β‑Cryptoxanthin Induces UCP‑1
Expression via a RAR Pathway in Adipose Tissue
Posted on 2019-09-11 - 18:37
While
β-cryptoxanthin is hypothesized to have a preventive
effect on lifestyle-related diseases, its underlying mechanisms are
unknown. We investigated the effect of β-cryptoxanthin on energy
metabolism in adipose tissues and its underlying mechanism. C57BL/6J
mice were fed a high-fat diet (60% kcal fat) containing 0 or 0.05%
β-cryptoxanthin for 12 weeks. β-cryptoxanthin treatment
was found to reduce body fat gain and plasma glucose level, while
increasing energy expenditure. The expression of uncoupling protein
(UCP) 1 was elevated in adipose tissues in the treatment group. Furthermore,
the in vivo assays showed that the Ucp1 mRNA expression
was higher in the β-cryptoxanthin treatment group, an effect
that disappeared upon cotreatment with a retinoic acid receptor (RAR)
antagonist. In conclusion, we report that β-cryptoxanthin reduces
body fat and body weight gain and that β-cryptoxanthin increases
the expression of UCP1 via the RAR pathway.
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Hara, Hideyuki; Takahashi, Haruya; Mohri, Shinsuke; Murakami, Hiroki; Kawarasaki, Satoko; Iwase, Mari; et al. (2019). β‑Cryptoxanthin Induces UCP‑1
Expression via a RAR Pathway in Adipose Tissue. ACS Publications. Collection. https://doi.org/10.1021/acs.jafc.9b01930
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AUTHORS (10)
HH
Hideyuki Hara
HT
Haruya Takahashi
SM
Shinsuke Mohri
HM
Hiroki Murakami
SK
Satoko Kawarasaki
MI
Mari Iwase
NT
Nobuyuki Takahashi
MS
Minoru Sugiura
TG
Tsuyoshi Goto
TK
Teruo Kawada