Total Synthesis and Biological Activity of the Arachidonic
Acid Metabolite Hemiketal E2

Sulikowski, Gary A.

Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal E₂

Posted on 2018-06-18 - 21:43

The total synthesis of hemiketal E₂ (HKE₂) has been accomplished using a gold(I)-mediated cycloisomerization followed by oxidation of the enol ether product to introduce a unique keto-hemiketal, the core structure of HKE₂. Synthetic hemiketal E₂ reproduced biosynthetically derived HKE₂ in the inhibition of human platelet aggregation.

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Boer, Robert E.; Giménez-Bastida, Juan Antonio; Boutaud, Olivier; Jana, Somnath; Schneider, Claus; Sulikowski, Gary A. (2018). Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal E₂. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.8b01578

https://doi.org/10.1021/acs.orglett.8b01578

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