Wide-field quantitative micro-elastography of human breast tissue
Posted on 2018-02-09 - 15:55
Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to insufficient surgical margins in the initial procedure. We have developed a wide-field quantitative micro-elastography system for the assessment of tumor margins. In this technique, we map tissue elasticity over a field-of-view of ~46 × 46 mm. We performed wide-field quantitative micro-elastography on thirteen specimens of freshly excised tissue acquired from patients undergoing mastectomy. We present wide-field optical coherence tomography (OCT) images, qualitative (strain) micro-elastograms and quantitative (elasticity) micro-elastograms, acquired in 10 minutes. We demonstrate, for the first time, that wide-field quantitative micro-elastography can extend the range of tumors visible using OCT-based elastography by providing contrast not present in either OCT or qualitative micro-elastography and, in addition, can reduce imaging artifacts caused by a lack of contact between tissue and the imaging window. Also, we describe how the combined evaluation of OCT, qualitative micro-elastograms and quantitative micro-elastograms can improve the visualization of tumor.
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Allen, Wes; Kennedy, Kelsey; Fang, Qi; Chin, Lixin; Curatolo, Andrea; Zilkens, Renate; et al. (2018). Wide-field quantitative micro-elastography of human breast tissue. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.3950623.v1
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AUTHORS (10)
WA
Wes Allen
KK
Kelsey Kennedy
QF
Qi Fang
LC
Lixin Chin
AC
Andrea Curatolo
RZ
Renate Zilkens
SC
Synn Lynn Chin
BD
Benjamin Dessauvagie
BL
Bruce Latham
CS
Christobel Saunders