBL255567 CCc1nc2cc3CCN(CCCSc4nnc(c5ocnc5C)n4C)CCc3cc2s1 5.9 CHEMBL948183 CHEMBL255618 CC(CCSc1nnc(c2cccc3nc(C)ccc23)n1C)N4CCc5cc6nc(oc6c(Br)c5CC4)C(F)(F)F 5.7 CHEMBL948183 CHEMBL255619 Cc1ncoc1c2nnc(SCCCN3CCc4cc5oc(CC6CC6)nc5cc4CC3)n2C 6 CHEMBL948183 CHEMBL255620 CN(C)c1oc2cc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 4.7 CHEMBL948183 CHEMBL255621 Cc1ncoc1c2nnc(SCCCN3CCc4cc5ocnc5cc4CC3)n2C 5.2 CHEMBL948183 CHEMBL255644 CC1(CCN(CC1)C(=O)c2c(Cl)cncc2Cl)N3CCC(CC3)N(c4ccccc4)c5cccnc5 5.7 CHEMBL928561 CHEMBL255645 CC1(CCN(CC1)C(=O)c2c(Cl)c[n+]([O-])cc2Cl)N3CCC(CC3)N(c4ccccc4)c5cccnc5 5.36 CHEMBL928561 CHEMBL255778 CCc1oc2c(Br)c3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 5.9 CHEMBL948183 CHEMBL255806 Cc1oc2c(Br)c3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 5.6 CHEMBL948183 CHEMBL255826 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6oc(nc6cc5CC4)N7CCCCC7)n3C 5.3 CHEMBL948183 CHEMBL255827 Cc1oc2cc3CCN(CCCSc4nnc(c5ocnc5C)n4C)CCc3cc2n1 4.5 CHEMBL948183 CHEMBL255857 Cc1nc(CN(C2CCN(CC2)C3(C)CCN(CC3)C(=O)c4c(C)cc[n+]([O-])c4C)c5ccccc5)cs1 4.91 CHEMBL928561 CHEMBL255863 Cc1cn(cn1)c2cc(NC(=O)c3ccc(C)c(Nc4nccc(n4)c5cccnc5)c3)cc(c2)C(F)(F)F 4.2 CHEMBL3430710 CHEMBL255968 C[C@H](Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)C(=O)N(C)C 5 CHEMBL930660 CHEMBL256015 CC(C)c1oc2cc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 5.7 CHEMBL948183 CHEMBL256016 CC(C)c1oc2cc3CCN(CCCSc4nnc(c5ocnc5C)n4C)CCc3cc2n1 5.4 CHEMBL948183 CHEMBL256060 C[C@H](Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)C(=O)N(C)CCO 4.96 CHEMBL930660 CHEMBL256154 CC(C)[C@@]1(CC[C@H](C1)N2CCC(CC2)c3cncnc3)C(=O)NCc4cc(cc(c4)C(F)(F)F)C(F)(F)F 5.75 CHEMBL944859 CHEMBL256362 C[C@@H](Oc1cccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c12)C(=O)N(C)C 5.1 CHEMBL930660 CHEMBL256442 CCc1nc2ccc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3c2s1 6.8 CHEMBL931097 CHEMBL256468 Cc1oc(nc1CCOc2ccc(C[C@H]3[C@H](N(C3=O)c4ccc(cc4)C(C)(C)C)C(=O)O)cc2)c5ccccc5 4.74 CHEMBL933193 CHEMBL256471 Cc1nc2cc3CCN(CCCSc4nnc(c5ocnc5C)n4C)CCc3cc2s1 5.5 CHEMBL948183 CHEMBL256473 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6oc(nc6cc5CC4)C(C)(F)F)n3C 5.9 CHEMBL948183 CHEMBL256475 Cc1ncoc1c2nnc(SCCCN3CCc4cc5onc(C)c5cc4CC3)n2C 5.2 CHEMBL948183 CHEMBL256477 CCc1nn(C)c2cc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc12 6 CHEMBL948183 CHEMBL256481 Cc1oc2c(C)c3CCN(CCCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 5.8 CHEMBL948183 CHEMBL256482 CCc1oc2c(Br)c3CCN(CCCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 5.8 CHEMBL948183 CHEMBL256488 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5ccc6nc(oc6c5CC4)C(C)(F)F)n3C 5.6 CHEMBL931097 CHEMBL256650 Cc1oc2cc3CCN(CCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 4.3 CHEMBL948183 CHEMBL256651 CCc1oc2cc3CCN(CCCSc4nnc(c5ccc(F)c(F)c5)n4C)CCc3cc2n1 5.9 CHEMBL948183 CHEMBL256652 CN1C(=O)COc2cc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc12 5.3 CHEMBL948183 CHEMBL256653 Cc1oc2cc3CCN(CCCSc4nnc(c5cccnc5)n4C)CCc3cc2n1 4.3 CHEMBL948183 CHEMBL256658 Cc1ccc2nc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3n2c1 5.6 CHEMBL931097 CHEMBL256659 Cc1ncoc1c2nnc(SCCCN3CCc4ccc5nc(oc5c4CC3)C(F)(F)F)n2C 5.3 CHEMBL931097 CHEMBL256954 CC(C)[C@@]1(CC[C@H](C1)N2CCC(CC2)c3ccncn3)C(=O)NCc4cc(cc(c4)C(F)(F)F)C(F)(F)F 6.89 CHEMBL944859 CHEMBL257023 CC([C@H](N)C(=C1CCCC1)F)c2onc(n2)c3ccc(cc3Cl)S(=O)(=O)C.OC(=O)C(F)(F)F 4.72 CHEMBL933468 CHEMBL257369 Cc1ccc2c(cccc2n1)c3nnc(SCCCCN4CCc5cc6nc(oc6c(Br)c5CC4)C(F)(F)F)n3C 6.6 CHEMBL948183 CHEMBL257478 C[C@@H](Oc1cccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c12)C(=O)N(C)CCO 4.92 CHEMBL930660 CHEMBL257517 COc1ccc(cc1)c2oc(C)c(CCOc3cccc(C[C@H]4[C@H](N(C4=O)c5ccc(cc5)C(C)(C)C)C(=O)O)c3)n2 5.5 CHEMBL933193 CHEMBL257524 CCc1oc2c(C)c3CCN(CCc3cc2n1)C(C)CCSc4nnc(c5cccc6nc(C)ccc56)n4C 5.4 CHEMBL948183 CHEMBL257525 CC(CCSc1nnc(c2cccc3nc(C)ccc23)n1C)N4CCc5cc6nc(oc6c(C)c5CC4)C(F)(F)F 6 CHEMBL948183 CHEMBL257534 CN1C(=O)COc2cc3CCN(CCCSc4nnc(c5ocnc5C)n4C)CCc3cc12 4.6 CHEMBL948183 CHEMBL257536 Cc1ncoc1c2nnc(SCCCN3CCc4cc5NC(=O)COc5cc4CC3)n2C 7.2 CHEMBL948183 CHEMBL257716 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5nc6ccc(Cl)cn6c5CC4)n3C 5.8 CHEMBL931097 CHEMBL257717 Cc1ccn2c3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3nc2c1 6.6 CHEMBL931097 CHEMBL257900 Cc1ccc2c(cccc2n1)c3nnc(SCCN4CCc5cc6nc(oc6c(C)c5CC4)C(F)(F)F)n3C 6.4 CHEMBL948183 CHEMBL257901 Cc1oc2c(C)c3CCN(CCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 4.9 CHEMBL948183 CHEMBL257946 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6onc(C)c6cc5CC4)n3C 6.1 CHEMBL948183 CHEMBL258090 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6oc(CC(F)(F)F)nc6cc5CC4)n3C 5.6 CHEMBL948183 CHEMBL258132 CN(C)C(=O)C(N)c1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3 5.17 CHEMBL934350 CHEMBL258175 CC(C)N1CCN(Cc2cnc(c(Cl)c2)c3ccc(cc3)C(=O)Nc4ccccc4N)CC1 5.15 CHEMBL927950 CHEMBL258177 CC(C)N1CCN(Cc2cnc(c3ccc(cc3)C(=O)Nc4ccccc4N)c(c2)C#N)CC1 4.72 CHEMBL927950 CHEMBL258246 CC(C)[C@@]1(CC[C@H](C1)N2CCC(CC2)c3cccc(F)c3)C(=O)NCc4cc(cc(c4)C(F)(F)F)C(F)(F)F 7.35 CHEMBL944859 CHEMBL258313 C[C@@H](Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)C(=O)N(C)CCO 4.92 CHEMBL930660 CHEMBL259243 Clc1ccc(cc1)C(=O)N2CCC3(CCN(Cc4ccccc4Oc5ccccc5)CC3)CC2 7.08 CHEMBL1045843 CHEMBL259732 CCCCN1CCC2(CC1)OC(OC)c3c2cnn3c4ccccc4 9.19 CHEMBL922329 CHEMBL261592 CC(C)c1c(cn2ncnc(Nc3cnc4[nH]c(C)cc4c3)c12)c5oc(C)nn5 5.18 CHEMBL929420 CHEMBL262341 O=C1N=CC=C2N=C(C(=CC12)c3ccccc3)c4ccc(CN5CCC(CC5)c6n[nH]c(n6)c7ccccn7)cc4 5.25 CHEMBL937425 CHEMBL262736 CC(C)(C)[C@H](O)C(=O)N1CC(=C[C@H]1c2cccc(O)c2)c3cc(F)ccc3F 5.11 CHEMBL869626 CHEMBL263101 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cc5cccnc5nc4C 4.4 CHEMBL1827362 CHEMBL266725 CN1C(=O)C=Cc2ccc(CN3CCC(CC3)NC(=O)C4=CC(=O)c5ccc(F)cc5O4)cc12 4.32 CHEMBL854890 CHEMBL267320 CN(C)Cc1ccc2C[C@H](CCc2c1)N(C)C(=O)c3ccc(cc3)c4ccccn4 4.52 CHEMBL854892 CHEMBL269352 CC(=O)Nc1cccc(CN2CCC(CC2)NC(=O)C3=CC(=O)c4ccc(F)cc4O3)c1 4.22 CHEMBL854890 CHEMBL269994 CCc1oc2c(C)c3CCN(CCCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 5.8 CHEMBL948183 CHEMBL269995 Cc1oc2cc3CCN(CCCSc4nnc(c5ccc(F)c(F)c5)n4C)CCc3cc2n1 5 CHEMBL948183 CHEMBL27 CC(C)NCC(O)COc1cccc2ccccc12 5.55 CHEMBL3430649 CHEMBL270227 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6oc(nc6cc5CC4)C(F)(F)C(F)(F)F)n3C 7 CHEMBL948183 CHEMBL270239 CC(CCSc1nnc(c2cccc3nc(C)ccc23)n1C)N4CCc5cc6nc(C)oc6c(C)c5CC4 4.9 CHEMBL948183 CHEMBL270314 CN(C)[C@H]1CCN(CCC(=O)Nc2cc(nc(n2)c3oc(C)cc3)n4nc(C)cc4C)C1 5.64 CHEMBL949251 CHEMBL270376 Cc1nc(C)c(s1)c2nnc(SCCCN3CCc4ccc5oc(nc5c4CC3)C(F)(F)F)n2C 6.1 CHEMBL931097 CHEMBL270387 Cn1c(SCCCN2CCc3ccc4oc(nc4c3CC2)C(F)(F)F)nnc1c5ccccc5 6.6 CHEMBL931097 CHEMBL270467 CN1CCN(CC(=O)Nc2cc(nc(n2)c3oc(C)cc3)n4nc(C)cc4C)CC1 6.02 CHEMBL949251 CHEMBL270567 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6oc(nc6cc5CC4)c7cc(C)nn7C)n3C 6.3 CHEMBL948183 CHEMBL270602 Cc1cnc(cn1)c2nnc(SCCCN3CCc4ccc5oc(nc5c4CC3)C(F)(F)F)n2C 5.9 CHEMBL931097 CHEMBL270852 CC(C)N1Cc2cc3CCN(CCCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2C1=O 5.4 CHEMBL948183 CHEMBL270853 CN1Cc2cc3CCN(CCCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2C1=O 4.5 CHEMBL948183 CHEMBL270969 COc1ccccc1Oc2ccccc2CN3CCC4(CC3)CCN(CC4)C(=O)c5cccc[n+]5[O-] 5.72 CHEMBL948146 CHEMBL270971 COc1ccccc1Oc2ccccc2CN3CCC4(CC3)CCN(CC4)C(=O)c5cc[n+]([O-])cc5 6.66 CHEMBL1045843 CHEMBL271034 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5ccc6oc(nc6c5CC4)C(F)(F)C(F)(F)F)n3C 6.6 CHEMBL931097 CHEMBL271066 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6NC(=O)COc6cc5CC4)n3C 8.2 CHEMBL948183 CHEMBL271072 Cc1oc2c(Br)c3CCN(CCCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 5.3 CHEMBL948183 CHEMBL271073 Cc1oc2cc3CCN(CCCCSc4nnc(c5ocnc5C)n4C)CCc3cc2n1 4.3 CHEMBL948183 CHEMBL271083 Cc1ncoc1c2nnc(SCCCN3CCc4cc5oc(nc5cc4CC3)C(F)(F)C(F)(F)F)n2C 6.7 CHEMBL948183 CHEMBL271096 CCc1oc2cc3CCN(CCCSc4nnc(c5ccc(cc5)C(F)(F)F)n4C)CCc3cc2n1 6.6 CHEMBL948183 CHEMBL271097 Cc1ccc2c(cccc2n1)c3nnc(SCCCCN4CCc5cc6nc(oc6c(C)c5CC4)C(F)(F)F)n3C 6.6 CHEMBL948183 CHEMBL271127 COc1ccccc1Oc2ccccc2CN3CCC4(CC3)CCN(CC4)C(=O)c5ccccn5 6.92 CHEMBL948146 CHEMBL271128 COc1ccccc1Oc2ccccc2CN3CCC4(CC3)CCN(CC4)C(=O)c5ccncc5 7.34 CHEMBL1045843 CHEMBL271220 CCOC[C@@]12CN(CCC1=Cc3c(C2)cnn3c4ccc(F)cc4)S(=O)(=O)c5ccc(cc5)C(F)(F)F 6.1 CHEMBL3736641 CHEMBL271449 Cc1ncoc1c2nnc(SCCCN3CCc4ccc5oc(nc5c4CC3)C(F)(F)F)n2C 5.9 CHEMBL931097 CHEMBL271511 Cc1ncoc1c2nnc(SCCCN3CCc4nc5ccc(cn5c4CC3)C(F)(F)F)n2C 5.7 CHEMBL931097 CHEMBL271606 CN(C)[C@H]1CCN(CC(=O)Nc2cc(nc(n2)c3oc(C)cc3)n4nc(C)cc4C)C1 6.22 CHEMBL949251 CHEMBL271631 CCc1nc2cc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2s1 6.6 CHEMBL948183 CHEMBL271632 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6nc(C)sc6cc5CC4)n3C 5.6 CHEMBL948183 CHEMBL271729 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5nc6ccc(cn6c5CC4)C(F)(F)F)n3C 5.3 CHEMBL931097 CHEMBL271768 O=C(N1CCC2(CCN(Cc3ccccc3Oc4ccccc4)CC2)CC1)c5ccncc5 7.68 CHEMBL948146 CHEMBL271801 O=C(N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1)c5ccncc5 6.35 CHEMBL1045843 CHEMBL271844 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6ocnc6cc5CC4)n3C 5.4 CHEMBL948183 CHEMBL271909 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5ccc6nc(C)sc6c5CC4)n3C 5.5 CHEMBL931097 CHEMBL272022 COc1ccccc1Oc2cccc(CN3CCC4(CC3)CCN(CC4)C(=O)c5cc[n+]([O-])cc5)c2 4.59 CHEMBL1045843 CHEMBL272086 CC(C)N1Cc2cc3CCN(CCc3cc2C1=O)C(C)CCSc4nnc(c5cccc6nc(C)ccc56)n4C 5.6 CHEMBL948183 CHEMBL272150 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5ccc6oc(nc6c5CC4)C(F)(F)F)n3C 5.7 CHEMBL931097 CHEMBL272297 Cc1cc(c2oc3ccc4CCN(CCCSc5nnc(c6ocnc6C)n5C)CCc4c3n2)n(C)n1 6.1 CHEMBL931097 CHEMBL272300 CC(CCSc1nnc(c2cccc3nc(C)ccc23)n1C)N4CCc5cc6CN(C)C(=O)c6cc5CC4 4.4 CHEMBL948183 CHEMBL272302 CCc1oc2cc3CCN(CCCSc4nnc(c5cccnc5)n4C)CCc3cc2n1 4.8 CHEMBL948183 CHEMBL272336 Cc1oc(nc1CCOc2cccc(C[C@H]3[C@H](N(C3=O)c4ccc(cc4)C(C)(C)C)C(=O)O)c2)c5ccc(Cl)cc5 5.89 CHEMBL933193 CHEMBL272378 CCc1oc2c(Br)c3CCN(CCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 5.6 CHEMBL948183 CHEMBL272379 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6OCCN(c6cc5CC4)S(=O)(=O)C)n3C 5.1 CHEMBL948183 CHEMBL272478 CC(C)N1Cc2cc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2C1=O 5.4 CHEMBL948183 CHEMBL272511 Cc1oc2ccc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3c2n1 5.6 CHEMBL931097 CHEMBL272545 CCc1oc2cc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 5.3 CHEMBL948183 CHEMBL272546 CCc1oc2cc3CCN(CCCSc4nnc(c5ocnc5C)n4C)CCc3cc2n1 5.2 CHEMBL948183 CHEMBL272588 Cc1ncoc1c2nnc(SCCCN3CCc4nc5cc(ccn5c4CC3)C(F)(F)F)n2C 6.1 CHEMBL931097 CHEMBL272637 CN(C)C[C@@H]1CCN(CC(=O)Nc2cc(nc(n2)c3oc(C)cc3)n4nc(C)cc4C)C1 6 CHEMBL949251 CHEMBL272679 CN1CCC(CC(=O)Nc2cc(nc(n2)c3oc(C)cc3)n4nc(C)cc4C)CC1 5.38 CHEMBL949251 CHEMBL272694 Cc1oc2c(C)c3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 5.3 CHEMBL948183 CHEMBL272695 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6oc(nc6cc5CC4)C7CC7)n3C 6 CHEMBL948183 CHEMBL272702 CC(=O)N1CCOc2cc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc12 5 CHEMBL948183 CHEMBL272775 Cc1ncoc1c2nnc(SCCCN3CCc4ccc5nc(oc5c4CC3)C(C)(F)F)n2C 5.3 CHEMBL931097 CHEMBL273165 CC(CCSc1nnc(c2cccc3nc(C)ccc23)n1C)N4CCc5cc6nc(C)oc6c(Br)c5CC4 5 CHEMBL948183 CHEMBL273166 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6oc(CC7CC7)nc6cc5CC4)n3C 5.9 CHEMBL948183 CHEMBL273199 Cc1cc2c(cccc2cn1)c3nnc(SCCCN4CCc5ccc(cc5CC4)c6cc(C)nn6C)n3C 5.7 CHEMBL948183 CHEMBL273208 CNCc1cnc(C)cc1Oc2ccccc2Oc3ccccc3 4.95 CHEMBL1062483 CHEMBL273235 Fc1ccc(cc1)n2cc(C3CCNCC3)c4cc(Cl)ccc24 6.69 CHEMBL766816 CHEMBL274168 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5cc[nH]c5c4)CC3 5.6 CHEMBL854890 CHEMBL289469 CN1C2CCCC1CC(C2)NC(=O)c3nn(C)c4ccccc34 5.43 CHEMBL691014 CHEMBL294029 C[C@@H](c1nc(cs1)c2ccc(cc2)C#N)[C@](O)(Cn3cncn3)c4ccc(F)cc4F 4.98 CHEMBL3266651 CHEMBL295124 COc1ccc2cc3c4cc5OCOc5cc4CC[n+]3cc2c1OC 4.18 CHEMBL1676103 CHEMBL295698 CC(=O)N1CCN(CC1)c2ccc(OC[C@@H]3CO[C@](Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2 5.72 CHEMBL766814 CHEMBL296419 COc1ccc(CCN2CCC(CC2)Nc3nc4ccccc4n3Cc5ccc(F)cc5)cc1 5.57 CHEMBL981950 CHEMBL298475 CN([C@@H]1[C@@H](O)C(C)(C)Oc2ccc(OCCCC(F)(F)F)cc12)S(=O)(=O)C 4.9 CHEMBL827807 CHEMBL298817 C[C@@H](N1C=Nc2cc(Cl)ccc2C1=O)[C@](O)(Cn3cncn3)c4ccc(F)cc4F 4.46 CHEMBL3266651 CHEMBL298978 Fc1ccc(cc1)n2cc(C3CCN(CCN4CCN=C4S)CC3)c5ccccc25 8.21 CHEMBL766816 CHEMBL299390 CCC(CC)c1cn(c2ccc(F)cc2)c3ccc(Cl)cc13 5.83 CHEMBL766816 CHEMBL299590 CC(C)(C)c1ccc2c(ccn2c3ccc(F)cc3)c1 5 CHEMBL1676103 CHEMBL30008 Fc1ccc(cc1)C(N2CCN(C\C=C\c3ccccc3)CC2)c4ccc(F)cc4 6.22 CHEMBL1909190 CHEMBL300117 CCC(=O)OC(Cc1ccccc1)(C(C)CN(C)C)c2ccccc2 5.56 CHEMBL1676103 CHEMBL300907 CCc1cn(c2ccc(F)cc2)c3ccc(Cl)cc13 5.46 CHEMBL766816 CHEMBL300927 OC(=O)c1ccc(cc1)n2cc(C3CCN(CCN4CCNC4=O)CC3)c5cc(Cl)ccc25 4.13 CHEMBL766816 CHEMBL301454 Cc1cccc(C)c1C(=O)N2CCC(C)(CC2)N3CCC(CC3)N(Cc4ccccc4)c5ccccc5 6.17 CHEMBL928561 CHEMBL301956 CN(C)Cc1cn(c2ccc(F)cc2)c3ccc(Cl)cc13 7.96 CHEMBL766816 CHEMBL301992 CC(=O)c1cn(c2ccc(F)cc2)c3ccc(Cl)cc13 5 CHEMBL1676103 CHEMBL305187 CC(C(O)c1ccc(O)cc1)N2CCC(Cc3ccccc3)CC2 7 CHEMBL1676103 CHEMBL305660 CC(C)(C)c1ccc(cc1)C(=O)CCCN2CCC(CC2)OC(c3ccccc3)c4ccccc4 5.52 CHEMBL829152 CHEMBL3084761 CN1[C@@H]2CCC[C@H]1C[C@@H](C2)NC(=O)c3cccc4oc(nc34)N5CCOCC5 5.85 CHEMBL1274536 CHEMBL3084776 C[C@H]1CNC[C@H](C)N1c2oc3cccc(C(=O)N[C@@H]4C[C@H]5CCC[C@@H](C4)N5C)c3n2 5.19 CHEMBL1274536 CHEMBL3084777 COc1ccccc1c2oc3cccc(C(=O)N[C@@H]4C[C@H]5CCC[C@@H](C4)N5C)c3n2 6.4 CHEMBL1274536 CHEMBL3084778 CN1[C@@H]2CCC[C@H]1C[C@@H](C2)NC(=O)c3cccc4oc(nc34)C5CC5 6.7 CHEMBL1274536 CHEMBL3085780 Fc1ccc(cc1)C(NC(=O)[C@@H]2CC[C@H](C[C@H]2c3ccc(Br)cc3)N4CCOCC4)c5ccncc5 5.08 CHEMBL3090534 CHEMBL3086028 CCN(CC)CC(=O)N[C@@H]1CC[C@H]([C@@H](C1)c2ccc(Br)cc2)C(=O)NC(c3ccc(F)cc3)c4ccc(F)cc4 6.11 CHEMBL3090534 CHEMBL3086029 Brc1ccc(cc1)[C@@H]2C[C@@H](CC[C@H]2C(=O)N3CC(C3)(c4ccccc4)c5ccccc5)N6CCOCC6 6.54 CHEMBL3090534 CHEMBL3086032 C[C@H](NC(=O)[C@@H]1CC[C@H](C[C@H]1c2ccc(Br)cc2)N3CCOCC3)c4ccc(F)cc4 5.66 CHEMBL3090534 CHEMBL3086035 Clc1ccc(cc1)C(NC(=O)[C@@H]2CC[C@H](C[C@H]2c3ccc(Br)cc3)N4CCOCC4)c5ccc(Cl)cc5 7.41 CHEMBL3090534 CHEMBL3086036 Fc1ccc(cc1)C(NC(=O)[C@@H]2CC[C@H](C[C@H]2c3ccc(Br)cc3)N4CCOCC4)c5ccc(F)cc5 7 CHEMBL3090534 CHEMBL3086037 Clc1ccc(cc1)C(NC(=O)[C@@H]2CC[C@H](C[C@H]2c3ccc(Br)cc3)N4CCOCC4)c5ccncc5 5.72 CHEMBL3090534 CHEMBL3086038 Cc1cc(ccn1)C(NC(=O)[C@@H]2CC[C@H](C[C@H]2c3ccc(Br)cc3)N4CCOCC4)c5ccc(Cl)cc5 5.82 CHEMBL3090534 CHEMBL3086039 Clc1ccc(cc1)C(NC(=O)[C@@H]2CC[C@H](C[C@H]2c3ccc(Br)cc3)N4CCOCC4)c5ccncc5Cl 6.16 CHEMBL3090534 CHEMBL3086040 Fc1cc(ccn1)C(NC(=O)[C@@H]2CC[C@H](C[C@H]2c3ccc(Br)cc3)N4CCOCC4)c5ccc(Cl)cc5 6.23 CHEMBL3090534 CHEMBL3086041 Fc1ccc(nc1)C(NC(=O)[C@@H]2CC[C@H](C[C@H]2c3ccc(Br)cc3)N4CCOCC4)c5ccc(Cl)cc5 6.75 CHEMBL3090534 CHEMBL3086042 Clc1ccc(cc1)C(NC(=O)[C@@H]2CC[C@H](C[C@H]2c3ccc(Br)cc3)N4CCOCC4)c5cnccn5 6 CHEMBL3090534 CHEMBL3086043 Clc1ccc(cc1)C(NC(=O)[C@@H]2CC[C@H](C[C@H]2c3ccc(Br)cc3)N4CCOCC4)c5ncccn5 5.92 CHEMBL3090534 CHEMBL3086045 Cc1ccccc1[C@H]2C[C@H](CC[C@@H]2C(=O)N3CC(C3)(c4ccccc4)c5ccccc5)NCc6ccc(Cl)cc6 8.52 CHEMBL3090534 CHEMBL3086047 O=C(NC(c1ccccc1)c2ccccc2)[C@@H]3CC[C@H](C[C@H]3c4ccccc4)N5CCOCC5 6.77 CHEMBL3090534 CHEMBL3086048 Brc1ccc(cc1)[C@@H]2C[C@@H](CC[C@H]2C(=O)NC(c3ccccc3)c4ccccc4)N5CCOCC5 6.28 CHEMBL3090534 CHEMBL3087669 C[C@H]1CCCN1[C@H]2CCN(C2)c3ccc(NC(=O)c4c(C)onc4C)c(C)c3 4.43 CHEMBL3089256 CHEMBL308954 Cc1cc(cc(C)c1Oc2nc(Nc3ccc(cc3)C#N)nc(N)c2Br)C#N 4.6 CHEMBL3430732 CHEMBL3092629 CN1Cc2cccc(Oc3ncccc3NC(=O)Nc4ccc(OC(F)(F)F)cc4)c2C1C(C)(C)C 5.14 CHEMBL3096002 CHEMBL3092631 CC(C)(C)CN1CCC(CC1)c2ccccc2Oc3ncccc3NC(=O)Nc4ccc(OC(F)(F)F)cc4 5.34 CHEMBL3096002 CHEMBL3092632 CC(C)CN1CCC(CC1)c2ccccc2Oc3ncccc3NC(=O)Nc4ccc(OC(F)(F)F)cc4 5.22 CHEMBL3096002 CHEMBL3093949 CCCCN(CC)CC#CCOC(c1ccccc1)c2ccccc2 5.32 CHEMBL3096732 CHEMBL3093950 CCCCCCCN(CC)CC#CCOCc1ccc(Cl)cc1 6.08 CHEMBL3096732 CHEMBL3093951 CCCCN(CC)CC#CCOCc1ccc(Cl)cc1 5.13 CHEMBL3096732 CHEMBL3093953 CCCCCCCN(CC)C\C=C\Cc1ccccc1 6.75 CHEMBL3096732 CHEMBL3093954 CCCCN(CC)C\C=C\CCc1ccc(Cl)cc1 5.73 CHEMBL3096732 CHEMBL3093955 CCCCCCCN(CC)C\C=C\CCc1ccc(Cl)cc1 6.62 CHEMBL3096732 CHEMBL3093956 CCCCCCCN(CC)C\C=C/Cc1ccccc1 5.93 CHEMBL3096732 CHEMBL3093957 [I-].CCCCCCC[N+](CC)(CC)C\C=C\Cc1ccc(Cl)cc1 8.82 CHEMBL3096732 CHEMBL3093958 CCCCCCCN(CC)CCCCc1ccccc1 6.3 CHEMBL3096732 CHEMBL3093959 CCCCCCCN(CC)CCCCc1ccc(Cl)cc1 7.37 CHEMBL3096732 CHEMBL3093960 CCCCN(CC)CCCCCc1ccc(Cl)cc1 5.6 CHEMBL3096732 CHEMBL3093961 CCCCCCCN(CC)CCCCCc1ccc(Cl)cc1 6.91 CHEMBL3096732 CHEMBL3093962 CCCCCCCN1CCC(Cc2ccccc2)CC1 7.24 CHEMBL3096732 CHEMBL3093963 CCCCCCCN1CCC(CC1)C(=O)c2ccccc2 6.91 CHEMBL3096732 CHEMBL3093964 CCCCCCCN(CC)CC#Cc1ccc(Cl)cc1 5.39 CHEMBL3096732 CHEMBL3093965 CCCCCCC[N+](CC)(CC)CC#Cc1ccc(Cl)cc1.Cc2ccc(cc2)S(=O)(=O)[O-] 7.4 CHEMBL3096732 CHEMBL3093966 CCCCN(CC)CC#CCc1ccccc1 5.11 CHEMBL3096732 CHEMBL3093967 CCCCCCCN(CC)CC#CCc1ccccc1 5.45 CHEMBL3096732 CHEMBL3093968 CCCCN(CC)CC#CCc1ccc(Cl)cc1 5.58 CHEMBL3096732 CHEMBL3093969 CCCCCCCN(CC)CC#CCc1ccc(Cl)cc1 6.06 CHEMBL3096732 CHEMBL3093970 CCCCN(CC)CC#CCc1ccc(C)cc1 5.46 CHEMBL3096732 CHEMBL3093971 CCCCCCCN(CC)CC#CCc1ccc(C)cc1 5.29 CHEMBL3096732 CHEMBL3093972 CCCCCCCN(CC)CC#CC(c1ccccc1)c2ccccc2 6.62 CHEMBL3096732 CHEMBL3093974 CCCCCCCN(CC)CC#CCCc1ccccc1 5.36 CHEMBL3096732 CHEMBL3093975 CCCCN(CC)CC#CCCc1ccc(Cl)cc1 5.22 CHEMBL3096732 CHEMBL3093976 CCCCCCCN(CC)CC#CCCc1ccc(Cl)cc1 6.12 CHEMBL3096732 CHEMBL3093977 CCCCN(CC)CC#CCCc1ccc(C)cc1 5.25 CHEMBL3096732 CHEMBL3093978 CCCCCCCN(CC)CC#CCCc1ccc(C)cc1 5.72 CHEMBL3096732 CHEMBL3093979 CCCCN(CC)CC#CC#Cc1ccc(Cl)cc1 5 CHEMBL3096732 CHEMBL3093981 CCCCN(CC)CC#CCOc1ccc(Cl)cc1 4.84 CHEMBL3096732 CHEMBL3093982 CCCCCCCN(CC)CC#CCOc1ccc(Cl)cc1 5.61 CHEMBL3096732 CHEMBL3093983 CCCCN(CC)C\C=C\c1ccc(Cl)cc1 5.98 CHEMBL3096732 CHEMBL3093984 CCCCCCCN(CC)C\C=C\c1ccc(Cl)cc1 6.61 CHEMBL3096732 CHEMBL3093985 CCCCN(CC)C\C=C\Cc1ccc(Cl)cc1 5.95 CHEMBL3096732 CHEMBL3093986 CCCCCCCN(CC)C\C=C\Cc1ccc(Cl)cc1 7.31 CHEMBL3096732 CHEMBL3093987 CCCCCCCN(CC)CC#CCOC(c1ccccc1)c2ccccc2 6.01 CHEMBL3096732 CHEMBL3099716 CC1(C)OC(=O)N([C@@H]2CC[C@H](CC2)c3cnc(N)c(c3)c4ncccn4)[C@H]1c5ccccc5 4.96 CHEMBL3101858 CHEMBL3099899 COc1ccc(CNC(=O)c2cc(cnc2c3cccnc3)c4cc(Cl)cc(Cl)c4)cc1OC 5.16 CHEMBL3102172 CHEMBL3099942 CNC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN2CCC3(CC2)Cc4cc(Cl)ccc4O3 5.34 CHEMBL3102091 CHEMBL3099943 O[C@H](COc1cc(O)c(Cl)cc1NC(=O)NC2CC2)CN3CCC4(CC3)Cc5cc(Cl)ccc5O4 6 CHEMBL3102091 CHEMBL3099944 COc1ccc(NC(=O)NC2CC2)c(OC[C@@H](O)CN3CCC4(CC3)Cc5cc(Cl)ccc5O4)c1 6.16 CHEMBL3102091 CHEMBL3099945 O[C@H](COc1cc(O)ccc1NC(=O)NC2CC2)CN3CCC4(CC3)Cc5cc(Cl)ccc5O4 5.62 CHEMBL3102091 CHEMBL3099947 O[C@H](COc1cc(O)ccc1NC(=O)NC2CC2)CN3CCC4(CC3)Cc5cc(F)ccc5O4 5.42 CHEMBL3102091 CHEMBL3099949 NC(=O)Nc1ccccc1OC[C@@H](O)CN2CCC3(CC2)Cc4cc(Cl)ccc4O3 6.4 CHEMBL3102091 CHEMBL3099950 NC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN2CCC3(CC2)Cc4cc(Cl)ccc4O3 6.4 CHEMBL3102091 CHEMBL3099951 O[C@H](COc1cccc2OCC(=O)Nc12)CN3CCC4(CC3)Cc5cc(Cl)ccc5O4 6.22 CHEMBL3102091 CHEMBL3099952 O[C@H](COc1cccc2CCC(=O)Nc12)CN3CCC4(CC3)Cc5cc(Cl)ccc5O4 6.3 CHEMBL3102091 CHEMBL3099953 O[C@H](COc1cccc2C=CC(=O)Nc12)CN3CCC4(CC3)Cc5cc(Cl)ccc5O4 6.22 CHEMBL3102091 CHEMBL3099958 N[C@H](COc1cccc2OCC(=O)Nc12)CN3CCC4(CC3)Cc5cc(F)ccc5O4 5.96 CHEMBL3102091 CHEMBL3099959 N[C@H](COc1cccc2C=CC(=O)Nc12)CN3CCC4(CC3)Cc5cc(F)ccc5O4 5.92 CHEMBL3102091 CHEMBL3099961 CNC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN2CCC3(CC2)Cc4cc(F)ccc4O3 4.88 CHEMBL3102091 CHEMBL3103191 CN(C)CCN(C)c1ccc(Nc2cc(NC3CC3)n4ncc(C#N)c4n2)cc1NC(=O)C 5.4 CHEMBL3810690 CHEMBL3109337 COCCOc1ccn2c(cnc2c1)c3ccc4cccc(O[C@@H]5CCNC[C@H]5F)c4n3 5.41 CHEMBL3111671 CHEMBL3112960 NC[C@@]1(CC[C@@H](CC1)N2N=C(C=CC2=O)c3cccnc3)c4cccc(Cl)c4 5.36 CHEMBL3118368 CHEMBL3112968 NC[C@@]1(CC[C@@H](CC1)N2CCc3c(nc(nc3C2=O)C(F)(F)F)C4CC4)c5cccc(Cl)c5 6.59 CHEMBL3118368 CHEMBL3115114 CCN1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCc4ncc(cc4C3)C(F)(F)F)NC5CCOCC5OC 4.37 CHEMBL3118391 CHEMBL3115116 COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCc5ncc(cc5C4)C(F)(F)F)C6CC6 4.38 CHEMBL3118391 CHEMBL3115192 CC(C)C(CCCN(C)CCCc1nc2ccccc2[nH]1)(C(=O)O)c3ccc(Br)cc3 5.63 CHEMBL3117583 CHEMBL3115193 COc1ccccc1N2CCN(CCCC(C(C)C)(C(=O)O)c3ccc(Br)cc3)CC2 5.4 CHEMBL3117583 CHEMBL3115194 COC(=O)C(CCC(=O)N(C)CCCc1nc2ccccc2[nH]1)(C(C)C)c3ccc(Br)cc3 4.9 CHEMBL3117583 CHEMBL3115195 COC(=O)C(CCC(=O)N1CCN(CC1)c2ccccc2OC)(C(C)C)c3ccc(Br)cc3 4.78 CHEMBL3117583 CHEMBL3115268 COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCc5ncc(cc5C4)C(F)(F)F)c6ccccc6 4.64 CHEMBL3118391 CHEMBL3115272 COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCc5ncc(cc5C4)C(F)(F)F)C(=O)\C=C\c6ccccc6 4.62 CHEMBL3118391 CHEMBL3115274 COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCc5ncc(cc5C4)C(F)(F)F)C(=O)C#CC6CC6 4.31 CHEMBL3118391 CHEMBL3115345 COC(=O)C(CCCN1CCC(=CC1)c2ccccc2OC)(C(C)C)c3ccc(Br)cc3 5.9 CHEMBL3117583 CHEMBL3115346 COC(=O)C(CCCN1CCC(CC1)c2ccccc2OC)(C(C)C)c3ccc(Br)cc3 6.11 CHEMBL3117583 CHEMBL311663 Oc1cc(O)c2CC(OC(=O)c3cc(O)c(O)c(O)c3)C(Oc2c1)c4cc(O)c(O)c(O)c4 5.22 CHEMBL1676103 CHEMBL3120265 CNc1nc(NCCCN(C)C)c2sc(cc2n1)c3ccccc3 5.07 CHEMBL3124427 CHEMBL3120274 CNc1nc(NCCCN(C)C)c2sc(cc2n1)c3ccc(cc3)C(F)(F)F 5.57 CHEMBL3124427 CHEMBL3120280 CNc1nc(NCCCN(C)C)c2sc(cc2n1)c3ccc(OC(F)(F)F)cc3 5.55 CHEMBL3124427 CHEMBL3120281 CNc1nc(NCCCN(C)C)c2sc(cc2n1)c3ccc(OC)nc3 5.17 CHEMBL3124427 CHEMBL3120287 CNc1nc(NCCCN(C)C)c2sc(cc2n1)c3ccc(cc3)N4CCOCC4 5.75 CHEMBL3124427 CHEMBL3120293 CNc1nc(NCCCN(C)C)c2sc(cc2n1)c3ccc4nonc4c3 5.7 CHEMBL3124427 CHEMBL3121095 O=C1NN=C([C@H]2C[C@@H]12)c3ccc(OC4CCN(CC4)C5CCC5)cc3 4.85 CHEMBL3123331 CHEMBL3121096 O=C1NN=C([C@@H]2C[C@H]12)c3ccc(OC4CCN(CC4)C5CCC5)cc3 5.22 CHEMBL3123331 CHEMBL3121151 CCN(CC)[C@@H](C(=O)N1CCC[C@H]1c2ncc([nH]2)c3ccc(cc3)c4ccc(cc4)c5cnc([nH]5)[C@@H]6CCCN6C(=O)[C@H](C)NC(=O)OC)c7ccccc7 5.04 CHEMBL3123626 CHEMBL312137 Clc1cccc(CN2CC[C@H](NCc3cncn3Cc4ccc(cc4)C#N)C2=O)c1 6.36 CHEMBL1027667 CHEMBL3121667 Fc1ccccc1c2nc3ccn(Cc4onc(c4)c5ccc(cc5C(F)(F)F)C(F)(F)F)cc3n2 6.1 CHEMBL3123230 CHEMBL3124980 CS(=O)(=O)c1ccc(cc1)c2cnc(N)c(n2)c3ccc(nc3)C(F)(F)F 5.09 CHEMBL3129034 CHEMBL3124982 Nc1ncc(nc1c2ccc(nc2)C(F)(F)F)c3ccc(cc3)C(=O)N4CCOCC4 4.7 CHEMBL3129034 CHEMBL3124985 CCS(=O)(=O)c1ccc(cc1)c2cnc(N)c(n2)c3ccc(nc3)C(F)(F)F 5.43 CHEMBL3129034 CHEMBL3126842 COc1ccc2c(c1)[C@@H]3C[C@@]3(Cn4c2c(C5CCCCC5)c6ccc(cc46)C(=O)NS(=O)(=O)N(C)C)C(=O)N7C8CCC7CN(C)C8 4.59 CHEMBL3762781 CHEMBL3127404 CN1[C@H](CN(Cc2ccc(Cl)cc2)S(=O)(=O)c3cccc(c3)C#N)CCC1=O 4.52 CHEMBL3129644 CHEMBL3127708 O=C(C1CC12CCN(CC2)C3CCCCC3)N4CCN(CC4)C5CCCCC5 4.68 CHEMBL3132256 CHEMBL3127992 N[C@@H](Cc1cc2OCOc2cc1Br)C(=O)N3C[C@@H](F)C[C@H]3C#N 4.32 CHEMBL3130759 CHEMBL3128178 O[C@@H]([C@H]1CC[C@@H](Cc2ccc(NC(=O)[C@@H]3CCc4scnc34)cc2)N1)c5cccnc5 5.22 CHEMBL3129316 CHEMBL3128180 Cc1nc2[C@@H](CCc2s1)C(=O)Nc3ccc(C[C@@H]4CC[C@@H](N4)[C@H](O)c5cccnc5)cc3 4.92 CHEMBL3129316 CHEMBL3128194 Nc1nc2[C@@H](CCc2s1)C(=O)Nc3ccc(C[C@@H]4CC[C@@H](N4)[C@H](O)c5ccccc5)cc3 4.9 CHEMBL3129316 CHEMBL3128198 Nc1nc2[C@@H](CCc2s1)C(=O)Nc3ccc(C[C@@H]4CC[C@@H](N4)[C@H](O)c5cccc(Cl)c5)cc3 5.82 CHEMBL3129316 CHEMBL3128199 Nc1nc2[C@@H](CCc2s1)C(=O)Nc3ccc(C[C@@H]4CC[C@@H](N4)[C@H](O)c5cccc(F)c5)cc3 5.4 CHEMBL3129316 CHEMBL3128200 Nc1nc2[C@@H](CCc2s1)C(=O)Nc3ccc(C[C@@H]4CC[C@@H](N4)[C@H](O)c5ccc(F)cc5)cc3 5.25 CHEMBL3129316 CHEMBL3128201 Nc1nc2[C@@H](CCc2s1)C(=O)Nc3ccc(C[C@@H]4CC[C@@H](N4)[C@H](O)c5cccnc5)cc3 4.63 CHEMBL3129316 CHEMBL316502 O=C1[C@H](CCN1Cc2ccccc2)NCc3cncn3Cc4ccc(cc4)C#N 5.14 CHEMBL1027667 CHEMBL317520 Clc1cccc(c1)C(=O)N2CC[C@@H](C2)NCc3cncn3Cc4ccc(cc4)C#N 5.24 CHEMBL1027667 CHEMBL3185736 Cc1cccc(c1)C(=O)Nc2cccc(NC(=O)c3cccc(C)c3)c2 4.91 CHEMBL3367864 CHEMBL319742 O=C(O[C@@H]1C[C@@H]2C[C@H]3C[C@@H](C1)N2CC3=O)C4CNc5ccccc45 5.23 CHEMBL766814 CHEMBL32 COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc4C(=O)C(=CN(C5CC5)c14)C(=O)O 4.1 CHEMBL3430338 CHEMBL3215681 Cl.Cl.CC(C)n1nc(C(=O)NCC2CCN(CCN3CCOCC3)CC2)c4ccccc14 4.49 CHEMBL2184356 CHEMBL3215850 Cl.Cl.Cl.Cc1c(Cl)cccc1N2CCN(CCCNC(=O)c3nc(c4ccccc4)n(c3Cn5cncn5)c6ccccc6)CC2 5.01 CHEMBL1827878 CHEMBL3215864 Cl.Cl.Cc1cccc(N2CCN(CCCNC(=O)c3nc(C)n(c3C)c4ccc5OCCOc5c4)CC2)c1C 5.06 CHEMBL1827878 CHEMBL3216098 Cl.Cl.Cl.Cl.Cc1nc(C(=O)NCCCN2CCN(CC2)c3cccc(Cl)c3Cl)c(C)n1c4ccccc4 5.09 CHEMBL1827878 CHEMBL3216126 Cl.Cl.CC(C)n1nc(C(=O)NCC2CCN(CCc3ccc(N)cc3)CC2)c4ccccc14 4.65 CHEMBL2184356 CHEMBL3216259 Cl.Cl.Cl.Cl.Cc1c(cc(c2ccccn2)n1C)C(=O)NCCCN3CCN(CC3)c4cccc(Cl)c4Cl 5.77 CHEMBL1217370 CHEMBL3216702 Cl.Cl.Cl.Cl.CCCn1c(C)c(cc1c2ccccn2)C(=O)NCCCN3CCN(CC3)c4cccc(Cl)c4Cl 6 CHEMBL1217370 CHEMBL3217125 Cl.Cl.Cl.Cn1cnc(c1)C(=O)N(Cc2cccc(Cl)c2)[C@@H]3CC[C@H](N)CC3 4.18 CHEMBL1074124 CHEMBL3217141 Cl.Cl.Cl.Cl.Cc1[nH]c(cc1C(=O)NCCCN2CCN(CC2)c3cccc(Cl)c3Cl)c4ccccn4 6.05 CHEMBL1217370 CHEMBL3217170 Cl.Cl.Cl.Cc1c(Cl)cccc1N2CCN(CCCNC(=O)c3nc(c4ccccc4)n(c3C)c5ccccc5)CC2 5.89 CHEMBL1827878 CHEMBL3217922 COC[C@H](C)Oc1cc(Oc2ccc(cc2)S(=O)(=O)C)cc(c1)C(=O)Nc3nccs3 5.16 CHEMBL3224183 CHEMBL3217923 COC[C@H](C)Oc1cc(Oc2ccc(cc2)S(=O)(=O)C)cc(c1)C(=O)Nc3nc(C)ns3 5.13 CHEMBL3224193 CHEMBL3217925 C[C@@H](CO)Oc1cc(Oc2ccc(cc2)C(=O)N3CCC3)cc(c1)C(=O)Nc4ccn(C)n4 4.16 CHEMBL3224193 CHEMBL3218118 OC1(COc2ccc(C#N)c(F)c2)CN(C1)S(=O)(=O)c3ccc(Cl)cc3Cl 5.02 CHEMBL3227119 CHEMBL3218480 Cc1oc2cc(cc(Oc3ccc(cc3)S(=O)(=O)C)c2c1)C(=O)Nc4cnc(C)cn4 4.66 CHEMBL3223962 CHEMBL3218481 Cc1oc2cc(cc(Oc3ccc(cc3)C#N)c2c1)C(=O)Nc4cnc(C)cn4 5.4 CHEMBL3223962 CHEMBL3218482 CN(C)C(=O)c1ccc(Oc2cc(cc3oc(C)cc23)C(=O)Nc4cnc(C)cn4)cc1 4.23 CHEMBL3223962 CHEMBL3218645 CC(C)N1CCC[C@H](CN2C(=O)c3cc(ccc3N=C2c4ccccc4C)c5ccc(Cl)cc5)C1 5.06 CHEMBL3227234 CHEMBL3218646 CC(C)N1CCCC(CN2C(=O)c3sc(cc3N=C2c4ccccc4C)c5ccc(Cl)cc5)C1 5.68 CHEMBL3227234 CHEMBL3218647 CC(C)N1CCCC(CN2C(=O)c3nn(cc3N=C2c4ccccc4C)c5ccc(Cl)cc5)C1 5.46 CHEMBL3227234 CHEMBL3218648 COCCN1CCC[C@@H](CN2C(=O)c3sc(cc3N=C2c4ccccc4C)c5ccc(Cl)cc5)C1 5.68 CHEMBL3227234 CHEMBL3218649 COCCN1CCC[C@@H](CN2C(=O)c3sc(nc3N=C2c4ccccc4C)c5ccc(Cl)cc5)C1 5.43 CHEMBL3227234 CHEMBL3218650 COCCN1CCC[C@@H](CN2C(=O)c3nn(cc3N=C2c4ccccc4C)c5ccc(Cl)cc5)C1 5.6 CHEMBL3227234 CHEMBL3218816 C[C@@H]1CN(CCN1c2ncc(OCc3ccncc3C#N)cn2)c4oc(nn4)C(F)(F)F 4.75 CHEMBL3226215 CHEMBL3218884 COc1ccc(cc1)n2cc3N=C(N(CC4CCCN(C4)C(C)C)C(=O)c3n2)c5ccccc5C 4.96 CHEMBL3227234 CHEMBL3218885 CC(C)N1CCCC(CN2C(=O)c3nn(cc3N=C2c4ccccc4C)c5cccc(Cl)c5)C1 5 CHEMBL3227234 CHEMBL3218886 COc1cccc(c1)n2cc3N=C(N(CC4CCCN(C4)C(C)C)C(=O)c3n2)c5ccccc5C 4.82 CHEMBL3227234 CHEMBL3218887 CC(C)N1CCCC(CN2C(=O)c3nn(cc3N=C2c4ccccc4C)c5cccc(c5)C#N)C1 4.66 CHEMBL3227234 CHEMBL3218888 COCCN1CCCC(CN2C(=O)c3nn(cc3N=C2c4cccnc4C)c5ccc(cc5)C#N)C1 4.68 CHEMBL3227234 CHEMBL3218890 COc1cccc(c1)n2cc3N=C(N(C[C@H]4CCCN(C4)C(C)C)C(=O)c3n2)c5cccnc5C 4.33 CHEMBL3227234 CHEMBL3218891 COCCN1CCC[C@H](CN2C(=O)c3nn(cc3N=C2c4cccnc4C)c5cccc(OC)c5)C1 4.37 CHEMBL3227234 CHEMBL3218897 COc1cccc(c1)n2cc3N=C(N(C[C@H]4CCCN(C[C@H]5CCCO5)C4)C(=O)c3n2)c6cccnc6C 4.36 CHEMBL3227234 CHEMBL3218908 COc1cccc(c1)n2cc3N=C(C)N(C[C@H]4CCCN(C[C@H]5CCCO5)C4)C(=O)c3n2 5.54 CHEMBL3227234 CHEMBL3218909 COc1cccc(c1)n2cc3N=C(CC(C)C)N(C[C@H]4CCCN(C[C@H]5CCCO5)C4)C(=O)c3n2 5.5 CHEMBL3227234 CHEMBL3218910 Cc1ncccc1C2=Nc3cn(nc3C(=O)N2C[C@H]4CCCN(C[C@H]5CCCO5)C4)c6ccccc6 4.92 CHEMBL3227234 CHEMBL3218911 COc1ccc(cc1)n2cc3N=C(N(C[C@H]4CCCN(C[C@H]5CCCO5)C4)C(=O)c3n2)c6cccnc6C 5.39 CHEMBL3227234 CHEMBL3218912 CCOc1cccc(c1)n2cc3N=C(N(C[C@H]4CCCN(C[C@H]5CCCO5)C4)C(=O)c3n2)c6cccnc6C 4.85 CHEMBL3227234 CHEMBL3218913 CCCOc1cccc(c1)n2cc3N=C(N(C[C@H]4CCCN(C[C@H]5CCCO5)C4)C(=O)c3n2)c6cccnc6C 5.14 CHEMBL3227234 CHEMBL3218914 CC(C)Oc1cccc(c1)n2cc3N=C(N(C[C@H]4CCCN(C[C@H]5CCCO5)C4)C(=O)c3n2)c6cccnc6C 5.17 CHEMBL3227234 CHEMBL3218915 Cc1ncccc1C2=Nc3cn(nc3C(=O)N2C[C@H]4CCCN(C[C@H]5CCCO5)C4)c6cccc(OC(F)F)c6 5.08 CHEMBL3227234 CHEMBL3218997 CC(=O)Nc1cccc(c1)C2CCN(Cc3ccc(cc3)C(=O)c4nc5ccccc5n4c6ccc(F)cc6)CC2 5.71 CHEMBL3224838 CHEMBL3219001 CC(=O)Nc1cccc(c1)C2CCN(Cc3ccc(cc3)C(=O)c4nc5ccccc5n4c6ccc(Cl)cc6)CC2 5.77 CHEMBL3224838 CHEMBL3219105 CCn1ccc(NC(=O)c2cc(O[C@@H](C)CO)cc(Oc3ccc(cc3)C(=O)N4CCC4)c2)n1 4.27 CHEMBL3223680 CHEMBL3219106 C[C@@H](CO)Oc1cc(Oc2ccc(cc2)C(=O)N3CCC3)cc(c1)C(=O)Nc4ccn(n4)C(C)C 4.51 CHEMBL3223680 CHEMBL3219108 C[C@@H](CO)Oc1cc(Oc2ccc(cc2)C(=O)N3CCC3)cc(c1)C(=O)Nc4nccs4 5.05 CHEMBL3223680 CHEMBL3219109 C[C@@H](CO)Oc1cc(Oc2ccc(cc2)C(=O)N3CCC3)cc(c1)C(=O)Nc4nc(C)ns4 4.96 CHEMBL3223680 CHEMBL3219110 C[C@@H](CO)Oc1cc(Oc2ccc(cc2)C(=O)N3CCC3)cc(c1)C(=O)Nc4cnc(C)cn4 4.42 CHEMBL3223680 CHEMBL3219115 COC[C@H](C)Oc1cc(Oc2ccc(cc2)C(=O)N3CCC3)cc(c1)C(=O)Nc4ccn(C)n4 4.44 CHEMBL3223680 CHEMBL3219116 