Walrobsins A and B, Two Anti-inflammatory Limonoids
from Root Barks of Walsura robusta

Luo, Jun

Walrobsins A and B, Two Anti-inflammatory Limonoids from Root Barks of Walsura robusta

Posted on 2017-08-18 - 18:48

Walrobsins A (1) and B (2), two limonoids featuring an unprecedented 5-oxatricyclo[5.4.1^1,4]hendecane ring system, were isolated from the root barks of Walsura robusta. Their structures, including their absolute configurations, were determined by analyses of HR-ESIMS, 1D/2D NMR, and X-ray crystallography. Compounds 1 and 2 possessed a stable hemiketal structure formed between the OH-11 and 3-carbonyl group in the hexatomic oxoheterocyclic ring. Compound 1 showed significant anti-inflammatory activity with an IC₅₀ value of 7.8 μM and inhibited the expression of iNOS and IL-1β in a dose-dependent manner.

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An, Fa-Liang; Sun, Dong-Mei; Li, Rui-Jun; Zhou, Miao-Miao; Yang, Ming-Hua; Yin, Yong; et al. (2017). Walrobsins A and B, Two Anti-inflammatory Limonoids from Root Barks of Walsura robusta. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.7b02173

https://doi.org/10.1021/acs.orglett.7b02173

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