Total Synthesis of Iheyamine
A via the Cyanide-Catalyzed
Imino-Stetter Reaction
Posted on 2020-06-01 - 13:03
The total synthesis of iheyamine
A from readily available ethyl
2-aminocinnamate and 5-methoxyindole-2-carboxaldehyde is described.
The cyanide-catalyzed imino-Stetter reaction of an aldimine derived
from ethyl 2-aminocinnamate and 5-methoxyindole-2-carboxaldehyde provided
the desired unsymmetrical 2,2′-bisindole-3-acetic acid derivative.
The subsequent introduction of an amino group at the C-3′ position,
followed by the formation of the azepine ring, completed the total
synthesis of iheyamine A.
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Jeon, Jiye; Kim, Hyung Joo; Cheon, Cheol-Hong (2020). Total Synthesis of Iheyamine
A via the Cyanide-Catalyzed
Imino-Stetter Reaction. ACS Publications. Collection. https://doi.org/10.1021/acs.joc.0c01051
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AUTHORS (3)
JJ
Jiye Jeon
HK
Hyung Joo Kim
CC
Cheol-Hong Cheon