CC(C)Oc1cc(Oc2ccc(cc2)C(=O)N3CCC3)cc(c1)C(=O)Nc4ccn(C)n4 4.57 CHEMBL3223680 CHEMBL3219117 Cn1ccc(NC(=O)c2cc(O[C@H]3CCOC3)cc(Oc4ccc(cc4)C(=O)N5CCC5)c2)n1 4.46 CHEMBL3223680 CHEMBL3219119 Cn1ccc(NC(=O)c2cc(OC(CF)CF)cc(Oc3ccc(cc3)C(=O)N4CCC4)c2)n1 4.55 CHEMBL3223680 CHEMBL3219120 COC[C@H](C)Oc1cc(Oc2ccc(cc2)C(=O)N3CCC3)cc(c1)C(=O)Nc4cnc(C)cn4 4.75 CHEMBL3223680 CHEMBL3219121 COC[C@H](C)Oc1cc(Oc2ccc(nc2)C(=O)N3CCC3)cc(c1)C(=O)Nc4cnc(C)cn4 4.4 CHEMBL3223680 CHEMBL3219123 COC[C@H](C)Oc1cc(Oc2ncc(cc2Cl)C(=O)N3CCC3)cc(c1)C(=O)Nc4cnc(C)cn4 4.75 CHEMBL3223680 CHEMBL3219265 CC(=O)Nc1cccc(c1)C2CCN(Cc3ccc(cc3)C(=O)c4nc5ccccc5n4C6CCOCC6)CC2 5.92 CHEMBL3224838 CHEMBL3219269 CC(=O)Nc1cccc(c1)C2CCN(Cc3ccc(cc3F)C(=O)c4nc5ccccc5n4c6ccc(F)cc6)CC2 5.72 CHEMBL3224838 CHEMBL3219276 CC(=O)Nc1cccc(c1)C2CCN(Cc3ccc(cc3)C(=O)c4nc(C)c(C)n4c5ccc(F)cc5)CC2 5.77 CHEMBL3224838 CHEMBL3219614 CC[C@@]1([C@@H]2CN(CCCC3(O)CCCCC3)C[C@H]12)c4cccc(NS(=O)(=O)C)c4 6.15 CHEMBL3225969 CHEMBL3219615 CC[C@@]1([C@@H]2CN(CC3(O)Cc4ccccc4C3)C[C@H]12)c5cccc(c5)C(=O)N 5.66 CHEMBL3225969 CHEMBL3219616 CC[C@@]1([C@@H]2CN(CC3(O)Cc4ccccc4C3)C[C@H]12)c5cccc(NS(=O)(=O)C)c5 5.8 CHEMBL3225969 CHEMBL322007 NCCCN(Cc1cncn1Cc2ccc(cc2)C#N)[C@H]3CCN(Cc4ccccc4)C3=O 6.32 CHEMBL1027667 CHEMBL3220615 COc1ccc(cc1)N2C(c3ccccc3OC)C(C)(C)C2=O 4.89 CHEMBL3225152 CHEMBL3220877 NCC(=O)N1CCN(CC1)c2cnc3cc(cc(NCc4cccc(c4)[N+](=O)[O-])c3c2)C(F)(F)F 4.74 CHEMBL3226599 CHEMBL3220878 C[C@H](N)C(=O)N1CCN(CC1)c2cnc3cc(cc(NCc4cccc(c4)[N+](=O)[O-])c3c2)C(F)(F)F 5.89 CHEMBL3226599 CHEMBL3220879 C[C@@H](N)C(=O)N1CCN(CC1)c2cnc3cc(cc(NCc4cccc(c4)[N+](=O)[O-])c3c2)C(F)(F)F 5.31 CHEMBL3226599 CHEMBL3220881 [O-][N+](=O)c1cccc(CNc2cc(cc3ncc(cc23)N4CCN(CC4)C(=O)\C=C\[C@@H]5CCCN5)C(F)(F)F)c1 4.06 CHEMBL3226599 CHEMBL3220882 CN(C)C\C=C\C(=O)N1CCN(CC1)c2cnc3cc(cc(NCc4cccc(c4)[N+](=O)[O-])c3c2)C(F)(F)F 4.04 CHEMBL3226599 CHEMBL3221107 CCNC(=O)N1CCN(CC1)c2cnc3cc(cc(NCc4cccc(c4)[N+](=O)[O-])c3c2)C(F)(F)F 6.68 CHEMBL3226599 CHEMBL3221108 CCCNC(=O)N1CCN(CC1)c2cnc3cc(cc(NCc4cccc(c4)[N+](=O)[O-])c3c2)C(F)(F)F 5.89 CHEMBL3226599 CHEMBL3221109 [O-][N+](=O)c1cccc(CNc2cc(cc3ncc(cc23)N4CCN(CC4)C(=O)N5CCOCC5)C(F)(F)F)c1 6.41 CHEMBL3226599 CHEMBL3221110 OCCN1CCN(CC1)c2cnc3cc(cc(NCc4cccc(c4)[N+](=O)[O-])c3c2)C(F)(F)F 7.43 CHEMBL3226599 CHEMBL3221111 CN1CCN(CC1)c2cnc3cc(cc(NCc4cccc(c4)C#N)c3c2)C(F)(F)F 6.76 CHEMBL3226599 CHEMBL3221113 CN1CCN(CC1)c2cnc3cc(cc(NCc4cccc(c4)C(=O)C)c3c2)C(F)(F)F 4.03 CHEMBL3226599 CHEMBL3221123 CCNC(=O)Nc1cccc(CNc2cc(cc3ncc(cc23)N4CCN(C)CC4)C(F)(F)F)c1 4.09 CHEMBL3226599 CHEMBL3221125 CN1CCN(CC1)c2cnc3cc(cc(NCc4cccc5nonc45)c3c2)C(F)(F)F 6.97 CHEMBL3226599 CHEMBL3221126 CN1CCN(CC1)c2cnc3cc(cc(NCc4ccc5cccnc5c4)c3c2)C(F)(F)F 4.12 CHEMBL3226599 CHEMBL3221131 [2H]C(Nc1cc(cc2ncc(cc12)N3CCN(C)CC3)C(F)(F)F)c4cccc(c4)[N+](=O)[O-] 5.9 CHEMBL3226599 CHEMBL3221133 [2H]C([2H])(O)CN1CCN(CC1)c2cnc3cc(cc(NCc4cccc(c4)[N+](=O)[O-])c3c2)C(F)(F)F 6.8 CHEMBL3226599 CHEMBL3221134 [2H]C(Nc1cc(cc2ncc(cc12)N3CCN(CC([2H])([2H])O)CC3)C(F)(F)F)c4cccc(c4)[N+](=O)[O-] 6.32 CHEMBL3226599 CHEMBL3221481 COCC[C@H](Oc1ncnc2c1cnn2c3ncccc3Cl)C(=O)Nc4ccc(C)cn4 4.1 CHEMBL3226991 CHEMBL3221482 COC[C@H](Oc1ncnc2c1cnn2c3ccccc3Cl)C(=O)Nc4ccc(C)cn4 4.3 CHEMBL3226991 CHEMBL3221485 CCOC[C@H](Oc1ncnc2c1cnn2c3ncccc3Cl)C(=O)Nc4ccc(C)cn4 4.2 CHEMBL3226991 CHEMBL3221486 CCOC[C@H](Oc1ncnc2c1cnn2c3ccccc3Cl)C(=O)Nc4cnc(C)cn4 4.3 CHEMBL3226991 CHEMBL3221487 CCOC[C@H](Oc1ncnc2c1cnn2c3ncccc3Cl)C(=O)Nc4cnc(C)cn4 4.8 CHEMBL3226991 CHEMBL3221488 CC(C)OC[C@H](Oc1ncnc2c1cnn2c3ccccc3Cl)C(=O)Nc4ccc(C)cn4 4.5 CHEMBL3226991 CHEMBL3221490 Cc1ccc(NC(=O)[C@H](COC2CCC2)Oc3ncnc4c3cnn4c5ncccc5Cl)nc1 4.4 CHEMBL3226991 CHEMBL3221491 Cc1cnc(NC(=O)[C@H](COC2CCC2)Oc3ncnc4c3cnn4c5ccccc5Cl)cn1 4.9 CHEMBL3226991 CHEMBL3221492 Cc1cnc(NC(=O)[C@H](COC2CCC2)Oc3ncnc4c3cnn4c5ncccc5Cl)cn1 4.4 CHEMBL3226991 CHEMBL3221493 CC(C)OC[C@H](Oc1ncnc2c1cnn2c3ncccc3Cl)C(=O)Nc4ccc(Cl)cn4 4.2 CHEMBL3226991 CHEMBL3221494 CC(C)OC[C@H](Oc1ncnc2c1cnn2c3ccccc3Cl)C(=O)Nc4ccc(Cl)cn4 4.8 CHEMBL3227002 CHEMBL3221495 CCOC[C@H](Oc1ncnc2c1cnn2c3ncccc3Cl)C(=O)Nc4ccc(Cl)cn4 5 CHEMBL3226991 CHEMBL3221496 CC(C)OC[C@H](Oc1ncnc2c1cnn2c3ncccc3Cl)C(=O)Nc4ccc(F)cn4 4.1 CHEMBL3227002 CHEMBL3221497 CC(C)OC[C@H](Oc1ncnc2c1cnn2c3ccccc3Cl)C(=O)Nc4ccc(F)cn4 4.6 CHEMBL3226991 CHEMBL3221498 CCOC[C@H](Oc1ncnc2c1cnn2c3ncccc3Cl)C(=O)Nc4ccc(F)cn4 4.2 CHEMBL3226991 CHEMBL3221500 CC(C)OC[C@H](Oc1ncnc2c1cnn2c3ccccc3Cl)C(=O)Nc4ccccn4 4.2 CHEMBL3226991 CHEMBL3221502 CC(C)OC[C@H](Oc1ncnc2c1cnn2c3ncccc3Cl)C(=O)Nc4ccc(cn4)C#N 4.3 CHEMBL3227002 CHEMBL3221503 CC(C)OC[C@H](Oc1ncnc2c1cnn2c3ccccc3Cl)C(=O)Nc4ccc(cn4)C#N 4.9 CHEMBL3226991 CHEMBL3221504 CCOC[C@H](Oc1ncnc2c1cnn2c3ncccc3Cl)C(=O)Nc4ccc(cn4)C#N 4.7 CHEMBL3226991 CHEMBL3221506 OCCOC[C@H](Oc1ncnc2c1cnn2c3ncccc3Cl)C(=O)Nc4ccc(Cl)cn4 4.3 CHEMBL3227002 CHEMBL3221507 OCCOC[C@H](Oc1ncnc2c1cnn2c3ncccc3Cl)C(=O)Nc4ccc(cn4)C#N 4.3 CHEMBL3227002 CHEMBL3221508 OCCOC[C@H](Oc1ncnc2c1cnn2c3ccccc3Cl)C(=O)Nc4ccc(Cl)cn4 4.8 CHEMBL3227002 CHEMBL3221511 C[C@@H](CO)OC[C@H](Oc1ncnc2c1cnn2c3ncccc3Cl)C(=O)Nc4ccc(cn4)C#N 4.2 CHEMBL3227002 CHEMBL3221514 C[C@H](CO)OC[C@H](Oc1ncnc2c1cnn2c3ncccc3Cl)C(=O)Nc4ccc(cn4)C#N 4.2 CHEMBL3227002 CHEMBL3221515 OC1CN(C[C@H](Oc2ncnc3c2cnn3c4ncccc4Cl)C(=O)Nc5ccc(Cl)cn5)C1 4.3 CHEMBL3227002 CHEMBL3221517 OC1CN(C[C@H](Oc2ncnc3c2cnn3c4ccccc4Cl)C(=O)Nc5ccc(Cl)cn5)C1 5 CHEMBL3227002 CHEMBL3221519 OC1CN(C[C@H](Oc2ncnc3c2cnn3c4ccccc4Cl)C(=O)Nc5ccc(cn5)C#N)C1 5 CHEMBL3227002 CHEMBL3221520 OC1CN(C[C@H](Oc2ncnc3c2cnn3c4ccccc4Cl)C(=O)Nc5ccc(F)cn5)C1 4.4 CHEMBL3227002 CHEMBL3221521 OCCOC[C@H](Oc1ncnc2c1cnn2c3ccccc3Cl)C(=O)Nc4ccc(F)cn4 4.4 CHEMBL3227002 CHEMBL3221522 OC1CN(C[C@H](Oc2ncnc3c2cnn3c4c(Cl)cccc4Cl)C(=O)Nc5ccc(cn5)C#N)C1 5.2 CHEMBL3227002 CHEMBL3221523 OC1CN(C[C@H](Oc2ncnc3c2cnn3c4c(Cl)cccc4Cl)C(=O)Nc5ccc(F)cn5)C1 4.7 CHEMBL3227002 CHEMBL3221524 OCCOC[C@H](Oc1ncnc2c1cnn2c3c(Cl)cccc3Cl)C(=O)Nc4ccc(F)cn4 4.7 CHEMBL3227002 CHEMBL3221525 OC1CN(C[C@H](Oc2ncnc3c2cnn3c4c(Cl)cccc4C#N)C(=O)Nc5ccc(cn5)C#N)C1 5.1 CHEMBL3227002 CHEMBL3221526 OC1CN(C[C@H](Oc2ncnc3c2cnn3c4c(Cl)cccc4C#N)C(=O)Nc5ccc(F)cn5)C1 4.3 CHEMBL3227002 CHEMBL3221527 OCCOC[C@H](Oc1ncnc2c1cnn2c3c(Cl)cccc3C#N)C(=O)Nc4ccc(F)cn4 4.2 CHEMBL3227002 CHEMBL3221528 OC1CN(C[C@H](Oc2ncnc3c2cnn3c4c(F)cccc4Cl)C(=O)Nc5ccccn5)C1 4.1 CHEMBL3227002 CHEMBL3221529 OC1CN(C[C@H](Oc2ncnc3c2cnn3c4c(F)cccc4Cl)C(=O)Nc5ccc(F)cn5)C1 4.6 CHEMBL3227002 CHEMBL3221530 OCCOC[C@H](Oc1ncnc2c1cnn2c3c(F)cccc3Cl)C(=O)Nc4ccc(F)cn4 4.5 CHEMBL3227002 CHEMBL3221531 Cc1cnc(NC(=O)[C@H](CN2CC(O)C2)Oc3ncnc4c3cnn4c5c(Cl)cccc5Cl)cn1 4.21 CHEMBL3227002 CHEMBL3233058 Cc1cccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(=O)N)n1 5 CHEMBL3240911 CHEMBL3233185 CCS(=O)(=O)C[C@@H]1C[C@@H](CC[C@@H]1N2CC[C@H](NC(=O)c3cccc(c3)c4ccccc4)C2=O)N(C)C(C)C 4.22 CHEMBL3243551 CHEMBL3233187 CC(C)N(C)[C@@H]1CC[C@@H]([C@H](CS(=O)(=O)C(C)C)C1)N2CC[C@H](NC(=O)c3cccc(c3)C(C)(C)C)C2=O 4.11 CHEMBL3243551 CHEMBL3234071 CS(=O)(=O)c1ccc(cc1)c2cnc3ccc(nn23)c4cccc(c4)S(=O)(=O)C 6.05 CHEMBL3631371 CHEMBL3234873 CC(C)(O)c1ccc(cc1)c2cc(C(=O)N)c(Nc3cccc(CN4CCOCC4)n3)s2 5.85 CHEMBL3239511 CHEMBL3234874 NC(=O)c1cc(sc1Nc2cccc(CN3CCOCC3)n2)c4ccccc4F 6.79 CHEMBL3239511 CHEMBL3234895 CC(C)(O)COCc1cccc(Nc2sc(cc2C(=O)N)c3c(F)cc(cc3F)C(C)(C)O)n1 4.92 CHEMBL3239511 CHEMBL32363 COC(=O)C1C(CC2CCC1N2C)OC(=O)c3ccccc3 5.14 CHEMBL1676103 CHEMBL3237443 Fc1nccc2c3cnc(Nc4ccc(cn4)N5CCNCC5)nc3n(C6CCCC6)c12 6.14 CHEMBL3240534 CHEMBL3237444 Clc1nccc2c3cnc(Nc4ccc(cn4)N5CCNCC5)nc3n(C6CCCC6)c12 5.7 CHEMBL3240534 CHEMBL3237556 CCc1cccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(=O)N)n1 5.2 CHEMBL3240911 CHEMBL3237557 CCCc1cccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(=O)N)n1 5.2 CHEMBL3240911 CHEMBL3237558 N[C@H]1CCCC[C@H]1Nc2cc(Nc3cccc(n3)C4CC4)c(nn2)C(=O)N 5.4 CHEMBL3240911 CHEMBL3237559 CC(C)c1cccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(=O)N)n1 5.1 CHEMBL3240911 CHEMBL3237560 Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(=O)N)ccc1F 4.8 CHEMBL3240911 CHEMBL3237561 Cc1ccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(=O)N)nc1C 4.7 CHEMBL3240911 CHEMBL3237562 Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(=O)N)ccc1Cl 5.4 CHEMBL3240911 CHEMBL3237564 N[C@H]1CCCC[C@H]1Nc2cc(Nc3ccc4CCCc4n3)c(nn2)C(=O)N 5.1 CHEMBL3240911 CHEMBL3237565 COc1ccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(=O)N)nc1OC 5.3 CHEMBL3240911 CHEMBL3237571 CC(C)(C)c1cccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(=O)N)n1 5.9 CHEMBL3240911 CHEMBL3237572 CC(C)C[C@H](CN)Nc1cc(Nc2cccc(n2)C(C)(C)C)c(nn1)C(=O)N 5.4 CHEMBL3240911 CHEMBL3237573 CC(C)c1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(=O)N)ccc1C 6 CHEMBL3240911 CHEMBL3237574 CCCc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(=O)N)ccc1OC 5.4 CHEMBL3240911 CHEMBL3237575 COc1ccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(=O)N)nc1C(C)C 5.7 CHEMBL3240911 CHEMBL3237576 COc1ccc(Nc2cc(N[C@@H]3CCOC[C@@H]3N)nnc2C(=O)N)nc1C(C)C 4.8 CHEMBL3240911 CHEMBL3237577 CC(C)c1nc(Nc2cc(NCCN)nnc2C(=O)N)ccc1C 5.2 CHEMBL3240911 CHEMBL3237578 COc1ccc(Nc2cc(NCCN)nnc2C(=O)N)nc1C(C)C 4.9 CHEMBL3240911 CHEMBL3237579 CCCc1nc(Nc2cc(NCCN)nnc2C(=O)N)ccc1OC 5 CHEMBL3240911 CHEMBL3237580 CC(C)c1nc(Nc2cc(N[C@@H]3CCOC[C@@H]3N)nnc2C(=O)N)ccc1F 5.1 CHEMBL3240911 CHEMBL3237581 CC(C)c1nc(Nc2cc(NCCN)nnc2C(=O)N)ccc1F 5.1 CHEMBL3240911 CHEMBL3237713 C[C@@H](O)CN(C)C1CCN(CC1)c2ccc(Nc3ncc4c5ccncc5n([C@@H]6CC[C@@H](C)CC6)c4n3)nn2 6.04 CHEMBL3240534 CHEMBL325109 COc1cc(N)c(Cl)cc1C(=O)NC2CCN(Cc3ccccc3)CC2 6.22 CHEMBL1676103 CHEMBL3260567 Cc1cccc(n1)c2[nH]c(CNc3ccccc3F)nc2c4ccc5ncnn5c4 4.51 CHEMBL3271188 CHEMBL3261919 O=C(N[C@@H](Cc1ccc(cc1)c2ccc(cc2)C#N)C#N)[C@@H]3CCCCN3 5.85 CHEMBL3266700 CHEMBL3261920 CSc1cc(ccc1C#N)c2ccc(C[C@H](NC(=O)[C@@H]3CCCCN3)C#N)cc2 5.57 CHEMBL3266700 CHEMBL3261924 NC1(CCCCC1)C(=O)N[C@@H](Cc2ccc(cc2)c3ccc(cc3)C#N)C#N 5.05 CHEMBL3266700 CHEMBL3261926 NC1(CCOCC1)C(=O)N[C@@H](Cc2ccc(cc2)c3ccc(cc3)C#N)C#N 4.59 CHEMBL3266700 CHEMBL3262132 Cl.C(Oc1cccnc1)[C@H]2CNCCN2c3oc4cccnc4n3 4.14 CHEMBL3268691 CHEMBL3262163 Cl.COc1ccc(NC(=O)N2CCNC[C@@H]2COc3cccnc3)cc1 4.51 CHEMBL3268691 CHEMBL3262358 N[C@H]1CCCC[C@H]1Nc2cc3N=CNC(=O)c3c(Nc4cccc5c(Cl)c[nH]c45)n2 4.7 CHEMBL3268715 CHEMBL3262624 N[C@H]1COCC[C@H]1Nc2cc3C=CNC(=O)c3c(Nc4cccc5cc[nH]c45)n2 4.6 CHEMBL3268715 CHEMBL3262625 Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)cc5C=CNC(=O)c35)cccc12 5.09 CHEMBL3268715 CHEMBL3263279 FC(F)(F)c1cnc2CCN(Cc2c1)C(=O)[C@@]34CCO[C@@H]3C[C@H](C4)NC5CCOCC5 4.37 CHEMBL3268528 CHEMBL3263282 FC(F)(F)c1cnc2CCN(Cc2c1)C(=O)[C@@]34CCO[C@@H]3C[C@H](C4)N5CCC(CC5)c6ccccc6 5.24 CHEMBL3268528 CHEMBL3263285 OC(=O)c1cccc(c1)C2CCN(CC2)[C@@H]3C[C@H]4OCC[C@]4(C3)C(=O)N5COc6ccc(cc6C5)C(F)(F)F 4.54 CHEMBL3268528 CHEMBL3263286 CNC(=O)c1cccc(c1)C2CCN(CC2)[C@@H]3C[C@H]4OCC[C@]4(C3)C(=O)N5COc6ccc(cc6C5)C(F)(F)F 5.51 CHEMBL3268528 CHEMBL327946 O=C1[C@H](CCN1Cc2ccccc2)N(Cc3cccnc3)Cc4cncn4Cc5ccc(cc5)C#N 6.06 CHEMBL1027667 CHEMBL327980 Cc1cccc(CCN2CCC(CC2)C(=O)c3ccc(NS(=O)(=O)C)cc3)n1 7.16 CHEMBL3807184 CHEMBL3286436 COc1cc(C#N)c2C=CC(=O)N(CCN3CCC(CC3)NCc4cnc(C)c(c4)C#N)c2c1 5.6 CHEMBL3294033 CHEMBL3287218 Cc1cc(ncn1)c2ccc3[C@@H](CCc3c2)N4CC5(CCN(CC5)C(=O)Cc6cn7cc(C)sc7n6)C4 5.16 CHEMBL3295453 CHEMBL3287739 Cc1cc(nn1C)C(=O)N[C@@H]2CC[C@@H](CC2)NC(=O)c3cc(F)cnc3Oc4cccc(c4)c5ccc(O)cc5CN6CCOCC6 4.5 CHEMBL3292514 CHEMBL3288029 C[C@@H]1CN(Cc2ccc(c(CN3CCOCC3)c2)c4cccc(Oc5ncc(F)cc5C(=O)N[C@@H]6CC[C@@H](CC6)NC(=O)c7nc(C)cs7)c4)C[C@H](C)N1 4.7 CHEMBL3292514 CHEMBL3288030 C[C@@H]1CN(Cc2ccc(c(CN3CCOCC3)c2)c4cccc(Oc5ncc(F)cc5C(=O)N[C@@H]6CC[C@@H](CC6)NC(=O)c7cc(C)ccc7O)c4)C[C@H](C)N1 5.2 CHEMBL3292514 CHEMBL3288810 Cl.COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 6.22 CHEMBL3295909 CHEMBL3288811 Cl.COc1ccc2ncc(F)c(C[C@H](O)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 4.75 CHEMBL3295909 CHEMBL3288854 CN1CCN(CCC(=O)Nc2c(C)[nH]c(\C=C\3/C(=O)Nc4ccc(F)cc34)c2C)CC1 4.73 CHEMBL3296755 CHEMBL3289440 CCOC(=O)N1CCC(CN2CCC3(CC2)CN(c4ncccc34)S(=O)(=O)C)CC1 5.72 CHEMBL3291975 CHEMBL3289442 CCOC(=O)N1CCC(C)(CN2CCC3(CC2)CN(c4ncccc34)S(=O)(=O)C)CC1 5.44 CHEMBL3291975 CHEMBL3289443 COC(=O)N1CCC(C)(CN2CCC3(CC2)CN(c4ncccc34)S(=O)(=O)C)CC1 4.77 CHEMBL3291975 CHEMBL3289444 CC(C)OC(=O)N1CCC(C)(CN2CCC3(CC2)CN(c4ncccc34)S(=O)(=O)C)CC1 5.56 CHEMBL3291975 CHEMBL3289792 Nc1nccn1CC(O)c2ccc(Cl)cc2F 4.22 CHEMBL3296720 CHEMBL3289794 Nc1nccn1CC(O)c2cccc(Cl)c2Cl 4.66 CHEMBL3296720 CHEMBL3289797 Nc1nc(cn1CC(O)c2ccc(Cl)cc2Cl)C3CC3 5.35 CHEMBL3296720 CHEMBL3289798 Nc1nc(cn1CC(O)c2ccc(cc2Cl)C(F)(F)F)c3ccc(F)cc3 4.6 CHEMBL3296720 CHEMBL3289799 Nc1nc2ccccc2n1CC(O)c3ccc(Cl)cc3Cl 4.99 CHEMBL3296720 CHEMBL3289806 CN1CCN(CC1)c2ccc3nc(N)n(CC(O)c4ccc(cc4Cl)C(F)(F)F)c3n2 4.91 CHEMBL3296720 CHEMBL3289807 Nc1nc2ccc(NCC(F)(F)F)nc2n1CC(O)c3ccc(Cl)cc3Cl 5.46 CHEMBL3296720 CHEMBL3289811 Nc1nc2ccc(OC3CCOC3)nc2n1CC(O)c4ccc(cc4Cl)C(F)(F)F 4.78 CHEMBL3296720 CHEMBL3290012 Fc1ccc2c(noc2c1)C3CCN(CCCCNS(=O)(=O)c4cc5ccccc5s4)CC3 5.4 CHEMBL3295404 CHEMBL3290336 COc1ccc2C=CC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2n1 4.64 CHEMBL3610296 CHEMBL3290338 Cc1nc(CNC2CCN(CCN3C(=O)C=Cc4ccc(cc34)C#N)CC2)ccc1C#N 5.28 CHEMBL3294033 CHEMBL3290339 Cc1ncc(CNC2CCN(CCN3C(=O)C=Cc4ccc(cc34)C#N)CC2)cc1C#N 4.59 CHEMBL3294033 CHEMBL3290340 Cc1ncc(CNC2CCN(CCN3C(=O)C=Cc4ncc(F)cc34)CC2)cc1C#N 4.16 CHEMBL3294033 CHEMBL3290341 COc1cnc2C=CC(=O)N(CCN3CCC(CC3)NCc4cnc(C)c(c4)C#N)c2c1 4.3 CHEMBL3294033 CHEMBL3290342 COc1ccc2N(CCN3CCC(CC3)NCc4cnc(C)c(c4)C#N)C(=O)C=Cc2n1 5 CHEMBL3294033 CHEMBL3290343 CN1C(=O)C=CC2=C1C=CC(=O)N2CCN3CCC(CC3)NCc4cnc(C)c(c4)C#N 4.48 CHEMBL3294033 CHEMBL3290344 COc1cnc2C=CC(=O)N(CCN3CCC(CC3)NC(=O)c4cnc(C)c(c4)C#N)c2c1 4.13 CHEMBL3294033 CHEMBL3290345 COc1cnc2C=CC(=O)N(CCN3CCC(CC3)NCc4cnc(OC)c(c4)C#N)c2c1 4.92 CHEMBL3294033 CHEMBL3290346 COc1cnc2C=CC(=O)N(CCN3CCC(CC3)NCc4cnc(C)c(n4)C#N)c2c1 4.16 CHEMBL3294033 CHEMBL3290347 COc1ccc2N=CC(=O)N(CCN3CCC(CC3)NCc4cnc(C)c(c4)C#N)c2n1 4.89 CHEMBL3294033 CHEMBL3290351 COc1cnc2C=CC(=O)N(CCN3CC[C@@H](NCc4cnc(C)c(c4)C#N)[C@@H](F)C3)c2c1 4.05 CHEMBL3294033 CHEMBL329067 O=C1[C@H](CCN1Cc2ccccc2)N(CCCc3ccccc3)Cc4cncn4Cc5ccc(cc5)C#N 7.62 CHEMBL1027667 CHEMBL3291062 CN1C(=O)C=C(N[C@H]2C[C@H]3CC[C@@H](C2)N3C(=O)c4noc(C)c4C)c5cc(F)c(F)cc15 4.8 CHEMBL3296306 CHEMBL3299132 Clc1ccc2OC=C(CC3SC(=O)NC3=O)C(=O)c2c1 6.87 CHEMBL3372547 CHEMBL3301626 Cc1nc(C#Cc2ccnc(Cl)c2)c(C)n1c3ccc(F)cc3 5.15 CHEMBL3412492 CHEMBL3305005 COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.68 CHEMBL3424851 CHEMBL3305167 COc1ccc2ncc(F)c(C[C@H](O)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 4.75 CHEMBL3607542 CHEMBL3310484 Fc1ccccc1OC(CC2CNC2)c3ccc(Cl)c(F)c3 5.85 CHEMBL3363907 CHEMBL3310485 Fc1cccc(OC(CC2CNC2)c3ccc(Cl)c(F)c3)c1 5.84 CHEMBL3363907 CHEMBL3310798 CCNC(=O)N1CC2(CCN(CC3CCN(CC3)C(=O)OCC)CC2)c4cccnc14 6.64 CHEMBL3380409 CHEMBL3310799 CCOC(=O)N1CCC(CN2CCC3(CC2)CN(C(=O)N(CC)CC)c4ncccc34)CC1 5.6 CHEMBL3380409 CHEMBL3310800 CCOC(=O)N1CCC(CN2CCC3(CC2)CN(C(=O)NC)c4ncccc34)CC1 6.52 CHEMBL3380409 CHEMBL3310801 CCOC(=O)N1CCC(CN2CCC3(CC2)CN(C(=O)N)c4ncccc34)CC1 6.72 CHEMBL3380409 CHEMBL3314349 CN(C)Cc1ccc2CN(CCc2c1)C(=O)c3cc4cc(Cl)ccc4n3C 5.31 CHEMBL3368358 CHEMBL3314352 CN(C)Cc1ccc2CN(CCc2c1)C(=O)c3cc4cc(Br)ncc4n3C 4.51 CHEMBL3368358 CHEMBL3314362 CN(C)Cc1cc2CCN(Cc2cc1C)C(=O)c3cc4cc(Cl)ccc4n3C 4.89 CHEMBL3368358 CHEMBL3314417 CNc1ccc(\C=C\c2c(F)cccc2F)cc1 4.31 CHEMBL3378079 CHEMBL3314420 CNc1ccc(\C=C\c2c(F)cccc2Cl)cc1 4.3 CHEMBL3378079 CHEMBL3314423 CN(C)c1ccc(\C=C\c2c(F)cccc2F)nc1 4.68 CHEMBL3378079 CHEMBL3314424 CN(C)c1ccc(\C=C\c2c(F)cccc2Cl)nc1 4.68 CHEMBL3378079 CHEMBL3314426 CN(C)c1ccc(\C=C\c2c(F)cccc2F)cn1 4.66 CHEMBL3378079 CHEMBL3314429 CN(C)c1ccc(\C=C\c2c(F)cccc2Cl)cn1 4.23 CHEMBL3378079 CHEMBL3314430 CNc1ccc(\C=C\c2c(F)cccc2Cl)cn1 4.7 CHEMBL3378079 CHEMBL3314433 CN(C)c1ncc(\C=C\c2c(F)cccc2F)cn1 4.39 CHEMBL3378079 CHEMBL3318928 Cl.CCOC[C@@H](CC(C)C)NC(=O)[C@@H]1CNC[C@@H](C1)C(=O)N(C2CC2)c3ccc(cn3)C(C)C 5.16 CHEMBL3365826 CHEMBL3318939 Cl.CCOC[C@@H](CC(C)C)NC(=O)[C@@H]1CNC[C@@H](C1)C(=O)N(C2CC2)c3cc(OCCCOC)c(cc3F)C(C)C 5.26 CHEMBL3365826 CHEMBL3318942 Cl.CCOC[C@@H](CC(C)C)NC(=O)[C@@H]1CNC[C@@H](C1)C(=O)N(C2CC2)c3ccc(C(C)C)c(OCCCOC)n3 5.48 CHEMBL3365826 CHEMBL3318982 COc1cnc2C=CC(=O)N(CCN3CCC(CC3)C4C(=O)Nc5ccc(Cl)cc45)c2c1 5.32 CHEMBL3366645 CHEMBL3318983 COc1cnc2C=CC(=O)N(CCN3CCC(CC3)c4nc5cc(ccc5[nH]4)C(F)(F)F)c2c1 6 CHEMBL3366645 CHEMBL3318984 COc1cnc2C=CC(=O)N(CCN3CCN(CC3)c4nc5cc(ccc5[nH]4)C(F)(F)F)c2c1 5 CHEMBL3366645 CHEMBL3318985 COc1cnc2C=CC(=O)N(CCN3CCN(CC3)c4nc5ccccc5[nH]4)c2c1 5.16 CHEMBL3366645 CHEMBL3318986 Fc1cnc2C=CC(=O)N(CCN3CCN(CC3)c4nc5cc(ccc5[nH]4)C(F)(F)F)c2c1 6 CHEMBL3366645 CHEMBL3318989 COc1cnc2C=CC(=O)N(CCN3CCC(CC3)c4nc5cc(Cl)ccc5[nH]4)c2c1 6 CHEMBL3366645 CHEMBL3318990 COc1cnc2C=CC(=O)N(CCN3CCC(CC3)c4nc5cc(ccc5[nH]4)C#N)c2c1 5.35 CHEMBL3366645 CHEMBL3318991 COc1cnc2C=CC(=O)N(CCN3CCC(CC3)c4nc5cc(Cl)c(F)cc5[nH]4)c2c1 5.92 CHEMBL3366645 CHEMBL3318992 COc1cnc2C=CC(=O)N(CCN3CCC(CC3)c4nc5cc(Cl)c(C)cc5[nH]4)c2c1 5.85 CHEMBL3366645 CHEMBL3318993 Cc1cc2[nH]c(nc2cc1Cl)C3CCN(CCN4C(=O)C=Cc5ncc(F)cc45)CC3 5.92 CHEMBL3366645 CHEMBL3318995 COc1cnc2N=CC(=O)N(CCN3CCC(CC3)c4nc5cc(Cl)c(C)cc5[nH]4)c2c1 5 CHEMBL3366645 CHEMBL3318997 COc1cnc2C=CC(=O)N(CCN3CCC(CC3)c4nc5cc(C#N)c(C)cc5[nH]4)c2c1 5 CHEMBL3366645 CHEMBL3318999 O=C1C=Cc2ncc(Oc3cccnc3)cc2N1CCN4CCC(CC4)c5nc6cc(ccc6[nH]5)C#N 5.85 CHEMBL3366645 CHEMBL3319003 COc1cnc2C=CC(=O)N(CCN3CCC(CC3)c4c[nH]c5ccc(cc45)C#N)c2c1 5.7 CHEMBL3366645 CHEMBL3319004 COc1cnc2C=CC(=O)N(CCN3CCC(CC3)c4c[nH]c5cc(ccc45)C(F)(F)F)c2c1 5.75 CHEMBL3366645 CHEMBL3321871 CN1CCN(CC1)c2ccc3nc(Nc4ccc(Br)cn4)[nH]c3c2 5.46 CHEMBL3371912 CHEMBL3321873 CN1CCN(CC1)c2ccc3nc(Nc4ccc(C)cn4)[nH]c3c2 4.9 CHEMBL3371912 CHEMBL3321963 CN1CCN(Cc2ccc3nc(Nc4ccc(cn4)C(F)(F)F)[nH]c3c2)CC1 4.67 CHEMBL3371912 CHEMBL3321968 CN1CCN(CC1)c2cc(Cl)c3nc(Nc4ccc(Br)cn4)[nH]c3c2 5.14 CHEMBL3371912 CHEMBL3321972 CN1CCC(CC1)c2ccc3nc(Nc4ccc(cn4)C(F)(F)F)[nH]c3c2 5.37 CHEMBL3371912 CHEMBL3321980 CN1CCN(CC1)c2cc3[nH]c(Nc4cc(C5CC5)c(F)c(C)n4)nc3cn2 5.06 CHEMBL3371912 CHEMBL3323072 CCOC(=O)c1cccc(n1)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cc6)c7cnn(C)c7 6.15 CHEMBL3378637 CHEMBL3323073 CCOC(=O)c1cccc(n1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cc6)c7cnn(C)c7 6.2 CHEMBL3378637 CHEMBL3323074 CCOC(=O)c1ccnc(c1)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cc6)c7cnn(C)c7 5.85 CHEMBL3378637 CHEMBL3323075 CCOC(=O)c1ccnc(c1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cc6)c7cnn(C)c7 5.92 CHEMBL3378637 CHEMBL3323076 CCOC(=O)c1cncc(c1)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cc6)c7cnn(C)c7 5.65 CHEMBL3378637 CHEMBL3323077 CCOC(=O)c1cncc(c1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cc6)c7cnn(C)c7 5.6 CHEMBL3378637 CHEMBL3323078 CCOC(=O)c1ccc(nc1)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cc6)c7cnn(C)c7 5.79 CHEMBL3378637 CHEMBL3323079 CCOC(=O)c1ccc(nc1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cc6)c7cnn(C)c7 5.55 CHEMBL3378637 CHEMBL3323080 Cn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cc6)c7cccc(n7)C(=O)O 5.06 CHEMBL3378637 CHEMBL3323082 Cn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cc6)c7cc(ccn7)C(=O)O 4.71 CHEMBL3378637 CHEMBL3323084 Cn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cc6)c7cncc(c7)C(=O)O 4.92 CHEMBL3378637 CHEMBL3323086 Cn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cc6)c7ccc(cn7)C(=O)O 4.02 CHEMBL3583383 CHEMBL3323181 CN1C[C@H](c2ccc3sccc3c2)c4ccc(cc4C1)N5CCOCC5 6 CHEMBL3379378 CHEMBL332826 CN1C(=O)[C@H](NC(=O)\C=C\c2ccc(Cl)cc2Cl)N=C(c3ccccc3)c4ccccc14 5.82 CHEMBL686879 CHEMBL3329684 COc1ccc(C(=O)NC(=O)Nc2ccc3\C(=C\c4[nH]c(C)c(C(=O)NCCN5CCCC5)c4C)\C(=O)Nc3c2)c(F)c1 5.02 CHEMBL3374453 CHEMBL3329813 CC(C(=O)O)c1ccc(CN2CCC(COC(=O)c3c4OCCCn4c5ccccc35)CC2)cc1 4.6 CHEMBL3367333 CHEMBL3329814 OCC(O)CN1CCC(COC(=O)c2c3OCCCn3c4ccccc24)CC1 4.09 CHEMBL3367333 CHEMBL3330060 N[C@@H](CC(=O)N1C[C@@H](F)C[C@H]1C#N)Cc2cc(F)c(F)cc2F 4.01 CHEMBL3370430 CHEMBL3330073 N[C@@H](CC(=O)N1[C@@H](C[C@@H]2CCC[C@H]12)C#N)Cc3cc(F)c(F)cc3F 4.26 CHEMBL3370430 CHEMBL3330442 Clc1ccc(s1)C(=O)NC[C@@H]2OC(=O)N3[C@H]2COc4cc(ccc34)N5CCOCC5=O 4.1 CHEMBL3384134 CHEMBL3330650 OCCONC(=O)c1ccc2cncn2c1Nc3ccc(I)cc3F 5.36 CHEMBL3377716 CHEMBL3330652 OCCONC(=O)c1ccn2cncc2c1Nc3ccc(I)cc3F 5.68 CHEMBL3377716 CHEMBL3330653 OCCONC(=O)c1ncc2cncn2c1Nc3ccc(I)cc3F 5.48 CHEMBL3377716 CHEMBL3330654 C[C@H](O)CONC(=O)c1ncc2cncn2c1Nc3ccc(I)cc3F 5.48 CHEMBL3377716 CHEMBL3330655 C[C@H](CO)CONC(=O)c1ncc2cncn2c1Nc3ccc(I)cc3F 4.85 CHEMBL3377716 CHEMBL3330811 COc1ccc(cc1)N2C=Nc3c(csc3C2=O)c4ccccc4 4.97 CHEMBL3361668 CHEMBL3330823 COc1ccc(cc1)N2C=Nc3c(csc3C2=O)c4ccccc4C 5.01 CHEMBL3361668 CHEMBL3331484 Clc1ccc(CN(C2CC2)C3CNC3)cc1Cl 5.33 CHEMBL3385976 CHEMBL3331502 OC(=O)C(F)(F)F.Clc1cccc(CN(CC2CNC2)c3ccccc3)c1Cl 5.73 CHEMBL3385976 CHEMBL3331503 Cl.CC(C)N(CC1CNC1)Cc2ccc(Cl)c(Cl)c2 5.26 CHEMBL3385976 CHEMBL3338194 CS(=O)(=O)c1ccc(N2C=C(Cl)C(=CC2=O)OC3CCN(CC3)c4ncc(Cl)cn4)c(F)c1 5.85 CHEMBL3382462 CHEMBL3338895 O=C1NC(=O)\C(=C/c2ccccc2OCc3oc(nn3)c4ccccc4)\S1 4.39 CHEMBL3382404 CHEMBL3342693 CC(C)C(=O)NCc1cnc(C(F)F)c(c1)C(=O)Nc2nc(C)c([nH]2)c3ccc(cc3)C(F)(F)F 7.08 CHEMBL3761681 CHEMBL3343216 OC(C1CCN(Cc2ccc(cc2)c3ccccc3)CC1)(c4ccccc4)c5ccccc5 6.68 CHEMBL3390017 CHEMBL3344385 OC(C1CCN(CCCOc2ccc(cc2)c3ccccc3)CC1)(c4ccccc4)c5ccccc5 6.85 CHEMBL3390017 CHEMBL334491 CC(C)(C)N1CCC(CC1)(c2ccccc2)c3ccccc3 6.07 CHEMBL1676103 CHEMBL3350235 Cl.CSc1ccc(cc1)[C@@H]2N=C(OCc3ccc(NS(=O)(=O)C)cc3)N(C)Cc4ccccc24 4.25 CHEMBL684971 CHEMBL3353403 COc1cc(N2CC[C@H](C2)N(C)C)c(NC(=O)C=C)cc1Nc3ncc(Cl)c(n3)c4cnn5ccccc45 5.25 CHEMBL3389028 CHEMBL3353404 COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc2ncc(Cl)c(n2)c3cnn4ccccc34 5.17 CHEMBL3389028 CHEMBL3353405 COc1cc(N2CC(C2)N(C)C)c(NC(=O)C=C)cc1Nc3ncc(Cl)c(n3)c4cnn5ccccc45 5.4 CHEMBL3389028 CHEMBL3353406 COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc2ncc(C#N)c(n2)c3cn(C)c4ccccc34 5.37 CHEMBL3389028 CHEMBL3353407 COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc2ncc(Cl)c(n2)c3cn(C)c4ccccc34 5.13 CHEMBL3389028 CHEMBL3353408 COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc2ncc(Cl)c(n2)c3c[nH]c4ccccc34 4.83 CHEMBL3389028 CHEMBL3353409 COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc2ncc(C)c(n2)c3cn(C)c4ccccc34 4.81 CHEMBL3389028 CHEMBL3353410 COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc2nccc(n2)c3cn(C)c4ccccc34 4.79 CHEMBL3389028 CHEMBL3353411 COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc2nccc(n2)c3c[nH]c4ccccc34 4.76 CHEMBL3389028 CHEMBL3355072 C[C@@H]1Cn2ncc(c2CN1c3ccnc4[nH]ccc34)c5ccc(cc5)S(=O)(=O)C 5.82 CHEMBL3379633 CHEMBL3355074 C[C@@H]1Cn2ncc(C3CCN(CC3)S(=O)(=O)C)c2CN1c4cc(Cl)nc5[nH]ccc45 4.9 CHEMBL3379633 CHEMBL3355541 CN1CCC(CNc2ccn3ncc(c4cccc(OC(F)(F)F)c4)c3n2)CC1 5.72 CHEMBL3375414 CHEMBL3355597 Clc1cccc(Cl)c1COc2oc(COc3ccccc3\C=C/4\SC(=O)NC4=O)nn2 4.54 CHEMBL3382404 CHEMBL3355624 CS(=O)c1cccc(c1)c2ccc3ncc(c4ccc(cc4)S(=O)(=O)C)n3n2 5.4 CHEMBL3381295 CHEMBL3355629 CS(=O)c1ccc(cc1)c2cnc3ccc(nn23)c4cccc(c4)S(=O)(=O)C 5.4 CHEMBL3381295 CHEMBL3355633 C[S+]([O-])c1ccc(cc1)c2cnc3ccc(nn23)c4cccc(c4)[S+](C)[O-] 4.92 CHEMBL3381295 CHEMBL3355638 CS(=O)c1ccc(cc1)c2cnc3ccc(nn23)c4cccc(c4)S(=O)(=O)C5CC5 6.4 CHEMBL3381295 CHEMBL3355639 CS(=O)(=O)c1ccc(cc1)c2cnc3ccc(nn23)c4cccc(c4)S(=O)(=O)C5CC5 6.4 CHEMBL3381295 CHEMBL3356239 COc1ccccc1CCNCC(=O)N2CCc3ccccc3C2C4CCCCC4 5.08 CHEMBL3381617 CHEMBL3356242 Clc1cccc(Cl)c1CCNCC(=O)N2CCc3ccccc3C2C4CCCCC4 4.26 CHEMBL3381617 CHEMBL3356246 O=C(CNCC1CCCCC1)N2CCc3ccccc3C2C4CCCCC4 4.59 CHEMBL3381617 CHEMBL3356247 OC1(CNCC(=O)N2CCc3ccccc3C2C4CCCCC4)CCCCC1 4.34 CHEMBL3381617 CHEMBL3356248 OC1(CNCC(=O)N2CCc3ccccc3C2C4CCCCC4)CCCC1 4.11 CHEMBL3381617 CHEMBL3356249 OC1(CNCC(=O)N2CCc3ccccc3C2C4CCCCC4)CCCCCC1 4.3 CHEMBL3381617 CHEMBL3356251 OC1(CNCC(=O)N2CCc3ccccc3[C@@H]2C4CCCCC4)CCCCC1 4.01 CHEMBL3381617 CHEMBL3356252 OC1(CNCC(=O)N2CCc3ccccc3[C@H]2C4CCCCC4)CCCCC1 4.12 CHEMBL3381617 CHEMBL3357994 C[C@@H]1CN(CCN1c2ncc(OCc3ccc(cc3F)S(=O)(=O)C)cn2)c4oc(nn4)C(F)(F)F 5.16 CHEMBL3383394 CHEMBL3357995 C[C@@H]1CN(CCN1c2ncc(OCc3ccc(cc3C#N)S(=O)(=O)C)cn2)c4oc(nn4)C(F)(F)F 5.19 CHEMBL3383394 CHEMBL3357996 C[C@@H]1CN(CCN1c2ncc(OCc3ccc(cc3C#N)C#N)cn2)c4oc(nn4)C(F)(F)F 5.44 CHEMBL3383394 CHEMBL3357997 C[C@@H]1CN(CCN1c2ncc(OCc3ccc(cc3)S(=O)(=O)C)cn2)c4oc(nn4)C(F)(F)F 5.03 CHEMBL3383394 CHEMBL3357999 C[C@@H]1CN(CCN1c2ncc(OCc3ccc(cc3F)C#N)cn2)c4oc(nn4)C(F)(F)F 4.96 CHEMBL3383394 CHEMBL3358000 C[C@@H]1CN(CCN1c2ncc(OCc3ccc(cc3F)n4cnnn4)cn2)c5oc(nn5)C(F)(F)F 5.24 CHEMBL3383394 CHEMBL3358002 C[C@@H]1CN(CCN1c2ncc(OCc3ccc(OS(=O)(=O)C)cc3F)cn2)c4oc(nn4)C(F)(F)F 4.77 CHEMBL3383394 CHEMBL3358005 C[C@@H]1CN(CCN1c2ncc(OCc3ccc(cc3F)S(=O)(=O)C)cn2)c4onc(n4)C(F)(F)F 5.44 CHEMBL3383394 CHEMBL3358007 C[C@@H]1CN(CCN1c2ncc(OCc3ccc(C[S+](C)[O-])cc3F)cn2)c4onc(n4)C(F)(F)F 4.55 CHEMBL3383394 CHEMBL3358012 C[C@@H]1CN(CCN1c2ncc(OCc3ccc(cc3F)S(=O)(=O)C)cn2)C(=O)OC4(COC4)C(F)(F)F 4.96 CHEMBL3383394 CHEMBL3358014 CC(C)c1noc(n1)N2CCN([C@H](C)C2)c3ncc(OCc4ccc(cc4F)S(=O)(=O)C)cn3 5.13 CHEMBL3383394 CHEMBL3358114 CN1CCC(CCCc2cc(Cl)c(c(Cl)c2)S(=O)(=O)N(C(F)F)c3c(C)nn(C)c3C)CC1 6.22 CHEMBL3387701 CHEMBL3358509 O=C(NCCCCN1CCN(CC1)c2ccccc2)c3ccc4ncccc4c3 5 CHEMBL3383594 CHEMBL3358687 OC1(Cc2ccc(F)cc2)CCN(CCNC(=O)Nc3ccnc4ccsc34)CC1 5.3 CHEMBL3382939 CHEMBL3358925 Cc1ccc(F)cc1C(C)(C)CC(O)(Cc2cc3cc(ncc3[nH]2)c4ccccc4)C(F)(F)F 5.42 CHEMBL3374297 CHEMBL3358937 CC(C)(CC(O)(Cc1cc2cc(ncc2[nH]1)N3CCOCC3)C(F)(F)F)c4ccccc4S(=O)(=O)C 4.7 CHEMBL3374297 CHEMBL3359220 Cc1nc(nc(OCCCN2CCCCC2)c1Cl)c3ccccc3 6.55 CHEMBL3382984 CHEMBL3359230 Cc1nc(nc(OCCCN2CCCC2)c1Cl)c3ccccc3 5.43 CHEMBL3382984 CHEMBL3359234 Cc1ccc(cc1)c2nc(C)c(Cl)c(OCCCN3CCCCC3)n2 6.02 CHEMBL3382984 CHEMBL3359236 Cc1nc(nc(OCCCN2CCCCC2)c1Cl)c3ccc(cc3)C(F)(F)F 5.58 CHEMBL3382984 CHEMBL3359237 Cc1nc(nc(OCCCN2CCCCC2)c1Cl)c3ccc(F)cc3 5.81 CHEMBL3382984 CHEMBL3359238 Cc1nc(nc(OCCCN2CCCCC2)c1Cl)c3ccc(F)c(F)c3 5.85 CHEMBL3382984 CHEMBL3359239 Cc1nc(nc(OCCCN2CCCCC2)c1Cl)c3ccc(Cl)cc3 5.16 CHEMBL3382984 CHEMBL3359261 CC(C)(C)n1ncc2CC3(CCN(CC3)C(=O)c4ccc5[nH]ncc5c4)CC(=O)c12 4.68 CHEMBL3385491 CHEMBL3359262 CC(C)n1ncc2CC3(CCN(CC3)C(=O)c4ccc5[nH]ncc5c4)CC(=O)c12 4.64 CHEMBL3385491 CHEMBL3359264 CC(C)n1ncc2CC3(CCN(CC3)C(=O)c4cnc5cc[nH]c5c4)CC(=O)c12 4.54 CHEMBL3385491 CHEMBL338109 CN1C(=O)[C@H](NC(=O)C(N)Cc2ccccc2)N=C(c3ccccc3)c4ccccc14 5.06 CHEMBL686879 CHEMBL3392292 CS(=O)(=O)O.NC[C@@H]1CC[C@@]2(CC1)OOC3(O2)C4CC5CC(CC3C5)C4 5.75 CHEMBL895925 CHEMBL339327 FC(F)(F)CN1C(=O)[C@H](NC(=O)Cc2cc(Cl)cc(Cl)c2)N=C(c3ccccc3)c4ccccc14 5.4 CHEMBL686879 CHEMBL3393706 Fc1cccc(F)c1c2ccc3[nH]nc(c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2 5.43 CHEMBL3396429 CHEMBL3393710 Fc1cccnc1c2ccc3[nH]nc(c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2 5.52 CHEMBL3396429 CHEMBL3393717 Oc1ccc(c(F)c1)c2ccc3[nH]nc(c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2 6.1 CHEMBL3396429 CHEMBL3393718 NC(=O)c1ccc(c(F)c1)c2ccc3[nH]nc(c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2 5.96 CHEMBL3396429 CHEMBL3393719 CS(=O)(=O)c1ccc(c(F)c1)c2ccc3[nH]nc(c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2 5.7 CHEMBL3396429 CHEMBL3393720 CS(=O)(=O)Nc1ccc(c(F)c1)c2ccc3[nH]nc(c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2 5.64 CHEMBL3396429 CHEMBL3393730 COC(=O)N[C@@H](C(C)C)C(=O)N1C[C@@H](C)C[C@H]1c2ncc([nH]2)c3ccc(cc3)c4ccc(s4)c5cc6[nH]c(nc6s5)[C@@H]7C[C@H](C)CN7C(=O)[C@@H](NC(=O)OC)C(C)C 4.6 CHEMBL3396520 CHEMBL3394201 COc1ccc(CC(=O)N2CCC3(CC2)CN(C3)[C@@H]4CCc5cc(ccc45)c6cc(C)ncn6)c(c1)C(=O)N 4.33 CHEMBL3396351 CHEMBL339457 CCN(CC)C(=O)c1ccc(cc1)C(=C2CCNCC2)c3cccc(F)c3 5.52 CHEMBL1947877 CHEMBL3398175 COc1ccccc1c2ccc3cnc(Nc4ccc(cc4OC)[C@H]5CCN(CCO)C[C@@H]5O)nn23 5.17 CHEMBL3398704 CHEMBL3398269 CC(C)N1Cc2cc(ccc2C1=O)c3onc(c3C)c4ccc(F)cc4F 5.98 CHEMBL3399089 CHEMBL3398278 CC(C)N1Cc2cc(ccc2C1=O)c3onc(c3)c4ccc(Cl)nc4 4.4 CHEMBL3399089 CHEMBL3398280 COc1ccc(cn1)c2cc(on2)c3ccc4C(=O)N(Cc4c3)C(C)C 4.92 CHEMBL3399089 CHEMBL3400819 Fc1cnc2C=CC(=O)N3CC(CC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c1c23 4.52 CHEMBL3404544 CHEMBL3400820 Fc1cnc2C=CC(=O)N3CC(F)(CC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c1c23 4.86 CHEMBL3404543 CHEMBL3400821 CO[C@@]1(CC23CCC(CC2)(CO3)NCc4ccc5OCC(=O)Nc5n4)CN6C(=O)C=Cc7ncc(F)c1c67 5.14 CHEMBL3404543 CHEMBL3400822 CO[C@]1(CC23CCC(CC2)(CO3)NCc4ccc5OCC(=O)Nc5n4)CN6C(=O)C=Cc7ncc(F)c1c67 4.61 CHEMBL3404543 CHEMBL3401350 CC(C)[C@]1(C)CC(=O)N(Cc2cc(F)cc(c2)C(=O)N[C@@H](C)c3ccccc3)C(=N)N1 5.05 CHEMBL3406751 CHEMBL3401424 Cl.C1CCN(C1)C23CNCC(C(C2)c4ccccc4)C(C3)c5ccccc5 5.58 CHEMBL3407223 CHEMBL3402185 O[C@@]1(CC23CCC(CC2)(CO3)NCc4ccc5OCC(=O)Nc5n4)CN6C(=O)C=Cc7ncc(Cl)c1c67 4.27 CHEMBL3404543 CHEMBL340353 CN1C(=O)[C@H](NC(=O)CCC2CCCCC2)N=C(c3ccccc3)c4ccccc14 6 CHEMBL686879 CHEMBL3403995 