Class a: All alpha proteins Class e: Multi-domain proteins (alpha and beta) Class i: Low resolution protein structures
Class b: All beta proteins Class f: Membrane and cell surface proteins and peptides Class j: Peptides
Class c: Alpha and beta proteins (a/b) Class g: Small proteins Class k: Designed proteins
Class d: Alpha and beta proteins (a+b) Class h: Coiled coil proteins SCOP Classes with more than 5 compatible hydrophobic patterns

SCOP folds with >5 compatible HCA patterns



Ribosome complexes 51 patterns
Transmembrane helical fragments 28 patterns
Large subunit 27 patterns
I set domains 26 patterns
Tyrosine-dependent oxidoreductases 24 patterns
Phosphate binding protein-like 21 patterns
Viruses and virus-receptor complexes 20 patterns
Amylase, catalytic domain 18 patterns
G proteins 18 patterns
Fibronectin type III 17 patterns
alpha-Amylases, C-terminal beta-sheet domain 17 patterns
RNA polymerase 17 patterns
Short-chain scorpion toxins 16 patterns
monodomain cytochrome c 16 patterns
Cold shock DNA-binding domain-like 15 patterns
Class I aminoacyl-tRNA synthetases (RS), catalytic domain 15 patterns
Nucleotide and nucleoside kinases 15 patterns
C-type lectin domain 15 patterns
EGF-type module 15 patterns
Spider toxins 15 patterns
Classic zinc finger, C2H2 15 patterns
beta-glycanases 14 patterns
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 14 patterns
Pleckstrin-homology domain (PH domain) 13 patterns
Extended AAA-ATPase domain 13 patterns
Ribonuclease A-like 13 patterns
Retinol binding protein-like 12 patterns
N-acetyl transferase, NAT 12 patterns
MHC antigen-recognition domain 12 patterns
Canonical RBD 12 patterns
SH2 domain 12 patterns
Snake venom toxins 12 patterns
Defensin 12 patterns
Glutathione S-transferase (GST), C-terminal domain 11 patterns
Single strand DNA-binding domain, SSB 11 patterns
Eukaryotic proteases 11 patterns
Aminoacid dehydrogenase-like, C-terminal domain 11 patterns
FAD-linked reductases, N-terminal domain 11 patterns
RecA protein-like (ATPase-domain) 11 patterns
Thioltransferase 11 patterns
Glutathione S-transferase (GST), N-terminal domain 11 patterns
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalyic domain 11 patterns
beta-Lactamase/D-ala carboxypeptidase 11 patterns
Leucine zipper domain 11 patterns
Cytochrome P450 10 patterns
Long-chain cytokines 10 patterns
Short-chain cytokines 10 patterns
Calmodulin-like 10 patterns
Class I aldolase 10 patterns
6-phosphogluconate dehydrogenase-like, N-terminal domain 10 patterns
GABA-aminotransferase-like 10 patterns
L-arabinose binding protein-like 10 patterns
Conotoxin 10 patterns
Globins 9 patterns
Plastocyanin/azurin-like 9 patterns
TBP-associated factors, TAFs 9 patterns
Picornaviridae-like VP (VP1, VP2, VP3 and VP4) 9 patterns
SH3-domain 9 patterns
FMN-linked oxidoreductases 9 patterns
Alcohol dehydrogenase-like, C-terminal domain 9 patterns
Nitrogenase iron protein-like 9 patterns
Protein kinases, catalytic subunit 9 patterns
Proteasome subunits 9 patterns
Animal Kazal-type inhibitors 9 patterns
RING finger domain, C3HC4 9 patterns
Tetratricopeptide repeat (TPR) 8 patterns
Di-heme elbow motif 8 patterns
Homeodomain 8 patterns
E-set domains of sugar-utilizing enzymes 8 patterns
Alcohol dehydrogenase-like, N-terminal domain 8 patterns
PDZ domain 8 patterns
Formate/glycerate dehydrogenases, NAD-domain 8 patterns
Thioltransferase 0 8 patterns
Phosphoribosyltransferases (PRTases) 8 patterns
2Fe-2S ferredoxin domains from multidomain proteins 8 patterns
Ankyrin repeat 8 patterns
Papain-like 8 patterns
Interleukin 8-like chemokines 8 patterns
Metallothionein 8 patterns
Peptide hormones 8 patterns
Nuclear receptor ligand-binding domain 7 patterns
