Clicking on the HCA plots will open the relevant PDB entry
Class a: All alpha proteins Class e: Multi-domain proteins (alpha and beta) Class i: Low resolution protein structures
Class b: All beta proteins Class f: Membrane and cell surface proteins and peptides Class j: Peptides
Class c: Alpha and beta proteins (a/b) Class g: Small proteins Class k: Designed proteins
Class d: Alpha and beta proteins (a+b) Class h: Coiled coil proteins SCOP Classes with more than 5 compatible hydrophobic patterns

Class: Alpha and beta proteins (a+b)

Folds

  • 4'-phosphopantetheinyl transferase
  • 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain
  • Acidic mitochondrial matrix protein p32
  • Acyl-CoA N-acyltransferases (Nat)
  • ADC synthase
  • ADP-ribosylation
  • Aldehyde ferredoxin oxidoreductase, N-terminal domain
  • Allophycocyanin linker chain (domain)
  • alpha/beta-Hammerhead
  • Alpha-L RNA-binding motif
  • Alpha-lytic protease prodomain-like
  • Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain
  • Anti-LPS factor/recA domain
  • Argininosuccinate synthetase, C-terminal domain
  • Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • ATP-grasp
  • B3/B4 domain of PheRS, PheT
  • Bacillus chorismate mutase-like
  • Bacterial protein-export protein SecB
  • Bactericidal permeability-increasing protein, BPI
  • Baseplate structural protein gp11
  • beta-Grasp (ubiquitin-like)
  • beta-hairpin-alpha-hairpin repeat
  • beta-lactamase-inhibitor protein, BLIP
  • CBS-domain
  • Cdc48 domain 2-like
  • Cell cycle regulatory proteins
  • Cell division protein MinE topological specificity domain
  • Chalcone isomerase
  • Chorismate lyase
  • CI-2 family of serine protease inhibitors
  • Class II aaRS and biotin synthetases
  • Clathrin adaptor appendage, alpha and beta chain-specific domain
  • ClpS-like
  • CO dehydrogenase flavoprotein C-domain-like
  • Conserved core of transcriptional regulatory protein vp16
  • Creatinase/aminopeptidase
  • C-type lectin-like
  • Cyanase C-terminal domain
  • Cystatin-like
  • Cysteine proteinases
  • Cytochrome b5
  • DCoH-like
  • Diaminopimelate epimerase-like
  • DNA breaking-rejoining enzymes
  • DNA clamp
  • DNA damage-inducible protein DinI
  • DNA topoisomerase I domain
  • DNA-binding C-terminal domain of the transcription factor MotA
  • DNA-binding domain
  • DNA-binding domain of Mlu1-box binding protein MBP1
  • DNA-binding protein Tfx
  • DNase I-like
  • Dodecin subunit-like
  • dsRBD-like
  • DsrC, the gamma subunit of dissimilatory sulfite reductase
  • Dynein light chain 8 (DLC8)
  • eIF1-like
  • Elongation factor Ts (EF-Ts), dimerisation domain
  • Enolase N-terminal domain-like
  • Eukaryotic type KH-domain (KH-domain type I)
  • FAD-binding domain
  • FAD-linked reductases, C-terminal domain
  • FAH
  • Fe,Mn superoxide dismutase (SOD), C-terminal domain
  • Ferredoxin-like
  • Fibrinogen C-terminal domain-like
  • FKBP-like
  • GCM domain
  • Gelsolin-like
  • GFP-like
  • GIY-YIG endonuclease
  • Glutamine synthase/guanido kinase
  • Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
  • gp120 core
  • GroEL-intermediate domain like
  • GTP cyclohydrolase I feedback regulatory protein, GFRP
  • GYF domain
  • Head-to-tail joining protein W, gpW
  • Hedgehog/DD-pepidase
  • Heme-binding protein A (HasA)
  • His-Me finger endonucleases
  • HIT-like
  • Homing endonuclease-like
  • HPr-like
  • Hsp33 domain
  • Hypothetical protein HI1434 (YbaK homologue)
  • Hypothetical protein MTH1880
  • Hypothetical protein TM0875
  • Hypothetical protein Yhr087W
  • Hypothetical protein YjiA, C-terminal domain
  • IF3-like
  • IL8-like
  • Inhibitor of vertebrate lysozyme, Ivy
  • Insert subdomain of RNA polymerase alpha subunit
  • Integrin beta tail domain
  • L9 N-domain-like
  • L-aminopeptidase D-Ala-esterase/amidase
  • LCCL domain
  • LDH C-terminal domain-like
  • LigT-like
  • LuxS/MPP-like metallohydrolase
  • LysM domain
  • Lysozyme-like
  • Mago nashi protein
  • Major capsid protein gp5
  • Metal cation-transporting ATPase, ATP-binding domain N
  • Metallo-dependent phosphatases
  • Metallo-hydrolase/oxidoreductase
  • Methenyltetrahydromethanopterin cyclohydrolase
  • Methionine synthase activation domain-like
  • MHC antigen-recognition domain
  • Microbial ribonucleases
  • Molybdemum cofactor-binding domain
  • Monooxygenase (hydroxylase) regulatory protein
  • Mosquitocidal delta-endotoxin CytB
  • mRNA triphosphatase CET1
  • MTH1598-like
  • Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains
  • MutS N-terminal domain-like
  • N domain of copper amine oxidase-like
  • N-acetylmuramoyl-L-alanine amidase-like
  • NADH oxidase/flavin reductase
  • Nitric oxide (NO) synthase oxygenase domain
  • Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase
  • Nitrile hydratase alpha chain
  • Non-globular alpha+beta subunits of globular proteins
  • N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
  • Ntn hydrolase-like
  • Nuclease A inhibitor (NuiA)
  • Nucleotidyltransferase
  • Nudix
  • Origin of replication-binding domain, RBD-like
  • Ornithine decarboxylase C-terminal domain
  • OsmC-like
  • Outer capsid protein sigma 3
  • Penicillin binding protein dimerisation domain
  • Penicillin-binding protein 2x (pbp-2x), c-terminal domain
  • Pentein, beta/alpha-propeller
  • Pepsin inhibitor-3
  • Peptide deformylase
  • Phoshotransferase/anion transport protein
  • Phospholipase D/nuclease
  • Photosystem I subunit PsaD
  • Pili subunits
  • Polo domain
  • Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
  • POZ domain
  • PR-1-like
  • Prion-like
  • Probable bacterial effector-binding domain
  • Profilin-like
  • Proguanylin
  • Prokaryotic ribosomal protein L17
  • Protein kinase-like (PK-like)
  • Protein serine/threonine phosphatase 2C, catalytic domain
  • Protein-L-isoaspartyl O-methyltransferase, C-terminal domain
  • Putative cell cycle protein MesJ, middle and C-terminal domain
  • PX domain
  • Pyruvoyl-dependent histidine and arginine decarboxylases
  • Ran-binding protein mog1p
  • Receptor-binding domain of short tail fibre protein gp12
  • Regulatory factor Nef
  • Replication modulator SeqA, C-terminal DNA-binding domain
  • Ribonuclease Rh-like
  • Ribosomal protein L11, N-terminal domain
  • Ribosomal protein L22
  • Ribosomal protein L30p/L7e
  • Ribosomal protein L31e
  • Ribosomal protein L5
  • Ribosomal protein L6
  • Ribosomal protein L9 C-domain
  • Ribosomal protein S16
  • Ribosomal protein S19
  • Ribosomal protein S3 C-terminal domain
  • Ribosomal protein S5 domain 2-like
  • Ribosomal protein S8
  • Ribosomal proteins L23 and L15e
  • Ribosome binding protein Y (YfiA homologue)
  • Ribosome inactivating proteins (RIP)
  • RNA bacteriophage capsid protein
  • RNase A-like
  • Rotavirus NSP2 fragment, N-terminal domain
  • RPB5-like RNA polymerase subunit
  • RRF/tRNA synthetase additional domain-like
  • RuBisCO, small subunit
  • S-adenosylmethionine decarboxylase
  • S-adenosylmethionine synthetase
  • SAICAR synthase-like
  • SAND domain-like
  • Secretion chaperone-like
  • SH2-like
  • Signal recognition particle alu RNA binding heterodimer, SRP9/14
  • SMAD MH1 domain
  • Smc hinge domain
  • Sporulation responce regulatory protein Spo0B
  • SRCR-like
  • SRF-like
  • SRP19
  • ssDNA-binding transcriptional regulator domain
  • Sterol carrier protein, SCP
  • Substrate-binding domain of HMG-CoA reductase
  • Subtilisin inhibitor
  • Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • SufE-like
  • Sulfite oxidase, middle catalytic domain
  • Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
  • Tautomerase/MIF
  • TBP-like
  • T-fold
  • The spindle assembly checkpoint protein mad2
  • Thioesterase/thiol ester dehydrase-isomerase
  • Thymidylate synthase/dCMP hydroxymethylase
  • Thymidylate synthase-complementing protein Thy1
  • TolA/TonB C-terminal domain
  • Transcription factor NusA, N-terminal domain
  • Transcriptional factor tubby, C-terminal domain
  • Transcription-state regulator AbrB, the N-terminal DNA recognition domain
  • Translation initiation factor eIF4e
  • Type 1 cytotoxic necrotizing factor, catalytic domain
  • UBC-like
  • Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
  • Urease, gamma-subunit
  • Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
  • VSV matrix protein
  • YbaB-like
  • Yest killer toxins
  • YggU-like
  • YlxR-like
  • YopH tyrosine phosphatase N-terminal domain
  • YrdC/RibB
  • Zincin-like


    Clicking on the HCA plots will open the relevant PDB entry
    Class a: All alpha proteins Class e: Multi-domain proteins (alpha and beta) Class i: Low resolution protein structures
    Class b: All beta proteins Class f: Membrane and cell surface proteins and peptides Class j: Peptides
    Class c: Alpha and beta proteins (a/b) Class g: Small proteins Class k: Designed proteins
    Class d: Alpha and beta proteins (a+b) Class h: Coiled coil proteins