COCCCOc1cc(ccc1OC)C(=O)N(C[C@@H]2CNC[C@H]2OC(=O)NCc3ccccc3)C(C)C 4.89 CHEMBL3406672 CHEMBL3407783 CNC(=O)[C@@]12C[C@@H]1[C@H]([C@H](O)[C@@H]2O)n3cnc4c(NC)nc(nc34)C#Cc5cccs5 4.94 CHEMBL3414402 CHEMBL3407784 CNC(=O)[C@@]12C[C@@H]1[C@H]([C@H](O)[C@@H]2O)n3cnc4c(NC)nc(nc34)C#Cc5ccc(Cl)s5 4.89 CHEMBL3414402 CHEMBL3408274 C[C@@H](N(C)c1cc(F)cc(F)c1)c2cc(cc3C(=O)C=C(Oc23)N4CCOCC4)C(=O)N(C)C 4.72 CHEMBL3411230 CHEMBL3408381 S=C(Nc1ccccc1)Nc2nc(cc(c3ccccc3)c2C#N)c4ccccc4 4.32 CHEMBL3413736 CHEMBL3408382 N#Cc1c(cc(nc1\N=C\2/SC(=NN2c3ccccc3)c4ccccc4)c5ccccc5)c6ccccc6 5.12 CHEMBL3413736 CHEMBL3408383 CC(=O)C1=NN(\C(=N\c2nc(cc(c3ccccc3)c2C#N)c4ccccc4)\S1)c5ccccc5 4.49 CHEMBL3413736 CHEMBL3408384 CC(=O)C1=NN(\C(=N\c2nc(cc(c3ccccc3)c2C#N)c4ccccc4)\S1)c5ccc(C)cc5 4.54 CHEMBL3413736 CHEMBL3408385 COc1ccc(cc1)N2N=C(S/C/2=N\c3nc(cc(c4ccccc4)c3C#N)c5ccccc5)C(=O)C 4.75 CHEMBL3413736 CHEMBL3408386 CC(=O)C1=NN(\C(=N\c2nc(cc(c3ccccc3)c2C#N)c4ccccc4)\S1)c5ccc(Cl)cc5 4.94 CHEMBL3413736 CHEMBL3408387 CCOC(=O)C1=NN(\C(=N\c2nc(cc(c3ccccc3)c2C#N)c4ccccc4)\S1)c5ccccc5 4.98 CHEMBL3413736 CHEMBL3408388 CCOC(=O)C1=NN(\C(=N\c2nc(cc(c3ccccc3)c2C#N)c4ccccc4)\S1)c5ccc(C)cc5 5.03 CHEMBL3413736 CHEMBL3408389 CCOC(=O)C1=NN(\C(=N\c2nc(cc(c3ccccc3)c2C#N)c4ccccc4)\S1)c5ccc(Cl)cc5 5.08 CHEMBL3413736 CHEMBL3408390 O=C(Nc1ccccc1)C2=NN(\C(=N\c3nc(cc(c4ccccc4)c3C#N)c5ccccc5)\S2)c6ccccc6 5.08 CHEMBL3413736 CHEMBL3408391 O=C1CS\C(=N/c2nc(cc(c3ccccc3)c2C#N)c4ccccc4)\N1c5ccccc5 4.34 CHEMBL3413736 CHEMBL3408392 N#Cc1c(cc(nc1\N=C\2/SC=C(N2c3ccccc3)c4ccccc4)c5ccccc5)c6ccccc6 5.17 CHEMBL3413736 CHEMBL3408393 O=C1N(\C(=N\c2nc(cc(c3ccccc3)c2C#N)c4ccccc4)\S/C/1=C/5\SC(=NN5c6ccccc6)c7ccccc7)c8ccccc8 5.6 CHEMBL3413736 CHEMBL3408394 CC(=O)C1=NN(\C(=C/2\S\C(=N/c3nc(cc(c4ccccc4)c3C#N)c5ccccc5)\N(C2=O)c6ccccc6)\S1)c7ccccc7 5.24 CHEMBL3413736 CHEMBL3408395 CCOC(=O)C1=NN(\C(=C/2\S\C(=N/c3nc(cc(c4ccccc4)c3C#N)c5ccccc5)\N(C2=O)c6ccccc6)\S1)c7ccccc7 5.34 CHEMBL3413736 CHEMBL3408396 O=C(Nc1ccccc1)C2=NN(\C(=C/3\S\C(=N/c4nc(cc(c5ccccc5)c4C#N)c6ccccc6)\N(C3=O)c7ccccc7)\S2)c8ccccc8 5.47 CHEMBL3413736 CHEMBL3408617 CCOc1nc(NC(=O)C2(CCC2)NC(=O)c3ccc4c(C5CCCC5)c(c6ccc(F)cn6)n(C)c4c3)ccc1\C=C\C(=O)O 5.68 CHEMBL3412836 CHEMBL3408622 CCOc1nc(NC(=O)C2(CCC2)NC(=O)c3ccc4c(c3)c(C)c(c5ccc(F)cn5)n4C6CCCCC6)ccc1\C=C\C(=O)O 5.85 CHEMBL3412836 CHEMBL3409256 NC(=O)c1ccccc1OCCCN2CCN(CC2)c3cccc4c3ccn4S(=O)(=O)c5ccccc5 5.21 CHEMBL3413549 CHEMBL3409588 OC[C@@H](N1C=CC(=CC1=O)c2ccnc(NC3CCOCC3)n2)c4ccc(Cl)c(F)c4 4.84 CHEMBL3413971 CHEMBL3410223 Cc1nc(C#Cc2ccnc(Cl)c2)c(C)n1c3ccc(OC(F)(F)F)cc3 6 CHEMBL3412492 CHEMBL3415583 Cc1cc(C)nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(=O)N)c1 5.8 CHEMBL3418525 CHEMBL3415585 Cc1cc(C)nc(Nc2cc(NC[C@@H](N)CC(F)F)cnc2C(=O)N)c1 5.28 CHEMBL3418525 CHEMBL3415586 Cc1cc(C)nc(Nc2cc(NC[C@@H](N)C(F)(F)F)cnc2C(=O)N)c1 4.38 CHEMBL3420425 CHEMBL3415587 Cc1cc(C)nc(Nc2cc(NCC3(N)CC3)cnc2C(=O)N)c1 5.77 CHEMBL3418525 CHEMBL3415588 COC[C@H](N)CNc1cnc(C(=O)N)c(Nc2cc(C)cc(C)n2)c1 5.8 CHEMBL3418525 CHEMBL3415589 Cc1cc(C)nc(Nc2cc(N[C@@H]3CS(=O)(=O)CC[C@@H]3N)cnc2C(=O)N)c1 4.54 CHEMBL3418525 CHEMBL3415591 Cc1cc(C)nc(Nc2cc(NC[C@@H](N)CCS(=O)(=O)C)cnc2C(=O)N)c1 4.85 CHEMBL3418525 CHEMBL3415592 N[C@H]1CCCC[C@H]1Nc2cnc(C(=O)N)c(Nc3cccc(n3)C(F)(F)F)c2 6.22 CHEMBL3418525 CHEMBL3415593 COc1cc(C)nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(=O)N)c1 5.77 CHEMBL3418525 CHEMBL3415594 Cc1cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(=O)N)nc(C)c1c4cnn(C)c4 6 CHEMBL3418525 CHEMBL3415595 Cc1cc(CC(C)(C)O)cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(=O)N)n1 5.23 CHEMBL3418525 CHEMBL3415596 Cc1cc(cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(=O)N)n1)C(C)(C)O 5.19 CHEMBL3418525 CHEMBL3415597 Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(=O)N)cc(OCC(C)(C)O)n1 4.75 CHEMBL3418525 CHEMBL3415598 Cc1cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(=O)N)nc(n1)n4nccn4 4.36 CHEMBL3418525 CHEMBL3415610 COc1cccc2[nH]c(cc12)c3nc(N[C@@H]4CCOC[C@@H]4N)cnc3C(=O)N 4.66 CHEMBL3418525 CHEMBL3416021 N[C@H]1CCCC[C@H]1Nc2ccc(C(=O)N)c(Nc3cccc(c3)n4nccn4)n2 5.07 CHEMBL3419125 CHEMBL3416023 N[C@H]1CCCC[C@H]1Nc2cnc(C(=O)N)c(Nc3cccc(c3)n4nccn4)n2 5 CHEMBL3419125 CHEMBL3416024 N[C@H]1CCCC[C@H]1Nc2cnc(C(=O)N)c(Nc3cccc4cc[nH]c34)n2 5.09 CHEMBL3419125 CHEMBL3416025 N[C@H]1CCCC[C@H]1Nc2nnc(C(=O)N)c(Nc3cccc(c3)n4nccn4)n2 5.43 CHEMBL3419125 CHEMBL3416026 N[C@H]1CCCC[C@H]1Nc2nnc(C(=O)N)c(Nc3cccc4cc[nH]c34)n2 4.55 CHEMBL3626606 CHEMBL3416027 N[C@H]1CCCC[C@H]1Nc2nnc(C(=O)N)c(Nc3cccc4[nH]ccc34)n2 5.43 CHEMBL3419125 CHEMBL3416047 NC[C@H]1C[C@@H]1c2cc(Cl)ccc2OCC=C.OC(=O)C(F)(F)F 6.57 CHEMBL3420397 CHEMBL3416051 Cl.NC[C@H]1C[C@@H]1c2cc(Cl)ccc2OCC(=C)F 5.4 CHEMBL3420397 CHEMBL3416055 Cl.NC[C@H]1C[C@@H]1c2cc(Cl)ccc2OCCF 5.7 CHEMBL3420397 CHEMBL3417042 Clc1ccc(cc1Cl)n2cc(NCCN3CCCCC3)nn2 5.77 CHEMBL3419515 CHEMBL3417043 Clc1ccc(c(Cl)c1)n2cc(NCCN3CCCCC3)nn2 5.31 CHEMBL3419515 CHEMBL3417044 Clc1ccc(cc1)n2cc(NCCN3CCCCC3)nn2 5.51 CHEMBL3419515 CHEMBL3417045 Fc1cccc(c1)n2cc(NCCN3CCCCC3)nn2 5.28 CHEMBL3419515 CHEMBL3417047 Fc1ccc(cc1F)n2cc(NCCN3CCCCC3)nn2 5.66 CHEMBL3419515 CHEMBL3417058 Clc1ccc(Cn2cc(NCCN3CCCCC3)nn2)cc1Cl 5.66 CHEMBL3419515 CHEMBL3417066 Clc1ccc(Cn2cc(NCCN3CCCCCC3)nn2)cc1Cl 5.41 CHEMBL3419515 CHEMBL3417071 C[C@@H]1CCC[C@H](C)N1CCNc2cn(Cc3ccc(F)cc3)nn2 6.22 CHEMBL3419515 CHEMBL3417505 C[C@H](COc1ccc(cc1)C2=NNC(=O)C3CC23)CN4CCC[C@H]4C 5.1 CHEMBL3421062 CHEMBL3417742 COc1ccc(Oc2ccc(cc2)S(=O)(=O)C3(CCC4(CCNCC4)C3)C(=O)NO)cc1 4.43 CHEMBL3419072 CHEMBL3417745 ONC(=O)C1(CCC2(CCNCC2)C1)S(=O)(=O)c3ccc(Oc4ccc(OC(F)(F)F)cc4)cc3 4 CHEMBL3419072 CHEMBL3417746 ONC(=O)C1(CCC2(CCNCC2)C1)S(=O)(=O)c3ccc(OCc4ccc(OC(F)(F)F)cc4)cc3 4.3 CHEMBL3419072 CHEMBL3417767 COc1ccc(cc1)C(=O)Oc2ccc(cc2)S(=O)(=O)C3(CCC4(CCNCC4)C3)C(=O)NO 4.2 CHEMBL3419072 CHEMBL3421646 COc1cc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2nc1OC 7.86 CHEMBL3424851 CHEMBL3422007 C[C@H]1N(CCn2c1nnc2c3cccc(C)n3)C(=O)c4ccc(cc4)c5cccs5 5.14 CHEMBL3425006 CHEMBL3422008 C[C@H]1N(CCn2c1nnc2c3cncc(C)n3)C(=O)c4ccc(cc4)c5cccs5 5.33 CHEMBL3425006 CHEMBL3422009 C[C@H]1N(CCn2c1nnc2c3csc(n3)c4ccc(F)cc4F)C(=O)c5ccc(cc5)c6cccs6 5.85 CHEMBL3610078 CHEMBL3422010 C[C@H]1N(CCn2c1nnc2c3csc(C)n3)C(=O)c4ccc(cc4)c5cccs5 4.62 CHEMBL3425006 CHEMBL3422012 Cc1nc(cs1)c2nnc3CN(CCn23)C(=O)c4ccc(cc4)c5cccs5 4.57 CHEMBL3425006 CHEMBL3422015 CC(C)c1occ(n1)c2nnc3[C@@H](C)N(CCn23)C(=O)c4ccc(cc4)c5cccs5 5.14 CHEMBL3425006 CHEMBL3422016 C[C@H]1N(CCn2c1nnc2c3nc(C)cs3)C(=O)c4ccc(cc4)c5cccs5 4.77 CHEMBL3425006 CHEMBL3422017 C[C@H]1N(CCn2c1nnc2c3onc(C)n3)C(=O)c4ccc(cc4)c5cccs5 5.29 CHEMBL3425006 CHEMBL3422018 C[C@H]1N(CCn2c1nnc2c3nc(C)ns3)C(=O)c4ccc(cc4)c5cccs5 5.1 CHEMBL3610078 CHEMBL3422235 NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c3occn3)c4ccc(F)cc4F 4.98 CHEMBL3423786 CHEMBL3422236 Cc1coc(n1)[C@H]2C[C@H]3CSC(=N[C@]3(CO2)c4ccc(F)cc4F)N 5.64 CHEMBL3423786 CHEMBL3422237 Cc1cc(on1)[C@H]2C[C@H]3CSC(=N[C@]3(CO2)c4ccc(F)cc4F)N 5.8 CHEMBL3423786 CHEMBL3422238 Cn1cc(cn1)[C@H]2C[C@H]3CSC(=N[C@]3(CO2)c4ccc(F)cc4F)N 5.31 CHEMBL3423786 CHEMBL3422241 C[C@H]1SC(=N[C@]2(CO[C@H](C[C@@H]12)c3occ(C)n3)c4ccc(F)cc4F)N 5.32 CHEMBL3423786 CHEMBL3422242 C[C@H]1SC(=N[C@]2(CO[C@H](C[C@@H]12)c3onc(C)c3)c4ccc(F)cc4F)N 5.68 CHEMBL3423786 CHEMBL3422243 C[C@H]1SC(=N[C@]2(CO[C@H](C[C@@H]12)c3cnn(C)c3)c4ccc(F)cc4F)N 5.32 CHEMBL3423786 CHEMBL3422244 Cc1coc(n1)[C@H]2C[C@H]3[C@@H](CF)SC(=N[C@]3(CO2)c4ccc(F)cc4F)N 4.71 CHEMBL3423786 CHEMBL3422245 Cc1cc(on1)[C@H]2C[C@H]3[C@@H](CF)SC(=N[C@]3(CO2)c4ccc(F)cc4F)N 5 CHEMBL3423786 CHEMBL3422246 Cn1cc(cn1)[C@H]2C[C@H]3[C@@H](CF)SC(=N[C@]3(CO2)c4ccc(F)cc4F)N 4.86 CHEMBL3423786 CHEMBL3422754 COc1ccc2ncc(Cl)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 6.5 CHEMBL3424851 CHEMBL3422755 COc1ccc2nccc(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.89 CHEMBL3424852 CHEMBL3422756 COc1ccc2ncc(C#N)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 6.43 CHEMBL3424851 CHEMBL3422757 COc1ccc2ncc(c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1)C(F)(F)F 6.14 CHEMBL3424852 CHEMBL3422758 COc1ccc2ncc(C(F)F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.23 CHEMBL3424851 CHEMBL3422759 COc1ccc2ncc(C)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 4.56 CHEMBL3424851 CHEMBL3422760 COc1ccc2ncc(CO)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.23 CHEMBL3424852 CHEMBL3422762 COc1ccc2ncc(c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1)S(=O)(=O)C 5.62 CHEMBL3424852 CHEMBL3422763 COc1ccc2ncc(OC)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.37 CHEMBL3424851 CHEMBL3422764 COc1ccc2ncc(O)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.71 CHEMBL3424851 CHEMBL3422765 Oc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 8.32 CHEMBL3424851 CHEMBL3422768 COC(=O)c1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 8.06 CHEMBL3424851 CHEMBL3422947 Fc1cnc2ccc(nc2c1CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)C#N 8.41 CHEMBL3424851 CHEMBL3422948 Nc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 8.49 CHEMBL3424851 CHEMBL3422949 CN(C)c1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 8.08 CHEMBL3424851 CHEMBL3422950 Fc1cnc2ccc(nc2c1CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)N7CCOCC7 7.94 CHEMBL3424851 CHEMBL3422952 COc1nc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c(F)cnc2cc1F 9.14 CHEMBL3424851 CHEMBL3422953 COc1cc(C)c2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 8.54 CHEMBL3424851 CHEMBL3422954 CCOc1cc(C)c2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 8.92 CHEMBL3424851 CHEMBL3422957 COc1nc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c(F)cnc2cc1C(F)(F)F 8.77 CHEMBL3424851 CHEMBL3422958 Cc1cc(nc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c(F)cnc12)S(=O)(=O)C 7.91 CHEMBL3424851 CHEMBL3422959 Fc1cnc2cc(cnc2c1CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)C(F)(F)F 9.05 CHEMBL3424851 CHEMBL3422960 CN(C)c1cnc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c(F)cnc2c1 7.74 CHEMBL3424851 CHEMBL3422961 Fc1cnc2cc(Cl)cnc2c1CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5 8.49 CHEMBL3424851 CHEMBL3422962 O=C1COc2ccc(CNC34CCC(CCc5c(cnc6ccc(nc56)C#N)C#N)(CC3)OC4)nc2N1 8.78 CHEMBL3424851 CHEMBL3422963 COc1nc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)ccnc2cc1Cl 8.38 CHEMBL3424851 CHEMBL3422964 COc1cc2nccc(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2nc1OC 8.85 CHEMBL3424851 CHEMBL3422965 COc1nc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)ccnc2cc1F 8.6 CHEMBL3424851 CHEMBL3422966 COc1nc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)ccnc2cc1C#N 8.8 CHEMBL3424851 CHEMBL3422967 COc1cc(C)c2nccc(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 8.28 CHEMBL3424851 CHEMBL3422968 COc1cc(OC)c2nccc(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 8.75 CHEMBL3424851 CHEMBL3422969 COc1ccc2nc(OC)cc(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 8.38 CHEMBL3424851 CHEMBL3422970 Cc1nc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)ccnc2cc1C#N 9.06 CHEMBL3424851 CHEMBL3422971 COc1cc2nccc(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2nc1C#N 8.71 CHEMBL3424851 CHEMBL3422972 COc1cc2nccc(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2nc1C(=O)O 7.88 CHEMBL3424851 CHEMBL3422973 Cc1cc(nc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)ccnc12)C#N 8.68 CHEMBL3424851 CHEMBL3422974 Cc1cc(nc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)ccnc12)S(=O)(=O)C 8.17 CHEMBL3424851 CHEMBL3422975 CN(C)c1nc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)ccnc2cc1C(F)(F)F 8.64 CHEMBL3424851 CHEMBL3422976 CN(C)c1nc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)ccnc2cc1F 8.92 CHEMBL3424851 CHEMBL3422977 FC(F)(F)c1ccc2nccc(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 9 CHEMBL3424851 CHEMBL3422978 FC(F)(F)c1cnc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)ccnc2c1 9.41 CHEMBL3424851 CHEMBL3422979 COc1cnc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)ccnc2c1 7.81 CHEMBL3424851 CHEMBL3422980 Clc1cnc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)ccnc2c1 8.31 CHEMBL3424851 CHEMBL3422981 Fc1cnc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)ccnc2c1 7.78 CHEMBL3424851 CHEMBL3422982 CCOC(=O)c1c(OC)cnc2c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)ccnc12 8.1 CHEMBL3424851 CHEMBL3422983 COc1ccc2ncc(C#N)c(CC(O)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 8.59 CHEMBL3424851 CHEMBL3425798 O[C@@]1(CC23CCC(CC2)(CO3)NCc4ccc5SCC(=O)Nc5n4)CN6C(=O)C=Cc7ncc(F)c1c67 4.59 CHEMBL3428450 CHEMBL3425800 O[C@@]1(CC23CCC(CC2)(CO3)NCc4nc5NC(=O)COc5cc4Cl)CN6C(=O)C=Cc7ncc(F)c1c67 4.56 CHEMBL3428449 CHEMBL3425805 O[C@@]1(CC23CCC(CC2)(CO3)NCc4nc5NC(=O)COc5cc4OC(=O)c6ccccc6)CN7C(=O)C=Cc8ncc(F)c1c78 4.52 CHEMBL3428450 CHEMBL3425806 O[C@@]1(CC23CCC(CC2)(CO3)NCc4cc5NC(=O)COc5cn4)CN6C(=O)C=Cc7ncc(F)c1c67 4.52 CHEMBL3428450 CHEMBL3425807 O[C@@]1(CC23CCC(CC2)(CO3)NCc4ncc5OCC(=O)Nc5n4)CN6C(=O)C=Cc7ncc(F)c1c67 4.52 CHEMBL3428450 CHEMBL3425808 O[C@@]1(CC23CCC(CC2)(CO3)NCc4ccc5OCC(=O)Nc5c4)CN6C(=O)C=Cc7ncc(F)c1c67 5.14 CHEMBL3428450 CHEMBL3425810 O[C@@]1(CC23CCC(CC2)(CO3)NCc4cc5OCCOc5cn4)CN6C(=O)C=Cc7ncc(F)c1c67 5.59 CHEMBL3428449 CHEMBL3425822 O[C@@]1(CC23CCC(CC2)(CO3)NCc4ccc5OCCOc5c4)CN6C(=O)C=Cc7ncc(F)c1c67 4.78 CHEMBL3428450 CHEMBL3425825 O[C@@]1(CC23CCC(CC2)(CO3)NCc4c(Cl)cc5OCCOc5c4Cl)CN6C(=O)C=Cc7ncc(F)c1c67 4.52 CHEMBL3428450 CHEMBL3425826 O[C@@]1(CC23CCC(CC2)(CO3)NCc4cc5OCCOc5c(Cl)c4Cl)CN6C(=O)C=Cc7ncc(F)c1c67 4.5 CHEMBL3428450 CHEMBL3425929 CN1CCN(C)c2nc(CNC34CCC(C[C@]5(O)CN6C(=O)C=Cc7ncc(F)c5c67)(CC3)OC4)ccc12 4.51 CHEMBL3428450 CHEMBL3425931 O[C@@]1(CC23CCC(CC2)(CO3)NCc4ccc5OC(F)(F)Oc5c4)CN6C(=O)C=Cc7ncc(F)c1c67 4.55 CHEMBL3428450 CHEMBL3425932 O[C@@]1(CC23CCC(CC2)(CO3)NCc4cc5SCOc5cn4)CN6C(=O)C=Cc7ncc(F)c1c67 4.47 CHEMBL3428450 CHEMBL3425934 O[C@@]1(CC23CCC(CC2)(CO3)NC\C=C\c4c(F)cccc4F)CN5C(=O)C=Cc6ncc(F)c1c56 7.5 CHEMBL3428449 CHEMBL3425935 O[C@@]1(CC23CCC(CC2)(CO3)NC\C=C\c4cc(F)ccc4F)CN5C(=O)C=Cc6ncc(F)c1c56 8.1 CHEMBL3428449 CHEMBL3425936 O[C@@]1(CC23CCC(CC2)(CO3)NC\C=C\c4ccc(F)cc4)CN5C(=O)C=Cc6ncc(F)c1c56 7.19 CHEMBL3428449 CHEMBL3425937 O[C@@]1(CC23CCC(CC2)(CO3)NC\C(=C/c4cc(F)ccc4F)\F)CN5C(=O)C=Cc6ncc(F)c1c56 7.8 CHEMBL3428449 CHEMBL3425938 O[C@@]1(CC23CCC(CC2)(CO3)NC\C(=C\c4cc(F)ccc4F)\F)CN5C(=O)C=Cc6ncc(F)c1c56 7.8 CHEMBL3428449 CHEMBL3425939 O[C@@]1(CC23CCC(CC2)(CO3)NC\C=C\c4ccccc4)CN5C(=O)C=Cc6ncc(F)c1c56 7.19 CHEMBL3428449 CHEMBL3425940 O[C@@]1(CC23CCC(CC2)(CO3)NC\C=C\c4ccccn4)CN5C(=O)C=Cc6ncc(F)c1c56 7.19 CHEMBL3428449 CHEMBL3425941 O[C@@]1(CC23CCC(CC2)(CO3)NCCCc4cc(F)ccc4F)CN5C(=O)C=Cc6ncc(F)c1c56 7.5 CHEMBL3428449 CHEMBL3425942 O[C@@]1(CC23CCC(CC2)(CO3)NCOc4cc(F)ccc4F)CN5C(=O)C=Cc6ncc(F)c1c56 7.19 CHEMBL3428449 CHEMBL3425943 O[C@@]1(CC23CCC(CC2)(CO3)NCc4cc(on4)c5cccs5)CN6C(=O)C=Cc7ncc(F)c1c67 7.8 CHEMBL3428449 CHEMBL344227 ONC(=O)\C=C\c1ccc(CNCCc2c[nH]c3ccccc23)cc1 4.56 CHEMBL1820401 CHEMBL351231 C[C@@H]1CCCN1CCc2oc3ccc(cc3c2)c4ccc(cc4)C#N 5.8 CHEMBL1827362 CHEMBL353985 COc1ccc(CCN(C)CCOc2ccc(NS(=O)(=O)C)cc2N)cc1OC 6 CHEMBL827807 CHEMBL3545367 Cc1ncc(OC[C@]2(C[C@H]2C(=O)Nc3ccc(F)cn3)c4cccc(F)c4)c(C)n1 5.22 CHEMBL3588589 CHEMBL356066 OCCN(CCc1c[nH]c2ccccc12)Cc3ccc(\C=C\C(=O)NO)cc3 4.91 CHEMBL1111711 CHEMBL3577935 CCC[C@@H]1C[C@@H](CC[C@@H]1NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)N(C)C(C)C 4.5 CHEMBL3579786 CHEMBL3577937 CCCC[C@@H]1C[C@@H](CC[C@@H]1NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)N(C)C(C)C 6.44 CHEMBL3579786 CHEMBL3577939 CC(C)CC[C@@H]1C[C@@H](CC[C@@H]1NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)N(C)C(C)C 5.57 CHEMBL3579786 CHEMBL3577940 CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)[C@H](CCc3ccccc3)C1 5.8 CHEMBL3579786 CHEMBL3577941 CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)[C@H](COc3ccccc3)C1 5.28 CHEMBL3579786 CHEMBL3577942 CCC[C@@H]1C[C@@H](CC[C@@H]1N2CC[C@H](NC(=O)c3cc(ccc3NC(=O)NCC)C(F)(F)F)C2=O)N(C)C(C)C 4.85 CHEMBL3579943 CHEMBL3577945 CCC[C@@H]1C[C@@H](CC[C@@H]1N2CC[C@H](Nc3ncnc4ccc(cc34)C(F)(F)F)C2=O)N(C)C(C)C 5.75 CHEMBL3579943 CHEMBL3580681 CCN1N=C(OC1=O)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7cnn(C)c7 4.29 CHEMBL3583383 CHEMBL3580774 C[C@@H](COc1ccc(F)cc1[C@@H](C)C(F)(F)F)N2CCN3C(=O)C(=CC=C3C2=O)n4cnc(C)c4 5.04 CHEMBL3582584 CHEMBL3581787 Clc1cc(Cl)cc(c1)C(=O)NCCCNc2nc3ccccc3[nH]2 5.93 CHEMBL3584390 CHEMBL3581788 FC(F)(F)c1cc(ccn1)C(=O)NCCCNc2nc3ccccc3[nH]2 4.65 CHEMBL3584390 CHEMBL3582294 CNC(=O)c1ccc(cc1F)c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2 4.03 CHEMBL3583096 CHEMBL3582312 C1CCC(CC1)C2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccn6 6.7 CHEMBL3583383 CHEMBL3582313 C1CCC(CC1)C2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6cccnc6 6.72 CHEMBL3583383 CHEMBL3582314 C1CCC(CC1)C2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccncc6 7.05 CHEMBL3583383 CHEMBL3582315 C1CCC(CC1)C2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6cnccn6 6.47 CHEMBL3583383 CHEMBL3582316 Fc1ccc(nc1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)C(N3)C6CCCCC6 6.77 CHEMBL3583383 CHEMBL3582317 Cc1onc(n1)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7cnn(C)c7 4.92 CHEMBL3583384 CHEMBL3582318 Cc1onc(n1)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7cn[nH]c7 5.38 CHEMBL3583383 CHEMBL3582319 CCn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7noc(C)n7 5.14 CHEMBL3583383 CHEMBL3582320 CCc1onc(n1)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7cnn(C)c7 5.02 CHEMBL3583383 CHEMBL3582321 Cc1onc(n1)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7cnn(CC8CC8)c7 5.5 CHEMBL3583383 CHEMBL3582322 Cn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7noc(O)n7 5.92 CHEMBL3583383 CHEMBL3582323 Cn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7noc(CN)n7 5.43 CHEMBL3583383 CHEMBL3582324 Cc1oc(nn1)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7cnn(C)c7 5.5 CHEMBL3583383 CHEMBL3582325 CCc1oc(nn1)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7cnn(C)c7 5.37 CHEMBL3583383 CHEMBL3582326 CCn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7oc(C)nn7 5.07 CHEMBL3583383 CHEMBL3582327 CCn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7oc(O)nn7 4.65 CHEMBL3583383 CHEMBL3582328 CCn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7oc(S)nn7 4.98 CHEMBL3583383 CHEMBL3582329 CCn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7oc(SC)nn7 5.8 CHEMBL3583383 CHEMBL3582330 Cn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7oc(N)nn7 4.45 CHEMBL3583383 CHEMBL3582331 CCn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7oc(NC)nn7 5.96 CHEMBL3583383 CHEMBL3582332 CCn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7oc(nn7)N(C)C 5.26 CHEMBL3583383 CHEMBL3582333 CN1N=C(OC1=O)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7cn[nH]c7 4.67 CHEMBL3583383 CHEMBL3582334 CN1N=C(OC1=O)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7cnn(C)c7 4.59 CHEMBL3583383 CHEMBL3582335 CC(C)N1N=C(OC1=O)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7cnn(C)c7 4.55 CHEMBL3583383 CHEMBL3582336 CCn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)C7=NN(C)C(=O)O7 4.49 CHEMBL3583383 CHEMBL3582337 CCn1cc(cn1)C2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)C7=NN(C)C(=O)O7 4.4 CHEMBL3583383 CHEMBL3582338 CCn1cc(cn1)C2(NC(Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)C7=NN(C)C(=O)O7 4.57 CHEMBL3583383 CHEMBL3582339 CCN1N=C(OC1=O)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7cnn(CC)c7 5.11 CHEMBL3583383 CHEMBL3582340 CCn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)C7=NN(C(C)C)C(=O)O7 5.11 CHEMBL3583383 CHEMBL3582341 CCn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)C7=NN(CC8CC8)C(=O)O7 5.26 CHEMBL3583383 CHEMBL3582342 CCn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)C7=NN(CCN(C)C)C(=O)O7 5.47 CHEMBL3583383 CHEMBL3582343 CCn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)C7=NN(CC(=O)O)C(=O)O7 4.52 CHEMBL3583383 CHEMBL3582344 CCn1cc(cn1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)C7=NN(CC(=O)N)C(=O)O7 4.46 CHEMBL3583383 CHEMBL3585946 Cc1ncc(OC[C@]2(C[C@H]2C(=O)Nc3ccc(F)cn3)c4ccccc4)c(C)n1 5.11 CHEMBL3588589 CHEMBL3585953 Cc1ncc(OC[C@]2(C[C@H]2C(=O)Nc3ccc(F)cn3)c4ccccc4F)c(C)n1 5.23 CHEMBL3588589 CHEMBL3585954 Cc1ncc(OC[C@]2(C[C@H]2C(=O)Nc3ccc(F)cn3)c4ccc(F)cc4)c(C)n1 5.66 CHEMBL3588589 CHEMBL3585955 Cc1ncc(OC[C@]2(C[C@H]2C(=O)Nc3ccc(F)cn3)c4cc(F)cc(F)c4)c(C)n1 5.32 CHEMBL3588589 CHEMBL3585956 Cc1ncc(OC[C@]2(C[C@H]2C(=O)Nc3ccc(F)cn3)c4ccc(F)c(F)c4)c(C)n1 5.66 CHEMBL3588589 CHEMBL3586404 CO[C@@H]1CC[C@H](CC1)N2C(=O)CNc3ncc(nc23)c4ccc(nc4)C(C)(C)O 4.48 CHEMBL3587475 CHEMBL3586433 Cc1cc(C)nc(n1)N2C[C@H]3CN(C[C@H]3C2)C(=O)c4cccc(F)c4n5nccn5 5.22 CHEMBL3587702 CHEMBL3586440 Cc1cc(C)nc(n1)N2C[C@H]3CN(C[C@H]3C2)C(=O)c4c(C)cccc4n5nccn5 5.16 CHEMBL3587702 CHEMBL3586441 COc1ccc(c(c1)C(=O)N2C[C@@H]3CN(C[C@@H]3C2)c4nc(C)cc(C)n4)n5nccn5 5.09 CHEMBL3587702 CHEMBL3589894 CNC(=O)c1ccc(c(N)n1)c2cc(Cl)cc(Cl)c2Cl 4.52 CHEMBL3590915 CHEMBL3593771 NC(=O)c1cnc2[nH]ccc2c1NC3CCN(CC3)c4ccc(cn4)C#N 4.87 CHEMBL3594793 CHEMBL3593779 C[C@H]1CN(CC[C@H]1Nc2c(cnc3[nH]ccc23)C(=O)N)c4ccc(cn4)C#N 4.54 CHEMBL3594793 CHEMBL3596502 COc1cccc2c1nc(N)n3nc(CN4CCN(C[C@H]4C)c5ccc(F)cc5)nc23 5.81 CHEMBL3598727 CHEMBL3596503 COc1cccc2c1nc(N)n3nc(CN4CCN(C[C@H]4C)c5ccccc5F)nc23 4.3 CHEMBL3598727 CHEMBL3596504 COc1cccc2c1nc(N)n3nc(CN4CCN(C[C@H]4C)c5cccc(F)c5)nc23 4.62 CHEMBL3598727 CHEMBL3596505 COc1cccc2c1nc(N)n3nc(CN4CCN(C[C@H]4C)c5ccc(F)cn5)nc23 4.66 CHEMBL3598727 CHEMBL3596506 COc1cccc2c1nc(N)n3nc(CN4CCN(C[C@H]4C)c5ccccc5)nc23 4.77 CHEMBL3598727 CHEMBL3596507 COc1cccc2c1nc(N)n3nc(CN4CCN(C[C@H]4C)c5ccccn5)nc23 4.59 CHEMBL3598727 CHEMBL3596508 COc1cccc2c1nc(N)n3nc(CN4CCN(C[C@H]4C)c5cccnc5)nc23 4.65 CHEMBL3598727 CHEMBL3596509 COc1cccc2c1nc(N)n3nc(CN4CCN(C[C@H]4C)c5ccncc5)nc23 5.66 CHEMBL3598727 CHEMBL3596511 COc1ccccc1N2CCN(Cc3nc4c5cccc(OC)c5nc(N)n4n3)[C@H](C)C2 4.32 CHEMBL3598727 CHEMBL3596512 COc1cccc(c1)N2CCN(Cc3nc4c5cccc(OC)c5nc(N)n4n3)[C@H](C)C2 4.68 CHEMBL3598727 CHEMBL3596513 COc1ccc(cc1)N2CCN(Cc3nc4c5cccc(OC)c5nc(N)n4n3)[C@H](C)C2 4.68 CHEMBL3598727 CHEMBL3596515 COc1cccc2c1nc(N)n3nc(CN4CCN(C[C@H]4C)c5ncc(C)s5)nc23 4.33 CHEMBL3598727 CHEMBL3596516 COc1cccc2c1nc(N)n3nc(CN4CCN(C[C@H]4C)c5cnc(C)s5)nc23 4.75 CHEMBL3598727 CHEMBL3596518 COc1cccc2c1nc(N)n3nc(CN4CCN(C[C@H]4C)c5nsnc5Cl)nc23 4.61 CHEMBL3598727 CHEMBL3596589 CCn1cc(cn1)N2CCN(Cc3nc4c5cccc(OC)c5nc(N)n4n3)[C@H](C)C2 4.41 CHEMBL3598727 CHEMBL3601322 CC[C@@H](C)Oc1cc2[C@@H](N(C(=O)Cc2cc1OC)c3ccc(cc3)N(C)C[C@@H]4CC[C@H](CC4)N(C)C)c5ccc(Cl)cc5 5.89 CHEMBL3602290 CHEMBL3601377 COc1ccc(COC2=CC(=O)N(CC(=O)c3ccc(CN(C)C)cc3C)N=C2)nc1 4.8 CHEMBL3602779 CHEMBL3601397 COc1cc2CC(=O)N([C@@H](c3ccc(Cl)cc3)c2cc1OC(C)C)c4ccc(cc4)N(C)C[C@@H]5CC[C@H](CC5)N6CCNC(=O)C6 4.8 CHEMBL3602290 CHEMBL3604687 COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5nc6NC(=O)COc6cc5Cl)c2n1 5.24 CHEMBL3607786 CHEMBL3604688 COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5nc6NC(=O)COc6cc5F)c2n1 5.89 CHEMBL3607786 CHEMBL3604690 COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5nc6NC(=O)COc6cc5C)c2n1 5.37 CHEMBL3607787 CHEMBL3604691 COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5cc(C)c6OCC(=O)Nc6n5)c2n1 5.7 CHEMBL3607787 CHEMBL3604692 COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5nc6NC(=O)COc6c(C)c5C)c2n1 5.34 CHEMBL3607787 CHEMBL3604693 CCc1c(C)c2OCC(=O)Nc2nc1CNC34CCC(CCc5c(F)cnc6ccc(OC)nc56)(CC3)OC4 6.16 CHEMBL3607786 CHEMBL3604694 COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5nc6NC(=O)COc6c(C)c5C(C)C)c2n1 5.92 CHEMBL3607786 CHEMBL3604701 Cc1cc(NCc2c(C)cccc2C)c3cccc(C(=O)N)c3n1 6.3 CHEMBL3607755 CHEMBL3604734 Cc1cc(NCc2c(F)cccc2C(F)(F)F)c3cccc(C(=O)N)c3n1 6.4 CHEMBL3607755 CHEMBL3604735 Cc1cc(NCc2c(Cl)ccc(Cl)c2Cl)c3cccc(C(=O)N)c3n1 6.3 CHEMBL3607755 CHEMBL3604797 COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5nc6NC(=O)COc6c(C)c5C=C)c2n1 6.3 CHEMBL3607786 CHEMBL3604798 COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5nc6NC(=O)COc6c(C)c5F)c2n1 6.05 CHEMBL3607786 CHEMBL3604799 COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OC(C)C(=O)Nc6n5)c2n1 5.75 CHEMBL3607786 CHEMBL3604800 COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OC(C)(C)C(=O)Nc6n5)c2n1 5.52 CHEMBL3607786 CHEMBL3604801 CCOC(=O)C1(C)Oc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(OC)nc56)(CC3)OC4)nc2NC1=O 5.44 CHEMBL3607786 CHEMBL3604802 COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)N(C)c6n5)c2n1 6.1 CHEMBL3607786 CHEMBL3604803 COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)N(C)Cc5ccc6OCC(=O)Nc6n5)c2n1 5.92 CHEMBL3607786 CHEMBL3604804 COC(=O)N(Cc1ccc2OCC(=O)Nc2n1)C34CCC(CCc5c(F)cnc6ccc(OC)nc56)(CC3)OC4 5.22 CHEMBL3607786 CHEMBL3604807 COc1ccc2ncc(F)c(C[C@H](O)C3CCC(CO3)NCc4nc5NC(=O)COc5cc4F)c2n1 5.62 CHEMBL3607786 CHEMBL3604999 OC(=O)CCCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 4.36 CHEMBL3607541 CHEMBL3605000 CCOC(=O)C(F)(F)CCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 4.6 CHEMBL3607541 CHEMBL3605002 COC(=O)[C@@H]1C[C@@H]1COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2 6.22 CHEMBL3607541 CHEMBL3605004 COC(=O)[C@H]1C[C@@H]1COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2 6.3 CHEMBL3607541 CHEMBL3605005 OC(=O)[C@H]1C[C@@H]1COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2 4.36 CHEMBL3607541 CHEMBL3605006 COC(=O)C1(COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2)CC1 5.8 CHEMBL3607541 CHEMBL3605010 NC(=O)C(F)(F)CCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.04 CHEMBL3607541 CHEMBL3605011 OC1=CNC(=CC1=O)COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2 5.28 CHEMBL3607541 CHEMBL3605012 OC1=CNC(=CC1=O)CCOc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2 6.05 CHEMBL3607541 CHEMBL3605013 OCCOc1ccc2ncc(F)c(C[C@H](O)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 4.53 CHEMBL3607541 CHEMBL3605014 NC1COCC1Oc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2 5.44 CHEMBL3607541 CHEMBL3605015 N[C@H]1COC[C@@H]1Oc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2 5.55 CHEMBL3607541 CHEMBL3605016 N[C@@H]1COC[C@H]1Oc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2 4.95 CHEMBL3607541 CHEMBL3605017 N[C@@H]1CO[C@H]1COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2 4.75 CHEMBL3607541 CHEMBL3605018 N[C@H]1CO[C@@H]1COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2 4.61 CHEMBL3607541 CHEMBL3605019 N[C@@H]1CO[C@@H]1COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2 5.48 CHEMBL3607541 CHEMBL3605020 N[C@H]1CO[C@H]1COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2 4.62 CHEMBL3607541 CHEMBL3605021 NCC(O)COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.48 CHEMBL3607541 CHEMBL3605022 N[C@@H]1[C@@H](COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2)NC1=O 4.54 CHEMBL3607541 CHEMBL3605023 N[C@H]1[C@@H](CNC1=O)Oc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2 4.4 CHEMBL3607541 CHEMBL3605024 Fc1cnc2ccc(OCCCC#N)nc2c1CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5 5.05 CHEMBL3607541 CHEMBL3605025 Fc1cnc2ccc(OCC3(CC3)C#N)nc2c1CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6 5.26 CHEMBL3607541 CHEMBL3605026 CCOC(=O)COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.07 CHEMBL3607541 CHEMBL3605117 CCOC(=O)CCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 6 CHEMBL3607541 CHEMBL3605119 COC(=O)CCCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 6.4 CHEMBL3607541 CHEMBL3605120 OCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 4.6 CHEMBL3607541 CHEMBL3605121 OCCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.62 CHEMBL3607541 CHEMBL3605122 OCCCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.62 CHEMBL3607541 CHEMBL3605123 OCCCCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 6.16 CHEMBL3607541 CHEMBL3605125 CC(C)(O)CCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.16 CHEMBL3607541 CHEMBL3605126 OCC1(COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2)CC1 5.57 CHEMBL3607541 CHEMBL3605127 OCC(O)COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.64 CHEMBL3607541 CHEMBL3605128 OCC(CO)COc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 4.98 CHEMBL3607541 CHEMBL3605129 O[C@@H]1C[C@@H](COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2)C[C@@H]1O 5.51 CHEMBL3607541 CHEMBL3605130 O[C@@H]1C[C@H](COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2)C[C@@H]1O 5.57 CHEMBL3607541 CHEMBL3605131 OC1(COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2)COC1 4.91 CHEMBL3607541 CHEMBL3605132 OC1CC(O)CC(C1)Oc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2 5.2 CHEMBL3607541 CHEMBL3605133 NCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 4.76 CHEMBL3607541 CHEMBL3605134 NCCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.1 CHEMBL3607541 CHEMBL3605135 NCCCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.1 CHEMBL3607541 CHEMBL3605137 NCC1(COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2)CC1 5.12 CHEMBL3607541 CHEMBL3605138 NC1(COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2)CC1 5.43 CHEMBL3607541 CHEMBL3605139 NC1CC1COc2ccc3ncc(F)c(CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c3n2 6.7 CHEMBL3607541 CHEMBL3605140 CCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 6.4 CHEMBL3607541 CHEMBL3605143 CC(C)CCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.46 CHEMBL3607541 CHEMBL3605145 Fc1cnc2ccc(OC3CCC3)nc2c1CCC45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6 6.3 CHEMBL3607541 CHEMBL3605146 Fc1cnc2ccc(OCC(F)(F)F)nc2c1CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5 5.96 CHEMBL3607541 CHEMBL3605147 FC(F)Oc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 6.16 CHEMBL3607541 CHEMBL3605148 COCCOc1ccc2ncc(F)c(CCC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 4.76 CHEMBL3607541 CHEMBL3608322 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4(C)CCc5ccccc5N(CC(F)(F)F)C4=O 5.22 CHEMBL3611641 CHEMBL360861 CN1C(=O)C=C(NCCN(CCO)CCCc2ccc(cc2)[N+](=O)[O-])N(C)C1=O 5 CHEMBL827807 CHEMBL3608683 CC(C)c1noc(n1)c2nnc3[C@@H](C)N(CCn23)C(=O)c4ccc(F)cc4 5.8 CHEMBL3610078 CHEMBL3608684 Cc1nsc(n1)c2nnc3CN(CCn23)C(=O)c4ccc(F)cc4 4.3 CHEMBL3610078 CHEMBL3608687 C[C@H]1N(CCn2c1nnc2c3nc(C)ns3)C(=O)c4ccc(Cl)cc4 4.18 CHEMBL3610078 CHEMBL3608688 C[C@H]1N(CCn2c1nnc2c3nc(ns3)C(F)(F)F)C(=O)c4ccc(F)cc4 4.41 CHEMBL3610078 CHEMBL3608740 C[C@H]1N(CCn2c1nnc2c3nc(C)ns3)C(=O)c4ccccc4 4.3 CHEMBL3610078 CHEMBL3608741 Cc1nsc(n1)c2nnc3[C@@H](CCO)N(CCn23)C(=O)c4ccc(F)cc4 4.3 CHEMBL3610078 CHEMBL3608744 Cc1ncc(CNC2CCN(CCN3C(=O)C=Cc4ncc(Oc5ccc(cc5)S(=O)(=O)N)cc34)CC2)cc1Cl 4.09 CHEMBL3610296 CHEMBL3608750 Fc1cncc(Oc2cnc3C=CC(=O)N(CCN4CCC(CC4)NCc5ccc6OCC(=O)Nc6n5)c3c2)c1 4.1 CHEMBL3610296 CHEMBL3608757 F[C@H]1CN(CCN2C(=O)C=Cc3ncc(Oc4cccnc4)cc23)CC[C@H]1NCc5ccc6OCC(=O)Nc6n5 4.13 CHEMBL3610296 CHEMBL3609521 CN(C)C[C@@H]1CCN([C@@H]1C(=O)N)C(=O)Nc2nc3CCc4sc(nc4c3s2)C(C)(C)C 5.24 CHEMBL3610728 CHEMBL3609622 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5ccccc5NC4=O 4.75 CHEMBL3611641 CHEMBL3609623 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5ccccc5N(C)C4=O 5.39 CHEMBL3611641 CHEMBL3609624 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5ccccc5N(CCF)C4=O 5.49 CHEMBL3611641 CHEMBL3609625 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5ccccc5N(CC(F)F)C4=O 5.05 CHEMBL3611641 CHEMBL3609626 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5ccccc5N(CC(F)(F)F)C4=O 5.45 CHEMBL3611641 CHEMBL3609627 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5ccccc5N(CC6CC6)C4=O 5.8 CHEMBL3611641 CHEMBL3609628 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5ccccc5N(Cc6ccccc6)C4=O 6 CHEMBL3611641 CHEMBL3609629 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5ccccc5N(Cc6ccccn6)C4=O 5.12 CHEMBL3611641 CHEMBL3609630 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5ccccc5N(Cc6ccncc6)C4=O 5.21 CHEMBL3611641 CHEMBL3609631 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5ccccc5N(Cc6cccnc6)C4=O 5.35 CHEMBL3611641 CHEMBL3609632 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5ccccc5N(CC6(C)COC6)C4=O 4.74 CHEMBL3611641 CHEMBL3609633 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)[C@H]4C[C@H](C)c5ccccc5N(CC(F)(F)F)C4=O 5.18 CHEMBL3611641 CHEMBL3609634 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CSc5ccccc5N(CC(F)(F)F)C4=O 5.32 CHEMBL3611641 CHEMBL3609635 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5c(ccc6ccccc56)N(CC(F)(F)F)C4=O 6.05 CHEMBL3611641 CHEMBL3609636 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5cc(F)ccc5N(CC(F)(F)F)C4=O 5.57 CHEMBL3611641 CHEMBL3609637 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5c(F)cccc5N(CC(F)(F)F)C4=O 4.89 CHEMBL3611634 CHEMBL3609638 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5c(F)cc(F)cc5N(CC(F)(F)F)C4=O 5.74 CHEMBL3611641 CHEMBL3609639 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5c(F)c(Br)ccc5N(CC(F)(F)F)C4=O 6.28 CHEMBL3611641 CHEMBL3609641 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CCc5cccnc5N(CC(F)(F)F)C4=O 5.06 CHEMBL3611641 CHEMBL3609642 COc1cc(ccc1n2cnc(C)c2)c3cn(nn3)C4CC[C@@H]5CCCC[C@H]5N(Cc6ccccc6)C4=O 5.05 CHEMBL3611641 CHEMBL3612795 [O-][N+](=O)c1ccc(CCN2CCN(CCc3ccc4C(=O)OCc4c3)CC2)cc1 6.82 CHEMBL3615683 CHEMBL3612796 COc1cc(CCN2CCN(CCc3ccc4C(=O)OCc4c3C)CC2)ccc1C#N 5.68 CHEMBL3615683 CHEMBL3612797 COc1cc(CCN2CCN(CC(C)c3ccc4C(=O)OCc4c3C)CC2)ccc1C#N 5.55 CHEMBL3615683 CHEMBL3612798 COc1cc(CCN2CCN(CC(F)c3ccc4C(=O)OCc4c3C)CC2)ccc1C#N 5.62 CHEMBL3615683 CHEMBL3612799 COc1cc(CCN2CCN(CC(O)c3ccc4C(=O)OCc4c3C)CC2)ccc1C#N 5.05 CHEMBL3615683 CHEMBL3612800 COC(CN1CCN(CCc2ccc(C#N)c(OC)c2)CC1)c3ccc4C(=O)OCc4c3C 5.05 CHEMBL3615683 CHEMBL3612801 CCOC(CN1CCN(CCc2ccc(C#N)c(OC)c2)CC1)c3ccc4C(=O)OCc4c3C 5.46 CHEMBL3615683 CHEMBL3612802 COc1cc(CC(C)N2CCN(CCc3ccc4C(=O)OCc4c3C)CC2)ccc1C#N 5.89 CHEMBL3615683 CHEMBL3612803 COc1cc(ccc1C#N)C(C)CN2CCN(CCc3ccc4C(=O)OCc4c3C)CC2 5.96 CHEMBL3615683 CHEMBL3612804 COc1cc(ccc1C#N)C(C)(C)CN2CCN(CCc3ccc4C(=O)OCc4c3C)CC2 5.92 CHEMBL3615683 CHEMBL3612805 COc1cc(ccc1C#N)C(O)CN2CCN(CCc3ccc4C(=O)OCc4c3C)CC2 5.66 CHEMBL3615683 CHEMBL3612806 COc1cc(ncc1C#N)C(O)CN2CCN(CCc3ccc4C(=O)OCc4c3C)CC2 5.19 CHEMBL3615683 CHEMBL3612807 Cc1c2COC(=O)c2ccc1[C@@H](O)CN3CCN(C[C@H](O)c4ccc(cn4)C#N)CC3 4.55 CHEMBL3615683 CHEMBL3612809 COc1cc(ncc1C#N)[C@H](O)CN2CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2 4.75 CHEMBL3615683 CHEMBL3612810 COc1cc(ncc1C#N)[C@@H](O)CN2CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2 4.48 CHEMBL3615686 CHEMBL3612811 COc1cc(ccc1C#N)C(O)CN2CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2 5.29 CHEMBL3615683 CHEMBL3612814 Cc1nc(ccc1C#N)C(O)CN2CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2 4.77 CHEMBL3615683 CHEMBL3612923 Cc1c2COC(=O)c2ccc1[C@@H](O)CN3CCN(CC(O)c4ncc(cc4Cl)C#N)CC3 4.8 CHEMBL3615683 CHEMBL3612924 Cc1c2COC(=O)c2ccc1[C@@H](O)CN3CCN(CC(O)c4cc(C5CC5)c(cn4)C#N)CC3 4.85 CHEMBL3615686 CHEMBL3612925 COc1cc(nc(C)c1C#N)C(O)CN2CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2 4.8 CHEMBL3615683 CHEMBL3612926 CCOc1cc(ncc1C#N)C(O)CN2CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2 4.92 CHEMBL3615686 CHEMBL3612927 Cc1c2COC(=O)c2ccc1[C@@H](O)CN3CCN(CC(O)c4cc(c(cn4)C#N)C(F)(F)F)CC3 5 CHEMBL3615683 CHEMBL3612928 [2H]C([2H])([2H])Oc1cc(ncc1C#N)C(O)CN2CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2 4.52 CHEMBL3615686 CHEMBL3617330 CNc1nc(NCCN2CCNCC2)c3sc(cc3n1)c4ccc(cc4)C(F)(F)F 5.85 CHEMBL3620197 CHEMBL3617353 Nc1nc(NC2CCNCC2)c3sc(cc3n1)c4ccc(cc4)C(F)(F)F 6.05 CHEMBL3620197 CHEMBL3617452 Nc1nc(NC2CCNC2)c3sc(cc3n1)c4ccc(cc4)C(F)(F)F 5.62 CHEMBL3620197 CHEMBL3617454 Nc1nc(NC2CCOCC2)c3sc(cc3n1)c4ccc(cc4)C(F)(F)F 6.16 CHEMBL3620197 CHEMBL3617456 NC1CCN(CC1)c2nc(N)nc3cc(sc23)c4ccc(cc4)C(F)(F)F 5.22 CHEMBL3620197 CHEMBL3618324 COc1cc(ccc1OCCN2CCCC2)N3C=Nn4cc(cc4C3=O)c5ccc(Cl)cc5 5.26 CHEMBL3619842 CHEMBL3618330 CNC1CCN(C1)c2ccc(cn2)N3C=Nn4cc(cc4C3=O)c5ccc(Cl)cc5 5.52 CHEMBL3619842 CHEMBL3618331 OC1CN(C1)c2ccc(cn2)N3C=Nn4cc(cc4C3=O)c5ccc(Cl)cc5 5.48 CHEMBL3619842 CHEMBL3618334 OC1CN(C1)C2CCN(C2)c3ccc(cn3)N4C=Nn5cc(cc5C4=O)c6ccc(Cl)cc6 5.7 CHEMBL3619842 CHEMBL362103 CCC[S+]([O-])CCCN(CC)CC(O)COc1ccc(cc1)C#N 6.6 CHEMBL827807 CHEMBL3622175 COCc1cnc(nc1)N2CCC(CC2)[C@H]3C[C@H]3COCc4ccc(cc4F)S(=O)(=O)C 4.89 CHEMBL3625553 CHEMBL3622956 Cc1nn(cc1CN2CC(O)C2)c3ccnc(Nc4ccc5c(c4)c(Cl)c(C)n5C)n3 4.62 CHEMBL3627070 CHEMBL3622958 Cc1nn(cc1CN2CC(O)C2)c3ccnc(Nc4ccc5c(c4)c(C)c(C)n5C)n3 4.9 CHEMBL3627070 CHEMBL3623278 COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN4CCOCC4 4.77 CHEMBL3624311 CHEMBL362721 CN1Cc2ccccc2[C@H](N=C1CCc3ccccc3)c4ccccc4 7.05 CHEMBL827807 CHEMBL3627894 COc1cc2nc([nH]c2cc1Cl)[C@@H](CNC(=O)c3c(Cl)cc(cc3Cl)n4cnc(C)n4)c5cccc(F)c5 4.96 CHEMBL3631137 CHEMBL3627895 Cc1ncn(n1)c2cc(Cl)c(C(=O)NC[C@@H](c3cccc(F)c3)c4nc5ccc(Cl)cc5[nH]4)c(Cl)c2 5.27 CHEMBL3631137 CHEMBL3627896 Cc1cc(Cl)cc2[nH]c(nc12)[C@@H](CNC(=O)c3c(Cl)cc(cc3Cl)n4cnc(C)n4)c5cccc(F)c5 5.52 CHEMBL3631137 CHEMBL3627897 Cc1ncn(n1)c2cc(Cl)c(C(=O)NC[C@@H](c3cccc(F)c3)c4ccc5[nH]c(C)nc5c4)c(Cl)c2 4.7 CHEMBL3631137 CHEMBL3628128 N\C\1=N/C(=O)[C@@H]2CCCN2c3ccc(OCCCCCCNCC(=O)Nc4c(Cl)cc(CN1)cc4Cl)cc3 4.5 CHEMBL3630432 CHEMBL3628216 CS(=O)(=O)c1ccc(cc1)c2cnc3ccc(cn23)c4cccc(c4)S(=O)(=O)C 5.32 CHEMBL3631371 CHEMBL3628220 CS(=O)(=O)c1ccc(cc1)c2cnn3ccc(cc23)c4cccc(c4)S(=O)(=O)C5CC5 5.85 CHEMBL3631371 CHEMBL3628223 CS(=O)(=O)c1ccc(cc1)c2cnn3ccc(nc23)c4cccc(c4)S(=O)(=O)C5CC5 6.3 CHEMBL3631371 CHEMBL363295 CC(CC(c1ccccc1)c2ccccc2)NC(C)(C)C 5.24 CHEMBL1676103 CHEMBL3634812 Fc1ccc(C(=O)C2CCN(CCCOc3ccc(cc3)c4oc5ccccc5n4)CC2)c(F)c1 6.07 CHEMBL3635896 CHEMBL3634813 Fc1ccc2c(noc2c1)C3CCN(CCCOc4ccc(cc4)c5oc6ccccc6n5)CC3 5.43 CHEMBL3635896 CHEMBL3634821 Fc1ccc2c(noc2c1)C3CCN(CCCOc4ccc(Cc5oc6ccccc6n5)cc4)CC3 5.22 CHEMBL3635896 CHEMBL3634824 Fc1ccc2c(noc2c1)C3CCN(CCCOc4ccc(CCc5oc6ccccc6n5)cc4)CC3 6.2 CHEMBL3635896 CHEMBL3634825 CC(c1ccc(OCCCN2CCC(CC2)c3noc4cc(F)ccc34)cc1)c5oc6ccccc6n5 6 CHEMBL3635896 CHEMBL3640290 COc1nc(nc(C)c1F)N2C[C@H]3C(=O)N(C)C(=N)N[C@]3(C2)c4ccc(F)cc4F 5.72 CHEMBL3801565 CHEMBL364102 CC(C)[C@@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)CC(N)Cc3cc(F)ccc3F)cc1)C(=O)O.OC(=O)C(F)(F)F 4.12 CHEMBL829261 CHEMBL364512 CC1=C(CCN2CCC(CC2)C3NOc4cc(F)ccc34)C(=O)N5CCCCC5=N1 6.82 CHEMBL829152 CHEMBL364912 COc1cccc(C(=O)N2CCCC2)c1OCc3csc(n3)c4ccc(Cl)cc4 5.11 CHEMBL827704 CHEMBL365062 NCc1ccc(F)c(c1)C2CCN(CC2)C(=O)c3cc(cc(c3)c4onc(n4)c5cccs5)C(=O)N 4.77 CHEMBL827842 CHEMBL3650825 Cc1cc(Cl)cnc1C(=O)Nc2ccc3OCC4(CC4)C5(COC(=N5)N)c3c2 5.31 CHEMBL3705667 CHEMBL3650827 NC1=NC2(CO1)c3cc(NC(=O)c4ccc(cn4)C#N)ccc3OCC25CC5 5.44 CHEMBL3705667 CHEMBL3650830 NC1=NC2(c3cccc(F)c13)c4cc(ccc4OCC25CC5)c6cncnc6 5.37 CHEMBL3705667 CHEMBL3650831 NC1=NC2(CO1)c3cc(ccc3OC(Cc4ccccc4)C25COC5)c6cncnc6 5.11 CHEMBL3705667 CHEMBL3650834 CC#Cc1cncc(c1)c2ccc3OC(CC4CC4)C5(COC5)C6(COC(=N6)N)c3c2 5.28 CHEMBL3705667 CHEMBL3650838 NC1=NC2(CO1)c3cc(ccc3OC4(CCC4)C25COC5)c6cncc7ccccc67 5.43 CHEMBL3705667 CHEMBL3650845 CC1(C)Oc2ccc(NC(=O)c3ccc(Cl)cn3)cc2[C@@]4(COC(=N4)N)C15COC5 4.69 CHEMBL3705667 CHEMBL3650848 CC1(C)Oc2ccc(NC(=O)c3ccc(Cl)cn3)cc2[C@@]4(COC(=N4)N)C15CC5 5.49 CHEMBL3705667 CHEMBL3650850 COc1cnc(cn1)C(=O)Nc2ccc3OC(C)(C)C4(CC4)[C@]5(COC(=N5)N)c3c2 4.68 CHEMBL3705667 CHEMBL3650851 CC1(C)Oc2ccc(NC(=O)c3cnc(cn3)C(F)F)cc2[C@@]4(COC(=N4)N)C15CC5 4.82 CHEMBL3705667 CHEMBL3651966 C[C@@H]1C[C@H](N)C[C@@H](C1)c2ccncc2NC(=O)c3ccc(F)c(n3)c4c(F)cccc4F 4.92 CHEMBL3749925 CHEMBL3670638 COc1ccc(cc1)c2oc(nn2)C(=O)N3CC(C3)Oc4ccc(CN5CC6(CCCO6)C5)cc4 4.89 CHEMBL3791472 CHEMBL3670640 O=C(N1CC(C1)Oc2ccc(CN3CC4(CCOC4)C3)cc2)c5oc(nn5)c6ccccc6 4.8 CHEMBL3791472 CHEMBL3670644 COc1ccc(cc1)c2oc(nn2)C(=O)N3CC(C3)Oc4ccc(CN5CCCC56COC6)cc4 4.92 CHEMBL3791472 CHEMBL3687984 CN1C(=O)CN2C(=O)c3c(N=C12)nc(N4CCC[C@@H](N)C4)n3Cc5cc(F)ccc5C#N 4.4 CHEMBL3816322 CHEMBL368895 CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c3cn(c4ccc5ccccc5c4)c6ccccc36)c7ccccc17 7.55 CHEMBL827917 CHEMBL3692706 Cc1c(CCN2CCN(CC2)C(=O)Cc3ccc(nc3)n4cnnn4)ccc5C(=O)OCc15 4.54 CHEMBL3797009 CHEMBL3696117 Clc1ccc(Cn2c(\C=C\C3CCN(CC4CCCCC4)C3)nc5cc(Br)ccc25)cc1 5.96 CHEMBL3706049 CHEMBL3696118 CN1CCCC1\C=C\c2nc3cc(C)c(C)cc3n2Cc4ccc(Cl)cc4 6.01 CHEMBL3706049 CHEMBL3696119 Cc1cc2nc(\C=C\C3CCNC3)n(Cc4ccc(Cl)cc4)c2cc1C 5.8 CHEMBL3706049 CHEMBL3696120 Cc1cc2nc(CC3CCNCC3)n(Cc4ccc(Cl)cc4)c2cc1C 5.96 CHEMBL3706049 CHEMBL3696121 Cc1cc2nc(CC3CC4CCC(C3)N4)n(Cc5ccc(Cl)cc5)c2cc1C 5.37 CHEMBL3706049 CHEMBL3699563 CC1CC(Cc2nc3cc(C)c(C)cc3n2Cc4ccc(Cl)cc4)CCN1 6.24 CHEMBL3706049 CHEMBL3699564 CC(Cc1ccncc1)c2nc3cc(C)c(C)cc3n2Cc4ccc(Cl)cc4 5.06 CHEMBL3706049 CHEMBL3699565 Cc1cc2nc(CC3CCCNC3)n(Cc4ccc(Cl)cc4)c2cc1C 6.31 CHEMBL3706049 CHEMBL3699567 CN1CCCC1CCc2nc3cc(C)c(C)cc3n2Cc4ccc(Cl)cc4 6.59 CHEMBL3706049 CHEMBL3699572 Clc1ccc(Cn2c(nc3cc(Cl)c(Cl)cc23)C4=CNC(=O)C=C4)cc1Cl 5.3 CHEMBL3706049 CHEMBL3699573 Cc1cc2nc(\C=C\c3ccccc3)n(Cc4ccc(Cl)cc4)c2cc1C 5.4 CHEMBL3706049 CHEMBL3699574 Clc1ccc(Cn2c(CN3CCCC3=O)nc4ccccc24)cc1 5.16 CHEMBL3706049 CHEMBL3699576 Cc1cc2nc(CC3CCCC3)n(Cc4ccc(Cl)cc4)c2cc1C 5.89 CHEMBL3706049 CHEMBL3699579 COc1ccc2nc(CN3CCC[C@H]3CO)n(Cc4ccc(Cl)cc4)c2c1 5.3 CHEMBL3706049 CHEMBL3699580 Cc1ccc2nc(CN3CCCC3)n(Cc4ccc(Cl)cc4)c2c1 6.19 CHEMBL3706049 CHEMBL370072 C[C@H]([C@H](N)C(=O)N1CC[C@H](F)C1)c2ccc(cc2)c3cccc(c3)c4noc(O)n4.OC(=O)C(F)(F)F 4.55 CHEMBL829377 CHEMBL3703220 NC1=NC2(CO1)c3cc(Br)ccc3OC(Cc4ccccc4)C25COC5 5.1 CHEMBL3705667 CHEMBL3703237 NC1=NC2(CO1)c3cc(NC(=O)c4ccc(Cl)cn4)ccc3OCC25CC5 5.66 CHEMBL3705667 CHEMBL3703254 CC#Cc1cncc(c1)c2ccc3OCC4(CC4)C5(COC(=N5)N)c3c2 5.32 CHEMBL3705667 CHEMBL3703255 CC#Cc1cncc(c1)c2ccc3OCC4(COC4)C5(COC(=N5)N)c3c2 5.03 CHEMBL3705667 CHEMBL3703258 NC1=NC2(CO1)c3cc(ccc3OCC24CC4)c5cncc(c5)C6CC6 5.46 CHEMBL3705667 CHEMBL3703259 NC1=NC2(CO1)c3cc(ccc3OCC24CC4)c5cncc(OCC(F)(F)F)c5 5.24 CHEMBL3705667 CHEMBL3703260 NC1=NC2(CO1)c3cc(ccc3OCC24CC4)c5cncc(OCC(F)F)c5 5.16 CHEMBL3705667 CHEMBL3703261 NC1=NC2(CO1)c3cc(ccc3OCC24CC4)c5cncc(OC(F)F)c5 5.56 CHEMBL3705667 CHEMBL3703262 NC1=NC2(CO1)c3cc(ccc3OCC24CC4)c5cnc6[nH]ccc6c5 5.04 CHEMBL3705667 CHEMBL3703263 NC1=NC2(CO1)c3cc(ccc3OCC24CC4)c5cnc6[nH]cc(Cl)c6c5 5.35 CHEMBL3705667 CHEMBL3703264 CCc1cncc(c1)c2ccc3OCC4(CC4)C5(COC(=N5)N)c3c2 5.35 CHEMBL3705667 CHEMBL3703265 NC1=NC2(CO1)c3cc(ccc3OCC24CC4)c5cncc(OCC(F)(F)C(F)F)c5 5.78 CHEMBL3705667 CHEMBL3703266 COc1ccnc(c1)c2ccc3OC(C)(C)C4(COC4)C5(COC(=N5)N)c3c2 5.01 CHEMBL3705667 CHEMBL3703268 CC#Cc1cncc(c1)c2ccc3OCC4(COC4)C5(CSC(=N5)N)c3c2 5.22 CHEMBL3705667 CHEMBL3703271 COc1cncc(c1)c2ccc3OC4(CCC4)C5(COC5)C6(COC(=N6)N)c3c2 5.09 CHEMBL3705667 CHEMBL3703285 CCC1Oc2ccc(cc2C3(COC(=N3)N)C14COC4)c5cncc(c5)C#CC 5.1 CHEMBL3705667 CHEMBL3703289 CCCC1Oc2ccc(cc2C3(COC(=N3)N)C14COC4)c5cncc(c5)C#CC 5.27 CHEMBL3705667 CHEMBL3703295 NC1=NC2(CO1)c3cc(ccc3OCC24CCC4)c5cncnc5 5.28 CHEMBL3705667 CHEMBL3703298 NC1=NC2(CO1)c3cc(ccc3OCC24CC4)c5cc(Cl)cnc5F 5.49 CHEMBL3705667 CHEMBL3703299 COc1cncc(c1)c2ccc3OCC4(CC4)C5(COC(=N5)N)c3c2 5.1 CHEMBL3705667 CHEMBL3703300 CCOc1cncc(c1)c2ccc3OCC4(CC4)C5(COC(=N5)N)c3c2 5.24 CHEMBL3705667 CHEMBL3703301 NC1=NC2(CO1)c3cc(ccc3OCC24CC4)c5cncc(Cl)c5 5.54 CHEMBL3705667 CHEMBL3703304 CC#Cc1cncc(c1)c2cc3c(OCC4(CC4)C35COC(=N5)N)cc2F 5.37 CHEMBL3705667 CHEMBL3706574 COCC(=O)OC1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc4cc(F)ccc4C1C(C)C 5.84 CHEMBL1676103 CHEMBL370805 COC(=O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(=O)c3ccccc3 5.14 CHEMBL766814 CHEMBL372575 Cc1noc(n1)\C(=C\c2cccc(c2)c3cc(cc4cccnc34)C(C)(C)S(=O)(=O)C)\c5ccc(cc5)S(=O)(=O)C 4.3 CHEMBL984535 CHEMBL3734774 Fc1ccc(cc1)n2ncc3C[C@@]4(CN(CCC4=Cc23)S(=O)(=O)c5ccc(cc5)C(F)(F)F)C(=O)c6ccccn6 5.3 CHEMBL3736641 CHEMBL3734797 Cc1noc(n1)[C@H]2C[C@@H]2C(=O)NCc3ccc(c4CCN(Cc34)C(=O)NC(C)(C)C)c5cccc(OC(F)(F)F)c5 5.63 CHEMBL3737860 CHEMBL3735329 N[C@H]1C[C@H](CO[C@@H]1c2cc(F)ccc2F)N3Cc4cn(nc4C3)S(=O)(=O)C5CC5 4.68 CHEMBL3738365 CHEMBL3735376 Fc1ccc(cc1)n2ncc3C[C@@]4(CN(CCC4=Cc23)S(=O)(=O)c5ccc(F)cc5)C(=O)c6ccccn6 6.01 CHEMBL3736641 CHEMBL3736345 CC(C)(C)n1nnc2CC(CCc12)n3cnc(n3)c4ccc(F)cc4 5.2 CHEMBL3738912 CHEMBL373860 O=C(N1CCN(CC1)C2CC2)N3Cc4ccccc4C3 4.28 CHEMBL1827362 CHEMBL3740256 Fc1ccc2c(noc2c1)C3CCN(CC4CCN(CC4)S(=O)(=O)c5ccc(cc5)C(F)(F)F)CC3 5.86 CHEMBL3744556 CHEMBL3740291 CC1(CN(C1)c2cc(COc3ccc(F)c(F)c3F)nc(n2)c4ccccn4)C#N 5 CHEMBL3744110 CHEMBL3740472 COCCCN1C[C@@H]2[C@@H](CNC(=O)c3nc(C(C)C)n4ccccc34)[C@@H]2C1 5.29 CHEMBL3744957 CHEMBL3741159 FC(F)(F)c1cc(ccc1Cl)C(=O)N2CCN(CC2)C3=CC(=O)NC(=O)N3Cc4ccc(OS(=O)(=O)c5cccc6cnccc56)cc4 4.32 CHEMBL3745212 CHEMBL3741292 [O-][N+](=O)c1ccc(cc1)S(=O)(=O)N2CCC(CN3CCC(CC3)c4noc5cc(F)ccc45)CC2 5.42 CHEMBL3744556 CHEMBL3741589 OC(=O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C1 4.11 CHEMBL3744630 CHEMBL3741735 Fc1ccc(OCc2cc(OCC3(F)COC3)nc(n2)c4ccccn4)c(F)c1F 5.2 CHEMBL3744110 CHEMBL374493 CC(C)N1CCN(CC1)C(=O)N2CCC(CC2)c3ccccc3 4.28 CHEMBL1827362 CHEMBL3745816 CC(C)(C)c1onc(NC(=O)n2ccc3cc(Oc4ncnc5CNCc45)ccc23)c1 4.63 CHEMBL3749265 CHEMBL3745890 Cn1nnc(n1)[C@H]2[C@@H]3CN(C[C@H]23)C(=O)c4ccc(C[C@@H]5CC[C@@H](N5)[C@H](O)c6ccccc6)cc4 4.77 CHEMBL3750698 CHEMBL3746204 CNCc1cc(Oc2ccc3c(ccn3C(=O)Nc4ccc(F)c(c4)C(F)(F)F)c2)ncn1 5.24 CHEMBL3749265 CHEMBL3746226 CC(C)(C)c1onc(NC(=O)n2ccc3cc(Oc4ncnc5CNCCc45)ccc23)c1 5.16 CHEMBL3749265 CHEMBL3746280 CC1(C)CC2(CCN(CC2)C(=O)c3ccc(C[C@@H]4CC[C@@H](N4)[C@H](O)c5ccccc5)cc3)C(=O)O1 4.51 CHEMBL3750698 CHEMBL3746776 C[C@H]1Cc2c(CN1)ncnc2Oc3ccc4c(ccn4C(=O)Nc5cc([nH]n5)C6(C)CC6)c3 4.56 CHEMBL3749265 CHEMBL3746885 CCOC(=O)[C@@H]1[C@@H]2CN(C[C@H]12)C(=O)c3ccc(C[C@@H]4CC[C@@H](N4)[C@H](O)c5ccccc5)cc3 4.92 CHEMBL3750698 CHEMBL3747226 FC(F)(F)c1cccc(NC(=O)n2ccc3cc(Oc4ncnc5CNCCc45)ccc23)c1 5.05 CHEMBL3749265 CHEMBL3747244 O[C@@H]([C@H]1CC[C@@H](Cc2ccc(cc2)C(=O)N3CCC4(CCOC4=O)CC3)N1)c5ccccc5 4.34 CHEMBL3750698 CHEMBL3747266 C[C@H]1Cc2c(CN1)ncnc2Oc3ccc4c(ccn4C(=O)Nc5cccc(c5)C(F)(F)F)c3 4.97 CHEMBL3749265 CHEMBL3747356 O[C@@H]([C@H]1CC[C@@H](Cc2ccc(cc2)C(=O)N3C[C@@H]4[C@H](C3)[C@H]4c5ocnn5)N1)c6ccccc6 4.26 CHEMBL3750698 CHEMBL3747455 CCc1oc(nn1)[C@H]2[C@@H]3CN(C[C@H]23)C(=O)c4ccc(C[C@@H]5CC[C@@H](N5)[C@H](O)c6ccccc6)cc4 4.44 CHEMBL3750698 CHEMBL3747481 FC(F)(F)c1cccc(NC(=O)n2ccc3cc(Oc4ncnc5CNCc45)ccc23)c1 4.81 CHEMBL3749265 CHEMBL3747487 CCOC(=O)C1CCN(CC1)C(=O)c2ccc(C[C@@H]3CC[C@@H](N3)[C@H](O)c4ccccc4)cc2 5.08 CHEMBL3750698 CHEMBL3747546 CCOC(=O)[C@H]1[C@@H]2CN(C[C@H]12)C(=O)c3ccc(C[C@@H]4CC[C@@H](N4)[C@H](O)c5ccccc5)cc3 5.16 CHEMBL3750698 CHEMBL3747669 C[C@H]1Cc2c(CN1)ncnc2Oc3ccc4c(ccn4C(=O)Nc5cc(on5)C(C)(C)C)c3 4.96 CHEMBL3749265 CHEMBL375131 FC(F)(F)Oc1ccccc1CC(N2CCNCC2)c3ccccc3 4.96 CHEMBL1120514 CHEMBL3752010 CO\N=C(\Cc1c(F)cnc2ccc(OC)nc12)/C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5 5.6 CHEMBL3755637 CHEMBL3752154 COc1ccc2ncc(F)c(CC(N)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 4.84 CHEMBL3755637 CHEMBL3752550 COc1ccc2ncc(F)c(CC(F)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.5 CHEMBL3755637 CHEMBL3752587 CO[C@@H](Cc1c(F)cnc2ccc(OC)nc12)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5 5.22 CHEMBL3755637 CHEMBL3752808 COc1ccc2ncc(F)c(C(CC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)C(=O)O)c2n1 6 CHEMBL3755637 CHEMBL3752949 COc1ccc2ncc(F)c(CC(NS(=O)(=O)C)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.48 CHEMBL3755637 CHEMBL3753081 CCOC(=O)C(CC12CCC(CC1)(CO2)NCc3ccc4OCC(=O)Nc4n3)c5c(F)cnc6ccc(OC)nc56 5.08 CHEMBL3755637 CHEMBL3753230 COc1ccc2ncc(F)c(CC(NOC(=O)C)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 4.74 CHEMBL3755637 CHEMBL3753257 COc1ccc2ncc(F)c(CC(OCCO)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.85 CHEMBL3755637 CHEMBL375330 CN([C@@H]1CCN(CCCc2ccc(Cl)cc2)C1)C(=O)N3CC[C@@H](C3)N(C)C(=O)c4ccc(cc4)c5ccc(cc5)C(F)(F)F 6.77 CHEMBL869869 CHEMBL3753613 COc1ccc2ncc(F)c(CC(C)(O)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.22 CHEMBL3755637 CHEMBL3753718 COc1ccc2ncc(F)c([C@H](O)[C@@H](O)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 4.44 CHEMBL3755637 CHEMBL3753861 COc1ccc2ncc(F)c(CC(O)(C(F)(F)F)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.62 CHEMBL3755637 CHEMBL3753902 COc1ccc2ncc(F)c(C(O)CC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.4 CHEMBL3755637 CHEMBL3753912 COc1ccc2ncc(F)c(C\C(=N/O)\C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.8 CHEMBL3755637 CHEMBL3753978 COc1ccc2ncc(F)c(C(CO)CC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 4.96 CHEMBL3755637 CHEMBL3753988 COc1ccc2ncc(F)c([C@@H](O)[C@H](O)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 4.22 CHEMBL3755637 CHEMBL3754022 COc1ccc2ncc(F)c(C\C(=N\O)\C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.27 CHEMBL3755637 CHEMBL3754125 COc1ccc2ncc(F)c([C@H]3OC(=O)O[C@@H]3C45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c2n1 4.95 CHEMBL3755637 CHEMBL3754192 COc1ccc2ncc(F)c(c2n1)C(C)(O)CC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5 5.19 CHEMBL3755637 CHEMBL3754258 COc1ccc2ncc(F)c(C(=O)CC34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.43 CHEMBL3755636 CHEMBL3754299 COc1ccc2ncc(F)c(CC(=O)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.03 CHEMBL3755637 CHEMBL3754515 Nc1ccc(cn1)c2cnc(N)c(c2)c3ccc(Cl)cc3 5.75 CHEMBL3755587 CHEMBL3754692 COc1ccc2ncc(F)c(CC(OCC(=O)O)C34CCC(CC3)(CO4)NCc5ccc6OCC(=O)Nc6n5)c2n1 5.52 CHEMBL3755637 CHEMBL3754742 COc1ccc2ncc(F)c([C@@H]3OC(=O)O[C@H]3C45CCC(CC4)(CO5)NCc6ccc7OCC(=O)Nc7n6)c2n1 5.31 CHEMBL3755637 CHEMBL375571 CC(C)N1CCN(CC1)C(=O)N2CCC(=CC2)c3ccccc3 4.65 CHEMBL1827362 CHEMBL375745 CS(=O)(=O)c1ccc(c(F)c1)c2noc(n2)[C@@H](CC3CC3)[C@H](N)C(=O)N4CC[C@H](F)C4.OC(=O)C(F)(F)F 4.23 CHEMBL855968 CHEMBL3758199 CO[C@@H]1CN(CCCn2ccnc2)CC[C@@H]1NC(=O)c3cc(Cl)c(N)cc3OC 5.14 CHEMBL3762972 CHEMBL3758288 COc1ccc2c(c1)[C@@H]3C[C@@]3(Cn4c2c(C5CCCCC5)c6ccc(cc46)C(=O)NS(=O)(=O)C(C)C)C(=O)N7C8CCC7CN(C)C8 4.39 CHEMBL3762781 CHEMBL3758397 CCC(=S)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@@H](C2)OC)CC1 5.54 CHEMBL3762972 CHEMBL3758398 CCOC(=O)N1CCC(CN2CC[C@H](NC(=O)c3cc(Cl)c(N)cc3OC)[C@@H](C2)OC)CC1 5.34 CHEMBL3762972 CHEMBL3758433 CO[C@@H]1CN(CC2CCN(CC2)C(=O)CC(C)C)CC[C@@H]1NC(=O)c3cc(Cl)c(N)cc3OC 5 CHEMBL3762972 CHEMBL3758674 CO[C@@H]1CN(CC2CCN(CC2)C(=S)C(C)C)CC[C@@H]1NC(=O)c3cc(Cl)c(N)cc3OC 5.95 CHEMBL3762972 CHEMBL3758932 CO[C@@H]1CN(CCCn2cccc2)CC[C@@H]1NC(=O)c3cc(Cl)c(N)cc3OC 5.17 CHEMBL3762972 CHEMBL3758976 CO[C@@H]1CN(CC2CCN(CC2)C(=O)NC(C)C)CC[C@@H]1NC(=O)c3cc(Cl)c(N)cc3OC 5.12 CHEMBL3762972 CHEMBL3759601 CO[C@@H]1CN(CCCn2cncn2)CC[C@@H]1NC(=O)c3cc(Cl)c(N)cc3OC 5.11 CHEMBL3762972 CHEMBL3759768 COc1ccc2c(c1)[C@@H]3C[C@@]3(Cn4c2c(C5CCCCC5)c6ccc(cc46)C(=O)NS(=O)(=O)C7CCC7)C(=O)N8C9CCC8CN(C)C9 4.42 CHEMBL3762781 CHEMBL3759928 CO[C@@H]1CN(CCC(=O)N2CCC(Cc3ccccc3)CC2)CC[C@@H]1NC(=O)c4cc(Cl)c(N)cc4OC 5.43 CHEMBL3762972 CHEMBL3759969 CO[C@@H]1CN(CC2CCN(CC2)C(=O)OC)CC[C@@H]1NC(=O)c3cc(Cl)c(N)cc3OC 5 CHEMBL3762972 CHEMBL3760108 COc1ccc2c(c1)[C@@H]3C[C@@]3(Cn4c2c(C5CCCCC5)c6ccc(cc46)C(=O)NS(=O)(=O)CC(C)C)C(=O)N7C8CCC7CN(C)C8 4.78 CHEMBL3762781 CHEMBL3763999 Cl.N[C@H](CO)c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C2 4.86 CHEMBL3767785 CHEMBL3764017 CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(=O)O)C3(CCC3)c4cccc(c4)c5cc(Cl)cc(Cl)c5 4.4 CHEMBL3768879 CHEMBL3764044 CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(=O)O)Cc3cccc(c3)c4ccccc4 4.7 CHEMBL3768879 CHEMBL3764101 Cl.Cl.NCc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C2 5.18 CHEMBL3767785 CHEMBL3764238 Cl.Cl.CNCc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C2 5 CHEMBL3767785 CHEMBL3764357 Cl.Cl.CN(C)Cc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C2 5.2 CHEMBL3767785 CHEMBL3764377 OC(=O)CN(Cc1cccc(c1)c2ccccc2OC(F)(F)F)S(=O)(=O)c3ccc(OC(F)F)cc3 4.96 CHEMBL3768879 CHEMBL3764650 Cl.COc1ccccc1N2CCN(CCCCCC(=O)n3c4ccccc4c5ccccc35)CC2 5.55 CHEMBL3768467 CHEMBL3764774 O[C@@H]([C@H]1CC[C@@H](Cc2ccc(NC(=O)CN3C=Nc4ccccc4C3=O)cc2)N1)c5ccccc5 5.7 CHEMBL3767769 CHEMBL3764870 Cl.Cl.OC1(CNC1)c2cc(cc(c2)C(F)(F)F)C(=O)N[C@@H]3CCc4ccc(Oc5ccnc6NC(=O)CCc56)cc4C3 5.31 CHEMBL3767785 CHEMBL3764895 Cl.Cl.CC(C)(N)c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C2 5.13 CHEMBL3767785 CHEMBL3765012 Cl.Cl.NC1(CCC1)c2cc(cc(c2)C(F)(F)F)C(=O)N[C@@H]3CCc4ccc(Oc5ccnc6NC(=O)CCc56)cc4C3 5.51 CHEMBL3767785 CHEMBL3765022 OC(=O)CN(C1(CCC1)c2ccc(cc2)c3ccccc3OC(F)(F)F)S(=O)(=O)c4ccc(OC(F)F)cc4 4.82 CHEMBL3768879 CHEMBL3765509 Cl.Cl.CCNCc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C2 5.25 CHEMBL3767785 CHEMBL376779 CN1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCNS(=O)(=O)c6ccccc6)c2)CC1 5.31 CHEMBL914755 CHEMBL3769968 Cl.NCC1CC1c2cc(F)c(F)cc2OCC=C 5.04 CHEMBL3774209 CHEMBL377114 Fc1ccc(cc1)C2CNC(=O)C23CCN(CC3)C4(CCCCC4)c5ccc(F)cc5 5.89 CHEMBL864852 CHEMBL377241 CN[C@@H]1CCN(C1)c2ccc(cn2)N3N=Cc4cc(sc4C3=O)c5ccc(cc5)C(F)(F)F 5.75 CHEMBL864914 CHEMBL377300 C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C 4.75 CHEMBL859790 CHEMBL3774411 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(cc4)C(F)(F)F)nnc1C5=CC(=O)NC=C5 5.6 CHEMBL3776609 CHEMBL3774412 COc1cccc(c1)N2CCC3CN(CCCSc4nnc(c5cnccn5)n4C)CC23 6.1 CHEMBL3776609 CHEMBL3774431 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(F)cc4)nnc1C5CCCCC5 6.5 CHEMBL3776609 CHEMBL3774462 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(cc4)C(F)(F)F)nnc1C5CCCC5 6.7 CHEMBL3776609 CHEMBL3774463 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(cc4)C(F)(F)F)nnc1C5CCCCC5 6.5 CHEMBL3776609 CHEMBL3774488 OC(=O)c1cccc(c1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 6.08 CHEMBL3779605 CHEMBL3774495 Fc1ccccc1c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 6.31 CHEMBL3779605 CHEMBL3774515 Cc1ncoc1c2nnc(SCCCN3CC4CN(C4C3)c5ccc(cc5)C(F)(F)F)n2C 6.2 CHEMBL3776609 CHEMBL3774519 Cn1c(SCCCN2CC3CCN(C3C2)c4c(F)cc(F)cc4F)nnc1c5cnccn5 6.3 CHEMBL3776609 CHEMBL3774540 Cc1ncoc1c2nnc(SCCCN3CC4CCN(C4C3)c5ccc(cc5)C(F)(F)F)n2C 6.7 CHEMBL3776609 CHEMBL3774569 CN1C=CC(=CC1=O)c2nnc(SCCCN3CC4CCN(C4C3)c5ccc(F)cc5)n2C 5.6 CHEMBL3776609 CHEMBL3774588 Cc1ncoc1c2nnc(SCCCN3CC4CCN(C4C3)c5ccc(F)cc5)n2C 6.1 CHEMBL3776609 CHEMBL3774591 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(F)cc4F)nnc1c5cnccn5 6.1 CHEMBL3776609 CHEMBL3774621 Cn1c(SCCCN2CC3CCN(C3C2)c4ccccc4OC(F)(F)F)nnc1c5cnccn5 6.2 CHEMBL3776609 CHEMBL3774626 C1CC(CCO1)[C@H]2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccsc6 6.84 CHEMBL3779605 CHEMBL3774649 Cn1c(SCCCN2CC3CCN(C3C2)c4ccccc4)nnc1C5CCOCC5 5.4 CHEMBL3776609 CHEMBL3774683 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(cc4)C(F)(F)F)nnc1c5cnccn5 6.6 CHEMBL3776609 CHEMBL3774684 COc1cccc(n1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@](N3)(c6cnn(C)c6)c7noc(C)n7 5.44 CHEMBL3779605 CHEMBL3774769 CN1C=C(C=CC1=O)c2nnc(SCCCN3CC4CCN(C4C3)c5ccc(cc5)C(F)(F)F)n2C 5.7 CHEMBL3776609 CHEMBL3774783 Cn1c(SCCCN2CC3CCN(C3C2)c4ccccc4C(F)(F)F)nnc1c5cnccn5 5.8 CHEMBL3776609 CHEMBL3774791 Cc1ccc(cc1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 7 CHEMBL3779605 CHEMBL3774800 Cc1onc(n1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccn6)c7cnn(C)c7 5.31 CHEMBL3779605 CHEMBL3774817 Fc1cccc(c1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 6.59 CHEMBL3779605 CHEMBL3774851 C1CC(CCO1)[C@H]2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6cccnc6 5.57 CHEMBL3779605 CHEMBL3774866 Clc1ccc(cc1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 6.84 CHEMBL3779605 CHEMBL3774869 Cn1c(SCCCN2CC3CCN(C3C2)c4cccc(F)c4)nnc1c5cnccn5 6.7 CHEMBL3776609 CHEMBL3774895 Cn1c(SCCCN2CC3CCN(C3C2)c4cccc(OC(F)(F)F)c4)nnc1c5cnccn5 6.9 CHEMBL3776609 CHEMBL3774903 C1CC(CCO1)[C@H]2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccncc6 5.12 CHEMBL3779605 CHEMBL3774909 Clc1ccc(nc1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 6.33 CHEMBL3779605 CHEMBL3774911 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(F)cc4C(F)(F)F)nnc1c5cnccn5 5.9 CHEMBL3776609 CHEMBL3774927 Cc1ccccc1N2CCC3CN(CCCSc4nnc(c5cnccn5)n4C)CC23 6.5 CHEMBL3776609 CHEMBL3774986 C1CC(CCO1)[C@H]2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6cscn6 5.36 CHEMBL3779605 CHEMBL3774996 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(F)cc4)nnc1c5cnccn5 6.5 CHEMBL3776609 CHEMBL3775005 Cc1ncoc1c2nnc(SCCCN3CC4CCN(C4C3)c5cccc(F)c5)n2C 6.6 CHEMBL3776609 CHEMBL3775023 COc1ccc(cc1)N2CCC3CN(CCCSc4nnc(c5cnccn5)n4C)CC23 6.1 CHEMBL3776609 CHEMBL3775031 COc1cccc(c1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 6.61 CHEMBL3779605 CHEMBL3775033 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(F)cc4)nnc1C5=CC(=O)NC=C5 5.3 CHEMBL3776609 CHEMBL3775036 Cn1cc(cn1)c2nnc(SCCCN3CC4CCN(C4C3)c5ccc(cc5)C(F)(F)F)n2C 6.8 CHEMBL3776609 CHEMBL3775042 Cc1onc(n1)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccc6)c7cnn(C)c7 5.74 CHEMBL3779605 CHEMBL3775050 Fc1ccc(c(F)c1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 6.2 CHEMBL3779605 CHEMBL3775061 Cc1onc(n1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cn6)c7cnn(C)c7 5.19 CHEMBL3779605 CHEMBL3775071 Cc1ccc(cc1)N2CCC3CN(CCCSc4nnc(c5cnccn5)n4C)CC23 6.4 CHEMBL3776609 CHEMBL3775097 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(cc4)C#N)nnc1c5cnccn5 6.6 CHEMBL3776609 CHEMBL3775197 Cn1c(SCCCN2CC3CCN(C3C2)c4ccccc4C(F)(F)F)nnc1c5cccnc5 5.3 CHEMBL3776609 CHEMBL3775214 Cn1c(SCCCN2CC3CCN(C3C2)c4ccccc4C(F)(F)F)nnc1c5ccncc5 5.8 CHEMBL3776609 CHEMBL3775226 Cc1ncoc1c2nnc(SCCCN3CC4CCN(C4C3)c5ccc(cc5F)C(F)(F)F)n2C 4.8 CHEMBL3776609 CHEMBL3775243 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(cc4)C(F)(F)F)nnc1N5CCOCC5 6.3 CHEMBL3776609 CHEMBL3775282 COc1ccc(cc1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 