Total Synthesis of (−)-Hippodamine by Stereocontrolled Construction of Azaphenalene Skeleton Based on Extended One-Pot Asymmetric Azaelectrocyclization

Katsumura, Shigeo

Total Synthesis of (−)-Hippodamine by Stereocontrolled Construction of Azaphenalene Skeleton Based on Extended One-Pot Asymmetric Azaelectrocyclization

Posted on 2013-06-07 - 00:00

The first asymmetric total synthesis of (−)-hippodamine has been accomplished via the concise construction of its azaphenalene core, which is featured by the 2,4,6-chiral piperidine synthesis based on one-pot asymmetric azaelectrocyclization in the partially activated substituent system and the subsequent intramolecular Mannich reaction.

CITE THIS COLLECTION

Fujita, Shintaro; Sakaguchi, Taku; Kobayashi, Toyoharu; Tsuchikawa, Hiroshi; Katsumura, Shigeo (2016). Total Synthesis of (−)-Hippodamine by Stereocontrolled Construction of Azaphenalene Skeleton Based on Extended One-Pot Asymmetric Azaelectrocyclization. ACS Publications. Collection. https://doi.org/10.1021/ol4010917

https://doi.org/10.1021/ol4010917

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