Trichloroisocyanuric Acid Promoted Cascade Cyclization/Trifluoromethylation
of Allylic Oximes: Synthesis of Trifluoromethylated Isoxazolines

Hu, Yulai

Trichloroisocyanuric Acid Promoted Cascade Cyclization/Trifluoromethylation of Allylic Oximes: Synthesis of Trifluoromethylated Isoxazolines

Posted on 2017-01-09 - 05:29

Cheap and commercially available trichloroisocyanuric acid has been used to promote trifluoromethylation by using TMSCF₃ as the trifluoromethyl source. The method provides a novel and efficient protocol for the construction of CF₃-containing 4,5-dihydroisoxazoles from allylic oximes in good to excellent yields.

CITE THIS COLLECTION

Zhang, Weigang; Su, Yingpeng; Wang, Ke-Hu; Wu, Lili; Chang, Bingbing; Shi, Ya; et al. (2017). Trichloroisocyanuric Acid Promoted Cascade Cyclization/Trifluoromethylation of Allylic Oximes: Synthesis of Trifluoromethylated Isoxazolines. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.6b03582

https://doi.org/10.1021/acs.orglett.6b03582

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