7.16 CHEMBL3779605 CHEMBL3775284 C1CC(CCO1)[C@H]2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6csc7ccccc67 7.06 CHEMBL3779605 CHEMBL3775294 Cn1c(SCCCN2CC3CCN(C3C2)c4ccccc4F)nnc1c5cnccn5 6 CHEMBL3776609 CHEMBL3775301 Cc1ncoc1c2nnc(SCCCN3CC4CCN(C4C3)c5ccc(Cl)cc5Cl)n2C 5.9 CHEMBL3776609 CHEMBL3775316 FC(F)(F)Oc1ccc(cc1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 6.89 CHEMBL3779605 CHEMBL3775350 CN1C=CC(=CC1=O)c2nnc(SCCCN3CC4CCN(C4C3)c5c(F)cc(F)cc5F)n2C 5.2 CHEMBL3776609 CHEMBL3775387 COc1cccc(n1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 5.99 CHEMBL3779605 CHEMBL3775398 Oc1ccc(cc1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 6.33 CHEMBL3779605 CHEMBL3775408 Cn1c(SCCCN2CC3CCN(C3C2)c4ccccc4C(F)(F)F)nnc1c5ccccn5 6.2 CHEMBL3776609 CHEMBL3775414 C1CC(CCO1)[C@H]2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(cc6)c7ccccc7 7.77 CHEMBL3779605 CHEMBL3775418 C1CC(CCO1)[C@H]2N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccn6 5.4 CHEMBL3779605 CHEMBL3775435 Clc1ccc(s1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 6.28 CHEMBL3779605 CHEMBL3775456 FC(F)(F)Oc1cccc(c1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 7.24 CHEMBL3779605 CHEMBL3775532 Fc1ccc(cc1F)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 6.46 CHEMBL3779605 CHEMBL3775534 Cc1ncoc1c2nnc(SCCCN3CC4CCN(C4C3)c5cccc(c5)C#N)n2C 6.1 CHEMBL3776609 CHEMBL3775554 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(cc4)C(F)(F)F)nnc1c5ccccn5 6.8 CHEMBL3776609 CHEMBL3775572 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(cc4)C(F)(F)F)nnc1c5cncnc5 6.8 CHEMBL3776609 CHEMBL3775580 C1CCC(CC1)c2c[nH]c(n2)C3Cc4c([nH]c5ccccc45)C(N3)C6CCOCC6 6.87 CHEMBL3779605 CHEMBL3775583 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(cc4)C(F)(F)F)nnc1c5cccnn5 6.9 CHEMBL3776609 CHEMBL3775589 Cc1ncoc1c2nnc(SCCCN3CC4CCN(C4C3)c5ccccc5)n2C 5.8 CHEMBL3776609 CHEMBL3775598 CC(C)Oc1ccccc1N2CCC3CN(CCCSc4nnc(c5cnccn5)n4C)CC23 5.7 CHEMBL3776609 CHEMBL3775604 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(cc4)C(F)(F)F)nnc1c5cccnc5 6.9 CHEMBL3776609 CHEMBL3775618 COc1ccccc1N2CCC3CN(CCCSc4nnc(c5cnccn5)n4C)CC23 5.7 CHEMBL3776609 CHEMBL3775630 Cc1onc(n1)[C@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccc6)c7cnn(C)c7 5.76 CHEMBL3779605 CHEMBL3775631 Cn1c(SCCCN2CC3CCN(C3C2)c4ccccc4C#N)nnc1c5cnccn5 6.7 CHEMBL3776609 CHEMBL377566 CN(C)C(=O)N1N=C(C[C@@]1(CCCN)c2ccccc2)c3cc(F)ccc3F 4.71 CHEMBL870149 CHEMBL3775667 Cn1c(SCCCN2CC3CCN(C3C2)c4cccc(c4)C#N)nnc1c5cnccn5 7 CHEMBL3776609 CHEMBL3775718 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(cc4)C(F)(F)F)nnc1C5=CNC(=O)C=C5 6 CHEMBL3776609 CHEMBL3775729 CC1(Cc2c([nH]c3ccccc23)C(N1)C4CCOCC4)c5nc(c[nH]5)c6ccccc6 5.53 CHEMBL3779605 CHEMBL3775734 Fc1ccc(nc1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 5.76 CHEMBL3779605 CHEMBL3775737 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(F)cc4)nnc1C5CCOCC5 5.2 CHEMBL3776609 CHEMBL3775753 COc1cc(ccc1F)N2CCC3CN(CCCSc4nnc(c5cnccn5)n4C)CC23 6.4 CHEMBL3776609 CHEMBL3775760 Cc1onc(n1)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccccn6)c7cnn(C)c7 5.26 CHEMBL3779605 CHEMBL3775771 Cn1c(SCCCN2CC3CCN(C3C2)c4c(F)cccc4F)nnc1c5cnccn5 5.6 CHEMBL3776609 CHEMBL3775793 FC(F)(F)c1ccc(cc1)c2c[nH]c(n2)[C@H]3Cc4c([nH]c5ccccc45)[C@H](N3)C6CCOCC6 6.8 CHEMBL3779605 CHEMBL3775810 Cn1c(SCCCN2CC3CCN(C3C2)c4ccc(cc4)C(F)(F)F)nnc1c5ccncn5 7 CHEMBL3776609 CHEMBL3775825 CC(C)(C)c1c[nH]c(n1)C2Cc3c([nH]c4ccccc34)C(N2)C5CCOCC5 5.53 CHEMBL3779605 CHEMBL3775836 Cc1cccc(c1)N2CCC3CN(CCCSc4nnc(c5cnccn5)n4C)CC23 6.5 CHEMBL3776609 CHEMBL3775851 C1CC(CCO1)C2NC(Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)C67CC8CC(CC(C8)C6)C7 6.3 CHEMBL3779605 CHEMBL3775872 Cc1ncoc1c2nnc(SCCCN3CC4CCN(C4C3)c5ccccc5OC(F)(F)F)n2C 6.2 CHEMBL3776609 CHEMBL3775946 Cn1c(SCCCN2CC3CCN(C3C2)c4c(F)cccc4C(F)(F)F)nnc1c5cnccn5 5.8 CHEMBL3776609 CHEMBL377596 O[C@@H](C1CC1)C(=O)N2CC(=C[C@H]2c3cccc(O)c3)c4cc(F)ccc4F 4.75 CHEMBL869626 CHEMBL3775967 Cc1ncoc1c2nnc(SCCCN3CC4CCN(C4C3)c5c(F)cccc5F)n2C 6 CHEMBL3776609 CHEMBL377697 O=C(Nc1cccc(c1)N2CCN(CCCCNS(=O)(=O)CC3CCCCC3)CC2)C4CC4 5.82 CHEMBL853270 CHEMBL377734 Fc1cc(F)c(cc1NCc2cnc(Nc3ccccn3)s2)C(=O)NC4CC4 4.78 CHEMBL867451 CHEMBL3780951 Cc1cc(C)n(Cc2ccc(cc2)C(=O)NCC3(CCOCC3)c4nc(cs4)c5ccccc5)n1 4.35 CHEMBL3783629 CHEMBL3785095 Oc1ccc(Br)c2CC(CN3CCC4(CC3)CCc5ccccc45)NCc12 6 CHEMBL3789775 CHEMBL3785102 COc1ccc(cc1)c2oc(nn2)C(=O)N3CC(C3)Oc4ccc(CN5CCOCC5)c(OC)c4 5.01 CHEMBL3791472 CHEMBL3785118 COc1ccc(cc1)c2oc(nn2)C(=O)N3CCC(CC3)Oc4ccc(CN5CCN(C)CC5)cc4 4.82 CHEMBL3791472 CHEMBL3785343 CN(Cc1ccc(OC2CN(C2)C(=O)c3oc(nn3)c4ccccc4)cc1)CC5(C)COC5 4.85 CHEMBL3791472 CHEMBL3785370 Cc1c(O)ccc2C(N(Cc3ccccc3c4ccc(F)c(F)c4)C(=O)c12)C(=O)NC(C)(C)C 4.57 CHEMBL3790041 CHEMBL378547 CC(C)(C)C(=O)N1CC(=C[C@H]1c2cccc(O)c2)c3cc(F)ccc3F 5.11 CHEMBL869626 CHEMBL3785486 CCCCNC(=O)C1N(CC(C)c2ccc(Cl)cc2)C(=O)c3ccccc13 4.5 CHEMBL3790041 CHEMBL3785500 Nc1ncnc2c1c(cn2[C@@H]3C[C@H](CN4CCC4)C3)c5cccc(OCC67CCC(CC6)O7)c5 5.96 CHEMBL3789676 CHEMBL3785555 COc1ccc2C(N(Cc3ccccc3c4ccccc4)C(=O)c2c1)C(=O)NC(C)(C)C 4.52 CHEMBL3790041 CHEMBL3785560 Oc1ccc(Cl)c2CC(CN3CCC4(CC3)CCc5ccccc45)NCc12 5.76 CHEMBL3789775 CHEMBL3785605 C(C1COc2ccccc2C1)N3CCC4(CC3)CCc5ccccc45 5.82 CHEMBL3789775 CHEMBL3785621 COc1ccc2C(N(Cc3ccccc3c4ccccc4)C(=O)c2c1C)C(=O)NC(C)(C)C 4.62 CHEMBL3790041 CHEMBL3785663 O=C(N1CC(C1)Oc2ccc(CN3CC4(COC4)C3)cc2)c5oc(nn5)c6ccccc6 4.55 CHEMBL3791472 CHEMBL3785718 Oc1cccc2CC(CN3CCC4(CC3)CCc5ccccc45)NCc12 6.03 CHEMBL3789775 CHEMBL3785728 Oc1ccc2CNC(CN3CCC4(CC3)CCc5ccccc45)Cc2c1 6.47 CHEMBL3789775 CHEMBL3785774 COc1cc2c(CC\C(=N/N3CCN(C)CC3)\C2(C)C)cc1Nc4ncc(Cl)c(Nc5ccccc5S(=O)(=O)C(C)C)n4 4.62 CHEMBL3789028 CHEMBL3785810 Cc1c(OC(F)F)ccc2C(N(Cc3ccccc3c4ccccc4)C(=O)c12)C(=O)NC(C)(C)C 4.66 CHEMBL3790041 CHEMBL3785865 Cc1c(O)ccc2C(N(Cc3ccccc3c4ccccc4)C(=O)c12)C(=O)NC(C)(C)C 4.34 CHEMBL3790041 CHEMBL3785952 Cc1cc(F)ccc1C2CCN(CC3Cc4c(Cl)ccc(O)c4CN3)CC2 6.01 CHEMBL3789775 CHEMBL3786094 Fc1ccc(cc1)[C@@H](OC(=O)c2ccccc2)C(=O)N3N=CC[C@H]3C(=O)NCc4cc(Cl)ccc4n5cnnn5 5.25 CHEMBL3790417 CHEMBL3786169 COc1ccc(cc1)c2oc(nn2)C(=O)N3CC(C3)Oc4ccc(CN5CCCC5)cc4 5.26 CHEMBL3791472 CHEMBL3786272 COc1ccc(cc1)c2oc(nn2)C(=O)N3CC(C3)Oc4ccc(CN(C)C)c(C)c4 5 CHEMBL3791472 CHEMBL3786303 CC(C)(C)NC(=O)C1N(Cc2ccccc2c3ccc(F)cc3)C(=O)c4ccccc14 4.25 CHEMBL3790041 CHEMBL3786311 COc1ccc(cc1)c2oc(nn2)C(=O)N3CC(C3)Oc4ccc(CN(C)CC5(C)COC5)cc4 4.8 CHEMBL3791472 CHEMBL3786346 O=C(N1CC(C1)Oc2ccc(CN3CC4(CCCO4)C3)cc2)c5oc(nn5)c6ccccc6 5.05 CHEMBL3791472 CHEMBL3786350 COC1CN(Cc2ccc(OC3CN(C3)C(=O)c4oc(nn4)c5ccc(OC)cc5)cc2)C1 5.07 CHEMBL3791472 CHEMBL3786352 O=C(N1CCC(CC1)Oc2ccc(CN3CCCC3)cc2)c4onc(n4)c5ccccc5 5.75 CHEMBL3791472 CHEMBL3786375 Clc1ccc(cc1)c2oc(nn2)C(=O)N3CCC(CC3)Oc4ccc(CN5CCCC5)cc4 5.26 CHEMBL3791472 CHEMBL3786469 Cc1cc(F)ccc1C2CCN(CC3Cc4ccccc4CN3)CC2 6.7 CHEMBL3789775 CHEMBL3786486 CN1C(CN2CCC3(CC2)CCc4ccccc34)Cc5ccccc5C1=O 5.16 CHEMBL3789775 CHEMBL3786542 CC(C)(C)NC(=O)C1N(Cc2ccccc2c3ccccc3)C(=O)c4ccccc14 4.21 CHEMBL3790041 CHEMBL3786572 COc1ccc(cc1)c2oc(nn2)C(=O)N3CCC(CC3)Oc4ccc(CN5CCCC5)cc4 4.96 CHEMBL3791472 CHEMBL3786609 COc1ccc(cc1)c2oc(nn2)C(=O)N3CCC(CC3)Oc4ccc(CN5CCCC5)nc4 4.6 CHEMBL3791472 CHEMBL3786662 COc1ccc(cc1)c2oc(nn2)C(=O)N3CCC(CC3)Oc4ccc(CN5CCOCC5)cc4 4.8 CHEMBL3791472 CHEMBL3786683 Cc1c(OCF)ccc2C(N(Cc3ccccc3c4ccccc4)C(=O)c12)C(=O)NC(C)(C)C 4.57 CHEMBL3790041 CHEMBL3786768 Cn1nc(cc1c2ccccc2)C(=O)N3CCC(CC3)Oc4ccc(CN5CCCC5)cc4 5.13 CHEMBL3791472 CHEMBL3786841 COc1ccc(cc1)c2oc(nn2)C(=O)N3CC(C3)Oc4ccc(CN5CC6(CCOC6)C5)cc4 4.8 CHEMBL3791472 CHEMBL3786892 COc1cc2c(CCC(N)C2(C)C)cc1Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3 4.36 CHEMBL3789028 CHEMBL3786923 Clc1ccccc1c2oc(nn2)C(=O)N3CCC(CC3)Oc4ccc(CN5CCCC5)cc4 5.28 CHEMBL3791472 CHEMBL3787028 COc1ccc(cc1)c2oc(nn2)C(=O)N3CC(C3)Oc4ccc(CN5CCCOCC5)cc4 4.6 CHEMBL3791472 CHEMBL3787036 CC(C)(C)NC(=O)C1N(Cc2ccccc2c3ccccc3)C(=O)c4cc(NS(=O)(=O)C)ccc14 4.82 CHEMBL3790041 CHEMBL3787051 CC(=O)N1Cc2ccccc2CC1CN3CCC4(CC3)CCc5ccccc45 6.3 CHEMBL3789775 CHEMBL3787069 CC(C)(C)NC(=O)C1N(Cc2ccccc2c3ccccc3)C(=O)c4cc(O)ccc14 4.35 CHEMBL3790041 CHEMBL3787112 Nc1ncnc2c1c(cn2[C@@H]3C[C@H](CN4CCC4)C3)c5cccc(O)c5 6.38 CHEMBL3789410 CHEMBL3787131 Fc1ccc(cc1)c2oc(nn2)C(=O)N3CCC(CC3)Oc4ccc(CN5CCCC5)cc4 5.21 CHEMBL3791472 CHEMBL3787134 COc1ccc(cc1)c2oc(nn2)C(=O)N3CC(C3)Oc4ccc(CN(C)C)cc4 4.68 CHEMBL3791472 CHEMBL3787166 O=C(N1CCC(CC1)Oc2ccc(CN3CCCC3)cc2)c4noc(n4)c5ccccc5 5.13 CHEMBL3791472 CHEMBL3787170 COc1ccc(cc1)c2oc(nn2)C(=O)N3CC(C3)Oc4ccc(CN(C)C)c(F)c4 4.82 CHEMBL3791472 CHEMBL3787237 Cc1oc(nc1C(=O)N2CCC(CC2)Oc3ccc(CN4CCCC4)cc3)c5ccccc5 5.52 CHEMBL3791472 CHEMBL3787261 COc1ccc(cc1)c2oc(nn2)C(=O)N3CC(C3)Oc4ccc(CN5CCC(C)(O)C5)cc4 4.59 CHEMBL3791472 CHEMBL3787333 CN(C)Cc1ccc(OC2CN(C2)C(=O)c3oc(nn3)c4ccccc4)c(C)c1 5.07 CHEMBL3791472 CHEMBL3787339 CCCC(=O)O[C@@H](C(=O)N1N=CC[C@H]1C(=O)NCc2cc(Cl)ccc2n3cnnn3)c4ccc(F)cc4 4.82 CHEMBL3790417 CHEMBL3787345 OC1CCN(Cc2ccc(OC3CCN(CC3)C(=O)c4oc(nn4)c5ccccc5)cc2)C1 4.51 CHEMBL3791472 CHEMBL3787356 CC(C)(C)NC(=O)C1N(Cc2ccccc2c3ccccc3)C(=O)c4cccc(O)c14 4.55 CHEMBL3790041 CHEMBL3787394 COc1ccc(cc1)c2oc(nn2)C(=O)N3CC(C3)Oc4ccc(CN5CC6(COC6)C5)cc4 4.66 CHEMBL3791472 CHEMBL3787417 O=C(N1CCC(CC1)Oc2ccc(CN3CCCC3)cc2)c4cc(on4)c5ccccc5 5.48 CHEMBL3791472 CHEMBL3787457 O=C(N1CCC(CC1)Oc2ccc(CN3CCCC3)cc2)c4oc(nn4)c5ccccc5 4.96 CHEMBL3791472 CHEMBL3787462 COc1ccc(cc1)c2oc(nn2)C(=O)N3CCC(CC3)Oc4ccc(CN5CC(O)C(C)(C)C5)cc4 5 CHEMBL3791472 CHEMBL3787614 Nc1ncnc2c1c(cn2[C@@H]3C[C@H](CN4CCC4)C3)c5cccc(OC[C@@H]6CCCO6)c5 5.44 CHEMBL3789410 CHEMBL3787636 CC(=O)N1CCN(CC1)[C@@H]2C[C@@H](C2)n3cc(c4cccc(OCC56CCC(CC5)O6)c4)c7c(N)ncnc37 4.82 CHEMBL3789676 CHEMBL3787639 FC(F)Oc1ccc(cc1)c2oc(nn2)C(=O)N3CCC(CC3)Oc4ccc(CN5CCCC5)cc4 5.38 CHEMBL3791472 CHEMBL3787642 COc1ccc(cc1)c2oc(nn2)C(=O)N3CCC(CC3)Oc4ccc(CN5CCC(O)C5)cc4 4.62 CHEMBL3791472 CHEMBL3787662 CN1CCN(CC1)c2ccc(Nc3nc(Oc4cccc(NC(=O)C=C)c4)c5cc[nH]c5n3)cc2 6 CHEMBL3790710 CHEMBL3787686 CCCCC(=O)O[C@@H](C(=O)N1N=CC[C@H]1C(=O)NCc2cc(Cl)ccc2n3cnnn3)c4ccc(F)cc4 4.85 CHEMBL3790417 CHEMBL379218 Cc1n[nH]c2ccc(cc12)c3cncc(OC[C@@H](N)Cc4ccccc4)c3 4.87 CHEMBL889269 CHEMBL3792410 COc1c2COC(=O)c2ccc1C(O)CN3CCN(CC3)C(=O)Cc4ccc(nc4)n5cnnn5 4.72 CHEMBL3797009 CHEMBL3792423 O=C(Cc1ccc(nc1)n2cnnn2)N3CCC(CCc4ccc5C(=O)OCc5c4)CC3 5.27 CHEMBL3797009 CHEMBL3792542 Cc1c(CCC2CCN(CC2)C(=O)Cc3ccc(cc3)n4cnnn4)ccc5C(=O)OCc15 5.23 CHEMBL3797009 CHEMBL3792700 Cc1cc(ncc1CC(=O)N2CCN(CCc3ccc4C(=O)OCc4c3C)CC2)n5cnnn5 5.04 CHEMBL3797009 CHEMBL3792861 OC1(CCc2ccc3C(=O)OCc3c2)CCN(CC1)C(=O)Cc4ccc(cc4)n5cnnn5 5.19 CHEMBL3797009 CHEMBL3792966 Cc1c(CCN2CCN(CC2)C(=O)Cc3ccc(cn3)n4cnnn4)ccc5C(=O)OCc15 4.48 CHEMBL3797009 CHEMBL3792978 Cc1c2COC(=O)c2ccc1C(F)CN3CCN(CC3)C(=O)Cc4ccc(nc4)n5cnnn5 4.66 CHEMBL3797007 CHEMBL3793060 O=C(Cc1ccc(cn1)n2cnnn2)N3CCC(CCc4ccc5C(=O)OCc5c4)CC3 5.1 CHEMBL3797009 CHEMBL3793143 Cc1c(CCN2CCN(CC2)C(=O)Cc3cnc(cn3)n4cnnn4)ccc5C(=O)OCc15 4.92 CHEMBL3797009 CHEMBL3793380 Cc1cc(cnc1CC(=O)N2CCN(CCc3ccc4C(=O)OCc4c3C)CC2)n5cnnn5 4.28 CHEMBL3797007 CHEMBL3793411 Cc1c(CCN2CCN(CC2)C(=O)Cc3cncc(c3)n4cnnn4)ccc5C(=O)OCc15 4.68 CHEMBL3797009 CHEMBL3793471 O=C(Cc1ccc(cn1)n2cnnn2)N3CCN(CCc4ccc5C(=O)OCc5c4)CC3 4.34 CHEMBL3797009 CHEMBL3793685 Cc1nc(ccc1CC(=O)N2CCN(CCc3ccc4C(=O)OCc4c3C)CC2)n5cnnn5 5.07 CHEMBL3797009 CHEMBL3793717 CC(C(=O)N1CCN(CCc2ccc3C(=O)OCc3c2C)CC1)c4cnc(cc4C)n5cnnn5 4.38 CHEMBL3797009 CHEMBL3793857 O=C(Cc1ccc(cc1)n2cnnn2)N3CCC(CCc4ccc5C(=O)OCc5c4)CC3 5.19 CHEMBL3797009 CHEMBL3794064 OC(=O)C1CN(Cc2ccc(cc2)c3noc(n3)c4onc(c5ccccc5)c4C(F)(F)F)C1 4.75 CHEMBL3803537 CHEMBL3794101 O=C(Cc1ccc(cc1)n2cnnn2)N3CCN(CCc4ccc5C(=O)OCc5n4)CC3 4.59 CHEMBL3797009 CHEMBL3794155 O=C(Cc1ccc(nc1)n2cnnn2)N3CCN(CCc4ccc5C(=O)OCc5c4)CC3 5.03 CHEMBL3797009 CHEMBL3794233 Cc1c2COC(=O)c2ccc1C(O)CN3CCN(CC3)C(=O)Cc4ccc(nc4)n5cnnn5 4.48 CHEMBL3797009 CHEMBL3794249 O=C(Cc1ccc(cc1)n2cnnn2)N3CC4C(CCc5ccc6C(=O)OCc6c5)C4C3 5.3 CHEMBL3797009 CHEMBL3794265 Fc1ccc2N=CC(=O)N3C[C@@H](CN4CCC(CC4)NCc5cc6OCCOc6nn5)c1c23 4.38 CHEMBL3794985 CHEMBL3794292 CC(CN1CCN(CC1)C(=O)Cc2ccc(nc2)n3cnnn3)c4ccc5C(=O)OCc5c4C 4.31 CHEMBL3797009 CHEMBL3794427 FC1(CCc2ccc3C(=O)OCc3c2)CCN(CC1)C(=O)Cc4ccc(cc4)n5cnnn5 5.68 CHEMBL3797009 CHEMBL3794510 O=C(Cc1ccc(cc1)n2cnnn2)N3CCC(CC3)\C=C\c4ccc5C(=O)OCc5c4 5.75 CHEMBL3797009 CHEMBL3794533 CC(C(=O)N1CCN(CCc2ccc3C(=O)OCc3c2C)CC1)c4ccc(nc4C)n5cnnn5 5.47 CHEMBL3797009 CHEMBL379690 CC(C)[C@H](N)C(=O)N1CC(=C[C@H]1c2ccccc2)c3cc(F)ccc3F 5.62 CHEMBL868944 CHEMBL3797717 CC(C)CS(=O)(=O)n1ccc2c(cc(nc12)N3CCN(C)CC3)c4ccc(cc4)C(F)(F)F 5.68 CHEMBL3800751 CHEMBL3799529 CC(C)CS(=O)(=O)n1ccc2c(cc(nc12)N3CCNCC3)c4ccc(cc4)C(F)(F)F 5.85 CHEMBL3800751 CHEMBL3799621 CNC(=O)c1cc(Oc2ccc3nc(NC(=O)c4cc(cc(c4)C(F)(F)F)C(F)(F)F)sc3c2)ccn1 4.32 CHEMBL3803792 CHEMBL3799831 CN(C)C(=O)c1cc(CN2CCOc3c(F)cccc23)c4OC(=CC(=O)c4c1)N5CCOCC5 4.03 CHEMBL3802897 CHEMBL379984 CC(C)CS(=O)(=O)NCCCCN1CCN(CC1)c2cccc(NC(=O)C)c2 5.52 CHEMBL853270 CHEMBL3800381 OC(COc1ccccc1C(=O)CCc2ccccc2)CN3CCN(CC3)C(c4ccccc4)(c5ccccc5)c6ccccc6 4.33 CHEMBL3801063 CHEMBL3804846 Fc1ccc(F)c(c1)[C@H]2OC(=O)N[C@@H]2c3cncc(c3)C#Cc4ccccc4 5.44 CHEMBL3808109 CHEMBL3804918 CCN(CC)c1ccc2C=C(C(=O)NCCCCN3CCC(CC3)Nc4nc5ccccc5n4Cc6ccc(F)cc6)C(=O)Oc2c1 6.36 CHEMBL3807756 CHEMBL3804950 Cc1ccnc2c3CN(Cc3nn12)[C@H]4CO[C@@H]([C@@H](N)C4)c5cc(F)ccc5F 4.01 CHEMBL3807664 CHEMBL3805081 Clc1ccc(cc1)N2N=C(OCCCN3CCCCC3)C=CC2=O 5.84 CHEMBL3806618 CHEMBL3805101 CC1CCN(CCCOC2=NN(C(=O)C=C2)c3ccc(Cl)cc3)CC1 5.79 CHEMBL3806618 CHEMBL3805216 CC1CCN(CCCOC2=NN(C(=O)C=C2)c3ccc(F)c(F)c3)CC1 5.57 CHEMBL3806618 CHEMBL3805335 CC(=O)Nc1ccc2C(=O)N(CCCCN3CCC(CC3)Nc4nc5ccccc5n4Cc6ccc(F)cc6)C(=O)c7cccc1c27 6.74 CHEMBL3807756 CHEMBL3805396 Clc1ccc(cc1Cl)N2N=C(OCCCN3CCCCC3)C=CC2=O 5.2 CHEMBL3806618 CHEMBL3805400 Cc1ccn2nc3CN(Cc3c2n1)[C@H]4CO[C@@H]([C@@H](N)C4)c5cc(F)ccc5F 4.75 CHEMBL3807664 CHEMBL3805518 CNC(=O)c1cc(OCCCCN2CCC(CC2)c3noc4cc(F)ccc34)ccc1F 6 CHEMBL3806884 CHEMBL3805559 CNC(=O)c1cccc(OCCCCN2CCC(CC2)c3noc4cc(F)ccc34)c1 5.99 CHEMBL3806884 CHEMBL3805844 CC1CCN(CCCOC2=NN(C(=O)C=C2)c3ccc(F)c(Cl)c3)CC1 5.67 CHEMBL3806618 CHEMBL3805852 COc1cnc(cn1)C(=O)Nc2cc(F)c(F)c(c2)[C@]3(C)C[C@H](SC(=N3)N)c4c(C)onc4C 6.19 CHEMBL3806671 CHEMBL3805898 [O-][N+](=O)c1ccc(NCCCCN2CCC(CC2)Nc3nc4ccccc4n3Cc5ccc(F)cc5)c6nonc16 7.6 CHEMBL3807756 CHEMBL3805966 Cc1cc2ncc3CN(Cc3n2n1)[C@H]4CC[C@@H]([C@@H](N)C4)c5cc(F)c(F)cc5F 6.22 CHEMBL3807664 CHEMBL3805989 Fc1ccc(cc1F)N2N=C(OCCCN3CCCCC3)C=CC2=O 5.72 CHEMBL3806618 CHEMBL3806029 Cc1cc2ncc3CN(Cc3n2n1)[C@H]4CO[C@@H]([C@@H](N)C4)c5cc(F)c(F)cc5F 5.19 CHEMBL3807664 CHEMBL3806041 N[C@H]1C[C@H](CC[C@@H]1c2cc(F)c(F)cc2F)N3Cc4cnc5nnc(C6CC6)n5c4C3 6.22 CHEMBL3807664 CHEMBL3806052 N[C@H]1C[C@H](CO[C@@H]1c2cc(F)ccc2F)N3Cc4nn5nccnc5c4C3 4.64 CHEMBL3807664 CHEMBL3806153 Fc1ccc(cc1Cl)N2N=C(OCCCN3CCCCC3)C=CC2=O 6.01 CHEMBL3806618 CHEMBL3806193 CC1CCN(CCCOC2=NN(C(=O)C=C2)c3ccc(Cl)c(Cl)c3)CC1 5.84 CHEMBL3806618 CHEMBL3808450 CC(C)(C)c1onc(NC(=O)c2cnc3cc(Oc4ncnc5CNCc45)ccn23)c1 5.04 CHEMBL3812630 CHEMBL3808653 CC(C)(C)c1onc(NC(=O)n2ccc3nc(Oc4ncnc5CNCc45)ccc23)c1 4.59 CHEMBL3812630 CHEMBL3808921 C[C@H]1Cc2c(CN1)ncnc2Oc3ccc4c(ccn4C(=O)Nc5cc(on5)C6(CC6)C(F)(F)F)c3 5.13 CHEMBL3812630 CHEMBL3808957 CC(C)(C)c1onc(NC(=O)n2ccc3ccc(Oc4ncnc5CNCc45)cc23)c1 4.68 CHEMBL3812630 CHEMBL3809643 C[C@H]1Cc2c(CN1)ncnc2Oc3ccc4ccn(C(=O)Nc5cc(on5)C6(CC6)C(F)(F)F)c4c3 5.07 CHEMBL3812630 CHEMBL3810135 CC(C)(C)c1onc(NC(=O)n2ncc3cc(Oc4ncnc5CNCc45)ccc23)c1 5.11 CHEMBL3812630 CHEMBL3810154 CC(C)(C)c1onc(NC(=O)n2ccc3cc(Oc4ncnc5CNCc45)cnc23)c1 5.24 CHEMBL3812630 CHEMBL381145 C[C@H]([C@H](N)C(=O)N1CC[C@H](F)C1)c2ccc(cc2)c3ccc(O)nc3.OC(=O)C(F)(F)F 5.08 CHEMBL866509 CHEMBL3813836 CC(C)Oc1cc(ccc1F)[C@@](Cc2ccccc2)(NC[C@@H](O)C(F)(F)F)c3cc(F)cc(OC(F)(F)C(F)F)c3 4.68 CHEMBL3815836 CHEMBL3814374 CC(C)Oc1cc(ccc1F)[C@@](Cc2ccccc2)(NC[C@H](O)CC(F)(F)F)c3cc(F)cc(OC(F)(F)C(F)F)c3 4.55 CHEMBL3815836 CHEMBL3814418 CC(C)Oc1cc(ccc1F)[C@@](Cc2ccccc2)(NC[C@H](O)C(F)(F)F)c3cc(F)cc(OC(F)(F)C(F)F)c3 4.92 CHEMBL3815836 CHEMBL3814424 Cl.CN(C\C=C\c1ccc(cc1)C(F)(F)F)Cc2cccc3ccoc23 5.43 CHEMBL3816785 CHEMBL3814963 CC(C)Oc1cc(ccc1F)[C@@](Cc2ccccc2)(NC[C@@H](O)CC(F)(F)F)c3cc(F)cc(OC(F)(F)C(F)F)c3 4.64 CHEMBL3815836 CHEMBL381526 CC(C)[C@H](N)C(=O)N1CC(=C[C@H]1c2cccc(O)c2)c3cc(F)ccc3F 5.07 CHEMBL869626 CHEMBL381533 CN(C)C(=O)N1CC(=C[C@H]1c2cccc(O)c2)c3cc(F)ccc3F 4.48 CHEMBL869626 CHEMBL382165 O[C@@H](C1CC1)C(=O)N2CC(=C[C@H]2c3ccccc3)c4cc(F)ccc4F 4.96 CHEMBL868944 CHEMBL3822583 CC(=O)N1CCC(CC1)n2ncc(Nc3ncc(Cl)c(n3)c4cnc5ccccn45)c2C 4.68 CHEMBL3825087 CHEMBL3822587 Cc1nn(C2CCN(CC2)C(=O)CO)c(C)c1Nc3ncc(Cl)c(n3)c4cnn5ccccc45 4.66 CHEMBL3825087 CHEMBL3822619 CCc1nn(cc1Nc2ncc(Cl)c(n2)c3cnn4ccccc34)C5CCN(CC5)C(=O)C 5.28 CHEMBL3825087 CHEMBL3822651 COCC(=O)N1CCC(CC1)n2nc(C)c(Nc3ncc(Cl)c(n3)c4cnn5ccccc45)c2C 4.77 CHEMBL3825087 CHEMBL3822858 COc1nn(cc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)C5CCN(CC5)C(=O)C 5.18 CHEMBL3825087 CHEMBL3822943 CCOc1nn(cc1Nc2ncc(Cl)c(n2)c3cnn4ccccc34)C5CCN(CC5)C(=O)C 5.19 CHEMBL3825087 CHEMBL3822947 C[C@H](O)C(=O)N1CCC(CC1)n2nc(C)c(Nc3ncc(Cl)c(n3)c4cnn5ccccc45)c2C 4.64 CHEMBL3825087 CHEMBL3822962 CCc1c(Nc2ncc(Cl)c(n2)c3cnn4ccccc34)cnn1C5CCN(CC5)C(=O)C 4.77 CHEMBL3825087 CHEMBL3822989 CC(=O)N1CCC(CC1)n2cc(Nc3ncc(Cl)c(n3)c4cnn5ccccc45)c(C)n2 5.14 CHEMBL3825087 CHEMBL3823007 Cc1nn(cc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)C5CCNCC5 4.54 CHEMBL3825087 CHEMBL3823030 C[C@@H](O)C(=O)N1CCC(CC1)n2nc(C)c(Nc3ncc(Cl)c(n3)c4cnn5ccccc45)c2C 4.54 CHEMBL3825087 CHEMBL3823095 CN(C)C(=O)CN1CCC(CC1)n2nc(C)c(Nc3ncc(Cl)c(n3)c4cnn5ccccc45)c2C 5.11 CHEMBL3825087 CHEMBL3823278 CC(=O)N1CCC(CC1)n2cc(Nc3ncc(Cl)c(n3)c4cnc5ccccn45)c(C)n2 5.28 CHEMBL3825087 CHEMBL3823522 COc1nn(cc1Nc2ncc(Cl)c(n2)c3cnn4ccccc34)C5CCN(CC5)C(=O)C 5 CHEMBL3825087 CHEMBL3823659 CC(=O)N1CCC(CC1)n2cc(Nc3ncc(Cl)c(n3)c4cnc5ccccn45)cn2 5.27 CHEMBL3825087 CHEMBL3823914 CC(=O)N1CCC(CC1)n2nc(C)c(Nc3ncc(Cl)c(n3)c4cnn5ccccc45)c2C 4.64 CHEMBL3825087 CHEMBL3823929 CC(=O)N1CCC(CC1)n2nc(C)c(Nc3ncc(Cl)c(n3)c4cnc5ccccn45)c2C 4.57 CHEMBL3825087 CHEMBL3823962 CNC(=O)CN1CCC(CC1)n2nc(C)c(Nc3ncc(Cl)c(n3)c4cnn5ccccc45)c2C 4.92 CHEMBL3825087 CHEMBL3824296 Cc1nn(C2CCNCC2)c(C)c1Nc3ncc(Cl)c(n3)c4cnn5ccccc45 4.62 CHEMBL3825087 CHEMBL3824323 Cc1nn(C2CCN(CCO)CC2)c(C)c1Nc3ncc(Cl)c(n3)c4cnn5ccccc45 5.03 CHEMBL3825087 CHEMBL382587 CN(CCCN)C(=O)N1CC(=C[C@H]1c2ccccc2)c3cc(F)ccc3F 5.89 CHEMBL868944 CHEMBL382741 CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3ccccc3C#N 8.5 CHEMBL1052905 CHEMBL382851 CN([C@H]1CCN(C1)C(=O)N2CC[C@H](C2)NCCC(C)(C)c3ccc(Cl)cc3)C(=O)c4ccc(cc4)c5ccc(cc5)C(F)(F)F 5.59 CHEMBL869869 CHEMBL383077 Cc1cc2c(F)c(Oc3ncnn4cc(OCCCS(=O)(=O)C)c(C)c34)ccc2[nH]1 4.7 CHEMBL859790 CHEMBL383997 COc1ccc2c(OC[C@H](O)CO)nc(C#N)c(c3ccccc3)c2c1 4.69 CHEMBL908975 CHEMBL384000 CCN(CC)Cc1ccc2C[C@H](CCc2c1)N3CCN(CCC4CCCCC4)CC3=O 5.48 CHEMBL854894 CHEMBL384030 CS(=O)(=O)N1CCN(Cc2ccc3C[C@H](CCc3c2)N4CCN(CCc5ccc(F)cc5)CC4=O)CC1 4.89 CHEMBL854894 CHEMBL384043 CCc1oc2ccc(CN3CCC(CC3)NC(=O)C4=CC(=O)c5ccc(F)cc5O4)cc2n1 4.7 CHEMBL854890 CHEMBL384111 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(CC3)C4CCc5cc6OC(=O)Nc6cc45 4.6 CHEMBL854891 CHEMBL384400 CCN(CC)Cc1ccc2C[C@H](CCc2c1)N3CCN(CCc4ccc(Cl)cc4)CC3=O 5.48 CHEMBL854894 CHEMBL384427 O=C(N1Cc2ccccc2C1)N3CCC[C@H]3CN4CCCC4 4.55 CHEMBL1827362 CHEMBL384487 CC(=O)c1ccc(CN2CCC(CC2)NC(=O)C3=CC(=O)c4ccc(F)cc4O3)cc1 7.69 CHEMBL909940 CHEMBL384919 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(CC3)C4CCc5cc6OCC(=O)Nc6cc45 4.84 CHEMBL854891 CHEMBL385710 CN(C)C(=O)C(CO)N(C)Cc1ccc2C[C@H](CCc2c1)N3CCN(CCc4ccc(F)cc4)CC3=O 4.6 CHEMBL854894 CHEMBL386281 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5C=CC(=O)Oc5c4)CC3 4.29 CHEMBL854890 CHEMBL386717 CC(=O)N1CCN(Cc2ccc3C[C@H](CCc3c2)N4CCN(CCc5ccc(F)cc5)CC4=O)CC1 4.6 CHEMBL854894 CHEMBL387178 Fc1cc2OC(=CC(=O)c2cc1F)C(=O)NC3CCN(Cc4ccc5OCOc5c4)CC3 8.21 CHEMBL909940 CHEMBL387309 COc1ccc(CN2CCC(CC2)NC(=O)C3=CC(=O)c4ccc(F)cc4O3)c(F)c1 7.83 CHEMBL909940 CHEMBL387417 O=C(NC1CCN(Cc2ccc3OCOc3c2)CC1)C4=CC(=O)c5ccc(cc5O4)C#N 8.3 CHEMBL909940 CHEMBL387418 Fc1cc2C(=O)C=C(Oc2cc1Cl)C(=O)NC3CCN(Cc4ccc5OCOc5c4)CC3 7.98 CHEMBL909940 CHEMBL387929 CN1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCOc6ccc(Cl)cc6)c2)CC1 5.45 CHEMBL914755 CHEMBL387971 COCCOCC#Cc1cc(cs1)c2n[nH]c3c4ccc(CN5CCN(C)CC5)cc4C(=O)c23 5.03 CHEMBL914755 CHEMBL387972 CC1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCOc6ccccc6)c2)CC1 7.1 CHEMBL914755 CHEMBL390353 CN1CCN(CCc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCOc6ccccc6)c2)CC1 5.23 CHEMBL914755 CHEMBL390429 COc1ccccc1c2nnc(SCCCN3CCc4ccc(cc4CC3)c5cc(C)on5)n2C 7.4 CHEMBL895464 CHEMBL390649 Cc1cc(c2ccc3CCN(CCCSc4nnc(c5ccc(cc5)C(F)(F)F)n4C)CCc3c2)n(C)n1 7.5 CHEMBL895464 CHEMBL390735 CN1CCN(CC1)C(=O)c2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCOc6ccccc6)c2 5.76 CHEMBL914755 CHEMBL391143 Cc1c(CN(C2CCOCC2)[C@H]3CCNC3)cccc1C(F)(F)F 5.54 CHEMBL903477 CHEMBL392354 OC=O.Fc1ccc(C(=O)N2CCN(C(=O)C2)c3ccc(OC4CCN(CC4)C5CCCC5)cc3)c(F)c1 4.6 CHEMBL903096 CHEMBL392573 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cnc5cc(C)nn5c4C 5.06 CHEMBL1827362 CHEMBL392713 C[C@H]1CCCN1CCCOc2ccc(cc2)N3CCN(CC3=O)C(=O)c4cc(F)cc(F)c4.OC=O 4.9 CHEMBL903096 CHEMBL392825 Cl.C[C@H]([C@H](N)C(=O)N1CC[C@H](F)C1)C2CCC(CC2)N(C)C(=O)C3CC3 4.41 CHEMBL887127 CHEMBL393581 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cnn(c4C)c5ccccn5 4.7 CHEMBL1827362 CHEMBL393718 CCOc1cc(CN2CCC(CC2)Nc3oc4ccc(cc4n3)S(=O)(=O)N)ccc1OC 5.46 CHEMBL902576 CHEMBL394015 Fc1cc(F)cc(c1)C(=O)N2CCN(C(=O)C2)c3ccc(OCCCN4CCCC4)cc3 5.1 CHEMBL903096 CHEMBL394144 C[C@@H]1CCCN1CCCOc2ccc(cc2)N3CCN(CC3=O)C(=O)c4ccc(F)cc4.OC=O 4.7 CHEMBL903096 CHEMBL394639 CC(C)CO\N=C\COc1ccc(CN2CCC(CC2)NC(=O)C3=CC(=O)c4ccc(F)cc4O3)cc1F 6.35 CHEMBL886903 CHEMBL395034 CN(C)C(=O)N1CC(=C[C@@]1(CC[C@H](N)C(F)F)c2ccccc2)c3cc(F)ccc3F 4.8 CHEMBL893743 CHEMBL395213 Cl.N[C@@H](C1CCC(CC1)NS(=O)(=O)c2ccc(F)cc2F)C(=O)N3CC[C@H](F)C3 4.31 CHEMBL887127 CHEMBL395332 CN(C)C(=O)N1CC(=C[C@@]1(CCCN)c2ccccc2)c3cc(F)ccc3F 5.15 CHEMBL893743 CHEMBL395742 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(c5ccc(C)cc5)n4C)CCc3c2 7.6 CHEMBL895464 CHEMBL395743 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(c5cccn5C)n4C)CCc3c2 6.6 CHEMBL895464 CHEMBL397222 Cc1onc(c1)c2ccc3CCN(CCCSc4nnc(c5ccc(Cl)c(Cl)c5)n4C)CCc3c2 8 CHEMBL895464 CHEMBL397392 Cc1ccccc1CN(C2CCOCC2)[C@H]3CCNC3 5.62 CHEMBL903477 CHEMBL397395 COc1ccc2nccc(C3CN(C4CCN(Cc5ccc(C)c(C)c5)CC4)C(=O)O3)c2c1 5.2 CHEMBL903467 CHEMBL397429 Cc1oc(nc1)c2ccc3CCN(CCCSc4nnc(c5cc6ccccc6[nH]5)n4C)CCc3c2 7.3 CHEMBL895464 CHEMBL398478 CC(=O)C1=NN2[C@@H](COc3ccc(F)cc23)[C@@]1(CCCN4CCOCC4)c5ccccc5 5.22 CHEMBL941016 CHEMBL398612 Cc1[nH]nc2c3cc(C4CCCCC4)c(cc3N(C[C@H](F)CN)C(=O)c12)C5CCCCC5 4.88 CHEMBL941012 CHEMBL399378 CC(=O)C1=NN2[C@@H](COc3ccc(C)cc23)[C@@]1(CCCN4CCOCC4)c5ccccc5 5.2 CHEMBL941016 CHEMBL399525 N[C@H]1CN(Cc2ccc(cc2)n3cncn3)C[C@H]1C(=O)N4CCC[C@H]4C#N 5.75 CHEMBL943040 CHEMBL399791 Cc1cc(CN2C[C@H](N)[C@@H](C2)C(=O)C3CCC[C@H]3C#N)cc(C)c1C#N 4.54 CHEMBL943040 CHEMBL400612 OC=O.O=C(N1CCN(C(=O)C1)c2ccc(OCCCN3CCCCCC3)cc2)c4ccc(cc4)C#N 4.9 CHEMBL903096 CHEMBL401258 Cc1cccc(NC(=O)c2oc(cc2)c3ccc(cc3)C#N)c1 5.24 CHEMBL944718 CHEMBL401407 CC(C(O)c1ccc2NC(=O)OCc2c1)N3CCC(O)(CC3)c4ccc(F)cc4 5.62 CHEMBL940929 CHEMBL401476 CC(=O)C1=NN2[C@@H](COc3ccc(F)cc23)[C@@]1(CCCN4CCNCC4)c5ccccc5 5.34 CHEMBL941016 CHEMBL401576 Cc1noc2cc3CCN(CCCSc4nnc(c5ccc(cc5)C(F)(F)F)n4C)CCc3cc12 6.9 CHEMBL948183 CHEMBL401608 CC(C)(O)[C@@]1(CC[C@H](C1)N2CCC(CC2)c3cc(Cl)ncn3)C(=O)NCc4cc(cc(c4)C(F)(F)F)C(F)(F)F 6.73 CHEMBL944859 CHEMBL401728 Cc1cc(c2oc3cc4CCN(CCCSc5nnc(c6ocnc6C)n5C)CCc4cc3n2)n(C)n1 6 CHEMBL948183 CHEMBL401752 CCc1oc2c(C)c3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 6.3 CHEMBL948183 CHEMBL401777 CCc1oc2c(C)c3CCN(CCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 5.6 CHEMBL948183 CHEMBL401895 CN(C)Cc1cccc(OCC(=O)Nc2cc(nc(n2)c3oc(C)cc3)n4nc(C)cc4C)c1 5.92 CHEMBL928993 CHEMBL402011 C[C@@H](Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc5ccccn5)c3)c12)C(=O)N(C)C 4.6 CHEMBL928906 CHEMBL402015 Cc1oc2c(Br)c3CCN(CCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 5.2 CHEMBL948183 CHEMBL402016 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6oc(nc6cc5CC4)C(F)(F)F)n3C 6 CHEMBL948183 CHEMBL402087 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6nc(oc6c(C)c5CC4)C(C)(C)C)n3C 6.6 CHEMBL948183 CHEMBL402163 CS(=O)(=O)c1ccc(c(Cl)c1)c2noc(n2)[C@@H](CC3CC3)[C@H](N)C(=C4CCCC4)F.OC(=O)C(F)(F)F 5.15 CHEMBL933468 CHEMBL402215 Cc1ncoc1c2nnc(SCCCN3CCc4ccc5oc(nc5c4CC3)C(F)(F)C(F)(F)F)n2C 6.5 CHEMBL931097 CHEMBL402422 Cc1oc2ccc3CCN(CCCSc4nnc(c5ocnc5C)n4C)CCc3c2n1 4.9 CHEMBL931097 CHEMBL402542 CCN1CCN(Cc2cnc(c(Cl)c2)c3ccc(cc3)C(=O)Nc4ccccc4N)CC1 5.08 CHEMBL927950 CHEMBL402624 CC(C)(O)[C@@]1(CC[C@H](C1)N2CCC(CC2)c3cccc(c3)C(=O)O)C(=O)NCc4cc(cc(c4)C(F)(F)F)C(F)(F)F 4.71 CHEMBL944859 CHEMBL402826 CCCc1oc2cc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc2n1 6.2 CHEMBL948183 CHEMBL402853 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5ccc6oc(nc6c5CC4)c7cc(C)nn7C)n3C 6.1 CHEMBL931097 CHEMBL402911 CCOC(=O)C(N)c1ccc(cc1)C(=O)Nc2cc(ccc2N)c3cccs3 5.24 CHEMBL934350 CHEMBL403033 COc1cccc(c1)C2CCN(CC2)[C@@H]3CC[C@](C3)(C(C)C)C(=O)NCc4cc(cc(c4)C(F)(F)F)C(F)(F)F 6.66 CHEMBL944859 CHEMBL403181 CCc1noc2cc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3cc12 6 CHEMBL948183 CHEMBL403441 CCOc1ccccc1C[C@@H](N2CCNCC2)c3ccccc3 5.16 CHEMBL1120514 CHEMBL403594 CNC(=O)[C@@H](C)Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12 4.5 CHEMBL930660 CHEMBL403774 C[C@@H](Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)C(=O)N5CCOCC5 5 CHEMBL930660 CHEMBL403804 CCc1nc2ccc3CCN(CCCSc4nnc(c5ocnc5C)n4C)CCc3c2s1 5.5 CHEMBL931097 CHEMBL403815 Cc1oc2cc(Cl)c3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3c2n1 5.8 CHEMBL931097 CHEMBL404363 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5ccc6nc(oc6c5CC4)C(F)(F)F)n3C 6 CHEMBL931097 CHEMBL404404 Cc1ccc(cn1)c2nnc(SCCCN3CCc4ccc5oc(nc5c4CC3)C(F)(F)F)n2C 5.8 CHEMBL931097 CHEMBL404646 COc1cccc(c1)c2oc(C)c(CCOc3cccc(C[C@H]4[C@H](N(C4=O)c5ccc(cc5)C(C)(C)C)C(=O)O)c3)n2 5.68 CHEMBL933193 CHEMBL404851 CC(C(O)c1ccc2NC(=O)CCc2c1)N3CCC(O)(CC3)c4ccc(F)cc4 5.07 CHEMBL940929 CHEMBL404852 CC(C(O)c1ccc2NC(=O)CCc2c1)N3CCC(O)(CC3)c4cccc(F)c4 5 CHEMBL940929 CHEMBL406678 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5nc6ccccn6c5CC4)n3C 5.6 CHEMBL931097 CHEMBL408169 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6NCCOc6cc5CC4)n3C 6.4 CHEMBL948183 CHEMBL408208 Cc1ccc2c(cccc2n1)c3nnc(SCCN4CCc5cc6nc(oc6c(Br)c5CC4)C(F)(F)F)n3C 6.2 CHEMBL948183 CHEMBL408479 CN(C)S(=O)(=O)N(C)[C@@H]1CCCN2C(=O)C(=C(N=C12)C(=O)NCc3ccc(F)cc3)O 4.7 CHEMBL932292 CHEMBL409224 COc1ccccc1Oc2ccccc2CN3CCC4(CC3)CCN(CC4)C(=O)c5ccc(Cl)cc5 7.06 CHEMBL1045843 CHEMBL409229 CCN[C@H]1CCN(CC(=O)Nc2cc(nc(n2)c3oc(C)cc3)n4nc(C)cc4C)C1 6.38 CHEMBL949251 CHEMBL409419 CN1CCCN(CC(=O)Nc2cc(nc(n2)c3oc(C)cc3)n4nc(C)cc4C)CC1 6.55 CHEMBL949251 CHEMBL409459 CN(C)CC1CCN(CC(=O)Nc2cc(nc(n2)c3oc(C)cc3)n4nc(C)cc4C)CC1 5.78 CHEMBL949251 CHEMBL409648 COc1ccccc1Oc2cccc(CN3CCC4(CC3)CCN(CC4)C(=O)c5ccc(Cl)cc5)c2 7 CHEMBL948146 CHEMBL409849 [O-][n+]1ccc(cc1)C(=O)N2CCC3(CCN(Cc4cccc(Oc5ccccc5)c4)CC3)CC2 4.85 CHEMBL948146 CHEMBL41 CNCCC(Oc1ccc(cc1)C(F)(F)F)c2ccccc2 4.91 CHEMBL1909190 CHEMBL410234 CN(C)CCC(=O)Nc1cc(nc(n1)c2oc(C)cc2)n3nc(C)cc3C 6.19 CHEMBL949251 CHEMBL410832 COC1OC2(CCN(Cc3ccccc3)CC2)c4cnn(c5ccccc5)c14 9.39 CHEMBL922329 CHEMBL410885 O=C(N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1)c5ccncn5 5.71 CHEMBL1045843 CHEMBL411118 COc1ccc(cc1)N2[C@@H]([C@H](Cc3ccc(OCCc4nc(oc4C)c5ccccc5)cc3)C2=O)C(=O)O 4.27 CHEMBL933193 CHEMBL411293 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5nc6cc(ccn6c5CC4)C(F)(F)F)n3C 6.6 CHEMBL931097 CHEMBL411651 COc1ccccc1Oc2cccc(CN3CCC4(CC3)CCN(CC4)C(=O)c5cccc[n+]5[O-])c2 4.82 CHEMBL948146 CHEMBL412663 COC(=O)C1=CCC2CCC1N2C 5.05 CHEMBL1676103 CHEMBL415944 COC(=O)Cc1ccc(cc1)n2cc(C3CCN(CCN4CCNC4=O)CC3)c5cc(Cl)ccc25 6.88 CHEMBL766816 CHEMBL416956 OC(C1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F 5.25 CHEMBL829152 CHEMBL42 CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24 4.98 CHEMBL1909190 CHEMBL422 CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 5.21 CHEMBL1909190 CHEMBL422330 CCCCN(CCCC)CC(O)c1cc(Cl)cc2\C(=C\c3ccc(Cl)cc3)\c4cc(Cl)ccc4c12 5.09 CHEMBL827807 CHEMBL424895 CN(C)C(=O)[C@@H]1CCCN1Cc2ccc3C[C@H](CCc3c2)N(C)C(=O)c4ccc(cc4)c5ccc(F)cc5 5.3 CHEMBL854892 CHEMBL425257 Fc1ccc2OC(=CC(=O)c2c1)C(=O)NC3CCN(CC3)C4CCc5c6OCOc6ccc45 5.23 CHEMBL854891 CHEMBL425448 Fc1ccc2C(=O)C=C(Oc2c1)C(=O)NC3CCN(Cc4ccc5OCCOc5c4)CC3 7.91 CHEMBL909940 CHEMBL42557 C1CNCC(C1)c2c([nH]c3ccccc23)c4ccccc4 5.31 CHEMBL1676103 CHEMBL426009 CN1CCN(Cc2ccc3c(Cc4c(n[nH]c34)c5csc(c5)C#CCNc6ccccc6)c2)CC1 