Cytochrome c3-like 7 patterns
Ribonucleotide reductase-like 7 patterns
Interferons/interleukin-10 (IL-10) 7 patterns
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 7 patterns
Superantigen toxins, N-terminal domain 7 patterns
Elongation factors 7 patterns
WD40-repeat 7 patterns
WW domain 7 patterns
Germine/Seed storage 7S protein 7 patterns
Type II chitinase 7 patterns
FAD/NAD-linked reductases, N-terminal and central domains 7 patterns
ABC transporter ATPase domain-like 7 patterns
Tandem AAA-ATPase domain 7 patterns
DnaQ-like 3'-5' exonuclease 7 patterns
AAT-like 7 patterns
Superantigen toxins, C-terminal domain 7 patterns
Enolase N-terminal domain-like 7 patterns
FAD/NAD-linked reductases, dimerisation (C-terminal) domain 7 patterns
LDL receptor-like module 7 patterns
Long-chain scorpion toxins 7 patterns
Small Kunitz-type ihibitors & BPTI-like toxins 7 patterns
SNARE fusion complex 7 patterns
Small subunit 7 patterns
alpha-conotoxin 7 patterns
Ferritin 6 patterns
DEATH domain, DD 6 patterns
DBL homology domain (DH-domain) 6 patterns
Tombusviridae-like VP 6 patterns
Rieske iron-sulfur protein (ISP) 6 patterns
Bacterial AB5 toxins, B-subunits 6 patterns
Prokaryotic proteases 6 patterns
Multidomain cupredoxins 6 patterns
D-glucarate dehydratase-like 6 patterns
LDH N-terminal domain-like 6 patterns
Class I glutamine amidotransferases (GAT) 6 patterns
N-type ATP pyrophosphatases 6 patterns
Purine and uridine phosphorylases 6 patterns
Cystathionine synthase-like 6 patterns
Tryptophan synthase beta subunit-like PLP-dependent enzymes 6 patterns
ADP-ribosylating toxins 6 patterns
Inositol monophosphatase/fructose-1,6-bisphosphatase-like 6 patterns
Complement control module/SCR domain 6 patterns
Plant defensins 6 patterns
Zn2/Cys6 DNA-binding domain 6 patterns
Virus ectodomain 6 patterns
Recombinase DNA-binding domain 5 patterns
Retrovirus capsid protein, N-terminal core domain 5 patterns
Regulator of G-protein signalling, RGS 5 patterns
C2 set domains 5 patterns
Viral proteases 5 patterns
Pepsin-like 5 patterns
Phosphotyrosine-binding domain (PTB) 5 patterns
Fatty acid binding protein-like 5 patterns
Sialidases (neuraminidases) 5 patterns
PLC-like (P variant) 5 patterns
Biotinyl/lipoyl-carrier proteins and domains 5 patterns
Aldo-keto reductases (NADP) 5 patterns
Formate/glycerate dehydrogenases, substrate-binding domain 5 patterns
Adenylyltransferase 5 patterns
Dual specificity phosphatase-like 5 patterns
Actin/HSP70 5 patterns
Bacterial dinuclear zinc exopeptidases 5 patterns
MurCDEF C-terminal domain 5 patterns
MurCDEF 5 patterns
ALDH-like 5 patterns
MutT-like 5 patterns
Ribonuclease Rh-like 5 patterns
GHMP Kinase, N-terminal domain 5 patterns
2Fe-2S ferredoxin-related 5 patterns
Class II glutamine amidotransferases 5 patterns
NTF2-like 5 patterns
FKBP immunophilin/proline isomerase 5 patterns
Eukaryotic type KH-domain (KH-domain type I) 5 patterns
Ferredoxin domains from multidomain proteins 5 patterns
Dihydrodipicolinate reductase-like 5 patterns
Kringle modules 5 patterns
Bowman-Birk inhibitor, BBI 5 patterns
Plant inhibitors of proteinases and amylases 5 patterns
HIPIP (high potential iron protein) 5 patterns
Retrovirus zinc finger-like domains 5 patterns
Heat-stable enterotoxin (HSE) 5 patterns


Class a: All alpha proteins Class e: Multi-domain proteins (alpha and beta) Class i: Low resolution protein structures
Class b: All beta proteins Class f: Membrane and cell surface proteins and peptides Class j: Peptides
Class c: Alpha and beta proteins (a/b) Class g: Small proteins Class k: Designed proteins
Class d: Alpha and beta proteins (a+b) Class h: Coiled coil proteins SCOP Classes with more than 5 compatible hydrophobic patterns