5.76 CHEMBL914755 CHEMBL427836 CCc1oc2ccc3CCN(CCCSc4nnc(c5ocnc5C)n4C)CCc3c2n1 5.3 CHEMBL931097 CHEMBL428411 Cc1nccn1C[C@H]2CCc3c(C2=O)c4ccccc4n3C 6.09 CHEMBL988126 CHEMBL428594 CC(C)[C@@]1(CC[C@H](C1)N2CCC(CC2)c3ccc(F)cc3)C(=O)NCc4cc(cc(c4)C(F)(F)F)C(F)(F)F 7.8 CHEMBL944859 CHEMBL428602 CC(C)(O)[C@@]1(CC[C@H](C1)N2CCC(CC2)c3ccc(F)cc3)C(=O)NCc4cc(cc(c4)C(F)(F)F)C(F)(F)F 7.27 CHEMBL944859 CHEMBL428777 C[C@@H](Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)C(=O)N(C)C 4.85 CHEMBL930660 CHEMBL429115 Cc1cc(CN2C[C@H](N)[C@@H](C2)C(=O)C3CCC[C@H]3C#N)ccc1C#N 4.71 CHEMBL943040 CHEMBL429132 Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5cc6oc(nc6cc5CC4)C(C)(C)C)n3C 6.1 CHEMBL948183 CHEMBL429436 Clc1ccc(cc1)C(=O)N2CCC3(CCN(Cc4cccc(Oc5ccccc5)c4)CC3)CC2 6.22 CHEMBL1045843 CHEMBL429458 OC=O.Fc1ccc(cc1)C(=O)N2CCN(C(=O)C2)c3ccc(OCCCN4CCCC4)cc3 5.2 CHEMBL903096 CHEMBL429553 CN(C)CCC[C@]1([C@@H]2COc3ccc(Cl)cc3N2N=C1C(=O)C)c4ccccc4 5.7 CHEMBL941016 CHEMBL429663 Cc1cccc(NC(=O)c2oc(cc2)c3ccc(Cl)cc3)c1 4.57 CHEMBL944718 CHEMBL429734 Cc1oc(nc1CCOc2cccc(C[C@H]3[C@H](N(C3=O)c4ccc(cc4)C(C)(C)C)C(=O)O)c2)c5cccc(Cl)c5 5.75 CHEMBL933193 CHEMBL429760 C[C@H](Oc1cccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c12)C(=O)N(C)C 4.96 CHEMBL930660 CHEMBL429761 CN(C)C[C@H]1CCN(CC(=O)Nc2cc(nc(n2)c3oc(C)cc3)n4nc(C)cc4C)C1 5.73 CHEMBL949251 CHEMBL429849 CC(C)(O)[C@@]1(CC[C@H](C1)N2CCC(CC2)c3cncnc3)C(=O)NCc4cc(cc(c4)C(F)(F)F)C(F)(F)F 6.07 CHEMBL944859 CHEMBL43 COc1cc(NS(=O)(=O)C)ccc1Nc2c3ccccc3nc4ccccc24 6.68 CHEMBL988126 CHEMBL434394 OC(CNCC(O)C1CCc2cc(F)ccc2O1)C3CCc4cc(F)ccc4O3 5.2 CHEMBL3430708 CHEMBL435882 NC(CC(=O)N1CCC[C@H]1C(=O)NCc2ccc(cc2)C(F)(F)F)Cc3ccccc3F.OC(=O)C(F)(F)F 6.06 CHEMBL829261 CHEMBL437206 C[C@@H]([C@H](N)C(=O)N1CCCC1)c2onc(n2)c3ccc(cc3Cl)S(=O)(=O)C.OC(=O)C(F)(F)F 4.43 CHEMBL933468 CHEMBL437728 CN([C@H]1CCc2cc(CN3CCN(CC3)C(=O)N)ccc2C1)C(=O)c4ccc(cc4)c5ccc(F)cc5 5.17 CHEMBL854892 CHEMBL437792 Cc1ncoc1c2nnc(SCCCN3CCc4ccc5oc(nc5c4CC3)C(C)(F)F)n2C 5.6 CHEMBL931097 CHEMBL438876 CC(=O)C1=NN2[C@@H](COc3ccc(F)cc23)[C@@]1(CCCN4CCNC(=O)CC4)c5ccccc5 4.77 CHEMBL941016 CHEMBL438992 C[C@@H]([C@H](N)C(=O)N1CCCC1)c2onc(n2)c3ccc(Cl)cc3Cl.OC(=O)C(F)(F)F 4.44 CHEMBL855968 CHEMBL439065 Cc1oc2cc3CCN(CCCSc4nnc(c5ccc(cc5)C(F)(F)F)n4C)CCc3cc2n1 5.4 CHEMBL948183 CHEMBL439304 O[C@H](COc1cc(O)ccc1C(=O)N2C[C@H](O)CO2)CN3CCC4(CC3)Cc5cc(Cl)ccc5O4 7.6 CHEMBL948146 CHEMBL441472 CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c3ncccc3Cl)cc1 6 CHEMBL1676103 CHEMBL441705 O=C(N1CCN(CC1)C2CCCC2)N3Cc4ccccc4C3 4.91 CHEMBL1827362 CHEMBL442242 C[C@@H]1CCCN1CCc2ccc3nc(ccc3c2)c4cn(C)nc4C 4.61 CHEMBL1827362 CHEMBL442272 FC(F)(F)c1ccccc1CN(C2CCOCC2)[C@H]3CCNC3 5.96 CHEMBL903477 CHEMBL442456 CCc1oc2ccc3CCN(CCCSc4nnc(c5cccc6nc(C)ccc56)n4C)CCc3c2n1 5.2 CHEMBL931097 CHEMBL442717 COc1cc2CCN(C)[C@H](Cc3ccc(Oc4cc(C[C@H]5N(C)CCc6cc(OC)c(OC)cc56)ccc4O)cc3)c2cc1OC 4.8 CHEMBL827807 CHEMBL442923 CNCc1cc(F)ccc1Oc2ccc(F)c(Cl)c2 5.08 CHEMBL962309 CHEMBL443476 Clc1ccc2c(c1)c(cn2c3ccccc3)C4CCN(CCN5CCNC5=O)CC4 7.06 CHEMBL766816 CHEMBL443620 CN1CCN(CC1)c2ccc3nc(c4ccccc4)c(nc3n2)c5ccc(CN6CCC(CC6)c7nnc([nH]7)c8ccccn8)cc5 5.04 CHEMBL947435 CHEMBL443661 CN(C)CCN1CCN(CC1)c2ncc3cc(c4ccccc4)c(nc3n2)c5ccc(CN6CCC(CC6)c7nnc([nH]7)c8ccccn8)cc5 5.68 CHEMBL947435 CHEMBL443922 CN(C)Cc1ccccc1Oc2ccc(Cl)c(Cl)c2 5.67 CHEMBL962309 CHEMBL444136 O=C1NC=Cc2nc(c3ccc(CN4CCC(CC4)c5nnc([nH]5)c6cnccn6)cc3)c(cc12)c7ccccc7 5.07 CHEMBL947435 CHEMBL444203 CNC(C)c1cc(F)ccc1Oc2ccc(Cl)cc2 5.28 CHEMBL962309 CHEMBL445212 CN1CCN(CC1)c2ncc3cc(c4ccccc4)c(nc3n2)c5ccc(CN6CCC(CC6)c7nnc([nH]7)c8ccc(N)nc8)cc5 5.22 CHEMBL947435 CHEMBL445464 Cc1nnc2c3cc(c4ccccc4)c(nc3ccn12)c5ccc(CN6CCC(CC6)c7n[nH]c(n7)c8ccccn8)cc5 5.56 CHEMBL939830 CHEMBL445674 CS(=O)(=O)c1ccc(c(Cl)c1)c2noc(n2)[C@@H](CCO)[C@H](N)C(=C3CCCC3)F.OC(=O)C(F)(F)F 4.33 CHEMBL933468 CHEMBL445754 CNCc1ccc(Cl)cc1Oc2ccc(Cl)c(F)c2 5.91 CHEMBL962309 CHEMBL445949 CC(C)[C@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)C[C@H](N)Cc3cc(F)ccc3F)cc1)C(=O)O.OC(=O)C(F)(F)F 4.12 CHEMBL1023104 CHEMBL446134 O=C1NCCc2nc(c3ccc(CN4CCC(CC4)c5nnc([nH]5)c6ccccn6)cc3)c(cc12)c7ccccc7 5.6 CHEMBL947435 CHEMBL446514 OC1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 5.52 CHEMBL981950 CHEMBL446966 COc1ccc(cn1)c2nnc([nH]2)C3CCN(Cc4ccc(cc4)c5nc6C=CNC(=O)c6cc5c7ccccc7)CC3 5.91 CHEMBL947435 CHEMBL447183 NC1=NC2(CCN(CC2)C(=O)c3ccc(nc3)C#N)Nc4c(F)ccc(F)c14 7 CHEMBL1763073 CHEMBL447864 CNCc1ccc(Cl)cc1Oc2ccc(C)cc2 5.79 CHEMBL962309 CHEMBL448461 CNCc1cc(F)ccc1Oc2ccc(Cl)c(F)c2 5.33 CHEMBL962309 CHEMBL449048 CNCc1ccc(Cl)cc1Oc2cccc(Cl)c2 5.68 CHEMBL962309 CHEMBL449542 CCc1cc(Oc2cc(Cl)ccc2CNC)ccc1Cl 5.94 CHEMBL962309 CHEMBL450714 CSc1ccc(Oc2ccccc2CN(C)C)cc1 5.52 CHEMBL962309 CHEMBL451076 CNCc1cc(ccc1Oc2ccc(Cl)c(Cl)c2)C#N 5.34 CHEMBL962309 CHEMBL451137 CNCc1ccc(Br)cc1Oc2ccc(Cl)c(Cl)c2 6.01 CHEMBL962309 CHEMBL451330 CNCc1ccc(Cl)cc1Oc2ccc(C)c(Cl)c2 5.98 CHEMBL962309 CHEMBL452091 CNCc1ccc(Cl)cc1Oc2ccc(Cl)c(C)c2 5.75 CHEMBL962309 CHEMBL452823 CN1CCN(CC1)c2ccc3nc(c4ccc(CN5CCC(CC5)c6nnc([nH]6)c7ccccn7)cc4)c(nc3n2)c8ccccc8 5.67 CHEMBL947435 CHEMBL452864 C(S\C(=N/C1CCCCC1)\NC2CCCCC2)C3=CSC4=NCCN34 5.07 CHEMBL958152 CHEMBL453630 CNC(C)c1cc(ccc1Oc2ccc(Cl)c(Cl)c2)C(F)(F)F 5.52 CHEMBL962309 CHEMBL453631 CNC(C)c1cc(C)ccc1Oc2ccc(Cl)c(Cl)c2 5.57 CHEMBL962309 CHEMBL453653 COc1cccc2N=C(N(C)C(=O)c12)c3ccc(OC4CCN(CC4)C5CCC5)cc3 5 CHEMBL1827362 CHEMBL453654 COc1ccc2N=C(N(C)C(=O)c2c1)c3ccc(OC4CCN(CC4)C5CCC5)cc3 5.42 CHEMBL956578 CHEMBL453655 CNC(=O)c1ccc(Nc2ncc(F)c(n2)c3cnc(C)n3C(C)C)cc1 4.92 CHEMBL1022593 CHEMBL453862 CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)C(=O)N(C)C)ncc2F 4.96 CHEMBL1022593 CHEMBL453879 CNCc1ccc(Cl)cc1Oc2ccc(F)c(Cl)c2 5.68 CHEMBL962309 CHEMBL453880 CNCc1ccc(Cl)cc1Oc2ccc(F)c(c2)C(F)(F)F 6.06 CHEMBL962309 CHEMBL453892 COc1cccc2C(=O)N(C)C(=Nc12)c3ccc(OC4CCN(CC4)C5CCC5)cc3 5 CHEMBL1827362 CHEMBL453893 CN1C(=O)c2cccc(Cl)c2N=C1c3ccc(OC4CCN(CC4)C5CCC5)cc3 5.96 CHEMBL956578 CHEMBL453894 CN1C(=O)c2cccc(c2N=C1c3ccc(OC4CCN(CC4)C5CCC5)cc3)C(F)(F)F 6.46 CHEMBL956578 CHEMBL454085 O=C(Nc1ccc(cc1)S(=O)(=O)Nc2ccccc2C(=O)c3ccccc3)OCC4CCCO4 5.09 CHEMBL1021907 CHEMBL454407 CN1[C@@H](C[C@H](CN2CCCCC2)C1=O)C#Cc3ccccc3 5.16 CHEMBL953566 CHEMBL454642 CN1C(=O)c2cccc(F)c2N=C1c3ccc(OC4CCN(CC4)C5CCC5)cc3 5.1 CHEMBL956578 CHEMBL454648 CC(C)n1c(C)ncc1c2nc(Nc3ccc(C(=O)N(C)C)c(F)c3)ncc2F 5.22 CHEMBL1022593 CHEMBL454657 CNCc1cc(F)c(OC)cc1Oc2ccc(Cl)c(Cl)c2 5.67 CHEMBL962309 CHEMBL454879 COc1ccc2C(=O)N(C)C(=Nc2c1)c3ccc(OC4CCN(CC4)C5CCC5)cc3 5.37 CHEMBL956578 CHEMBL455071 CN(C)CCN1CCN(CC1)c2ncc3cc(c4ccccc4)c(nc3n2)c5ccc(CN6CCC(CC6)c7nnc([nH]7)c8cc[n+]([O-])cc8)cc5 5.1 CHEMBL947435 CHEMBL455184 CNCc1ccc(Cl)cc1Oc2ccc(F)c(C)c2 5.52 CHEMBL962309 CHEMBL455423 COc1ccc(CN(C)C)c(Oc2ccc(Cl)c(Cl)c2)c1 6.63 CHEMBL962309 CHEMBL455424 CNCc1cc(ccc1Oc2ccc(Cl)c(Cl)c2)S(=O)(=O)NC 5.32 CHEMBL962309 CHEMBL455425 CNCc1cc(C)c(C)cc1Oc2ccc(Cl)c(Cl)c2 5.83 CHEMBL962309 CHEMBL455426 CNCc1cc(ccc1Oc2ccc(Cl)c(Cl)c2)C(=O)N 5.26 CHEMBL962309 CHEMBL455427 CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(C(=O)N)c(F)c3)n2 5 CHEMBL1022593 CHEMBL455428 CNC(=O)c1ccc(Nc2nccc(n2)c3cnc(C)n3C(C)C)cc1F 4.8 CHEMBL1022593 CHEMBL455429 CC(C)n1c(C)ncc1c2nc(Nc3ccc(C(=O)N)c(F)c3)ncc2F 4.7 CHEMBL1022593 CHEMBL455511 CN(C)Cc1cc(C)ccc1Oc2ccc(Cl)c(Cl)c2 5.47 CHEMBL962309 CHEMBL455651 CNC(=O)c1ccc(Nc2ncc(F)c(n2)c3cnc(C)n3C(C)C)cc1F 4.72 CHEMBL1022593 CHEMBL455675 CNCc1cc(F)c(Cl)cc1Oc2ccc(Cl)c(Cl)c2 5.49 CHEMBL962309 CHEMBL455681 CN1C(=O)c2ccccc2N=C1c3ccc(OC4CCN(CC4)C5CCCC5)cc3 5.54 CHEMBL956578 CHEMBL456019 CCN([C@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C3CCC3)c4ccccc4)C(=O)Cc5ccc(OC)cc5 6.61 CHEMBL1034067 CHEMBL456171 Clc1ccc(cc1)N2C=C(C(=O)Nc3c(Cl)cncc3Cl)C(=O)c4cccnc24 6.7 CHEMBL984535 CHEMBL456172 CC(C)NC(=O)C1=CN(c2cccc(Br)c2)c3ncccc3C1=O 4.5 CHEMBL984535 CHEMBL456173 CC(C)NC(=O)C1=CN(c2ccccc2)c3ncccc3C1=O 4.15 CHEMBL984535 CHEMBL456808 CCOc1cccc(c1)c2cccc(c2)N3C=C(C(=O)NC(C)C)C(=O)c4cccnc34 5.57 CHEMBL984535 CHEMBL457614 CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)ncc2Cl)n[nH]1 5.28 CHEMBL2154697 CHEMBL457930 N#Cc1cc2cc(ccc2[nH]1)C3(Cc4ccccc4)CCNC3 5.85 CHEMBL944378 CHEMBL45816 COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc4cc(F)ccc4[C@@H]1C(C)C 5.48 CHEMBL2344015 CHEMBL458242 COc1cncc(c1)c2cc(NC(=O)C)nc(n2)n3nc(C)cc3C 4.62 CHEMBL950430 CHEMBL458359 CC1=Nc2ccc(Cl)cc2C(=O)N1c3ccc(OC4CCN(CC4)C5CCC5)cc3 5.27 CHEMBL981857 CHEMBL458953 CC1=Nc2cc(Cl)ccc2C(=O)N1c3ccc(OC4CCN(CC4)C5CCC5)cc3 5.41 CHEMBL981857 CHEMBL458954 CC1=Nc2c(Cl)cccc2C(=O)N1c3ccc(OC4CCN(CC4)C5CCC5)cc3 5.48 CHEMBL981857 CHEMBL459176 Cn1ccc2cc(ccc12)C3(Cc4ccccc4)CCNC3 5.16 CHEMBL944378 CHEMBL459357 CN(C)C(=O)[C@H]([C@H](N)C(=O)N1CC[C@H](F)C1)c2ccc(cc2)C3=CN4N=CNC4C=C3 4.07 CHEMBL1023104 CHEMBL459598 CC(C[C@H](NC(=O)C1CCC1)c2ccccc2)N3CCC(CC3)c4oc(CN(C)C)nn4 5.51 CHEMBL1034067 CHEMBL459600 CC(C)c1noc(n1)C2CCN(CC2)C(C)C[C@H](NC(=O)C3CCC3)c4ccccc4 5.78 CHEMBL1034067 CHEMBL46 Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C 6.09 CHEMBL766814 CHEMBL460009 CC(C[C@H](NC(=O)C1CCC1)c2ccccc2)N3CCC(CC3)N4C=C(NC4=O)c5ccccc5 8.33 CHEMBL1034067 CHEMBL460217 CC(C[C@H](NC(=O)C1CCC1)c2ccccc2)N3CCC(CC3)c4[nH]ncc4c5ccncc5 6.93 CHEMBL1034067 CHEMBL460491 CC1(C)CN2C(=CSC2=N1)CS\C(=N/C3CCCCC3)\NC4CCCCC4 4.88 CHEMBL958152 CHEMBL460893 Cc1nn(cc1CN2CCC3(CC2)OCc4ccccc34)c5ccccc5 6.13 CHEMBL953933 CHEMBL461101 CC1=NN(C(=O)/C/1=N\Nc2cccc(c2O)c3cccc(c3)C(=O)O)c4ccc(C)c(C)c4 6.16 CHEMBL3773319 CHEMBL461571 C[C@@H](Oc1cccc(Cn2c(C)c(C(=O)c3ccc(Cl)cc3)c4ccc(OC(F)(F)F)cc24)c1)C(=O)O 5.49 CHEMBL980758 CHEMBL461631 CNC(C)c1ccc(Cl)cc1Oc2ccc(C)cc2 5.43 CHEMBL962309 CHEMBL462225 CNCc1cc(Cl)ccc1Oc2ccc(C)c(C)c2 5.28 CHEMBL962309 CHEMBL462226 CNCc1cc(Cl)ccc1Oc2ccc(Cl)cc2 5.32 CHEMBL962309 CHEMBL462387 CNCc1ccc(Cl)cc1Oc2ccc(Cl)cc2 6.19 CHEMBL962309 CHEMBL463585 CCCCC1(CCNC1)c2ccc3[nH]ccc3c2 5.36 CHEMBL944378 CHEMBL464600 CC(C)CNC(=O)C1=CN(c2cccc(Br)c2)c3ncccc3C1=O 4.5 CHEMBL984535 CHEMBL464804 CC(C)NC(=O)C1=CN(c2cccc(c2)c3cccc(c3)C(=O)C)c4ncccc4C1=O 5.16 CHEMBL984535 CHEMBL46516 Fc1ccc(cc1)C(CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4)c5ccc(F)cc5 5.64 CHEMBL827807 CHEMBL465417 O=C1[C@@H]2CCN1[C@@H]3CCOc4ccc(Oc5cc(Cn6cncc6CN2)ccc5C#N)cc34 5.04 CHEMBL1027667 CHEMBL465956 C[C@@H]1CN(CC2(CCC2)C(=O)N)CCN1S(=O)(=O)c3ccc(cc3)C(C)(O)C(F)(F)F 4.19 CHEMBL1018632 CHEMBL466112 CCN1CCN(CC1)c2cc3[nH]c(nc3cc2C)C(=O)[C@@]4(C)CC[C@@H](CC4)NC(=O)OC 5.52 CHEMBL1014963 CHEMBL466222 CCOC(=O)N1CCC(C)(CC1)Sc2nc3cc(Cl)c(cc3[nH]2)N4CCN(CC)CC4 5.41 CHEMBL972465 CHEMBL466252 CCN1CCN(CC1)c2cc3[nH]c(S[C@@]4(C)CC[C@@H](CC4)c5onc(C)n5)nc3cc2Cl 6.42 CHEMBL972465 CHEMBL466307 CCN1CCN(CC1)c2cc3[nH]c(nc3cc2Cl)C(=O)C4(C)CCC(=O)CC4 5.07 CHEMBL1014963 CHEMBL466308 CCN1CCN(CC1)c2cc3[nH]c(nc3cc2Cl)C(=O)[C@@]4(C)CC[C@](C)(O)CC4 4.7 CHEMBL1014963 CHEMBL466448 CCN1CCN(CC1)c2cc3[nH]c(S[C@@]4(C)CC[C@@H](CC4)c5nnn(C)n5)nc3cc2Cl 5.36 CHEMBL972465 CHEMBL466648 Cc1ncc(cc1F)c2c(C)c(CN[C@H]3CC[C@@H](F)C3)nn2c4ncccc4Cl 4.39 CHEMBL1007470 CHEMBL466702 CCN1CCN(CC1)c2cc3[nH]c(nc3cc2Cl)C(=O)[C@@]4(C)CC[C@@H](CC4)NC(=O)OC 5.31 CHEMBL1014963 CHEMBL467279 CCN1CCN(CC1)c2cc3[nH]c(S[C@@]4(C)CC[C@@H](CC4)c5ocnn5)nc3cc2Cl 5.47 CHEMBL972465 CHEMBL467473 CCN1CCN(CC1)c2cc3[nH]c(SC4(C)CCC(C4)NC(=O)OC)nc3cc2Cl 5.7 CHEMBL972465 CHEMBL467533 CCN1CCN(CC1)c2cc3[nH]c(nc3cc2Cl)C(=O)[C@@]4(CC)CC[C@](C)(O)CC4 4.96 CHEMBL1014963 CHEMBL468176 Fc1ccc(c(Cl)c1)c2noc(n2)C3CCN(CC3)c4cnc5ccc(Cl)cc5c4 6.3 CHEMBL976349 CHEMBL468301 CCN1CCN(CC1)c2cc3[nH]c(S[C@@]4(C)CC[C@H](CC4)NC(=O)OC)nc3cc2Cl 5.82 CHEMBL972465 CHEMBL468302 CCN1CCN(CC1)c2cc3[nH]c(S[C@@]4(C)CC[C@@H](CC4)NC(=O)OC)nc3cc2Cl 5.46 CHEMBL972465 CHEMBL468307 Cc1ccc(cn1)c2c(C)c(CNC3CCCC3)nn2c4ncc(Cl)cc4Cl 5.92 CHEMBL1007470 CHEMBL468308 Cc1ccc(cn1)c2c(C)c(CN[C@H]3CC[C@@H](F)C3)nn2c4ncccc4Cl 4.54 CHEMBL1007470 CHEMBL468397 COC(=O)C(CCCN(C)CCCc1nc2ccccc2[nH]1)(C(C)C)c3ccc(Br)cc3 6.75 CHEMBL978140 CHEMBL468504 CCN1CCN([C@H](C)C1)c2cc3[nH]c(SC(C)(C)C)nc3cc2Cl 6 CHEMBL972465 CHEMBL468518 Cc1ccc(cn1)c2c(C)c(CNC3CCC(F)(F)C3)nn2c4ncccc4Cl 4.68 CHEMBL1007470 CHEMBL468937 Cc1c(CNC2CCCC2)nn(c3ccc(Cl)cc3Cl)c1c4cccnc4 5.54 CHEMBL1007470 CHEMBL469542 CC(C[C@H](NC(=O)C1CCC1)c2ccccc2)N3CCC(CC3)n4c(C)nnc4C 6.07 CHEMBL1034067 CHEMBL469724 CC(C)c1nnc(C)n1C2CCN(CC2)C(C)C[C@H](NC(=O)C3CCC3)c4ccccc4 5.4 CHEMBL1034067 CHEMBL470633 COc1cc(ccc1OCCN2CCCC2)N3C=CN=C(NCCc4ccccc4)C3=O 5.21 CHEMBL993708 CHEMBL470753 C(Cc1ccc(Oc2nc3ccccc3s2)cc1)N4CCCCC4 5.7 CHEMBL981950 CHEMBL470840 COc1cc(ccc1OCCN2CCCC2)N3C=CN=C(CCCc4ccccc4)C3=O 5.14 CHEMBL993708 CHEMBL470929 O=C1CCCCN1C2CCN(CCOc3ccc(Oc4nc5ccccc5s4)cc3)CC2 5.75 CHEMBL981950 CHEMBL470951 Cc1cccnc1n2cc(CN3CCC4(CC3)OCc5ccccc45)c(C)n2 4.89 CHEMBL953933 CHEMBL471299 Cc1nn(cc1CN2CCC3(CC2)OCc4ccccc34)c5c(Cl)cccc5NS(=O)(=O)C 4.77 CHEMBL953933 CHEMBL471623 Cc1cccc(C)c1C(=O)N2CCC(CC2)N3CC[C@H](C3)N(Cc4ccccc4)C(=O)C5CC5 5.01 CHEMBL1026571 CHEMBL471757 CC(C)(C)CNc1nc(nc(N2CCOCC2)c1N)C#N 4.16 CHEMBL1021997 CHEMBL471994 Cc1ccccc1C2CCN(C[C@H]3CCc4cccnc4[C@@H](O)C3)CC2 6.51 CHEMBL948532 CHEMBL472 COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3 4.13 CHEMBL749472 CHEMBL472125 Cc1ccccc1[C@@H]2CCN(C[C@@H]3CCc4cccnc4[C@@H](O)C3)C[C@H]2CO 4.7 CHEMBL948532 CHEMBL472138 O=C1OCCN1C2CCN(CCOc3ccc(Oc4nc5ccccc5s4)cc3)CC2 5.57 CHEMBL981950 CHEMBL472168 Cc1ccccc1C2CCN(C[C@@H]3CCc4cccnc4[C@@H](O)C3)CC2 5.57 CHEMBL948532 CHEMBL472260 Cc1cccc(C)c1C(=O)N2CCC(CC2)N3CCC(CC3)N(Cc4ccccc4)C(=O)C5CCC5 5.47 CHEMBL1026571 CHEMBL472304 Cc1cc(F)ccc1[C@@H]2CCN(C[C@@H]3CCc4cccnc4[C@@H](O)C3)C[C@H]2O 4.89 CHEMBL948532 CHEMBL472363 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC3)NC(=O)COc4cccc(Cl)c4)c2 6.25 CHEMBL973619 CHEMBL472388 CNCc1cc(ccc1Oc2ccc(C)cc2)C(F)(F)F 4.98 CHEMBL962309 CHEMBL473 CN(CCOc1ccc(NS(=O)(=O)C)cc1)CCc2ccc(NS(=O)(=O)C)cc2 4.36 CHEMBL684971 CHEMBL473271 Nc1ccc(cc1NC(=O)c2ccc(CN3CCC4(CCCN4)CC3)cc2)c5ccccc5F 6.74 CHEMBL1027290 CHEMBL473475 Nc1ccc(cc1NC(=O)c2ccc(CN3CCC4(CCCN4)CC3)cc2)c5cccc(F)c5 6.78 CHEMBL1027290 CHEMBL473478 Nc1ccc(cc1NC(=O)c2ccc(CN3CCC4(CCNC4)CC3)cc2)c5ccc(F)cc5 6.63 CHEMBL1027290 CHEMBL473479 Nc1ccc(cc1NC(=O)c2ccc(cc2)C(=O)N3CCC4(CCCN4)CC3)c5cccs5 4.6 CHEMBL1027290 CHEMBL473484 Nc1ccc(cc1NC(=O)c2ccc(cc2)C(=O)N3CCC4(CCCN4)CC3)c5ccccc5 4.91 CHEMBL1027290 CHEMBL473485 Nc1ccc(cc1N)c2ccsc2 5.82 CHEMBL1027290 CHEMBL474421 F[C@@H]1CN(C[C@@H]1F)C(=O)[C@@H]2C[C@@H](CN2)N3CCN(CC3)c4ncccn4 4.27 CHEMBL1022018 CHEMBL474484 CC(C)CNc1nc(nc(N2CCNCC2)c1N)C#N 4.28 CHEMBL1021997 CHEMBL474890 Nc1ccc(cc1NC(=O)c2ccc(CN3CCC4(CCCN4)CC3)cc2)c5cccs5 5.8 CHEMBL1027290 CHEMBL475121 CNCc1ccc(Cl)cc1Oc2ccc(C)c(C)c2 5.76 CHEMBL962309 CHEMBL475534 CCOC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OC)C 5 CHEMBL766814 CHEMBL476106 CC1=Nc2cc(F)ccc2C(=O)N1c3ccc(OCCCN4CCCC4)cc3 5.22 CHEMBL986351 CHEMBL476116 CC(C)C(=O)N(Cc1ccccc1c2ccccc2)[C@H]3CCNC3 5.52 CHEMBL1062483 CHEMBL476130 CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(nc1OCC4CCNCC4)C#N 5.63 CHEMBL988836 CHEMBL476322 CC1=Nc2c(cccc2C(F)(F)F)C(=O)N1c3ccc(OCCCN4CCCC4)cc3 6.46 CHEMBL986351 CHEMBL476323 CC1=Nc2cccc(c2C(=O)N1c3ccc(OCCCN4CCCC4)cc3)C(F)(F)F 5 CHEMBL1827362 CHEMBL476373 CC1=Nc2ccccc2C(=O)N1c3ccc(OCCCN4CCCC4)cc3 5 CHEMBL1827362 CHEMBL476579 CC1=Nc2ccccc2C(=O)N1c3ccc(OCCCN4CCCCCC4)cc3 5.18 CHEMBL986351 CHEMBL476723 CCC1=Nc2ccccc2C(=O)N1c3ccc(OCCCN4CCCC4)cc3 5.3 CHEMBL986351 CHEMBL476954 CC(C)C(=O)N(Cc1cccc(Cl)c1Cl)[C@H]2CCNC2 4.61 CHEMBL979037 CHEMBL476993 CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)N4CCN(CC4)C(=O)CO)ncc2F 4.75 CHEMBL984727 CHEMBL477015 CS(=O)(=O)Nc1ccc2OC3(CCN(CC3)[C@@H]4CCc5cc(ccc5C4)C#N)C[C@@H](O)c2c1 6.17 CHEMBL1105740 CHEMBL477152 COc1cccc2C(=O)N(C(=Nc12)C)c3ccc(OCCCN4CCCC4)cc3 5 CHEMBL1827362 CHEMBL477201 COc1ccc2C(=O)N(C(=Nc2c1)C)c3ccc(OCCCN4CCCC4)cc3 5 CHEMBL1827362 CHEMBL477356 CC1=Nc2cccc(F)c2C(=O)N1c3ccc(OCCCN4CCCC4)cc3 5 CHEMBL1827362 CHEMBL477360 C[C@H]1CCCN1CCCOc2ccc(cc2)N3C(=Nc4ccccc4C3=O)C 5.22 CHEMBL986351 CHEMBL477363 CC1=Nc2cccc(Cl)c2C(=O)N1c3ccc(OCCCN4CCCC4)cc3 5.09 CHEMBL986351 CHEMBL477364 CC1=Nc2cc(ccc2C(=O)N1c3ccc(OCCCN4CCCC4)cc3)C(F)(F)F 5.59 CHEMBL986351 CHEMBL477567 CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)N4CCN(CC4)S(=O)(=O)C)n2 5.26 CHEMBL984727 CHEMBL477785 CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)N4CCN(CC4)S(=O)(=O)CCN(C)C)n2 4.75 CHEMBL984727 CHEMBL477990 COc1cccc2N=C(C)N(C(=O)c12)c3ccc(OCCCN4CCCC4)cc3 5 CHEMBL1827362 CHEMBL477991 COc1ccc2N=C(C)N(C(=O)c2c1)c3ccc(OCCCN4CCCC4)cc3 5 CHEMBL1827362 CHEMBL478011 CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(nc1OCCC4CCN(C)CC4)C#N 6.38 CHEMBL988836 CHEMBL478012 CNC(=O)c1c(NCCC2CCCC2)nc(nc1OCC3CCN(C)CC3)C#N 6.44 CHEMBL988836 CHEMBL478013 CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(nc1OCC4CCN(CC4)C(C)C)C#N 6.27 CHEMBL988836 CHEMBL478224 CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(nc1OC4CC(C)(C)NC(C)(C)C4)C#N 5.3 CHEMBL988836 CHEMBL478395 C[C@H]1CCCN(CCCOc2ccc(cc2)N3C(=Nc4ccccc4C3=O)C)C1 5.28 CHEMBL986351 CHEMBL478406 CC1=Nc2ccc(C)cc2C(=O)N1c3ccc(OCCCN4CCCC4)cc3 5 CHEMBL1827362 CHEMBL478462 CNC(=O)c1c(NCC2CCC3(CCCC3)CC2)nc(nc1OCC4CCN(C)CC4)C#N 5.84 CHEMBL988836 CHEMBL478615 CC1=Nc2cc(C)ccc2C(=O)N1c3ccc(OCCCN4CCCC4)cc3 5.17 CHEMBL986351 CHEMBL478616 CC1=Nc2c(C)cccc2C(=O)N1c3ccc(OCCCN4CCCC4)cc3 5.8 CHEMBL986351 CHEMBL478834 CCOC(=O)N(Cc1ccccc1c2ccccc2)[C@H]3CCNC3 5.3 CHEMBL1062483 CHEMBL479 CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1 5.8 CHEMBL1909190 CHEMBL479036 CC(C)C1=Nc2ccccc2C(=O)N1c3ccc(OCCCN4CCCC4)cc3 5.41 CHEMBL986351 CHEMBL479241 O=C1N(C(=Nc2ccccc12)c3ccccc3)c4ccc(OCCCN5CCCC5)cc4 5.96 CHEMBL986351 CHEMBL479242 CC1=Nc2cccc(C)c2C(=O)N1c3ccc(OCCCN4CCCC4)cc3 5.18 CHEMBL986351 CHEMBL479252 CC1=Nc2ccc(F)cc2C(=O)N1c3ccc(OCCCN4CCCC4)cc3 5.6 CHEMBL986351 CHEMBL479382 CC(=O)OCC(=O)NC1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1 4.52 CHEMBL981950 CHEMBL479383 OCC(=O)NC1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1 5 CHEMBL2210904 CHEMBL479796 CN(C1CCN(C)CC1)C(=O)N2CC(=C[C@@]2(CO)c3ccccc3)c4cc(F)ccc4F 4.84 CHEMBL1020033 CHEMBL480130 O=C1CCCN1C2CCN(Cc3ccc(Oc4nc5ccccc5s4)cc3)CC2 4.82 CHEMBL981950 CHEMBL480131 CC(=O)NC1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1 4.7 CHEMBL981950 CHEMBL48029 C(Cc1ccc(OCc2ccccc2)cc1)Nc3ccncc3 6.89 CHEMBL856827 CHEMBL481008 CCOc1cc2ncc(C(=O)N)c(Nc3cccc(Cl)c3Cl)c2cc1N4CCN(C)CC4 5.1 CHEMBL2411831 CHEMBL481717 CCOc1cc2ncc(C(=O)N)c(Nc3ccc(F)cc3F)c2cc1N4CCC(O)CC4 4.77 CHEMBL2411831 CHEMBL481806 CCOc1cc2ncc(C(=O)N)c(Nc3ccc(F)cc3F)c2cc1N4CCN(C)CC4 4.64 CHEMBL2411831 CHEMBL481863 C(CN1CCCCC1)Oc2ccc(Oc3oc4ccccc4n3)cc2 6 CHEMBL981950 CHEMBL481920 CN(C1CCN(CCF)CC1)C(=O)N2CC(=C[C@@]2(CO)c3ccccc3)c4cc(F)ccc4F 4.86 CHEMBL1020033 CHEMBL481921 CN(C1CCN(CC1)C2CC2)C(=O)N3CC(=C[C@@]3(CO)c4ccccc4)c5cc(F)ccc5F 4.82 CHEMBL1020033 CHEMBL481931 CN([C@H]1CCN(C)C[C@H]1F)C(=O)N2CC(=C[C@@]2(CO)c3ccccc3)c4cc(F)ccc4F 4.69 CHEMBL1020033 CHEMBL481932 CN([C@H]1CCN(C)C[C@@H]1F)C(=O)N2CC(=C[C@@]2(CO)c3ccccc3)c4cc(F)ccc4F 4.43 CHEMBL1020033 CHEMBL481959 CN(C1CCN(C)CC1)C(=O)N2CC(=C[C@H]2c3ccccc3)c4cc(F)ccc4F 5.92 CHEMBL1020033 CHEMBL482056 O=C1OCCN1C2CCN(CCc3ccc(Oc4nc5ccccc5s4)cc3)CC2 6.3 CHEMBL981950 CHEMBL482057 CC(=O)OCC(=O)NC1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 5.3 CHEMBL981950 CHEMBL482058 O=C1CCCN1C2CCN(CCc3ccc(Oc4nc5ccccc5s4)cc3)CC2 6 CHEMBL981950 CHEMBL483805 Cc1ncccc1C(=O)N2CC[C@H](NCc3cncn3Cc4ccc(cc4)C#N)C2=O 5 CHEMBL1027667 CHEMBL483810 Sc1ncccc1C(=O)N2CC[C@H](NCc3cncn3Cc4ccc(cc4)C#N)C2=O 4.96 CHEMBL1027667 CHEMBL483964 Clc1cccc(c1)C(=O)N2CC[C@H](NCc3cncn3Cc4ccc(cc4)C#N)C2=O 5.24 CHEMBL1027667 CHEMBL484528 Cc1cc2ncc(C(=O)N3CCC(CC3)[C@H](N)Cc4cc(F)c(F)cc4F)c(C)n2n1 4.75 CHEMBL975252 CHEMBL484740 CC1=Nc2ccccc2C(=O)N1c3ccc(OC4CCC(C4)N5CCCC5)cc3 5 CHEMBL981857 CHEMBL484753 CC(C)NC(=O)C1=CN(c2cccc(c2)c3ccc(cc3)S(=O)(=O)C)c4ncccc4C1=O 4.64 CHEMBL984535 CHEMBL484754 O=C(NC1CC1)C2=CN(c3cccc(c3)c4ccncc4)c5ncccc5C2=O 4.73 CHEMBL984535 CHEMBL484816 Nc1ncccc1C(=O)N2CC[C@H](NCc3cncn3Cc4ccc(cc4)C#N)C2=O 4.3 CHEMBL1027667 CHEMBL484931 CS(=O)(=O)c1ccc(cn1)c2cccc(c2)N3C=C(C(=O)NC4CC4)C(=O)c5cccnc35 4.87 CHEMBL984535 CHEMBL485123 Cc1ncc(C)c(n1)C(=O)N2CCC(CC2)[C@H](N)Cc3cc(F)c(F)cc3F 4.07 CHEMBL975252 CHEMBL485124 Cc1nccnc1C(=O)N2CCC(CC2)[C@H](N)Cc3cc(F)c(F)cc3F 4.26 CHEMBL975252 CHEMBL485125 N[C@H](Cc1cc(F)c(F)cc1F)C2CCN(CC2)C(=O)c3cnc4ncccn34 4.23 CHEMBL975252 CHEMBL485161 Oc1ncccc1C(=O)N2CC[C@H](NCc3cncn3Cc4ccc(cc4)C#N)C2=O 4.3 CHEMBL1027667 CHEMBL485162 COc1ncccc1C(=O)N2CC[C@H](NCc3cncn3Cc4ccc(cc4)C#N)C2=O 4.68 CHEMBL1027667 CHEMBL485242 CC1=Nc2ccccc2C(=O)N1c3ccc(OC4CCCN(CC4)C5CCC5)cc3 5.14 CHEMBL981857 CHEMBL485547 CSc1ccc(cc1)c2cccc(c2)N3C=C(C(=O)NC(C)C)C(=O)c4cccnc34 6.02 CHEMBL984535 CHEMBL485620 CC(C)(O)c1ccc(c[n+]1[O-])c2cccc(c2)N3C=C(C(=O)NC4CC4)C(=O)c5cccnc35 4.3 CHEMBL984535 CHEMBL485629 [O-][n+]1cccc(c1)C#Cc2cccc(c2)N3C=C(C(=O)NC4CC4)C(=O)c5cccnc35 4.18 CHEMBL984535 CHEMBL486162 CN1CCN(CC1)c2cccc(n2)c3cc(NC(=O)C)nc(n3)n4nc(C)cc4C 6.27 CHEMBL950430 CHEMBL486247 CC(C)(C)CCN1CCC(F)(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 5.65 CHEMBL952419 CHEMBL486278 COc1ccc(CC(C)(C)NC[C@H](O)COc2cccc3NC(=O)Nc23)cc1 4.93 CHEMBL939877 CHEMBL486537 C(c1ccccc1)C2(CCNC2)c3ccc4sccc4c3 4.96 CHEMBL944378 CHEMBL486644 O[C@H]1C[C@H](CN2CCC(CC2)c3c(Cl)cccc3Cl)CCc4cccnc14 6.03 CHEMBL948532 CHEMBL487053 CC(N(C)C)c1ccccc1Oc2ccc(Cl)c(Cl)c2 6.05 CHEMBL962309 CHEMBL487059 O=C1N(Cc2ccccc2)C(=Nc3ccccc13)c4ccc(OCCCN5CCCCC5)cc4 6.77 CHEMBL956578 CHEMBL487060 O=C1N(C(=Nc2ccccc12)c3ccc(OCCCN4CCCCC4)cc3)c5ccccc5 6.34 CHEMBL956578 CHEMBL487063 CC1=Nc2ccccc2C(=O)N1c3ccc(OCCCN4CCCCC4)cc3 5.07 CHEMBL986351 CHEMBL487064 CN1C(=O)c2ccccc2N=C1c3ccc(OCCCN4CCCCC4)cc3 5.55 CHEMBL956578 CHEMBL487066 CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)C(=O)NC4CC4)n2 5.16 CHEMBL1022593 CHEMBL487188 CNCc1cc(OC)c(OC)cc1Oc2ccc(Cl)c(Cl)c2 5 CHEMBL962309 CHEMBL487221 CNC(C)c1ccccc1Oc2ccc(Cl)c(Cl)c2 5.42 CHEMBL962309 CHEMBL487223 CNCc1ccc(F)cc1Oc2ccc(Cl)c(Cl)c2 5.52 CHEMBL962309 CHEMBL487230 CCCN1C(=O)c2ccccc2N=C1c3ccc(OCCCN4CCCCC4)cc3 5.75 CHEMBL956578 CHEMBL487355 C(c1ccccc1)C2(CCNC2)c3ccc4[nH]ccc4c3 5.05 CHEMBL944378 CHEMBL487445 O=C(NCCCN1CCCCC1)Nc2ccc(cc2)S(=O)(=O)Nc3ccccc3C(=O)c4ccccc4 6 CHEMBL1021907 CHEMBL487485 O[C@H]1C[C@H](CN2CCC(CC2)c3ccccc3Cl)CCc4cccnc14 5.82 CHEMBL948532 CHEMBL487500 FC(F)(F)c1ccc(cc1)[C@@H]2C[C@H]2C(=O)N3CCN(CC3)S(=O)(=O)c4cc(cc(c4)C(F)(F)F)c5nocn5 5.92 CHEMBL1011901 CHEMBL487708 FC(F)(F)c1ccc(cc1)[C@@H]2C[C@H]2C(=O)N3CCN(CC3)S(=O)(=O)c4cc(cc(c4)C(F)(F)F)c5ccn[nH]5 6.3 CHEMBL1011901 CHEMBL487763 CNCCC(c1ccccc1)c2c[nH]c3ccccc23 6 CHEMBL944378 CHEMBL487826 Cc1ccccc1N2CCN(C[C@@H]3CCc4cccnc4[C@@H](O)C3)CC2 5.64 CHEMBL948532 CHEMBL487827 O[C@H]1C[C@H](CN2CCC(CC2)c3ccccc3)CCc4cccnc14 4.96 CHEMBL948532 CHEMBL487912 Cc1n[nH]cc1c2cc(cc(c2)S(=O)(=O)N3CCN(CC3)C(=O)[C@@H]4C[C@H]4c5ccc(cc5)C(F)(F)F)C(F)(F)F 7.4 CHEMBL1011901 CHEMBL488021 CNCc1cc(F)ccc1Oc2ccc(C)c(C)c2 4.7 CHEMBL962309 CHEMBL488060 CNCc1cc(F)ccc1Oc2ccc(Cl)c(Cl)c2 5.25 CHEMBL962309 CHEMBL488069 CN(C)Cc1ccc(cc1Oc2ccc(Cl)c(Cl)c2)C(F)(F)F 5.95 CHEMBL962309 CHEMBL488084 CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)C(=O)N)n2 4.77 CHEMBL1022593 CHEMBL488085 CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)C(=O)N(C)C)n2 4.75 CHEMBL1022593 CHEMBL488248 CN1C(=O)c2ccccc2N=C1c3ccc(OCCCN4CCCC4)cc3 5.54 CHEMBL956578 CHEMBL488249 CN1C(=O)c2ccccc2N=C1c3ccc(OC4CCN(CC4)C5CCC5)cc3 5.25 CHEMBL956578 CHEMBL488251 CC(C)N1C(=O)c2ccccc2N=C1c3ccc(OCCCN4CCCCC4)cc3 5.52 CHEMBL956578 CHEMBL488260 CNCc1ccc(cc1Oc2ccc(Cl)c(Cl)c2)C(F)(F)F 5.92 CHEMBL962309 CHEMBL488261 CNCc1ccc(Cl)cc1Oc2ccc(Cl)c(Cl)c2 5.91 CHEMBL962309 CHEMBL488294 CC(C)(C)CCN1CCC(CNC(=O)Nc2cccc(Cl)c2)(CC1)c3ccccc3 7.06 CHEMBL952419 CHEMBL488295 Cc1ccc(CN2CCC(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)cc1 6.87 CHEMBL952419 CHEMBL488434 CNCc1cc(F)ccc1Oc2ccc(Cl)cc2 5.13 CHEMBL962309 CHEMBL488435 CNCc1cc(Br)ccc1Oc2ccc(Cl)c(Cl)c2 5.79 CHEMBL962309 CHEMBL488436 CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)S(=O)(=O)C)n2 5.5 CHEMBL1022593 CHEMBL488437 CNC(C)c1cc(F)ccc1Oc2ccc(Cl)c(Cl)c2 5.17 CHEMBL962309 CHEMBL488468 CC(C)(C)CCN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 5.71 CHEMBL952419 CHEMBL488653 CC1(C)C[C@H](CN2CCC(F)(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)CCO1 5.3 CHEMBL952419 CHEMBL488730 Cc1nnc([nH]1)c2cc(cc(c2)S(=O)(=O)N3CCN(CC3)C(=O)[C@@H]4C[C@H]4c5ccc(cc5)C(F)(F)F)C(F)(F)F 5.89 CHEMBL1011901 CHEMBL488817 CC1(C)C[C@@H](CN2CCC(F)(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)CCO1 5.42 CHEMBL1033089 CHEMBL488912 CNCc1ccccc1Oc2ccc(Cl)c(Cl)c2 5.41 CHEMBL962309 CHEMBL489095 C[C@H]1CN(Cc2ccc(CC(=O)N3CCC(CC3)Nc4cccc(F)c4)cc2)CCN1 4.8 CHEMBL1008907 CHEMBL489324 Cl.CC(C)c1nnc(C)n1C2CCN(CC2)C(C)C[C@H](NC(=O)C3CCC(F)(F)CC3)c4ccccc4 5.68 CHEMBL1019465 CHEMBL49 O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4ncccn4 5.4 CHEMBL1676103 CHEMBL490 Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3 4.98 CHEMBL1909190 CHEMBL490026 OCCc1cc(cc(c1)S(=O)(=O)N2CCN(CC2)C(=O)[C@@H]3C[C@H]3c4ccc(cc4)C(F)(F)F)C(F)(F)F 6.05 CHEMBL1011901 CHEMBL490027 CC(C)(O)c1cc(cc(c1)S(=O)(=O)N2CCN(CC2)C(=O)[C@@H]3C[C@H]3c4ccc(cc4)C(F)(F)F)C(F)(F)F 5.92 CHEMBL1011901 CHEMBL490902 COc1ccnc(c1)C2=N[C@@]([C@H](C)N2)(c3ccc(F)cc3)c4ccc(F)nc4 5.2 CHEMBL1021966 CHEMBL490903 Cl.C[C@@H]1NC(=N[C@@]1(c2ccc(F)cc2)c3ccc(F)nc3)c4cc(Cl)ccn4 5.11 CHEMBL1021966 CHEMBL490937 Fc1ccc(cc1)C2(CNC(=N2)c3cnccn3)c4ccc(F)cc4 5.47 CHEMBL1021966 CHEMBL490949 CCC[C@@H]1NC(=NC1(c2ccc(F)cc2)c3ccc(F)cc3)c4cc(ccn4)C#N 6.31 CHEMBL1021966 CHEMBL491679 Cl.CC(C)c1nnc(C)n1C2CCN(CC2)C(C)C[C@H](NC(=O)C3CC(F)(F)C3)c4ccccc4 5.64 CHEMBL1019465 CHEMBL492396 Cc1c(CNC2CCCC2)nn(c1c3cccnc3)c4ncccc4Cl 4.64 CHEMBL1007470 CHEMBL492438 CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(Cl)c(Cl)c2)cc1 6.14 CHEMBL1027247 CHEMBL492447 C1CC2(CCN1)Oc3ccccc3C(=C2)c4ccccc4 6.17 CHEMBL989030 CHEMBL492448 Cc1ccc(cc1)C2=CC3(CCNCC3)Oc4ccccc24 6.34 CHEMBL989030 CHEMBL492449 FC(F)(F)c1ccc(cc1)C2=CC3(CCNCC3)Oc4ccccc24 6.42 CHEMBL989030 CHEMBL492585 Cc1c(CNC2CCCC2)nn(c1c3ccc(Cl)nc3)c4ncccc4Cl 5.57 CHEMBL1007470 CHEMBL492620 CCN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc2ccc(NS(=O)(=O)C)cc2 6.77 CHEMBL1027247 CHEMBL492846 CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(Cl)cc2)cc1 5.86 CHEMBL1027247 CHEMBL493053 CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(Cl)c(F)c2)cc1 5.72 CHEMBL1027247 CHEMBL493060 CC(C)(C)CCN1CCC(CNC(=O)C2(CCCCC2)c3ccc(F)cc3)CC1 5.44 CHEMBL1033089 CHEMBL493061 CC(C)(C)C(=O)CN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 5.69 CHEMBL1033089 CHEMBL493078 CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc3ccc(F)c(F)c3F)cc1 5.77 CHEMBL1027247 CHEMBL493087 CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc3ccccc3)cc1 6.37 CHEMBL1027247 CHEMBL493454 CCN(CC)C(=O)c1ccccc1C2=CC3(CCNCC3)Oc4ccccc24 5.19 CHEMBL989030 CHEMBL493677 CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1 5.39 CHEMBL1033089 CHEMBL493678 CC(C)(C)CCN1CCC(CNC(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)CC1 5.75 CHEMBL1033089 CHEMBL493679 CC(C)(C)CCN1CCC(CNC(=O)c2ccc(Cl)c(Cl)c2)CC1 5.98 CHEMBL1033089 CHEMBL493680 CC(C)(C)CCN1CCC(CNC(=O)c2cccc(Cl)c2)CC1 5.32 CHEMBL1033089 CHEMBL493712 CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc3cccc(O)c3)cc1 6.11 CHEMBL1027247 CHEMBL494061 Cc1ccc(CCNC[C@H](O)COc2ccc(NS(=O)(=O)C)cc2)cc1C 5.62 CHEMBL1027247 CHEMBL494105 CC(C)CN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc2ccc(NS(=O)(=O)C)cc2 6.14 CHEMBL1027247 CHEMBL494230 CC(C)NCc1nn(c(c1C)c2ccc(Cl)cc2)c3ccc(Cl)cc3Cl 7.64 CHEMBL1007470 CHEMBL494265 COC(=O)c1ccc(cc1)C2=CC3(CCNCC3)Oc4ccccc24 6.18 CHEMBL989030 CHEMBL494274 CCN(CC)C(=O)c1ccc(cc1)C2=CC3(CCN(CC3)C(=O)C)Oc4ccccc24 4.32 CHEMBL989030 CHEMBL494275 CCN(CC)C(=O)c1ccc(cc1)C2=CC3(CCN(C)CC3)Oc4ccccc24 6.12 CHEMBL989030 CHEMBL494350 C[C@@H]1CN(CCO)CCN1c2cc3[nH]c(SC(C)(C)C)nc3cc2Cl 5.8 CHEMBL972465 CHEMBL494406 Cc1cncc(c1)c2c(C)c(CNC3CCCC3)nn2c4ncccc4Cl 5.05 CHEMBL1007470 CHEMBL494462 CCN(CC)C(=O)c1ccc(cc1)C2=CC3(CCNCC3)Oc4ccccc24 5.1 CHEMBL989030 CHEMBL494472 CCN(CC)C(=O)c1ccc(cc1)C2=CC3(CCN(CC)CC3)Oc4ccccc24 5.74 CHEMBL989030 CHEMBL494478 CC(CC(C)(C)C)N1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 5.66 CHEMBL1033089 CHEMBL494479 CCN(CC)C(=O)c1ccc(cc1)C2=CC3(CCNCC3)Oc4ccc(O)cc24 4.7 CHEMBL989030 CHEMBL494480 CCN(CC)C(=O)c1ccc(cc1)C2=CC3(CCNCC3)Oc4cccc(O)c24 4.11 CHEMBL989030 CHEMBL494504 CCCCN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc2ccc(NS(=O)(=O)C)cc2 7.16 CHEMBL1027247 CHEMBL494767 Cc1ccc(cn1)c2c(C)c(CNC3CCCC3)nn2c4ncccc4Cl 4.8 CHEMBL1007470 CHEMBL495073 COc1ccc(cc1)C2=CC3(CCNCC3)Oc4ccccc24 6.23 CHEMBL989030 CHEMBL495074 Oc1ccc(cc1)C2=CC3(CCNCC3)Oc4ccccc24 6.19 CHEMBL989030 CHEMBL495094 CCN(CC)C(=O)c1ccc(cc1)C2=CC3(CCNCC3)Oc4cc(O)ccc24 4.22 CHEMBL989030 CHEMBL495095 CC(Oc1ccccc1CC=C)C2=NCCN2 4.77 CHEMBL2091208 CHEMBL495114 CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc3ccccc3F)cc1 5.92 CHEMBL1027247 CHEMBL495302 CC(C)(C)C(O)CN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 5.32 CHEMBL1033089 CHEMBL495303 CC(C)(C)C(F)CN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 5.33 CHEMBL1033089 CHEMBL495328 CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc3ccccc3O)cc1 6.08 CHEMBL1027247 CHEMBL495702 Nc1ccc(cc1N)c2cccs2 5.8 CHEMBL1027290 CHEMBL496065 CN1Cc2cncn2Cc3ccc(C#N)c(Oc4ccc5CC[C@@H](N6CC[C@@H]1C6=O)c5c4)c3 5.59 CHEMBL1027667 CHEMBL496555 CN1CCN(CC1)c2ncnc3c2nc(c4ccccc4Cl)n3c5ccc(Cl)cc5 6.2 CHEMBL1016403 CHEMBL496770 Clc1ccc(cc1)n2c(nc3c(NN4CCCCC4)ncnc23)c5ccc(Cl)cc5Cl 5.57 CHEMBL1016403 CHEMBL496879 O=C1[C@H]2CCN1c3cccc4ccc(Oc5cc(Cn6cncc6CN2)ccc5C#N)cc34 5.08 CHEMBL1027667 CHEMBL497048 CN1Cc2cncn2Cc3ccc(C#N)c(Oc4ccc5cccc(N6CC[C@H]1C6=O)c5c4)c3 5.36 CHEMBL1027667 CHEMBL497171 CCCCNc1nccc2[nH]c3ccccc3c12 5.8 CHEMBL1008798 CHEMBL497999 CS(=O)(=O)c1ccc(OCC2CC2)c(c1)C(=O)N3CCN(CC3)c4ccc(cc4F)C#N 6.22 CHEMBL1006160 CHEMBL498042 CC1c2ccc(C#N)c(Oc3cccc(CN4CC[C@@H](NCc5cncn15)C4=O)c3)c2 4.7 CHEMBL1027667 CHEMBL498100 CN1CCc2cncn2Cc3ccc(C#N)c(Oc4ccc5cccc(N6CC[C@@H]1C6=O)c5c4)c3 6.75 CHEMBL1027667 CHEMBL498101 O=C1[C@@H]2CCN1[C@@H]3CCc4ccc(Oc5cc(Cn6cncc6CN2)ccc5C#N)cc34 5.37 CHEMBL1027667 CHEMBL498260 O=C1[C@H]2CCN1c3cccc4ccc(Oc5cc(Cn6cncc6CCN2)ccc5C#N)cc34 6.68 CHEMBL1027667 CHEMBL498411 CN1CCN(CC1)c2ncnc3c2nc(c4ccc(Cl)cc4Cl)n3c5ccc(Cl)cc5 6.46 CHEMBL1016403 CHEMBL498572 OC1CN2C3CC(CC2CC1C3)OC(=O)c4c[nH]c5ccccc45 4.92 CHEMBL1676103 CHEMBL499477 Cc1noc(n1)\C(=C\c2cccc(c2)N3C=C(C(=O)Nc4c(Cl)cncc4Cl)C(=O)c5cccnc35)\c6ccc(cc6)S(=O)(=O)C 6.17 CHEMBL984535 CHEMBL499554 CN(C)CCN1CCN(CC1)c2ccc3nc(c4ccccc4)c(nc3n2)c5ccc(CN6CCC(CC6)c7nnc([nH]7)c8ccccn8)cc5 5.22 CHEMBL947435 CHEMBL499555 Nc1nnc2c3cc(c4ccccc4)c(nc3ccn12)c5ccc(CN6CCC(CC6)c7n[nH]c(n7)c8ccccn8)cc5 5.27 CHEMBL939830 CHEMBL499961 CN1CCN(CC1)c2ccc3nc(c4ccccc4)c(nc3n2)c5ccc(CN6CCC(CC6)c7nnc([nH]7)c8ccc(N)nc8)cc5 5.33 CHEMBL947435 CHEMBL500329 CNCc1ccc(OC)cc1Oc2ccc(Cl)c(Cl)c2 6.16 CHEMBL962309 CHEMBL500945 CCSc1ncccc1C(=O)N2CC[C@H](NCc3cncn3Cc4ccc(cc4)C#N)C2=O 4.85 CHEMBL1027667 CHEMBL500946 Brc1cncc(c1)C(=O)N2CC[C@H](NCc3cncn3Cc4ccc(cc4)C#N)C2=O 5.22 CHEMBL1027667 CHEMBL501480 O=C1[C@H]2CCN1C(c3ccccc3)c4cccc(Oc5cc(Cn6cncc6CN2)ccc5C#N)c4 5.54 CHEMBL1027667 CHEMBL502 COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC 5.7 CHEMBL1676103 CHEMBL502113 OCCN1CCN(CC1)c2ncc3cc(c4ccccc4)c(nc3n2)c5ccc(CN6CCC(CC6)c7nnc([nH]7)C8=CNC(=O)C=C8)cc5 5.17 CHEMBL947435 CHEMBL502288 CSc1ncccc1C(=O)N2CC[C@H](NCc3cncn3Cc4ccc(cc4)C#N)C2=O 5.11 CHEMBL1027667 CHEMBL502393 Nc1ccc(cn1)c2nnc([nH]2)C3CCN(Cc4ccc(cc4)c5nc6C=CNC(=O)c6cc5c7ccccc7)CC3 5 CHEMBL947435 CHEMBL502560 O=C1[C@H]2CCN1Cc3cccc(Oc4cc(Cn5cncc5CN2)ccc4C#N)c3 5.33 CHEMBL1027667 CHEMBL503270 CN(C)CCN1CCN(CC1)c2ncc3cc(c4ccccc4)c(nc3n2)c5ccc(CN6CCC(CC6)c7nnc([nH]7)c8ccc(N)nc8)cc5 5.46 CHEMBL947435 CHEMBL503652 CN(C)CCN1CCN(CC1)c2ncc3cc(c4ccccc4)c(nc3n2)c5ccc(CN6CCC(CC6)c7nnc([nH]7)C8=CNC(=O)C=C8)cc5 6.1 CHEMBL947435 CHEMBL503810 Nc1ccc(cn1)c2nnc([nH]2)C3CCN(Cc4ccc(cc4)c5nc6nc(ncc6cc5c7ccccc7)N8CCN(CCO)CC8)CC3 5.13 CHEMBL947435 CHEMBL504479 COc1ccc(CC(C)(C)NCC(O)COc2ccccc2C#N)cc1 5.46 CHEMBL939877 CHEMBL505 CN(C)CCC(c1ccc(Cl)cc1)c2ccccn2 4.68 CHEMBL766814 CHEMBL505091 CNCc1cc(Cl)ccc1Oc2ccc(Cl)c(Cl)c2 5.51 CHEMBL962309 CHEMBL505848 CN(C)CCN1CCN(CC1)c2ncc3cc(c4ccccc4)c(nc3n2)c5ccc(CN6CCC(CC6)c7nnc([nH]7)c8ncccn8)cc5 5.32 CHEMBL947435 CHEMBL505914 Cl.CN1CC(C)(NC(=O)Nc2cccc(c2)c3nnnn3C)C(CN4CCC[C@@H](Cc5ccc(F)cc5)C4)OC1=O 4.8 CHEMBL1019587 CHEMBL506077 Oc1nnc2c3cc(c4ccccc4)c(nc3ccn12)c5ccc(CN6CCC(CC6)c7n[nH]c(n7)c8ccccn8)cc5 5.28 CHEMBL939830 CHEMBL506163 Cl.COc1ccc(cn1)[C@@]2(N=C(N[C@H]2C)c3cc(ccn3)C#N)c4ccc(F)cc4 5.2 CHEMBL1021966 CHEMBL507075 CNCc1ccc(cc1Oc2ccc(Cl)cc2)C(F)(F)F 5.29 CHEMBL962309 CHEMBL507130 O=C1NC=Cc2nc(c3ccc(CN4CCC(CC4)c5n[nH]c(n5)c6ccccn6)cc3)c(cc12)c7ccccc7 5.25 CHEMBL939830 CHEMBL507204 CN1CCN(CC1)c2ncc3cc(c4ccccc4)c(nc3n2)c5ccc(CN6CCC(CC6)c7nnc([nH]7)c8cc[n+]([O-])cc8)cc5 5.01 CHEMBL947435 CHEMBL507360 COc1nccc2C(=O)N(C)C(=Nc12)c3ccc(OC4CCN(CC4)C5CCC5)cc3 5 CHEMBL1827362 CHEMBL507721 CCc1cc(Oc2ccc(F)cc2CNC)ccc1Cl 5.34 CHEMBL962309 CHEMBL507884 CNCc1cc(ccc1Oc2ccc(Cl)c(Cl)c2)C(F)(F)F 5.88 CHEMBL962309 CHEMBL508098 CN1CCN(CC1)c2ccc3nc(c4ccccc4)c(nc3n2)c5ccc(CN6CCC(CC6)c7nnc([nH]7)c8ncccn8)cc5 5.08 CHEMBL947435 CHEMBL508368 C[C@@H](N[C@@H]1CCCc2c1[nH]c3ccc(Br)cc23)c4ccccc4 5.77 CHEMBL1063963 CHEMBL508712 CN1C(=O)c2cccc(C)c2N=C1c3ccc(OC4CCN(CC4)C5CCC5)cc3 5.7 CHEMBL956578 CHEMBL508861 ClCc1nnc2c3cc(c4ccccc4)c(nc3ccn12)c5ccc(CN6CCC(CC6)c7n[nH]c(n7)c8ccccn8)cc5 5.7 CHEMBL939830 CHEMBL509881 CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)C(=O)N)ncc2F 4.7 CHEMBL1022593 CHEMBL510435 CNCc1ccc(cc1Oc2ccc(Cl)c(Cl)c2)C#N 5.88 CHEMBL962309 CHEMBL510436 CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(C(=O)N(C)C)c(F)c3)n2 5.52 CHEMBL1022593 CHEMBL511 COc1ccc(CN(CCN(C)C)c2ccccn2)cc1 4.9 CHEMBL1909190 CHEMBL511099 Cc1ccc(cc1)C23CNCC2C3 4.35 CHEMBL1676103 CHEMBL511142 CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]4Cc5ccc(O)c6O[C@@H]2[C@]3(CCN4CC7CC7)c56 5.1 CHEMBL1676103 CHEMBL511205 CCN1CCN(CC1)c2cc3[nH]c(S[C@@]4(C)CC[C@@H](CC4)c5nnnn5C)nc3cc2Cl 5.2 CHEMBL972465 CHEMBL511658 C[C@@H]1CN(C[C@@H]2CCc3cccnc3[C@@H](O)C2)CC[C@H]1c4ccccc4C 5.04 CHEMBL948532 CHEMBL511742 CCN1CCN(CC1)c2cc3[nH]c(nc3cc2Cl)C(=O)[C@@]4(C)CC[C@@](C)(O)CC4 5.51 CHEMBL1014963 CHEMBL512185 FC(F)(F)Oc1ccc(cc1)n2ccc(CN3CCC(CC3)NC(=O)COc4cccc(Cl)c4)c2 6.31 CHEMBL973619 CHEMBL512351 COc1ccc(NC(=O)c2ccc(cc2)C(=N)N(C)C)c(c1)C(=O)Nc3ccc(Cl)cn3 5.05 CHEMBL968701 CHEMBL512520 Cc1nn(cc1CN2CCC3(CC2)OCc4ccccc34)c5ncccc5Cl 5.11 CHEMBL953933 CHEMBL512827 Cc1c(CNC2CCCC2)nn(c3ccc(Cl)cc3Cl)c1c4ccc(Cl)cc4 7.64 CHEMBL1007470 CHEMBL512896 Cc1ccccc1[C@@H]2CCN(C[C@@H]3CCc4cccnc4[C@@H](O)C3)C[C@H]2O 4.4 CHEMBL948532 CHEMBL512975 Cc1ncc(cc1F)c2c(C)c(CNC3CCCC3)nn2c4ncccc4Cl 4.64 CHEMBL1007470 CHEMBL513139 CC(C)C(=O)N(Cc1ccc(Cl)cc1Cl)[C@H]2CCNC2 4.4 CHEMBL979037 CHEMBL513258 Fc1ccc(CC2(CCNC2)c3ccc4[nH]ccc4c3)cc1 5.05 CHEMBL944378 CHEMBL513338 COC(=O)C(CCCN1CCN(CC1)c2ccccc2OC)(C(C)C)c3ccc(Br)cc3 5.86 CHEMBL3117583 CHEMBL513423 O[C@H]1CN(C[C@@H]2CCc3cccnc3[C@@H](O)C2)CC[C@@H]1c4ccc(F)cc4Cl 4.89 CHEMBL948532 CHEMBL513585 Cc1cccc2[C@@H](O)C[C@H](CN3CCC(CC3)c4ccccc4C)CCc12 7.07 CHEMBL948532 CHEMBL513608 CN(C)c1cn(c2ccc(F)cc2)c3ccc(Cl)cc13 7.96 CHEMBL988126 CHEMBL513629 CNC(C)c1ccc(Cl)cc1Oc2ccc(C)c(C)c2 5.61 CHEMBL962309 CHEMBL513855 Cc1ccc(cn1)c2c(C)c(CNC3CCCC3F)nn2c4ncccc4Cl 4.52 CHEMBL1007470 CHEMBL513921 CNC(=O)c1c(NCC2CCC3(CC2)OCCO3)nc(nc1OCC4CCN(C)CC4)C#N 5.24 CHEMBL988836 CHEMBL514042 CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(nc1OCC4CCN(CCO)CC4)C#N 6.05 CHEMBL988836 CHEMBL514304 Nc1ccc(cc1NC(=O)c2ccc(CN3CCC4(CCCN4)CC3)cc2)c5ccsc5 5.83 CHEMBL1027290 CHEMBL514384 COCCS(=O)(=O)N1CCN(CC1)c2ccc(Nc3nccc(n3)c4cnc(C)n4C(C)C)cc2 5.08 CHEMBL984727 CHEMBL514564 CC(=O)c1cccc(c1)c2cccc(c2)N3C=C(C(=O)Nc4nccc(Cl)c4Cl)C(=O)c5cccnc35 6.13 CHEMBL984535 CHEMBL515001 CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)N4CCOCC4)ncc2F 4.96 CHEMBL984727 CHEMBL515004 CCCC1=Nc2ccccc2C(=O)N1c3ccc(OCCCN4CCCC4)cc3 5.55 CHEMBL986351 CHEMBL515025 CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(nc1OCC4CCN(C)CC4)C#N 6.15 CHEMBL988836 CHEMBL515150 CC1=Nc2c(F)cccc2C(=O)N1c3ccc(OCCCN4CCCC4)cc3 5 CHEMBL1827362 CHEMBL515477 CC1CCN(CCCOc2ccc(cc2)N3C(=Nc4ccccc4C3=O)C)C1 5.19 CHEMBL986351 CHEMBL515757 Cc1cccc(Nc2nc(NCCN)ncc2C(=O)N)c1 5.7 CHEMBL1838283 CHEMBL515919 COc1ccc(NC(=O)c2ccc(cc2F)C(=N)N(C)C)c(c1)C(=O)Nc3ccc(Cl)cn3 5.38 CHEMBL968701 CHEMBL516 CN1CCC(=C2c3ccccc3C=Cc4ccccc24)CC1 4.77 CHEMBL1909190 CHEMBL516636 C[C@@H]1CN(CC2(CC2)c3ccc(cc3)C(=O)N)CCN1S(=O)(=O)c4ccc(cc4)C(C)(O)C(F)(F)F 5.19 CHEMBL1018632 CHEMBL516874 O=C1[C@H]2CCN1[C@@H]3CCOc4ccc(Oc5cc(Cn6cncc6CN2)ccc5C#N)cc34 6.82 CHEMBL1027667 CHEMBL517 CC(C)N(CCC(C(=O)N)(c1ccccc1)c2ccccn2)C(C)C 4.04 CHEMBL766814 CHEMBL517533 NC(=O)C1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1 5.82 CHEMBL2210904 CHEMBL518148 CN(C1CCNCC1)C(=O)N2CC(=C[C@@]2(CO)c3ccccc3)c4cc(F)ccc4F 4.72 CHEMBL1020033 CHEMBL518155 O=C1OCCN1C2CCN(Cc3ccc(Oc4nc5ccccc5s4)cc3)CC2 4.62 CHEMBL981950 CHEMBL518431 O=C1N(C=Nc2ccccc12)c3ccc(OCCCN4CCCC4)cc3 6.15 CHEMBL986351 CHEMBL518922 CC1(CCN(C[C@@H]2CCc3cccnc3[C@@H](O)C2)CC1)c4ccccc4 4.96 CHEMBL948532 CHEMBL519018 CC1=Nc2ccccc2C(=O)N1c3ccc(OC4CCCN(CC4)C5CCCC5)cc3 5.17 CHEMBL981857 CHEMBL519067 CCN1C(=O)c2ccccc2N=C1c3ccc(OCCCN4CCCCC4)cc3 5.77 CHEMBL956578 CHEMBL519193 CC(C)NC(=O)C1=CN(c2cccc(c2)c3ccc(cc3)C(=O)C)c4ncccc4C1=O 5.05 CHEMBL984535 CHEMBL519252 FC(F)(F)c1ccc(cc1)[C@@H]2C[C@H]2C(=O)N3CCN(CC3)S(=O)(=O)c4cc(cc(c4)C(F)(F)F)c5cn[nH]c5 6.3 CHEMBL1011901 CHEMBL519355 O=C(NC1CC1)C2=CN(c3cccc(c3)c4cccnc4)c5ncccc5C2=O 4.47 CHEMBL984535 CHEMBL519389 OCC(F)(F)c1cc(cc(c1)S(=O)(=O)N2CCN(CC2)C(=O)[C@@H]3C[C@H]3c4ccc(cc4)C(F)(F)F)C(F)(F)F 5.6 CHEMBL1011901 CHEMBL519418 CN(C)[C@@H]1CCC[C@H]1Nc2nc(Nc3ccc(cc3)S(=O)(=O)C)ncc2C(F)(F)F 5.33 CHEMBL1787952 CHEMBL520431 CCOc1cc2ncc(C(=O)N)c(Nc3ccc(F)cc3F)c2cc1N4CCCN(C)CC4 5.22 CHEMBL2411831 CHEMBL520463 CC(C)(O)c1ccc(c[n+]1[O-])C#Cc2cccc(c2)N3C=C(C(=O)NC4CC4)C(=O)c5cccnc35 4.05 CHEMBL984535 CHEMBL520502 CC(C)(O)c1ccc(cn1)c2cccc(c2)N3C=C(C(=O)NC4CC4)C(=O)c5cccnc35 4.44 CHEMBL984535 CHEMBL520543 OC(c1cc(cc(c1)S(=O)(=O)N2CCN(CC2)C(=O)[C@@H]3C[C@H]3c4ccc(cc4)C(F)(F)F)C(F)(F)F)C(F)(F)F 7.22 CHEMBL1011901 CHEMBL520942 CC(=O)NC1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 5.05 CHEMBL981950 CHEMBL521022 CC1=Nc2ccccc2C(=O)N1c3ccc(O[C@@H]4CC[C@@H](CC4)N5CCCC5)cc3 5.1 CHEMBL981857 CHEMBL521096 CCOc1cc2ncc(C(=O)N)c(Nc3ccc(C)cc3F)c2cc1N4CCN(C)CC4 4.82 CHEMBL2411831 CHEMBL521509 O=C(NC1CC1)C2=CN(c3cccc(c3)C#Cc4cccnc4)c5ncccc5C2=O 4.78 CHEMBL984535 CHEMBL521523 C[C@H]1CN(Cc2cccc(c2)c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)CCN1 5 CHEMBL1035711 CHEMBL521833 CC(C)(C)CCN1CC[C@@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1 5.52 CHEMBL1033089 CHEMBL521851 CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)c5cccc6[nH]ncc56)CC1 4.19 CHEMBL980868 CHEMBL521947 C[C@@H]1NC(=N[C@@]1(c2ccc(F)cc2)c3ccc(F)nc3)c4cccc(c4)C#N 5.36 CHEMBL1021966 CHEMBL522456 Fc1ccc(cc1)C2(CNC(=N2)c3cc(ccn3)C#N)c4ccc(F)cc4 7 CHEMBL1021966 CHEMBL522568 O=C1[C@H](CCN1Cc2ccccc2)N(CCN3CCNCC3)Cc4cncn4Cc5ccc(cc5)C#N 5.96 CHEMBL1027667 CHEMBL522697 CCC(C)C(C)CN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 6.05 CHEMBL1033089 CHEMBL522793 CC[C@@H]1NC(=NC1(c2ccc(F)cc2)c3ccc(F)cc3)c4cc(ccn4)C#N 6.31 CHEMBL1021966 CHEMBL522843 CC(C)(C)OCCN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 5.9 CHEMBL1033089 CHEMBL522964 C[C@@H]1CN(CC2(CC2)c3ccncc3)CCN1S(=O)(=O)c4ccc(cc4)C(C)(O)C(F)(F)F 6.36 CHEMBL1018632 CHEMBL523080 O=C1Cc2cncn2Cc3ccc(C#N)c(Oc4ccc5cccc(N6CC[C@H](N1)C6=O)c5c4)c3 5 CHEMBL1027667 CHEMBL523134 C[C@@H]1NC(=NC1(c2ccc(F)cc2)c3ccc(F)cc3)c4cc(ccn4)C#N 5.76 CHEMBL1021966 CHEMBL523167 CN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc2ccc(NS(=O)(=O)C)cc2 6.43 CHEMBL1027247 CHEMBL523204 CCN(CC)C(=O)c1cccc(c1)C2=CC3(CCNCC3)Oc4ccccc24 6.52 CHEMBL989030 CHEMBL523305 OC[C@@H]1NC(=NC1(c2ccc(F)cc2)c3ccc(F)cc3)c4cc(ccn4)C#N 5.22 CHEMBL1021966 CHEMBL523374 CNc1noc2c(c(C)ccc12)c3ccc4c(nncc4c3)N5CCOC[C@@H]5C 4.89 CHEMBL1024839 CHEMBL523475 COc1ccc(CC(C)(C)NCC(O)COc2cccc(Cl)c2C#N)cc1 5.44 CHEMBL939877 CHEMBL52348 CCCc1cn(c2ccc(F)cc2)c3ccc(Cl)cc13 4.59 CHEMBL766816 CHEMBL523507 CCN(CC)C(=O)c1ccc(cc1)C2=CC3(CCNCC3)Oc4c(O)cccc24 4.74 CHEMBL989030 CHEMBL523508 CC(C)(C)CCN1CCC(CNC(=O)Cc2ccc(cc2)C(C)(C)C)CC1 5.99 CHEMBL1033089 CHEMBL523525 FC(F)(F)c1cccc(CN2CCC(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)c1 6.32 CHEMBL1033089 CHEMBL523535 Clc1cc(Cl)cc(c1)C(=O)NCC2CCN(Cc3ccc(Br)nc3)CC2 6.18 CHEMBL1033089 CHEMBL523570 O=C1[C@@H]2CCN1[C@H]3CCc4ccc(Oc5cc(Cn6cncc6CN2)ccc5C#N)cc34 5.57 CHEMBL1027667 CHEMBL523671 CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(F)c(F)c2)cc1 5.79 CHEMBL1027247 CHEMBL523821 C[C@@H]1NC(=N[C@@]1(c2ccc(F)cc2)c3ccc(F)nc3)c4cccc(n4)C#N 5.16 CHEMBL1021966 CHEMBL524038 CCCN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc2ccc(NS(=O)(=O)C)cc2 6.89 CHEMBL1027247 CHEMBL524082 O=C1Cc2cncn2Cc3ccc(C#N)c(Oc4ccc5cccc(N6CC[C@@H](N1)C6=O)c5c4)c3 5 CHEMBL1027667 CHEMBL524352 Clc1cc2CN3CC[C@@H](NCc4cncn4Cc5ccc(C#N)c(Oc(c1)c2)c5)C3=O 6.66 CHEMBL1027667 CHEMBL524862 O=C1[C@H]2CCN1c3ccccc3c4cccc(Oc5cc(Cn6cncc6CN2)ccc5C#N)c4 5.59 CHEMBL1027667 CHEMBL524909 O=C1[C@@H]2CCN1Cc3cccc(Oc4cc(Cn5cncc5CN2)ccc4C#N)c3 4.96 CHEMBL1027667 CHEMBL524997 Brc1ccc2Oc3cc(Cn4cncc4CN[C@@H]5CCN(Cc1c2)C5=O)ccc3C#N 5.34 CHEMBL1027667 CHEMBL525368 CN1CCc2cncn2Cc3ccc(C#N)c(Oc4ccc5cccc(N6CC[C@H]1C6=O)c5c4)c3 5.31 CHEMBL1027667 CHEMBL525369 O=C1[C@H]2CCN1[C@@H]3CCCc4ccc(Oc5cc(Cn6cncc6CN2)ccc5C#N)cc34 5.16 CHEMBL1027667 CHEMBL525413 Clc1cccc(c1)C2N3CC[C@@H](NCc4cncn4Cc5ccc(C#N)c(Oc6cccc2c6)c5)C3=O 6.28 CHEMBL1027667 CHEMBL52627 CS(=O)(=O)Nc1ccc2OC3(CCN(CC3)C4CCc5cc(ccc5C4)C#N)CC(O)c2c1 7.47 CHEMBL766816 CHEMBL526277 O=C1[C@H](CCN1Cc2ccccc2)N(CCN3CCOCC3)Cc4cncn4Cc5ccc(cc5)C#N 6.72 CHEMBL1027667 CHEMBL526466 O=C1[C@H]2CCN1[C@@H]3CCc4ccc(Oc5cc(Cn6cncc6CN2)ccc5C#N)cc34 7.1 CHEMBL1027667 CHEMBL526521 O=C1[C@@H]2CCN1[C@@H]3CCCc4ccc(Oc5cc(Cn6cncc6CN2)ccc5C#N)cc34 4.92 CHEMBL1027667 CHEMBL526656 O=C1[C@H]2CCN1[C@H]3CCc4ccc(Oc5cc(Cn6cncc6CN2)ccc5C#N)cc34 5.33 CHEMBL1027667 CHEMBL527094 CNC(C)c1ccc(OC)cc1Oc2ccc(Cl)c(Cl)c2 6.11 CHEMBL962309 CHEMBL52794 CC(O)c1cn(c2ccc(F)cc2)c3ccc(Cl)cc13 5.34 CHEMBL766816 CHEMBL52832 CC(C)(O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4 6.34 CHEMBL766816 CHEMBL528995 Clc1ccc(cc1Cl)C23CNCC2C3 5 CHEMBL944378 CHEMBL528997 FC(F)(F)c1ccc(cc1)[C@@H]2C[C@H]2C(=O)N3CCN(CC3)S(=O)(=O)c4cc(cc(c4)C(F)(F)F)c5cn[nH]n5 5.46 CHEMBL1011901 CHEMBL529213 FC(F)(F)c1ccc(cc1)[C@@H]2C[C@H]2C(=O)N3CCN(CC3)S(=O)(=O)c4cc(cc(c4)C(F)(F)F)c5nnc[nH]5 6 CHEMBL1011901 CHEMBL529214 FC(F)(F)c1ccc(cc1)[C@@H]2C[C@H]2C(=O)N3CCN(CC3)S(=O)(=O)c4cc(cc(c4)C(F)(F)F)C5=NC(=O)CS5 5.4 CHEMBL1011901 CHEMBL529445 CC1(C)CC(CN2CCC(F)(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)CCO1 5.08 CHEMBL952419 CHEMBL52999 COC(=O)c1ccc(cc1)n2cc(C3CCN(CCN4CCNC4=O)CC3)c5cc(Cl)ccc25 7.44 CHEMBL766816 CHEMBL53089 CC(C)c1cn(c2ccc(F)cc2)c3ccc(Cl)cc13 5 CHEMBL1676103 CHEMBL531 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc3c[nH]c4cccc2c34 6.92 CHEMBL1676103 CHEMBL531475 COc1ccc(cn1)c2cc(cnc2N)c3ccc(cc3)S(=O)(=O)C 5.46 CHEMBL2432226 CHEMBL532 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 4.41 CHEMBL827807 CHEMBL533 CCCCCCCN(CC)CCCC(O)c1ccc(NS(=O)(=O)C)cc1 7.7 CHEMBL827807 CHEMBL53321 CCC(=O)c1cn(c2ccc(F)cc2)c3ccc(Cl)cc13 5.71 CHEMBL766816 CHEMBL534723 Cl.CCOc1ccccc1C[C@@H](N2CCNCC2)c3ccccc3 4.8 CHEMBL864238 CHEMBL535 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C\2/C(=O)Nc3ccc(F)cc23)c1C 5 CHEMBL3430718 CHEMBL535650 Cl.OC(C1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F 5.25 CHEMBL766814 CHEMBL536480 Cl.Cl.Cc1cccc(CCN2CCC(CC2)C(=O)c3ccc(NS(=O)(=O)C)cc3)n1 7.05 CHEMBL3295404 CHEMBL53661 Clc1ccc2c(c1)c(cn2C3CCCCC3)C4CCN(CCN5CCNC5=O)CC4 6.86 CHEMBL766816 CHEMBL536991 Cl.Cc1ccc(cc1)C(=O)N2CCN(C(=O)C2)c3ccc(OCCCN4CCCCC4)cc3 4.5 CHEMBL903096 CHEMBL537847 Cl.CN1CCN(CCCCN2C(=O)CN(\N=C\c3oc(cc3)c4ccc(Cl)cc4)C2=O)CC1 6.25 CHEMBL832277 CHEMBL53821 O=C1[C@@H]2CCN1c3cccc4ccc(Oc5cc(Cn6cncc6CN2)ccc5C#N)cc34 4.98 CHEMBL1027667 CHEMBL538380 COc1ccc(cc1)[C@H](N[C@@H]2CC[C@@H](C(=O)N3CCC(CC3)(C(=O)N4CCCC4)c5ccccc5)C(C)(C)C2)C(F)(F)F 5.13 CHEMBL1053229 CHEMBL53866 CCC(O)c1cn(c2ccc(F)cc2)c3ccc(Cl)cc13 5.66 CHEMBL766816 CHEMBL53871 CCC(O)(CC)c1cn(c2ccc(F)cc2)c3ccc(Cl)cc13 4.8 CHEMBL766816 CHEMBL538936 Fc1ccc(cc1)C(NC(=O)CC2CCN(Cc3ccn(c3)c4ccc(cn4)C(F)(F)F)CC2)c5ccc(F)cc5 6.1 CHEMBL1063190 CHEMBL539475 Cc1cc(C)n(CC(NC(=O)NC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2)c5ccccc5)n1 5.55 CHEMBL1061741 CHEMBL539863 Cl.Cc1cccc(NC(=N)c2oc(cc2)c3ccc(Cl)cc3)c1 5.68 CHEMBL944718 CHEMBL54 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3 5.85 CHEMBL827807 CHEMBL540241 CC(C)c1cccc(c1)N2CCN(CCN3Cc4ccccc4C3)C2=O 5.3 CHEMBL1057876 CHEMBL540359 [I-].CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]3CCC[N+](C)(Cc4cccc(O)c4)C3)cc1 5.6 CHEMBL996060 CHEMBL540634 Cl.Clc1ccc(cc1)C(=O)N2CCN(C(=O)C2)c3ccc(OC4CCN(CC4)C5CCC5)cc3 4.5 CHEMBL903096 CHEMBL541226 Clc1cccc(OC(C2CCNCC2)c3ccccc3)c1Cl 6.02 CHEMBL1024556 CHEMBL541435 COCC1[C@@H]2CC[C@H]1CN(CCN3CCN(C3=O)c4cccc(Cl)c4)C2 6 CHEMBL1059865 CHEMBL541438 N[C@H]1Cn2c(C[C@@H]1c3cc(F)c(F)cc3F)nc4cnc(cc24)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F 4.24 CHEMBL1054110 CHEMBL541944 Fc1ccc(cc1)C(NC(=O)CN2CCN(Cc3ccn(c3)c4ccc(cn4)C(F)(F)F)CC2)c5ccc(F)cc5 6.1 CHEMBL1063190 CHEMBL548279 COc1ccc2nccc([C@@H](O)CN3CCC(CC3)NCc4ccc5OCCOc5c4)c2c1 4.4 CHEMBL1931724 CHEMBL549 CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3 4.78 CHEMBL1909190 CHEMBL549433 CC[C@@H]1Sc2ccccc2O[C@@H]1c3ccc(OCCCN4CCCC4)cc3 7.96 CHEMBL1061548 CHEMBL549438 CN(CCN1CCN(C1=O)c2cccc(Cl)c2)Cc3onc(C)c3 4.3 CHEMBL1059865 CHEMBL549584 O=C(N(CC1CCC1)[C@H]2CCNC2)c3ccccc3Oc4ccccc4 6.12 CHEMBL1062483 CHEMBL549635 OCCCN(Cc1ccc(F)cc1)C(=O)CC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2 6.2 CHEMBL1063190 CHEMBL549636 COCC(O)CN(Cc1ccc(F)cc1)C(=O)CC2CCN(Cc3oc(cc3)c4ccc(Cl)cc4)CC2 5.96 CHEMBL1063190 CHEMBL549639 COc1cccc2OC(C(C)S(=O)(=O)c12)c3ccc(OCCCN4CCCC4)cc3 5.2 CHEMBL1061548 CHEMBL549759 CC(=O)n1ccc2cc(ccc12)N3CCN(CCN4Cc5ccccc5C4)C3=O 5 CHEMBL1057876 CHEMBL549825 Clc1cccc(OC([C@@H]2CCCNC2)c3cccnc3)c1Cl 5.18 CHEMBL1024556 CHEMBL549851 COc1ccc(cc1)[C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(CC3)(c4ccccc4)c5ccccc5)C(C)(C)C2 6.28 CHEMBL1053229 CHEMBL549894 CC(C)N1CCN(CCN2CCN(C2=O)c3cccc(OC(F)(F)F)c3)CC1 5.8 CHEMBL1057876 CHEMBL549908 C[C@H]1[C@H](Oc2ccccc2S1(=O)=O)c3ccc(OCCCN4CCCC4)cc3 6.36 CHEMBL1061548 CHEMBL549984 CCCCC(NC(=O)CC1CCN(Cc2ccn(c2)c3ccc(cc3)C(F)(F)F)CC1)c4ccc(OC)nc4 6 CHEMBL1063190 CHEMBL55 NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(=N)N)cc1 4.8 CHEMBL1909190 CHEMBL550050 COc1cccc2c1OC(C(C)S2(=O)=O)c3ccc(OCCCN4CCCCC4)cc3 5.32 CHEMBL1061548 CHEMBL550063 NC(=O)c1ccc(cc1)C2=CC3(CCNCC3)Oc4ccccc24 4.94 CHEMBL1056550 CHEMBL550068 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC3)NC(=O)N4CCn5cccc5C4c6ccccc6)c2 5.89 CHEMBL1061741 CHEMBL550242 O=C(NC1CCc2ccccc2C1)N3CCC(CC3)c4onc(n4)c5ccccn5 5.22 CHEMBL1051701 CHEMBL550261 O=C(N1CCCCC1)c2ccc(cc2)C3=CC4(CCNCC4)Oc5ccccc35 5.52 CHEMBL1056550 CHEMBL550308 Oc1ccc(CNC(=O)C2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2)c(Cl)c1 5.81 CHEMBL1063190 CHEMBL550358 COc1cccc(c1)N2CCN(CCN3CCN(CC3)C(C)C)C2=O 4.2 CHEMBL1057876 CHEMBL550393 C[C@H]1Sc2ccccc2O[C@@H]1c3ccc(OCCCN4CCCC4)cc3 7.6 CHEMBL1061548 CHEMBL550402 CC(C)c1ccccc1C(=O)N(CC2CCCC2)[C@H]3CCNC3 5.63 CHEMBL1062483 CHEMBL550405 COCCNS(=O)(=O)c1ccc(cc1)c2ccc(CCN3CCC[C@H]3C)cc2 5.13 CHEMBL1827362 CHEMBL550410 Fc1cccc(CNC(=O)NC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2)c1 5.92 CHEMBL1061741 CHEMBL550455 Cn1cccc1CNC(=O)CC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2 5.62 CHEMBL1063190 CHEMBL550471 CCN(CC)C(=O)c1ccc(cc1)[C@@H]2CC3(CCNCC3)Oc4ccccc24 4.73 CHEMBL1056550 CHEMBL550472 CCN(CC)C(=O)c1ccc(s1)C2=CC3(CCNCC3)Oc4ccccc24 5.9 CHEMBL1056550 CHEMBL550502 Clc1ccc(cc1Cl)N2CCN(CCN3Cc4ccccc4C3)C2=O 6 CHEMBL1057876 CHEMBL550513 CN(CCC(=O)N1CCCC1)C(=O)CC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2 4.55 CHEMBL1063190 CHEMBL550517 COc1cccc2c1OC(C(C)S2(=O)=O)c3ccc(OCCCN4CCC[C@H](C)C4)cc3 5.6 CHEMBL1061548 CHEMBL550535 FC(F)(F)C1CCN(CC1)C2CN(C2)C(=O)NC3CCN(Cc4ccn(c4)c5ccc(cc5)C(F)(F)F)CC3 5.41 CHEMBL1061741 CHEMBL550669 CCN(CC)C(=O)c1oc(cc1)C2=CC3(CCNCC3)Oc4ccccc24 5.29 CHEMBL1056550 CHEMBL550816 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC3)NC(=O)NC(CN4CCOCC4)c5ccccc5)c2 5.16 CHEMBL1061741 CHEMBL550818 CN(CC1CCOCC1)C2CCN(CC2)c3nc4ccccc4n3Cc5ccc(F)cc5 7.54 CHEMBL1060930 CHEMBL550849 Fc1c(Cl)cccc1N2CCN(CCN3CCC(CC3)C(F)(F)F)C2=O 4.9 CHEMBL1057876 CHEMBL550876 Fc1ccc(cc1)C2CCCN2C(=O)NC3CCN(Cc4ccn(c4)c5ccc(cc5)C(F)(F)F)CC3 5.74 CHEMBL1061741 CHEMBL550943 OCc1cc(Cl)ccc1NC(=O)NC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2 5.48 CHEMBL1061741 CHEMBL551058 CS(=O)(=O)c1ccc(cc1)c2noc(n2)C3CCN(CC3)C(=O)NC4CC4c5ccccc5 5.05 CHEMBL1051701 CHEMBL551197 CCc1oc(SCc2cc(cc(NCC#N)n2)N3CCOCC3)nc1C 5.08 CHEMBL1055593 CHEMBL551206 COc1ccc(cc1)[C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(CC3)(c4ccccc4)c5ccc(Cl)nc5)C(C)(C)C2 5.68 CHEMBL1053229 CHEMBL551208 Cc1ccc(cn1)n2c(C)c(CN[C@H]3CC[C@@H](F)C3)nc2c4ncccc4Cl 4.51 CHEMBL1059781 CHEMBL551281 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC3)NC(=O)N4CC(C4)N5CCCOCC5)c2 5.52 CHEMBL1061741 CHEMBL551386 Clc1ccccc1CN2CCN(CCN3Cc4ccccc4C3)C2=O 5.7 CHEMBL1057876 CHEMBL551412 CCNC(=O)c1ccc(cc1)C2=CC3(CCNCC3)Oc4ccccc24 4.92 CHEMBL1056550 CHEMBL551414 O=C(N1CCOCC1)c2ccc(cc2)C3=CC4(CCNCC4)Oc5ccccc35 4.27 CHEMBL1056550 CHEMBL551536 CN(Cc1ccccc1)C(=O)c2ccc(cc2)C3=CC4(CCNCC4)Oc5ccccc35 5.8 CHEMBL1056550 CHEMBL551543 OCC1CCCN(C1)C(=O)NC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2 5.31 CHEMBL1061741 CHEMBL551613 O=C(N1Cc2ccccc2C1)c3ccc(cc3)C4=CC5(CCNCC5)Oc6ccccc46 5.46 CHEMBL1056550 CHEMBL551615 CCN1CCc2cc(ccc2C1=O)C3=CC4(CCNCC4)Oc5ccccc35 4.87 CHEMBL1056550 CHEMBL551684 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC3)NC(=O)N4CCCC(C4)C(=O)N5CCCC5)c2 4.93 CHEMBL1061741 CHEMBL551876 C[C@@H](N[C@@H]1CC[C@@H](C(=O)N2CCC(CC2)(C(=O)N3CCCC3)c4ccccc4)C(C)(C)C1)c5ccc(Cl)cc5 5.89 CHEMBL1053229 CHEMBL551886 Oc1ccccc1C2CCN(CC2)C(=O)NC3CCN(Cc4ccn(c4)c5ccc(cc5)C(F)(F)F)CC3 5.39 CHEMBL1061741 CHEMBL551914 CC1CCN(CCN2CCN(C2=O)c3cccc(Cl)c3)CC1 5.8 CHEMBL1057876 CHEMBL551921 O=C(NC1CC1c2ccccc2)N3CCC(CC3)c4onc(n4)c5ccc6ccccc6n5 5.59 CHEMBL1051701 CHEMBL551924 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC(=O)NC(c4ccncc4)c5ccc(Cl)cc5)CC3)c2 5.77 CHEMBL1063190 CHEMBL551927 C[C@]12C[C@H](CC(C1)c3ccccc3)N(CCN4CCN(C4=O)c5cccc(Cl)c5)C2 7.2 CHEMBL1059865 CHEMBL552023 CCN1C[C@H](CC1=O)N(Cc2cc(F)ccc2Cl)c3ccc(C#N)c(Cl)c3 5.51 CHEMBL1062741 CHEMBL552061 O=C(NC1CC1c2ccccc2)N3CCC(CC3)c4onc(n4)c5nccc6ccccc56 5.16 CHEMBL1051701 CHEMBL552279 C[C@@H]1CCCN1CCc2ccc(cc2)c3ccc(cc3)S(=O)(=O)Nc4ccccc4 6.53 CHEMBL1827362 CHEMBL552366 FC(F)(F)c1cccc(CN2CCN(CCN3Cc4ccccc4C3)C2=O)c1 5.2 CHEMBL1057876 CHEMBL552367 Clc1ccc(Cl)c(CN2CCN(CCN3Cc4ccccc4C3)C2=O)c1 6.4 CHEMBL1057876 CHEMBL552371 CC1CCCN(CCN2CCN(C2=O)c3cccc(Cl)c3)C1 5.5 CHEMBL1057876 CHEMBL552373 FC(F)(F)C1CCN(CCN2CCN(C2=O)c3cccc(c3)C#N)CC1 5.1 CHEMBL1057876 CHEMBL552402 O=C(NC1CC1c2ccccc2)N3CCC(CC3)c4oc5ccccc5n4 5.09 CHEMBL1051701 CHEMBL552460 Cc1ccc(s1)N2CCN(CCN3Cc4ccccc4C3)C2=O 4.5 CHEMBL1057876 CHEMBL552479 N[C@H]1Cn2c(C[C@@H]1c3cc(F)c(F)cc3F)nc4cc(ccc24)C(F)(F)F.OC(=O)C(F)(F)F 5.13 CHEMBL1054110 CHEMBL552762 COc1ccc(cc1)[C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(CC3)(C(=O)N4CCCCC4)c5ccccc5)C(C)(C)C2 5.05 CHEMBL1053229 CHEMBL553196 COc1ccc(cn1)C(NC(=O)CC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2)c5ccc(F)cc5 5.76 CHEMBL1063190 CHEMBL553238 Clc1ccc(CN2CCN(CCN3Cc4ccccc4C3)C2=O)cc1 5.7 CHEMBL1057876 CHEMBL553395 CSc1ccccc1C(=O)N(C2CCCCC2)[C@H]3CCNC3 5.64 CHEMBL1062483 CHEMBL554 CS(=O)(=O)CCNCc1oc(cc1)c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2 6 CHEMBL3430336 CHEMBL554073 Fc1ccc(cc1C#N)N2CCN(CCN3CCC(CC3)C(F)(F)F)C2=O 5.2 CHEMBL1057876 CHEMBL554299 Cc1ccc(cn1)n2c(C)c(CNC3CCCC3)nc2c4ncccc4Cl 4.72 CHEMBL1059781 CHEMBL554336 CN([C@H]1CCNC1)C(=O)c2ccccc2Oc3ccccc3 5.04 CHEMBL1062483 CHEMBL554506 COC1CCN(CC1)S(=O)(=O)c2ccc(cc2)c3ccc(CCN4CCC[C@H]4C)cc3 5.7 CHEMBL1827362 CHEMBL554511 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCN(CC3)C(=O)NCc4ccc(Cl)cc4Cl)c2 5.8 CHEMBL1063193 CHEMBL554693 COc1ccc(CCN(C)CCN2CCN(C2=O)c3cccc(Cl)c3)cc1OC 5.6 CHEMBL1059865 CHEMBL554738 CN(CCN1CCN(C1=O)c2cccc(Cl)c2)Cc3cc4ccccc4s3 5.8 CHEMBL1059865 CHEMBL554914 O=C1N(CCN2Cc3ccccc3C2)CCN1Cc4ccccc4 4.6 CHEMBL1057876 CHEMBL555347 FC(F)(F)c1ccc(NC(=O)N2CCC(CC2)c3onc(n3)c4ccccn4)cc1 5.1 CHEMBL1051701 CHEMBL555563 Clc1ccc(cc1)[C@H](OC2CN(C2)C(=O)N3CCCCC3)c4cccnc4Cl 4.51 CHEMBL1954249 CHEMBL555744 COC[C@@H]1CCCN1N2CCN(C2=O)c3cccc(Cl)c3 5.3 CHEMBL1059865 CHEMBL556100 CC1=C(Oc2ccccc2S1(=O)=O)c3ccc(OCCCN4CCCC4)cc3 6.33 CHEMBL1061548 CHEMBL556183 CCc1oc(CCc2cc(cc(NCC#N)n2)N3CCOCC3)nc1C 5.37 CHEMBL1055593 CHEMBL556247 CN1C[C@@H]2[C@@H](CN(Cc3cccc(OC(F)(F)F)c3)C(=O)c4cn(C)cn4)[C@@H]2C1 5.42 CHEMBL1023476 CHEMBL556272 Fc1cc(Cl)cc(c1)N2CCN(CCN3Cc4ccccc4C3)C2=O 5.5 CHEMBL1057876 CHEMBL556300 CC(C)c1c(CN[C@H]2CC[C@@H](F)C2)nc(C)n1c3cc(F)cc(F)c3 4.47 CHEMBL1059781 CHEMBL556312 Fc1ccc(cc1)N2CC(C3CCN(CCN4CCNC4=O)CC3)c5ccccc25 7.63 CHEMBL766816 CHEMBL556439 CCN(CC)C(=O)c1ccc(cc1)C2=CC3(CCNC3)Oc4ccccc24 5.19 CHEMBL1056550 CHEMBL556450 Cc1cnn(c1)C2CCN(CC2)c3nc4ccccc4n3Cc5ccc(F)cc5 6.09 CHEMBL1060930 CHEMBL556478 O=C1N(CCN2Cc3ccccc3C2)CCN1c4ccc5sccc5c4 5.7 CHEMBL1057876 CHEMBL556487 O=C(NC1CC1c2ccccc2)N3CCC(CC3)c4onc(n4)c5ccncc5 5 CHEMBL1051701 CHEMBL556496 COc1cccc(c1)C2CCCN(CCN3CCN(C3=O)c4cccc(Cl)c4)C2 6.7 CHEMBL1059865 CHEMBL556506 C[C@H](C1=C(CCN(C)C)Cc2ccccc12)c3cnccn3 5.85 CHEMBL1051824 CHEMBL556539 CCSc1ccccc1C(=O)N(CC2CCC2)[C@H]3CCNC3 5.12 CHEMBL1062483 CHEMBL556648 CCN(CC)C(=O)c1ccc(cc1)[C@H]2CC3(CCNCC3)Oc4ccccc24 5.6 CHEMBL1056550 CHEMBL556927 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC3)NC(=O)NC(Cn4cccn4)c5ccccc5)c2 5.39 CHEMBL1061741 CHEMBL557032 O=C(NC1CC1c2ccccc2)N3CCC(CC3)c4onc(n4)c5cnccn5 4.57 CHEMBL1051701 CHEMBL557054 CCN(CC)C(=O)c1ccc(cn1)C2=CC3(CCNCC3)Oc4ccccc24 4.36 CHEMBL1056550 CHEMBL557110 Clc1cccc(c1)N2CCN(CCN3CCCC(C3)OCc4ccccc4)C2=O 7.1 CHEMBL1059865 CHEMBL557121 CCN(CC)C(=O)c1ccc(cc1)C2CC3(CCNCC3)Oc4ccccc24 5.29 CHEMBL1056550 CHEMBL557257 CCN(CC)C(=O)c1ccc(cc1C)C2=CC3(CCNCC3)Oc4ccccc24 5.35 CHEMBL1056550 CHEMBL557306 OC(CNC(=O)CC1CCN(Cc2oc(cc2)c3ccc(Cl)cc3)CC1)C(F)(F)F 5.99 CHEMBL1063190 CHEMBL557329 OC[C@@H](NC(=O)NC1CCN(Cc2ccn(c2)c3ccc(cc3)C(F)(F)F)CC1)c4ccccc4 4.62 CHEMBL1061741 CHEMBL557458 CCN(CC)C(=O)c1ccc(cc1O)C2=CC3(CCNCC3)Oc4ccccc24 4.68 CHEMBL1056550 CHEMBL557502 Cl.COc1cccnc1C(=O)N2CCN(CC2)c3ccc(NC(=O)C(C)(C)c4ccccc4)cc3Cl 4.3 CHEMBL1063998 CHEMBL557648 CCc1oc(CCc2cc(cc(NC(C)C)n2)N3CCOCC3)nc1C 6.27 CHEMBL1055593 CHEMBL557715 OC1(CNC(=O)C2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2)CCCCC1 4.93 CHEMBL1063190 CHEMBL557718 COc1cccc2c1O[C@@H]([C@@H](C)S2(=O)=O)c3ccc(OCCCN4CCCC4)cc3 5.21 CHEMBL1061548 CHEMBL557853 C[C@@H]1Sc2ccccc2O[C@@H]1c3ccc(OCCCN4CCCC4)cc3 8.3 CHEMBL1061548 CHEMBL557873 COc1ccc(OC2CN(C2)C(=O)NC3CCN(Cc4ccn(c4)c5ccc(cc5)C(F)(F)F)CC3)cc1 5.69 CHEMBL1061741 CHEMBL557932 COc1ccc(CN[C@@H]2CC[C@@H](C(=O)N3CCC(CC3)(C(=O)N4CCCC4)c5ccccc5)C(C)(C)C2)cc1 6.05 CHEMBL1053229 CHEMBL558 CC(N)COc1c(C)cccc1C 5 CHEMBL1676103 CHEMBL558052 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC3)NC(=O)NC(c4ccccc4)c5ccccc5)c2 5.42 CHEMBL1063190 CHEMBL558058 CN(CCN1CCN(C1=O)c2cccc(c2)C(F)(F)F)C[C@@]34CC[C@@H](CC3)C4(C)C 5.2 CHEMBL1059865 CHEMBL558248 C[C@@H]1[C@H](Oc2ccccc2S1(=O)=O)c3ccc(OCCCN4CCCC4)cc3 5.89 CHEMBL1061548 CHEMBL55826 O=C1[C@@H]2CCN1c3cccc4ccc(Oc5cc(Cn6cncc6CCN2)ccc5C#N)cc34 5.09 CHEMBL1027667 CHEMBL558260 C[C@@H]1CCCN1CCc2ccc(cc2)c3ccc(cc3)S(=O)(=O)NCC4CC4 5.59 CHEMBL1827362 CHEMBL55835 OC(=O)Cc1ccc(cc1)n2cc(C3CCN(CCN4CCNC4=O)CC3)c5cc(Cl)ccc25 6.24 CHEMBL766816 CHEMBL558442 Oc1cc(Cl)ccc1CNC(=O)C2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2 5.81 CHEMBL1063190 CHEMBL558456 C[C@@H]1CCCN1CCc2ccc(cc2)c3ccc(cc3)S(=O)(=O)NCc4ccccc4 6.24 CHEMBL1827362 CHEMBL558532 CN1CCN(C(C1)c2ccccc2)C(=O)NC3CCN(Cc4ccn(c4)c5ccc(cc5)C(F)(F)F)CC3 5.33 CHEMBL1061741 CHEMBL558533 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC3)NC(=O)NCc4nc5ccccc5[nH]4)c2 4.83 CHEMBL1061741 CHEMBL558651 CC(C)CN([C@H]1CCNC1)C(=O)c2ccccc2Oc3ccccc3 5.97 CHEMBL1062483 CHEMBL558655 C[C@@H]1CCCN1CCc2ccc(cc2)c3ccc(cc3)S(=O)(=O)NCc4ccncc4 5.09 CHEMBL1827362 CHEMBL558664 CN1CC[C@@H](C1)N(Cc2ccccc2C(F)(F)F)c3ccc(C#N)c(Cl)c3 6.11 CHEMBL1072651 CHEMBL558726 OC1(Cc2ccccc2)CCN(CC1)C(=O)NC3CCN(Cc4ccn(c4)c5ccc(cc5)C(F)(F)F)CC3 5.1 CHEMBL1061741 CHEMBL558863 CN(CC1(O)CCCCC1)C(=O)NC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2 5.67 CHEMBL1061741 CHEMBL558923 C[C@@H]1CCCN1CCc2ccc(cc2)c3ccc(cc3)S(=O)(=O)N 5.11 CHEMBL1827362 CHEMBL558928 OCCC1CCCCN1C(=O)NC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2 5.51 CHEMBL1061741 CHEMBL559004 O=C1N(CCN2Cc3ccccc3C2)CCN1c4ccc5occc5c4 5.1 CHEMBL1057876 CHEMBL559029 FC(F)(F)c1cccc(c1)N2CCN(CCN3Cc4ccccc4C3)C2=O 6.1 CHEMBL1057876 CHEMBL559045 COc1ccc(cc1)[C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(CC3)(c4ccccc4)c5cccnc5)C(C)(C)C2 5.02 CHEMBL1053229 CHEMBL559118 C[C@@H]1CCCN1CCc2ccc(cc2)c3ccc(cc3)S(=O)(=O)NC4CCOCC4 4.89 CHEMBL1827362 CHEMBL559206 Cl.O=C(N1CCN(C(=O)C1)c2ccc(OCCCN3CCCCC3)cc2)c4ccccc4 4.2 CHEMBL903096 CHEMBL559237 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC(=O)N4CCCCC4C(=O)N5CCCC5)CC3)c2 5 CHEMBL1063190 CHEMBL559251 CN(C)CCC1=C(Cc2cnccn2)c3ccccc3C1 5.26 CHEMBL1051824 CHEMBL559329 O[C@@H]1CCCC[C@@H]1CNC(=O)NC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2 5.4 CHEMBL1061741 CHEMBL559386 CC(C)Oc1cccc(c1)N2CCN(CCN3Cc4ccccc4C3)C2=O 5.4 CHEMBL1057876 CHEMBL559414 CCN(CC)C(=O)c1ccc(C2=CC3(CCNCC3)Oc4ccccc24)c(F)c1 6.38 CHEMBL1056550 CHEMBL559456 Clc1cccc(OC(C2CCNCC2)c3cccnc3)c1Cl 5.29 CHEMBL1024556 CHEMBL559477 N[C@H]1Cn2c(C[C@@H]1c3cc(F)c(F)cc3F)nc4cnc(F)cc24.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F 4.09 CHEMBL1054110 CHEMBL559535 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC(=O)NC(c4ccccc4)c5cnc[nH]5)CC3)c2 4.94 CHEMBL1063190 CHEMBL559593 CCCNc1cc(cc(CCc2oc(CC)c(C)n2)n1)N3CCOCC3 6.32 CHEMBL1055593 CHEMBL559691 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC3)NC(=O)C4=CNC(=O)C(=C4)Cl)c2 4.71 CHEMBL1061741 CHEMBL559780 Cc1nc2cc(ccc2s1)N3CCN(CCN4Cc5ccccc5C4)C3=O 5.4 CHEMBL1057876 CHEMBL559856 O=C1N(CCN2Cc3ccccc3C2)CCN1c4cccc(c4)C#N 5.5 CHEMBL1057876 CHEMBL559873 Clc1cccc(c1)N2CCN(CCN3CCCc4sccc4C3)C2=O 6.1 CHEMBL1059865 CHEMBL559919 FC(F)(F)Oc1cccc(c1)N2CCN(CCN3CCC(CC3)C(F)(F)F)C2=O 5.4 CHEMBL1057876 CHEMBL559920 COc1cccc(c1)N2CCN(CCN3CCC(CC3)C(F)(F)F)C2=O 4.6 CHEMBL1057876 CHEMBL559940 CS(=O)(=O)c1ccc2c(c1)nc3C[C@@H]([C@@H](N)Cn23)c4cc(F)c(F)cc4F.OC(=O)C(F)(F)F 4.42 CHEMBL1054110 CHEMBL559987 CCc1oc(CCc2cc(cc(NC(=O)C)n2)N3CCOCC3)nc1C 5.16 CHEMBL1055593 CHEMBL560063 FC(F)(F)c1ccc(nc1)n2ccc(CN3CCC(CC3)C(=O)NCc4ccc(Cl)cc4Cl)c2 5.46 CHEMBL1063193 CHEMBL560140 C[C@@H]1CCCN1CCc2ccc(cc2)c3ccc(cc3)S(=O)(=O)N4CCS(=O)(=O)CC4 5.02 CHEMBL1827362 CHEMBL560177 Clc1cccc(c1)N2CCN(CCN3Cc4ccccc4C3)C2=O 5.5 CHEMBL1057876 CHEMBL560182 CCc1oc(CCc2cc(cc(NCC(F)(F)F)n2)N3CCOCC3)nc1C 5.8 CHEMBL1055593 CHEMBL560270 CN(CCN1CCN(C1=O)c2cccc(C)c2)C[C@@]34CC[C@@H](CC3)C4(C)C 5.8 CHEMBL1059865 CHEMBL560283 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC3)NC(=O)N4CCCC4c5cccnc5)c2 5.51 CHEMBL1061741 CHEMBL560289 Cn1cnc(c1)C(=O)N(C[C@@H]2[C@H]3CNC[C@@H]23)Cc4ccc(F)c(Cl)c4 4.84 CHEMBL1023476 CHEMBL560386 COc1cccc2c1O[C@H]([C@H](C)S2(=O)=O)c3ccc(OCCCN4CCCC4)cc3 5.31 CHEMBL1061548 CHEMBL560574 FC(F)(F)C1CCN(CCN2CCN(C2=O)c3cccc(I)c3)CC1 6.7 CHEMBL1057876 CHEMBL560584 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC3)C(=O)NCCc4ccccn4)c2 5 CHEMBL1063190 CHEMBL560650 Clc1ccc(CN2CCN(CCN3Cc4ccccc4C3)C2=O)cc1Cl 6.1 CHEMBL1057876 CHEMBL560667 Cc1c(CN[C@H]2CC[C@@H](F)C2)nn(CCC#N)c1c3cc(F)cc(F)c3 5.02 CHEMBL1060814 CHEMBL560669 N[C@H]1Cn2c(C[C@@H]1c3cc(F)c(F)cc3F)nc4ccc(F)cc24.OC(=O)C(F)(F)F 4.77 CHEMBL1054110 CHEMBL560715 CC(C)N1CCN(CCN2CCN(C2=O)c3cccc(Cl)c3)CC1 5.2 CHEMBL1057876 CHEMBL560750 Cn1cnc(c1)C(=O)N(C[C@@H]2[C@H]3CN(CC4CC4)C[C@@H]23)Cc5cccc(OC(F)(F)F)c5 6.28 CHEMBL1023476 CHEMBL560863 COc1cccc2c1OC(C(C)S2(=O)=O)c3ccc(OCCCN4CCC[C@H]4C)cc3 5.54 CHEMBL1061548 CHEMBL560921 CCc1oc(CCc2cc(cc(NCCC#N)n2)N3CCOCC3)nc1C 5.8 CHEMBL1055593 CHEMBL560923 CC1=C(Oc2ccccc2S1)c3ccc(OCCCN4CCCC4)cc3 8.36 CHEMBL1061548 CHEMBL561054 CC1CCCCN1CCN2CCN(C2=O)c3cccc(Cl)c3 5.7 CHEMBL1057876 CHEMBL561128 Clc1ccc(cc1)C2CCN(CCN3CCN(C3=O)c4cccc(Cl)c4)CC2 8.1 CHEMBL1059865 CHEMBL561138 CCN(CC)C(=O)c1ccc(nc1)C2=CC3(CCNCC3)Oc4ccccc24 4.15 CHEMBL1056550 CHEMBL561279 C[C@@H]1CCCN1CCc2ccc(cc2)c3ccc(cc3)S(=O)(=O)N4C(C)COCC4C 5.93 CHEMBL1827362 CHEMBL561324 COc1ccc2c(OC(C(C)S2(=O)=O)c3ccc(OCCCN4CCCC4)cc3)c1 5.77 CHEMBL1061548 CHEMBL561326 Clc1cccc(c1)N2CCN(CCN3CCC(CC3)c4oc(nn4)c5ccccc5)C2=O 6.6 CHEMBL1059865 CHEMBL561339 CCN(CC)C(=O)c1ccc(C2=CC3(CCNCC3)Oc4ccccc24)c(O)c1 4.25 CHEMBL1056550 CHEMBL561344 CC(C)C(Cn1ccnc1)NC(=O)NC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2 4.68 CHEMBL1061741 CHEMBL561379 O=C(NC1CC1c2ccccc2)N3CCC(CC3)c4ocnn4 4.57 CHEMBL1051701 CHEMBL561396 CC(C)c1c(CNC2CCCC2)nc(c3ncccc3Cl)n1c4ccc(C)nc4 5 CHEMBL1059781 CHEMBL561397 CC(C)c1c(CN[C@H]2CC[C@@H](F)C2)nc(c3ncccc3Cl)n1c4ccc(C)nc4 4.82 CHEMBL1059781 CHEMBL561463 CCN(CC)C(=O)C1CCCN(C1)C(=O)CC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2 4.8 CHEMBL1063190 CHEMBL561512 Clc1cc(Cl)cc(c1)N2CCN(CCN3Cc4ccccc4C3)C2=O 5.8 CHEMBL1057876 CHEMBL561584 Cc1nccn1CC(NC(=O)CC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2)c5ccccc5 4.58 CHEMBL1063190 CHEMBL561585 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC(=O)NC(c4ccccc4)c5ccccn5)CC3)c2 5.64 CHEMBL1063190 CHEMBL561594 COc1ccc(cc1)[C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(CC3)(N4CCCCC4)c5ccccc5)C(C)(C)C2 5.17 CHEMBL1053229 CHEMBL561788 FC(F)(F)c1ccccc1c2noc(n2)C3CCN(CC3)C(=O)NC4CC4c5ccccc5 5.22 CHEMBL1051701 CHEMBL561793 CS(=O)(=O)Nc1ccc2c(c1)nc3C[C@@H]([C@@H](N)Cn23)c4cc(F)c(F)cc4F.OC(=O)C(F)(F)F 5.6 CHEMBL1054110 CHEMBL561805 CN(C)C(=O)c1ccc(cc1)C2=CC3(CCNCC3)Oc4ccccc24 4.64 CHEMBL1056550 CHEMBL561878 O=C(N(C1CCC1)[C@H]2CCNC2)c3ccccc3Oc4ccccc4 5.53 CHEMBL1062483 CHEMBL561882 CC(C)N(C(C)C)C(=O)c1ccc(cc1)C2=CC3(CCNCC3)Oc4ccccc24 5.17 CHEMBL1056550 CHEMBL562176 Fc1ccc(cc1C#N)N2CCN(CCN3Cc4ccccc4C3)C2=O 5 CHEMBL1057876 CHEMBL562188 N[C@H]1Cn2c(C[C@@H]1c3cc(F)c(F)cc3F)nc4cnccc24.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F 4.05 CHEMBL1054110 CHEMBL562285 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC3)NC(=O)NC(Cc4cnccn4)c5ccccc5)c2 5.27 CHEMBL1061741 CHEMBL562326 CC1C(Oc2ccccc2S1(=O)=O)c3ccc(OCCCN4CCCC4)cc3 5.89 CHEMBL1061548 CHEMBL562388 N[C@H]1Cn2c(C[C@@H]1c3cc(F)c(F)cc3F)nc4ncccc24.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F 4.05 CHEMBL1054110 CHEMBL562464 Clc1cccc(c1)N2CCN(CCN3C[C@@H]4CC[C@H]3Cc5ccccc5C4)C2=O 7.2 CHEMBL1059865 CHEMBL562478 CCN(CC)C(=O)c1ccc(C2=CC3(CCNCC3)Oc4ccccc24)c(C)c1 5.37 CHEMBL1056550 CHEMBL562569 O=C(N(CC1CCC1)[C@H]2CCNC2)c3ccccc3C4CCCC4 5.66 CHEMBL1062483 CHEMBL562624 FC(F)(F)C1CCN(CCN2CCN(C2=O)c3cccc(Cl)c3)CC1 5.9 CHEMBL1057876 CHEMBL562629 C[C@@H]1CCCN1CCc2ccc(cc2)c3ccc(cc3)S(=O)(=O)N4CCCCC4 5.96 CHEMBL1827362 CHEMBL562663 CC(C)n1c(CNC2CCCC2)nc(C)c1c3ccc(Cl)cc3 5.5 CHEMBL1059781 CHEMBL562677 CCc1oc(CCc2cc(cc(NCCOC)n2)N3CCOCC3)nc1C 6.05 CHEMBL1055593 CHEMBL562722 COc1cccc2c1OC(C(C)S2(=O)=O)c3ccc(OCCCN4CCCC4)cc3 5.16 CHEMBL1061548 CHEMBL562788 Oc1cc(Cl)cc(Cl)c1CNC(=O)C2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2 5.38 CHEMBL1063190 CHEMBL562831 CCOC(=O)CNc1cc(cc(CCc2oc(CC)c(C)n2)n1)N3CCOCC3 6.04 CHEMBL1055593 CHEMBL562833 CC1(C)[C@@H]2CC[C@]13CCN(CCN4CCN(C4=O)c5cccc(Cl)c5)C3C2 6.1 CHEMBL1059865 CHEMBL562836 CN(CCN1CCN(C1=O)c2ccc(F)cc2)C[C@@]34CC[C@@H](CC3)C4(C)C 5.5 CHEMBL1059865 CHEMBL562870 COc1cccc2c1OC(C(C)S2(=O)=O)c3ccc(OC4CCN(CC4)C5CCC5)cc3 4.85 CHEMBL1061548 CHEMBL562873 CCN(CC)C(=O)c1ccc(cc1F)C2=CC3(CCNCC3)Oc4ccccc24 5.42 CHEMBL1056550 CHEMBL562898 CCN(CC)C(=O)c1cc(cs1)C2=CC3(CCNCC3)Oc4ccccc24 5.46 CHEMBL1056550 CHEMBL562905 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC(=O)N4CCN(CC4)C(=O)N5CCCC5)CC3)c2 4.85 CHEMBL1063190 CHEMBL562926 O=C(NC1CCc2ccccc2CC1)N3CCC(CC3)c4onc(n4)c5ccccn5 4.6 CHEMBL1051701 CHEMBL562948 CN(CCN1CCN(C1=O)c2ccccc2)C[C@@]34CC[C@@H](CC3)C4(C)C 5.4 CHEMBL1059865 CHEMBL562983 Fc1ccc(cc1Cl)N2CCN(CCN3Cc4ccccc4C3)C2=O 5.3 CHEMBL1057876 CHEMBL563005 OC[C@H](NC(=O)NC1CCN(Cc2ccn(c2)c3ccc(cc3)C(F)(F)F)CC1)c4ccccc4 4.59 CHEMBL1061741 CHEMBL563052 COc1ccc(cc1)[C@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(CC3)(C(=O)N4CCCC4)c5ccccc5)C(C)(C)C2 5.33 CHEMBL1053229 CHEMBL563117 CCN([C@H]1CCNC1)C(=O)c2ccccc2Oc3ccccc3 5.3 CHEMBL1062483 CHEMBL563118 C[C@@H]1CCCN1CCc2ccc(cc2)c3ccc(cc3)S(=O)(=O)NC4CCC4 6.13 CHEMBL1827362 CHEMBL563137 CC(C)CNC(=O)c1ccc(cc1)C2=CC3(CCNCC3)Oc4ccccc24 5.5 CHEMBL1056550 CHEMBL563220 Cn1cnc(c1)C(=O)N(C[C@@H]2[C@H]3CN(CC4CCCC4)C[C@@H]23)Cc5cccc(OC(F)(F)F)c5 6.34 CHEMBL1023476 CHEMBL563247 O=C1N(CCN2Cc3ccccc3C2)CCN1c4csc5ccccc45 5.1 CHEMBL1057876 CHEMBL563251 CN1C[C@@H]2[C@@H](CN(Cc3ccc(F)c(Cl)c3)C(=O)c4cn(C)cn4)[C@@H]2C1 5.07 CHEMBL1023476 CHEMBL563274 CN(CCN1CCN(C1=O)c2cccc(Cl)c2)C[C@@]34CC[C@@H](CC3)C4(C)C 5.5 CHEMBL1059865 CHEMBL563283 CN1C[C@H](CC1=O)N(Cc2ccccc2F)c3ccc(C#N)c(Cl)c3 5.19 CHEMBL1062741 CHEMBL563341 CN1CC[C@H](C1)N(Cc2ccccc2C(F)(F)F)c3ccc(C#N)c(Cl)c3 6.11 CHEMBL1062741 CHEMBL563435 COc1cccc(c1)N2CCN(CCN(C)C[C@@]34CC[C@@H](CC3)C4(C)C)C2=O 5.7 CHEMBL1059865 CHEMBL563495 Clc1cccc(OC([C@H]2CCNC2)c3ccccn3)c1Cl 5 CHEMBL1024556 CHEMBL563563 CC1(C)C[C@@H]2C[C@@](C)(CN2CCN3CCN(C3=O)c4cccc(Cl)c4)C1 5.9 CHEMBL1059865 CHEMBL563580 Clc1cccc(c1)N2CCN(CCN3[C@@H]4CCC[C@H]3CC4)C2=O 5.8 CHEMBL1059865 CHEMBL563593 COCCc1nc(CN[C@H]2CC[C@@H](F)C2)n(C(C)C)c1c3ccc(Cl)cc3 4.8 CHEMBL1059781 CHEMBL563635 CCN(CC)CCN1CCN(C1=O)c2cccc(Cl)c2 5.5 CHEMBL1059865 CHEMBL563700 CCN(CC)C(=O)c1ccc(cc1)C2=CC3(CCCNC3)Oc4ccccc24 4.9 CHEMBL1056550 CHEMBL563761 Cn1cnc(c1)C(=O)N(Cc2cccc(Cl)c2)[C@@H]3CC[C@H](N)CC3 4.18 CHEMBL1023476 CHEMBL563779 COc1cccc2c1OC(C(C)S2(=O)=O)c3ccc(OCCCN4CCC[C@@H]4C)cc3 5.42 CHEMBL1061548 CHEMBL563791 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC3)NC(=O)NC(c4ccccc4)c5ncc[nH]5)c2 4.9 CHEMBL1061741 CHEMBL563860 Clc1cccc(c1)N2CCN(CCN3C[C@H]4CC[C@@H]3C4)C2=O 4.9 CHEMBL1059865 CHEMBL563893 CCN(CC)C(=O)c1ccc(cc1)C2=CC3(CCCNCC3)Oc4ccccc24 4.93 CHEMBL1056550 CHEMBL563920 C[C@@H](c1ccccn1)c2c(CCN(C)C)oc3ccccc23 5.92 CHEMBL1051824 CHEMBL563926 COc1cccc(CCN(C)CCN2CCN(C2=O)c3cccc(Cl)c3)c1 6.2 CHEMBL1059865 CHEMBL564032 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC(=O)N4CCCC(C4)C(=O)N5CCCC5)CC3)c2 4.51 CHEMBL1063190 CHEMBL564071 CC(C)CN([C@H]1CCNC1)C(=O)c2ccccc2c3ccccc3 5.84 CHEMBL1062483 CHEMBL564108 CC(C)N1CCN(CCN2CCN(C2=O)c3ccc(F)c(c3)C#N)CC1 4.8 CHEMBL1057876 CHEMBL564144 C[C@@H](c1ccccn1)c2c(CCN(C)C)sc3ccccc23 5.85 CHEMBL1051824 CHEMBL564226 C[C@H](C1=C(CCN(C)C)Cc2ccccc12)c3ccccn3 6.05 CHEMBL1051824 CHEMBL564243 O[C@@H]1CCCC[C@H]1CNC(=O)NC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2 5.14 CHEMBL1061741 CHEMBL564298 CC(C)(C)c1ccc(cc1)N2CCN(CCN3Cc4ccccc4C3)C2=O 6 CHEMBL1057876 CHEMBL564347 CN(CCN1CCN(C1=O)c2ccc3OCOc3c2)C[C@@]45CC[C@@H](CC4)C5(C)C 5.2 CHEMBL1059865 CHEMBL564380 C[C@@H]1CCCN1CCc2ccc(cc2)c3ccc(cc3)S(=O)(=O)N4CCOCC4 5.44 CHEMBL1827362 CHEMBL564477 Cc1ccc(cn1)N2CCN(CCN3Cc4ccccc4C3)C2=O 4.5 CHEMBL1057876 CHEMBL564501 FC(F)(F)c1ccc(cc1)n2ccc(CN3CCC(CC3)NC(=O)N4CCCC4Cc5cccnc5)c2 5.76 CHEMBL1061741 CHEMBL564513 CCNc1cc(cc(CCc2oc(CC)c(C)n2)n1)N3CCOCC3 6.4 CHEMBL1055593 CHEMBL564514 C(COc1ccc(cc1)[C@H]2Oc3ccccc3S[C@H]2c4ccccc4)CN5CCCC5 7.92 CHEMBL1061548 CHEMBL564536 CCc1sc(CCc2cc(cc(NC(C)c3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)N4CCOCC4)nc1C 7.44 CHEMBL1055593 CHEMBL564674 OCC1CCCN(C1)C(=O)CC2CCN(Cc3oc(cc3)c4ccc(Cl)cc4)CC2 5.63 CHEMBL1063190 CHEMBL564741 CC(N1CCN(CCN2Cc3ccccc3C2)C1=O)c4cccc(c4)C(F)(F)F 5.9 CHEMBL1057876 CHEMBL564757 O=C(NC1CC1c2ccccc2)N3CCC(CC3)c4onc(n4)c5cccnc5 5.7 CHEMBL1051701 CHEMBL564812 CCc1c(CN[C@H]2CC[C@@H](F)C2)nc(c3ncccc3Cl)n1c4ccc(C)nc4 4.82 CHEMBL1059781 CHEMBL564840 Cl.OC[C@H](O)CN1C(=O)N(C2CCN(C[C@H]3[C@H]4CC[C@H](C4)C35CC5)CC2)c6ccccc16 4.6 CHEMBL1025211 CHEMBL564919 CCN1C[C@@H]2[C@@H](CN(Cc3cccc(OC(F)(F)F)c3)C(=O)c4cn(C)cn4)[C@@H]2C1 5.66 CHEMBL1023476 CHEMBL564922 O=C(N1CCCC1)c2ccc(cc2)C3=CC4(CCNCC4)Oc5ccccc35 4.98 CHEMBL1056550 CHEMBL564930 C[C@@]12CC[C@@H](CN(CCN3CCN(C3=O)c4cccc(Cl)c4)C1)C2(C)C 5.9 CHEMBL1059865 CHEMBL564935 O=C(N([C@H]1CCNC1)c2ccccc2)c3ccccc3Oc4ccccc4 5.55 CHEMBL1062483 CHEMBL564948 CN(CCN1CCN(C1=O)c2ccc(C)cc2)C[C@@]34CC[C@@H](CC3)C4(C)C 5.6 CHEMBL1059865 CHEMBL565007 COc1ccc2OC(C(C)S(=O)(=O)c2c1)c3ccc(OCCCN4CCCC4)cc3 6 CHEMBL1061548 CHEMBL565017 FC(F)(F)Oc1cccc(c1)N2CCN(CCN3Cc4ccccc4C3)C2=O 6.2 CHEMBL1057876 CHEMBL565031 Fc1ccc(Cl)cc1N2CCN(CCN3Cc4ccccc4C3)C2=O 4.7 CHEMBL1057876 CHEMBL565073 Fc1ccc(cc1)C(NC(=O)CC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2)c5cccnc5 5.66 CHEMBL1063190 CHEMBL565075 Clc1cccc(c1)N2CCN(CCN3C[C@@H]4CC[C@@H](CC4)C3)C2=O 6.4 CHEMBL1059865 CHEMBL565614 O\N=C(/c1ccc(CN2CCC3(CC2)OCc4cc(F)ncc34)cc1)\c5ccc(F)c(F)c5 6.55 CHEMBL1039122 CHEMBL565829 CCc1n[nH]c(CC)c1Oc2cc(cc(c2)C#N)C#N 5.01 CHEMBL1039906 CHEMBL565833 CCCNCc1ccc(CCN2C=CC(=CC2=O)OCc3ccc(F)cc3)nc1 5.29 CHEMBL1043534 CHEMBL566257 Fc1cc2COC3(CCN(Cc4ccc(cc4)C(=O)c5ccc(F)c(F)c5)CC3)c2cn1 7.77 CHEMBL1039122 CHEMBL566324 CC1(C)Cc2cccc(CN3CCC4(CC3)CCN(CC4)C(=O)c5ncccc5N)c2O1 4.49 CHEMBL1036929 CHEMBL566543 CC1(C)Cc2c(CN3CCC4(CC3)CCN(CC4)C(=O)c5ccc(N)cn5)cccc2O1 4.78 CHEMBL1045843 CHEMBL566759 CC(=C)COc1ccccc1CN2CCC3(CC2)CCN(CC3)C(=O)c4ccncc4 5.63 CHEMBL1045843 CHEMBL566880 CO\N=C(\c1ccc(CN2CCC3(CC2)OCc4cc(F)ncc34)cc1)/c5ccc(F)c(F)c5 6.6 CHEMBL1039122 CHEMBL566974 O=C(N1CCC2(CCN(Cc3ccccc3Oc4ccccc4)CC2)CC1)c5ccncn5 6.64 CHEMBL1045843 CHEMBL567 OCCN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1 5.38 CHEMBL1909190 CHEMBL567202 CC1(C)CCc2cc(CN3CCC4(CC3)CCN(CC4)C(=O)c5ccc(N)cn5)ccc2O1 4.49 CHEMBL1036929 CHEMBL567252 CCCOCCN1C(=O)C(=Nc2cnc(cc12)c3ccc(OC)nc3)NCCNCCO 5.35 CHEMBL1073649 CHEMBL567417 CCCC1(CC)Cc2c(CN3CCC4(CC3)CCN(CC4)C(=O)c5ccc(N)cn5)cccc2O1 5.4 CHEMBL1036929 CHEMBL567419 CC(C)COc1ccccc1CN2CCC3(CC2)CCN(CC3)C(=O)c4ccncc4 4.82 CHEMBL1036929 CHEMBL567620 CC(C)COc1ccccc1CN2CCC3(CC2)CCN(CC3)C(=O)c4ccncn4 4.72 CHEMBL1036929 CHEMBL567627 CC1(C)Cc2c(CN3CCC4(CC3)CCN(CC4)C(=O)c5ccnc(N)c5)cccc2O1 4.54 CHEMBL1045843 CHEMBL567916 CCc1n[nH]c(CC)c1Oc2cc(Cl)cc(c2)C#N 4.41 CHEMBL1039906 CHEMBL567919 CN(CCN1CCN(C2COOC2)C1=O)C[C@@]34CC[C@@H](CC3)C4(C)C 5.2 CHEMBL1044431 CHEMBL568294 CC(C)(C)C1(C)Cc2c(CN3CCC4(CC3)CCN(CC4)C(=O)c5ccc(N)cn5)cccc2O1 4.51 CHEMBL1036929 CHEMBL568296 CC1Cc2cccc(CN3CCC4(CC3)CCN(CC4)C(=O)c5ccncc5)c2O1 4.68 CHEMBL1045843 CHEMBL568361 CC(O)(c1ccc(CN2CCC3(CC2)OCc4cc(F)ncc34)cc1)c5ccc(F)c(F)c5 6.28 CHEMBL1039122 CHEMBL568503 CC1(C)CCc2cc(CN3CCC4(CC3)CCN(CC4)C(=O)c5ccncn5)ccc2O1 4.95 CHEMBL1045843 CHEMBL568522 CC1(C)Oc2c(CN3CCC4(CC3)CCN(CC4)C(=O)c5ccnc(N)c5)cccc2C=C1 4.42 CHEMBL1045843 CHEMBL568523 CC1(C)Cc2cccc(CN3CCC4(CC3)CCN(CC4)C(=O)c5ccc(N)cn5)c2O1 4.36 CHEMBL1045843 CHEMBL568571 CCO\N=C(\c1ccc(CN2CCC3(CC2)OCc4cc(F)ncc34)cc1)/c5ccc(F)c(F)c5 6.85 CHEMBL1039122 CHEMBL568572 OC(c1ccc(CN2CCC3(CC2)OCc4cc(F)ncc34)cc1)c5ccc(F)c(F)c5 6.28 CHEMBL1039122 CHEMBL569184 COc1ccc(CCN2[C@H](CN(NS(=O)(=O)C)C2=O)c3ccc(OC)cc3)cc1 4.57 CHEMBL1039568 CHEMBL569185 COc1ccc(CCN2[C@@H](CN(NS(=O)(=O)C)C2=O)c3ccc(OC)cc3)cc1 4.82 CHEMBL1039568 CHEMBL569628 COc1ccc(CCN2[C@H](CN(NS(=O)(=O)Cc3ccccc3)C2=O)c4ccc(OC)cc4)cc1 5.36 CHEMBL1039568 CHEMBL569832 CCNS(=O)(=O)c1ccc(cc1)c2ccc(CCN3CCC[C@H]3C)cc2 5.47 CHEMBL1827362 CHEMBL569846 Oc1cccc(c1)N2CCN(CCN3CCC(CC3)C(F)(F)F)C2=O 4.8 CHEMBL1057876 CHEMBL570033 OC(=O)c1ccc(CCCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4)cc1 4.96 CHEMBL1048091 CHEMBL570274 C[C@@H]1CNCCN1C2=NN(CCOc3ccccc3C(F)(F)F)C(=O)C=C2 5.43 CHEMBL1047263 CHEMBL570296 CCCNCc1ccc(CCN2C=CC(=CC2=O)OCc3ccc(F)cc3)cc1 5.38 CHEMBL1043534 CHEMBL570360 COc1ccc(CCCN2[C@@H](CN(NS(=O)(=O)C)C2=O)c3ccc(OC)cc3)cc1 4.85 CHEMBL1039568 CHEMBL570593 CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3ccc(CCC(=O)O)cc3C#N 7.49 CHEMBL1052905 CHEMBL570805 CCOc1ccc(CCN2[C@H](CN(NS(=O)(=O)C)C2=O)c3ccc(OC)cc3)cc1 4.91 CHEMBL1039568 CHEMBL570815 COc1ccc(CCN2[C@H](CN(NS(=O)(=O)CC#N)C2=O)c3ccc(OC)cc3)cc1 4.48 CHEMBL1039568 CHEMBL570998 CC(C)N1CCN(CCN2CCN(C2=O)c3cccc(Cl)c3F)CC1 4.7 CHEMBL1057876 CHEMBL571013 CCc1oc(CCc2cc(cc(NC)n2)N3CCOCC3)nc1C 6.08 CHEMBL1055593 CHEMBL571039 COc1ccc(CCN2[C@H](CN(NS(=O)(=O)CF)C2=O)c3ccc(OC)cc3)cc1 4.55 CHEMBL1039568 CHEMBL571041 COc1ccc(CCN2C(CN(NS(=O)(=O)C)C2=O)c3ccc(cc3)C(F)(F)F)cc1 5.04 CHEMBL1039568 CHEMBL571221 CN1CCN(CCN2CCN(C2=O)c3cccc(Cl)c3)CC1 5.4 CHEMBL1057876 CHEMBL571229 Clc1cccc(CN2CCN(CCN3Cc4ccccc4C3)C2=O)c1 5.6 CHEMBL1057876 CHEMBL571389 Cc1ccc(CCCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4)cc1 6.4 CHEMBL1048091 CHEMBL571456 CC(C)N1CCN(CCN2CCN(C2=O)c3cccc(c3)C#N)CC1 4.9 CHEMBL1057876 CHEMBL571952 COc1ccc(CCN2C(CN(NS(=O)(=O)C)C2=O)c3ccc(OC(C)C)cc3)cc1 4.77 CHEMBL1039568 CHEMBL571953 COCCOc1ccc(cc1)C2CN(NS(=O)(=O)C)C(=O)N2CCc3ccc(OC)cc3 4.48 CHEMBL1039568 CHEMBL572153 COc1ccc(CCN2C(CN(NS(=O)(=O)C)C2=O)c3ccc(C)cc3)cc1 4.95 CHEMBL1039568 CHEMBL572163 CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3ccc(CCC(=O)O)cc3 7.42 CHEMBL1052905 CHEMBL572537 O=C(N1CCC2(CCN(Cc3cccc4CCOc34)CC2)CC1)c5ccncc5 5.11 CHEMBL1036929 CHEMBL572558 N#Cc1ccc(cc1)c2cnc3nc(sc3c2)N4CCC(CC4)N5CCCCC5 5.95 CHEMBL1827362 CHEMBL572559 Cc1ccc(cn1)c2cc3sc(nc3cn2)N4CCC(CC4)N5CCCCC5 5.09 CHEMBL1827362 CHEMBL572737 N#Cc1cncc(c1)c2cc3sc(nc3cn2)N4CCC(CC4)N5CCCCC5 5.18 CHEMBL1827362 CHEMBL572996 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C(C)C)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O 6.39 CHEMBL1054535 CHEMBL573034 COc1cc(ccn1)c2cnc3nc(sc3c2)N4CCC(CC4)N5CCCCC5 6.69 CHEMBL1827362 CHEMBL573216 COc1ccccc1Oc2ccccc2CN3CCC4(CC3)CCN(CC4)C(=O)c5ccncn5 6.92 CHEMBL1036929 CHEMBL573485 COc1ccc(cn1)c2cnc3nc(sc3c2)N4CCC(CC4)N5CCCCC5 7 CHEMBL1827362 CHEMBL573493 Nc1cnc(cn1)c2cnc3nc(sc3c2)N4CCC(CC4)N5CCCCC5 4.4 CHEMBL1827362 CHEMBL574180 Cc1ccc(cn1)c2cnc3nc(sc3c2)N4CCC(CC4)N5CCCCC5 5.12 CHEMBL1827362 CHEMBL574387 CC(=O)Nc1ccc(cn1)c2cnc3nc(sc3c2)N4CCC(CC4)N5CCCCC5 4.4 CHEMBL1827362 CHEMBL574655 COc1ccccc1Oc2cccc(CN3CCC4(CC3)CCN(CC4)C(=O)c5ccncn5)c2 5.72 CHEMBL1045843 CHEMBL574826 Fc1cc(ccn1)c2cc3sc(nc3cn2)N4CCC(CC4)N5CCCCC5 5.75 CHEMBL1827362 CHEMBL574837 Fc1ccc(cn1)c2cnc3nc(sc3c2)N4CCC(CC4)N5CCCCC5 6.51 CHEMBL1827362 CHEMBL575022 COc1cc(ccn1)c2cc3sc(nc3cn2)N4CCC(CC4)N5CCCCC5 6.01 CHEMBL1827362 CHEMBL575023 Fc1ccc(cn1)c2cc3sc(nc3cn2)N4CCC(CC4)N5CCCCC5 5.02 CHEMBL1827362 CHEMBL575234 C1CCN(CC1)C2CCN(CC2)c3nc4cnc(cc4s3)c5cncnc5 5.19 CHEMBL1827362 CHEMBL575241 Nc1ccc(cn1)c2cnc3nc(sc3c2)N4CCC(CC4)N5CCCCC5 4.71 CHEMBL1827362 CHEMBL575474 Clc1cc2sc(nc2cn1)N3CCC(CC3)N4CCCCC4 5.16 CHEMBL1827362 CHEMBL575475 Fc1ncccc1c2cnc3nc(sc3c2)N4CCC(CC4)N5CCCCC5 5.58 CHEMBL1827362 CHEMBL575476 C1CCN(CC1)C2CCN(CC2)c3nc4ncc(cc4s3)c5cncnc5 4.63 CHEMBL1827362 CHEMBL575483 COc1ccc(cn1)c2cc3sc(nc3cn2)N4CCC(CC4)N5CCCCC5 5.95 CHEMBL1827362 CHEMBL575693 CC(=O)Nc1ccc(cn1)c2cc3sc(nc3cn2)N4CCC(CC4)N5CCCCC5 5.07 CHEMBL1827362 CHEMBL576256 CCc1n[nH]c(CC)c1Oc2cc(C)cc(c2)C#N 4 CHEMBL1039906 CHEMBL578862 N#Cc1cncc(c1)c2cnc3nc(sc3c2)N4CCC(CC4)N5CCCCC5 5.91 CHEMBL1827362 CHEMBL579072 CC1(C)Oc2c(CN3CCC4(CC3)CCN(CC4)C(=O)c5ccc(N)cn5)cccc2C1(F)F 4.32 CHEMBL1036929 CHEMBL58 OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12 5.45 CHEMBL1909190 CHEMBL58004 Cc1nc[n+]([O-])c(C)c1C(=O)N2CCC(C)(CC2)N3CCC(CC3)N(c4ccccc4)c5ccccc5 5.92 CHEMBL928561 CHEMBL582792 CCO\N=C(\c1ccc(F)c(F)c1)/c2ccc(CN3CCC4(CC3)OCc5cc(F)ncc45)cn2 5.75 CHEMBL1039122 CHEMBL582876 Fc1ncccc1c2cc3sc(nc3cn2)N4CCC(CC4)N5CCCCC5 5.87 CHEMBL1827362 CHEMBL582978 O\N=C(\c1ccc(CN2CCC3(CC2)OCc4cc(F)ncc34)cc1)/c5ccc(F)c(F)c5 6.51 CHEMBL1039122 CHEMBL583 CC1CN(CCN1)c2cc3N(C=C(C(=O)O)C(=O)c3c(C)c2F)C4CC4 4.11 CHEMBL832277 CHEMBL583047 COc1ccc(cc1)[C@H]2CN(NS(=O)(=O)C)C(=O)N2CCc3ccc(OC(F)(F)F)cc3 5.25 CHEMBL1039568 CHEMBL583091 CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]3N(C4CN(Cc5ccnc6ncccc56)C4)C(=O)O[C@]13C 4.1 CHEMBL1042376 CHEMBL583093 CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]3N(C4CN(C4)[C@H](C)c5ccnc6ncccc56)C(=O)O[C@]13C 4.37 CHEMBL1042376 CHEMBL583212 FC(F)C(F)(F)Oc1ccccc1CN2CCC3(CC2)CCN(CC3)C(=O)c4ccncc4 4.77 CHEMBL1036929 CHEMBL583254 COc1ccc(CCN2C(CN(NS(=O)(=O)C)C2=O)c3ccc(cc3)C4CC4)cc1 5.08 CHEMBL1039568 CHEMBL583299 CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]3N(C4CN(Cc5c(O)cnc6cccnc56)C4)C(=O)O[C@]13C 4.17 CHEMBL1042376 CHEMBL583430 COc1ccc(CCCN2[C@H](CN(NS(=O)(=O)C)C2=O)c3ccc(OC)cc3)cc1 4.85 CHEMBL1039568 CHEMBL583465 COc1ccc(CCN2C(CN(NS(=O)(=O)C)C2=O)c3ccc(Cl)cc3)cc1 5.06 CHEMBL1039568 CHEMBL583582 Fc1cc(ccn1)c2cnc3nc(sc3c2)N4CCC(CC4)N5CCCCC5 6.69 CHEMBL1827362 CHEMBL583621 CC1(C)Cc2c(CN3CCC4(CC3)CCN(CC4)C(=O)c5ccncc5)cccc2O1 4.52 CHEMBL1036929 CHEMBL583843 COc1ccccc1Oc2ccccc2CN3CCC4(CC3)CCN(CC4)C(=O)C5=CC=CNC5=O 4.85 CHEMBL1045843 CHEMBL58387 Cc1ccnc(C)c1C(=O)N2CCC(C)(CC2)N3CCC(CC3)N(c4ccccc4)c5ccccc5 6.24 CHEMBL928561 CHEMBL584 Cc1c(O)cccc1C(=O)N[C@@H](CSc2ccccc2)[C@H](O)CN3C[C@H]4CCCC[C@H]4C[C@H]3C(=O)NC(C)(C)C 4.9 CHEMBL3430340 CHEMBL584087 CC1(C)Oc2cccc(CN3CCC4(CC3)CCN(CC4)C(=O)c5ccnc(N)c5)c2O1 4.78 CHEMBL1045843 CHEMBL584538 Fc1ccc(COC2=CC(=O)N(C=C2)c3ccc(OCCN4CCCC4)cc3)cc1 8.05 CHEMBL1648563 CHEMBL584549 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C(C)C)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O 8 CHEMBL1054535 CHEMBL584766 Fc1ccc(cc1C#N)c2cnc3nc(sc3c2)N4CCC(CC4)N5CCCCC5 7 CHEMBL1827362 CHEMBL585163 COc1ccc(CCN2C(CN(NS(=O)(=O)C)C2=O)c3ccc(C)c(C)c3)cc1 4.8 CHEMBL1039568 CHEMBL585509 Fc1cc2COC3(CCN(Cc4ccc(Nc5ccc(F)c(F)c5)cc4)CC3)c2cn1 7.64 CHEMBL1039122 CHEMBL585664 CCO\N=C(\c1ccc(F)c(F)c1)/c2ccc(CN3CCC4(CC3)OCC5=CN(C)C(=O)C=C45)cn2 5.44 CHEMBL1039122 CHEMBL585856 CN(c1ccc(CN2CCC3(CC2)OCc4cc(F)ncc34)cc1)c5ccc(F)c(F)c5 7.6 CHEMBL1039122 CHEMBL589069 CCCOCCN1C(=O)C(=Nc2cnc(cc12)c3ccc(OC)nc3)N4CCN(CC4)[C@@H](C)[C@@H](C)O 7.27 CHEMBL1073649 CHEMBL589833 Fc1ccc(CC2=CNC(=O)c3cc(Cl)c(Cl)n23)cc1C(=O)N4CCC(CC4)N5CCCC5 5.1 CHEMBL1069754 CHEMBL590036 CCCOCCN1C(=O)C(=Nc2cnc(cc12)c3ccc(OC)nc3)N4CCN(C[C@@H](C)O)CC4 6.64 CHEMBL1073649 CHEMBL590280 CCCOCCN1C(=O)C(=Nc2cnc(cc12)c3ccc(OC)nc3)N4CCN(CC)CC4 6.5 CHEMBL1073649 CHEMBL590593 C[C@H](O)C(=O)N1CC[C@@H](C1)N(Cc2cc(Cl)ccc2Cl)c3ccc(C#N)c(Cl)c3 5.66 CHEMBL1072651 CHEMBL590791 CNC(C)(C)C(=O)N1CCN(CC1)C(=O)c2cc(CC3=CNC(=O)c4cc(Cl)c(Cl)n34)ccc2F 4.96 CHEMBL1069754 CHEMBL591477 CCCOCCN1C(=O)C(=Nc2cnc(cc12)c3ccc(OC)nc3)N4CCNCC4 6.17 CHEMBL1073649 CHEMBL591501 CCCOCCN1C(=O)C(=Nc2cnc(cc12)c3ccc(OC)nc3)N4CCN(CCO)CC4 5.75 CHEMBL1073649 CHEMBL593521 Fc1cc2COC3(CCN(Cc4ccc(Oc5ccc(F)c(F)c5)cc4)CC3)c2cn1 7.62 CHEMBL1039122 CHEMBL594534 Cc1cc(Nc2ccccc2)nc(NCc3ccccn3)n1 4.8 CHEMBL1070001 CHEMBL594717 C[C@@H]1CNCCN1c2ccc3CC[C@H](OCc4cc(F)ccc4C)c3n2 5.41 CHEMBL1069964 CHEMBL594752 Cc1cc(Nc2ccccc2)nc(NCc3ccc4OCOc4c3)n1 5.02 CHEMBL1070001 CHEMBL594979 FC(F)(F)c1cc(Nc2ccccc2)nc(NCc3ccccn3)n1 4.4 CHEMBL1070001 CHEMBL59511 Cc1cc[n+]([O-])c(C)c1C(=O)N2CCC(C)(CC2)N3CCC(CC3)N(Cc4cccc(c4)C#N)c5ccccc5 5.89 CHEMBL928561 CHEMBL595944 Cc1occc1c2nc(N)c(OC[C@@H](N)Cc3c[nH]c4ccccc34)cc2c5cnc6[nH]nc(C)c6n5 4.98 CHEMBL1072008 CHEMBL596 CCC(=O)N(C1CCN(CCc2ccccc2)CC1)c3ccccc3 5.74 CHEMBL829152 CHEMBL596699 Cn1cnc(c1)C(=O)N(Cc2ccc(F)c(c2)C(F)(F)F)[C@H]3C[C@H]4CNC[C@H]4C3 5.36 CHEMBL1074124 CHEMBL596700 Cn1cnc(c1)C(=O)N(Cc2cccc(OC(F)(F)F)c2)[C@H]3C[C@H]4CNC[C@H]4C3 4.88 CHEMBL1074124 CHEMBL597 Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3 4.7 CHEMBL1909190 CHEMBL597241 Clc1cnc2nc(oc2c1)N3CCN4CCC3CC4 5.48 CHEMBL1069497 CHEMBL597276 Clc1cnc2oc(nc2c1)N3CCN4CCC3CC4 5.66 CHEMBL1069497 CHEMBL597440 Fc1cnc2nc(oc2c1)N3CCN4CCC3CC4 5.06 CHEMBL1069497 CHEMBL597737 Fc1ccccc1c2ccc3oc(nc3n2)N4CCN5CCC4CC5 5.55 CHEMBL1069497 CHEMBL598194 NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)NCc4ccc(Cl)cc4 5.28 CHEMBL2330875 CHEMBL598270 CCCCCCC[N+](CC)(CC)CCCCc1ccc(Cl)cc1.Cc2ccc(cc2)S(=O)(=O)[O-] 7.3 CHEMBL3096731 CHEMBL598555 CCc1ccc2oc(nc2n1)N3CCN4CCC3CC4 4.56 CHEMBL1069497 CHEMBL599480 CCN1C[C@H]2C[C@H](C[C@H]2C1)N(Cc3ccc(F)c(c3)C(F)(F)F)C(=O)c4cn(C)cn4 5.81 CHEMBL1074124 CHEMBL601500 Cc1ccccc1CN([C@H]2CCN(C2)S(=O)(=O)C)c3ccc(C#N)c(Cl)c3 5.55 CHEMBL1072651 CHEMBL601821 NCC(=O)N1CCn2c(C1)nc(c2Nc3ccc4OCOc4c3)c5ccccc5 4.72 CHEMBL1803471 CHEMBL601873 CC(C)OC(=O)C1=CN(CC(C)(C)c2c1[nH]c3ccccc23)C(=O)c4ccc(OCCCN5CCOCC5)cc4 5.24 CHEMBL1070849 CHEMBL602875 COc1cc2CC[C@@H](Oc2c(c1)N3CCN(C)CC3)C(=O)Nc4ccc(cc4)N5CCOCC5 4.72 CHEMBL1065722 CHEMBL603052 Cc1nc2nc(oc2cc1Cl)N3CCN4CCC3CC4 4.79 CHEMBL1069497 CHEMBL603584 COc1ccc(cc1)C2Sc3ccccc3N(CCN(C)C)C(=O)C2OC(=O)C 4.76 CHEMBL1676103 CHEMBL603695 CN1C[C@H]2C[C@H](C[C@H]2C1)N(Cc3ccc(F)c(c3)C(F)(F)F)C(=O)c4cn(C)cn4 5.76 CHEMBL1074124 CHEMBL604798 Cc1ccc2oc(nc2n1)N3CCN4CCC3CC4 4.4 CHEMBL1069497 CHEMBL605785 COC1(CCOCC1)c2ccc(NC(=O)C3=CC(=O)c4cc(F)cc(c4O3)c5c(C)nn(C)c5C)cn2 4.02 CHEMBL1065722 CHEMBL606029 Fc1ccc(CC2=CNC(=O)c3cc(Cl)c(Cl)n23)cc1C(=O)N4CCC5(CCCN5)CC4 4.92 CHEMBL1069754 CHEMBL607 CCOC(=O)C1(CCN(C)CC1)c2ccccc2 4.12 CHEMBL1036648 CHEMBL60796 Oc1ccc(CCN2CCC(CC2)Nc3nc4ccccc4n3Cc5ccc(F)cc5)cc1 9 CHEMBL766814 CHEMBL608151 CCOC[C@H]1[C@@H]2CNC[C@]12c3ccc(Cl)c(Cl)c3 5.38 CHEMBL1068919 CHEMBL60889 CCOc1cc(N)c(Cl)cc1C(=O)NCC2CN(Cc3ccc(F)cc3)CCO2 5.32 CHEMBL1011678 CHEMBL611 COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4 4.75 CHEMBL1676103 CHEMBL611369 Brc1cnc2nc(oc2c1)N3CCN4CCC3CC4 5.64 CHEMBL1069497 CHEMBL61301 Fc1ccc(Cn2c(NC3CCNCC3)nc4ccccc24)cc1 7.55 CHEMBL766814 CHEMBL61536 Cc1cc[n+]([O-])c(C)c1C(=O)N2CCC(C)(CC2)N3CCC(CC3)N(Cc4ccccc4)c5ccccc5 6.26 CHEMBL928561 CHEMBL62152 Cc1cccc(C)c1C(=O)N2CCC(C)(CC2)N3CCC(CC3)N(c4ccccc4)c5ccccc5 6.82 CHEMBL928561 CHEMBL629 CN(C)CCC=C1c2ccccc2CCc3ccccc13 4.76 CHEMBL1909190 CHEMBL631 CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2 5.54 CHEMBL1918925 CHEMBL633 CCCCc1oc2ccccc2c1C(=O)c3cc(I)c(OCCN(CC)CC)c(I)c3 5 CHEMBL766814 CHEMBL639 CN1CCCC(CC1)N2N=C(Cc3ccc(Cl)cc3)c4ccccc4C2=O 7 CHEMBL1769661 CHEMBL641 CNCC[C@@H](Oc1ccccc1C)c2ccccc2 5.68 CHEMBL948485 CHEMBL651 CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c2ccccc2 5.01 CHEMBL829152 CHEMBL652 FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC2CCCCN2 5.41 CHEMBL766814 CHEMBL657 CN(C)CCOC(c1ccccc1)c2ccccc2 4.5 CHEMBL1909190 CHEMBL6966 COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC 5.51 CHEMBL827807 CHEMBL70099 CN1CCc2cccc3c2C1Cc4ccc(O)c(O)c34 5.62 CHEMBL1676103 CHEMBL70380 CN1C(=O)[C@@H](NC(=O)Nc2cccc(C)c2)N=C(c3ccccc3)c4ccccc14 5 CHEMBL686879 CHEMBL707 COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4COc5ccccc5O4 5.66 CHEMBL1909190 CHEMBL708 Clc1cc2NC(=O)Cc2cc1CCN3CCN(CC3)c4nsc5ccccc45 6.82 CHEMBL822598 CHEMBL709 COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C3CCCO3 4.7 CHEMBL3430689 CHEMBL71 CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13 5.24 CHEMBL1909190 CHEMBL715 CN1CCN(CC1)C2=Nc3ccccc3Nc4sc(C)cc24 4 CHEMBL1909190 CHEMBL716 OCCOCCN1CCN(CC1)C2=Nc3ccccc3Sc4ccccc24 5.24 CHEMBL1676103 CHEMBL72 CNCCCN1c2ccccc2CCc3ccccc13 4.56 CHEMBL1909190 CHEMBL723 COc1ccccc1OCCNCC(O)COc2cccc3[nH]c4ccccc4c23 4.9 CHEMBL1676103 CHEMBL726 OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 5.24 CHEMBL1909190 CHEMBL728 CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1 5.73 CHEMBL1909190 CHEMBL729 CC(C)[C@H](N1CCCNC1=O)C(=O)N[C@H](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)COc3c(C)cccc3C)Cc4ccccc4 5.07 CHEMBL1676103 CHEMBL7463 CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15 6 CHEMBL1676103 CHEMBL74656 CO[C@@H]1CN(CCCOc2ccc(F)cc2)CC[C@@H]1NC(=O)c3cc(Cl)c(N)cc3OC 7.1 CHEMBL3266651 CHEMBL75880 C(C(C1CCCCC1)C2CCCCC2)C3CCCCN3 5.11 CHEMBL766814 CHEMBL76 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 5.6 CHEMBL827807 CHEMBL779 CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c5ccc6OCOc6c5)C1=O 4 CHEMBL1036648 CHEMBL809 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc13 5.08 CHEMBL1909190 CHEMBL811 CN(C)CCC(c1ccc(Br)cc1)c2ccccn2 6.05 CHEMBL1676103 CHEMBL814 COCCCC\C(=N/OCCN)\c1ccc(cc1)C(F)(F)F 5.51 CHEMBL3430638 CHEMBL83 CC\C(=C(/c1ccccc1)\c2ccc(OCCN(C)C)cc2)\c3ccccc3 5.8 CHEMBL1676103 CHEMBL845 Clc1ccc2Nc3ccccc3C(=Nc2c1)N4CCNCC4 4.5 CHEMBL1676103 CHEMBL85 CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCCC5=N1 5.38 CHEMBL1909190 CHEMBL850 C[C@@H]1CN(C[C@H](C)N1)c2c(F)c(N)c3C(=O)C(=CN(C4CC4)c3c2F)C(=O)O 4.33 CHEMBL1909190 CHEMBL85606 O=C(N[C@@H]1CC[C@@H](CCN2CCc3cc(ccc3C2)C#N)CC1)c4ccnc5ccccc45 5.7 CHEMBL895464 CHEMBL86304 Clc1ccc(cc1)C(=O)NCCN2CCOCC2 4.1 CHEMBL1676103 CHEMBL87045 C1CN=C(N1)C2CC2(c3ccccc3)c4ccccc4 4.65 CHEMBL3430632 CHEMBL900 CN(C)CCOC(c1ccccc1)c2ccccc2C 6.07 CHEMBL1676103 CHEMBL914 CC(C)(C(=O)O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4 4.19 CHEMBL1011678 CHEMBL92870 Cc1cccc(C)c1NC(=O)CN2CCN(CCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2 7.8 CHEMBL829152 CHEMBL9387 CN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(c3ccccc3)c4ccccc14 5.3 CHEMBL686879 CHEMBL94454 CN(C1CCN(CC1)c2nc3ccccc3n2Cc4ccc(F)cc4)C5=NC=CC(=O)N5 6.36 CHEMBL766814 CHEMBL94664 COc1ccc(cc1OC)C2CCN(CCC3CCOc4ccccc34)CC2 6.7 CHEMBL766814 CHEMBL9484 CCCCCCC[N+](CC)(CC)CCCCc1ccc(Cl)cc1 6.82 CHEMBL827807 CHEMBL96153 COc1ccc(cc1OC)C2CCN(CC[C@H]3CCOc4ccccc34)CC2 6.6 CHEMBL766814 CHEMBL98553 CC(C)(C)OC(=O)NCCCN(Cc1cncn1Cc2ccc(cc2)C#N)[C@H]3CCN(Cc4ccccc4)C3=O 6.96 CHEMBL1027667 CHEMBL99371 O=C1[C@H](CCN1c2ccncc2)NCc3cncn3Cc4ccc(cc4)C#N 5.5 CHEMBL1027667 CHEMBL998 CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc4cccnc24)CC1 4.41 CHEMBL1909190